Best TWAS P=5.61e-08 · Best GWAS P=7.57e-08 conditioned to 0.365
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Coronary | OIP5-AS1 | 0.12 | 0.13 | lasso | 2 | 0.14 | 2.3e-05 | 5.2 | 5.2 | 1.8e-07 | 0.73 | 0.06 | 0.90 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | NUSAP1 | 0.31 | 0.38 | lasso | 9 | 0.40 | 1.1e-12 | 4.9 | 5.1 | 3.0e-07 | 0.77 | 0.06 | 0.94 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | NDUFAF1 | 0.20 | 0.23 | lasso | 6 | 0.22 | 2.2e-06 | 5.1 | -5.3 | 1.5e-07 | -0.76 | 0.05 | 0.94 | FALSE |
4 | GTEx | Brain Frontal Cortex BA9 | NDUFAF1 | 0.55 | 0.37 | lasso | 8 | 0.40 | 1.6e-11 | 5.1 | -5.2 | 1.7e-07 | -0.73 | 0.05 | 0.95 | FALSE |
5 | GTEx | Brain Nucleus accumbens basal ganglia | NDUFAF1 | 0.12 | 0.11 | lasso | 6 | 0.10 | 9.7e-04 | 5.1 | -5.2 | 1.7e-07 | -0.71 | 0.06 | 0.82 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | CHP1 | 0.13 | 0.11 | lasso | 6 | 0.11 | 2.1e-08 | 5.2 | -5.4 | 5.6e-08 | -0.93 | 0.04 | 0.96 | TRUE |
7 | GTEx | Cells Transformed fibroblasts | OIP5-AS1 | 0.28 | 0.32 | lasso | 2 | 0.32 | 3.5e-24 | 5.1 | 5.2 | 2.2e-07 | 0.72 | 0.03 | 0.96 | FALSE |
8 | GTEx | Colon Sigmoid | OIP5-AS1 | 0.21 | 0.27 | lasso | 3 | 0.25 | 3.3e-09 | 5.1 | 5.2 | 1.8e-07 | 0.75 | 0.07 | 0.92 | FALSE |
9 | GTEx | Heart Atrial Appendage | NDUFAF1 | 0.36 | 0.28 | enet | 24 | 0.34 | 9.5e-16 | 5.0 | -5.4 | 5.8e-08 | -0.72 | 0.04 | 0.96 | FALSE |
10 | GTEx | Heart Atrial Appendage | RTF1 | 0.14 | 0.07 | lasso | 4 | 0.08 | 2.4e-04 | 5.4 | -5.3 | 1.2e-07 | -0.99 | 0.02 | 0.95 | FALSE |
11 | GTEx | Heart Left Ventricle | NDUFAF1 | 0.49 | 0.62 | lasso | 8 | 0.62 | 2.0e-41 | 5.2 | -5.2 | 1.9e-07 | -0.74 | 0.04 | 0.96 | FALSE |
12 | GTEx | Nerve Tibial | NUSAP1 | 0.15 | 0.09 | enet | 10 | 0.15 | 9.8e-11 | 5.0 | 5.3 | 1.0e-07 | 0.84 | 0.08 | 0.92 | FALSE |
13 | GTEx | Nerve Tibial | OIP5-AS1 | 0.20 | 0.22 | enet | 21 | 0.26 | 1.3e-18 | 5.2 | 5.3 | 1.4e-07 | 0.72 | 0.05 | 0.95 | FALSE |
14 | GTEx | Pancreas | NDUFAF1 | 0.41 | 0.39 | enet | 20 | 0.42 | 2.7e-19 | 5.1 | 5.4 | 7.3e-08 | 0.74 | 0.04 | 0.95 | FALSE |
15 | GTEx | Prostate | NDUFAF1 | 0.30 | 0.12 | lasso | 2 | 0.14 | 2.7e-04 | 5.1 | 5.3 | 1.1e-07 | 0.87 | 0.04 | 0.84 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | OIP5-AS1 | 0.13 | 0.17 | lasso | 3 | 0.23 | 5.0e-19 | 4.8 | 5.1 | 3.0e-07 | 0.79 | 0.16 | 0.83 | FALSE |
17 | GTEx | Thyroid | OIP5 | 0.06 | 0.03 | lasso | 5 | 0.02 | 1.1e-02 | 5.0 | 5.4 | 7.9e-08 | 0.75 | 0.07 | 0.84 | FALSE |
18 | GTEx | Thyroid | NDUFAF1 | 0.25 | 0.21 | lasso | 6 | 0.22 | 9.3e-17 | 5.0 | 5.2 | 2.5e-07 | 0.79 | 0.05 | 0.95 | FALSE |