Best TWAS P=1.63e-11 · Best GWAS P=1.03e-09 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ABHD12 | 0.10 | 0.17 | blup | 405 | 0.17 | 1.7e-20 | 5.7 | 6.6 | 3.4e-11 | 0.77 | 0.08 | 0.92 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | NINL | 0.19 | 0.17 | lasso | 20 | 0.23 | 1.2e-27 | 5.6 | 6.7 | 1.6e-11 | 0.83 | 0.09 | 0.91 | TRUE |
3 | CommonMind | Brain Pre-frontal Cortex | PYGB | 0.10 | 0.05 | lasso | 3 | 0.05 | 6.9e-07 | 4.8 | -5.3 | 1.5e-07 | -0.48 | 0.32 | 0.65 | FALSE |
4 | GTEx | Adipose Visceral Omentum | ABHD12 | 0.06 | 0.00 | lasso | 8 | 0.00 | 4.6e-01 | 5.6 | 5.8 | 6.5e-09 | 0.65 | 0.09 | 0.63 | FALSE |
5 | GTEx | Artery Aorta | NINL | 0.17 | 0.18 | lasso | 6 | 0.19 | 1.5e-10 | 5.6 | 6.2 | 7.5e-10 | 0.80 | 0.09 | 0.91 | FALSE |
6 | GTEx | Artery Tibial | ABHD12 | 0.12 | 0.12 | enet | 25 | 0.15 | 7.1e-12 | 5.4 | 5.6 | 2.0e-08 | 0.78 | 0.14 | 0.86 | FALSE |
7 | GTEx | Brain Caudate basal ganglia | ABHD12 | 0.09 | 0.05 | enet | 13 | 0.04 | 2.9e-02 | 5.6 | 5.7 | 1.1e-08 | 0.80 | 0.09 | 0.74 | FALSE |
8 | GTEx | Brain Cerebellar Hemisphere | PYGB | 0.20 | 0.16 | lasso | 5 | 0.12 | 5.8e-04 | 5.3 | -5.2 | 2.4e-07 | -0.65 | 0.09 | 0.73 | FALSE |
9 | GTEx | Brain Cerebellar Hemisphere | ENTPD6 | 0.22 | 0.26 | lasso | 3 | 0.17 | 3.8e-05 | 5.3 | -5.3 | 1.0e-07 | -0.77 | 0.14 | 0.85 | FALSE |
10 | GTEx | Brain Cortex | ABHD12 | 0.08 | 0.11 | lasso | 8 | 0.09 | 1.4e-03 | 5.8 | 5.4 | 6.3e-08 | 0.78 | 0.07 | 0.74 | FALSE |
11 | GTEx | Breast Mammary Tissue | ABHD12 | 0.08 | 0.09 | lasso | 5 | 0.09 | 3.3e-05 | 5.6 | 5.8 | 6.6e-09 | 0.69 | 0.12 | 0.83 | FALSE |
12 | GTEx | Breast Mammary Tissue (Male) | ABHD12 | 0.06 | 0.01 | lasso | 3 | 0.02 | 1.3e-01 | 4.8 | 5.6 | 2.8e-08 | 0.44 | 0.05 | 0.18 | FALSE |
13 | GTEx | Cells EBV-transformed lymphocytes | PYGB | 0.38 | 0.08 | lasso | 5 | 0.06 | 7.0e-03 | 5.3 | 5.3 | 1.3e-07 | 0.65 | 0.10 | 0.77 | FALSE |
14 | GTEx | Cells Transformed fibroblasts | ABHD12 | 0.24 | 0.33 | lasso | 4 | 0.35 | 6.3e-27 | 5.7 | 5.8 | 7.3e-09 | 0.81 | 0.09 | 0.91 | FALSE |
15 | GTEx | Colon Sigmoid | ABHD12 | 0.17 | 0.17 | lasso | 15 | 0.17 | 1.0e-06 | 5.3 | 5.3 | 9.5e-08 | 0.76 | 0.12 | 0.87 | FALSE |
16 | GTEx | Esophagus Gastroesophageal Junction | ABHD12 | 0.15 | 0.14 | lasso | 13 | 0.14 | 7.0e-06 | 5.2 | 5.1 | 2.8e-07 | 0.74 | 0.09 | 0.91 | FALSE |
17 | GTEx | Heart Atrial Appendage | ABHD12 | 0.07 | 0.06 | enet | 16 | 0.06 | 1.0e-03 | 5.8 | 5.6 | 2.2e-08 | 0.81 | 0.08 | 0.90 | FALSE |
18 | GTEx | Heart Left Ventricle | ABHD12 | 0.15 | 0.14 | lasso | 10 | 0.12 | 4.0e-07 | 5.8 | 6.1 | 1.3e-09 | 0.82 | 0.07 | 0.93 | FALSE |
19 | GTEx | Heart Left Ventricle | NINL | 0.08 | 0.03 | enet | 11 | 0.05 | 1.1e-03 | 5.4 | 5.3 | 1.5e-07 | 0.69 | 0.24 | 0.61 | FALSE |
20 | GTEx | Liver | ABHD12 | 0.20 | 0.20 | lasso | 19 | 0.15 | 7.3e-05 | 5.7 | 5.7 | 1.2e-08 | 0.81 | 0.09 | 0.91 | FALSE |
21 | GTEx | Lung | ABHD12 | 0.06 | 0.00 | lasso | 6 | 0.00 | 2.7e-01 | 5.6 | 6.1 | 8.5e-10 | 0.54 | 0.11 | 0.69 | TRUE |
22 | GTEx | Nerve Tibial | ABHD12 | 0.24 | 0.44 | lasso | 11 | 0.44 | 5.1e-34 | 5.7 | -5.6 | 2.4e-08 | -0.81 | 0.08 | 0.92 | FALSE |
23 | GTEx | Pancreas | ENTPD6 | 0.11 | 0.05 | enet | 23 | 0.05 | 5.0e-03 | 5.6 | -6.2 | 7.3e-10 | -0.58 | 0.09 | 0.84 | FALSE |
24 | GTEx | Pituitary | ABHD12 | 0.27 | 0.31 | enet | 25 | 0.31 | 1.8e-08 | 5.7 | 6.2 | 4.2e-10 | 0.77 | 0.09 | 0.91 | FALSE |
25 | GTEx | Skin Sun Exposed Lower leg | ABHD12 | 0.07 | 0.03 | lasso | 10 | 0.05 | 7.3e-05 | 4.8 | 5.9 | 3.4e-09 | 0.72 | 0.16 | 0.82 | FALSE |
26 | GTEx | Spleen | PYGB | 0.15 | 0.09 | lasso | 6 | 0.04 | 2.6e-02 | 5.7 | 5.3 | 1.3e-07 | 0.84 | 0.09 | 0.81 | FALSE |
27 | GTEx | Testis | ABHD12 | 0.21 | 0.18 | enet | 25 | 0.23 | 1.1e-10 | 5.7 | 5.9 | 2.9e-09 | 0.71 | 0.08 | 0.92 | FALSE |
28 | GTEx | Thyroid | ABHD12 | 0.05 | 0.04 | lasso | 5 | 0.03 | 3.9e-03 | 5.7 | -5.7 | 1.0e-08 | -0.80 | 0.08 | 0.89 | FALSE |
29 | GTEx | Thyroid | NINL | 0.13 | 0.18 | enet | 17 | 0.20 | 6.2e-15 | -3.6 | -5.6 | 1.9e-08 | -0.72 | 0.50 | 0.50 | FALSE |
30 | ROSMAP | Brain Pre-frontal Cortex | PYGB | 0.20 | 0.10 | bslmm | 414 | 0.11 | 3.2e-14 | 5.5 | -5.8 | 6.0e-09 | -0.66 | 0.12 | 0.88 | TRUE |
31 | ROSMAP | Brain Pre-frontal Cortex | ABHD12 | 0.26 | 0.35 | enet | 35 | 0.42 | 7.9e-58 | 5.4 | 5.9 | 4.3e-09 | 0.69 | 0.11 | 0.89 | FALSE |
32 | ROSMAP | Brain Pre-frontal Cortex | NINL | 0.19 | 0.19 | enet | 18 | 0.25 | 2.1e-32 | 5.7 | 5.4 | 7.9e-08 | 0.81 | 0.08 | 0.92 | FALSE |
33 | ROSMAP | Brain Pre-frontal Cortex | ENTPD6 | 0.32 | 0.10 | bslmm | 432 | 0.12 | 1.8e-15 | 5.6 | 6.7 | 2.3e-11 | 0.23 | 0.12 | 0.88 | TRUE |
34 | YFS | Blood | ABHD12 | 0.15 | 0.35 | bslmm | 390 | 0.34 | 2.2e-118 | 5.8 | 6.0 | 1.6e-09 | 0.83 | 0.07 | 0.93 | TRUE |
35 | YFS | Blood | NINL | 0.04 | 0.03 | lasso | 8 | 0.03 | 2.8e-10 | 5.7 | 5.6 | 2.0e-08 | 0.60 | 0.09 | 0.91 | FALSE |
36 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ABHD12 | 0.04 | 0.00 | blup | 77 | 0.02 | 6.6e-03 | 5.7 | 5.2 | 1.6e-07 | 0.85 | 0.04 | 0.53 | FALSE |
37 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PYGB | 0.08 | 0.02 | enet | 7 | 0.03 | 1.7e-07 | 5.4 | -5.2 | 1.7e-07 | -0.51 | 0.20 | 0.79 | FALSE |
38 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PYGB | 0.08 | 0.04 | blup | 74 | 0.06 | 1.0e-03 | 5.7 | -5.8 | 5.0e-09 | -0.69 | 0.04 | 0.86 | FALSE |
39 | The Cancer Genome Atlas | Colon Adenocarcinoma | NINL | 0.20 | 0.06 | lasso | 4 | 0.08 | 2.7e-05 | 4.7 | 5.7 | 1.1e-08 | 0.76 | 0.03 | 0.94 | FALSE |
40 | The Cancer Genome Atlas | Glioblastoma Multiforme | ABHD12 | 0.14 | 0.10 | lasso | 5 | 0.13 | 1.1e-04 | 5.3 | 5.6 | 2.8e-08 | 0.77 | 0.06 | 0.88 | TRUE |
41 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ABHD12 | 0.04 | 0.03 | blup | 77 | 0.04 | 4.0e-05 | 5.8 | 5.6 | 2.3e-08 | 0.86 | 0.06 | 0.94 | FALSE |
42 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ABHD12 | 0.03 | 0.01 | blup | 77 | 0.01 | 8.7e-03 | 4.0 | 5.7 | 9.5e-09 | 0.67 | 0.07 | 0.73 | FALSE |
43 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ABHD12 | 0.04 | 0.06 | blup | 77 | 0.06 | 2.2e-07 | 5.7 | 5.9 | 3.7e-09 | 0.83 | 0.06 | 0.93 | FALSE |
44 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABHD12 | 0.07 | 0.05 | blup | 77 | 0.05 | 2.4e-03 | 5.7 | 5.5 | 4.6e-08 | 0.77 | 0.05 | 0.83 | FALSE |
45 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ABHD12 | 0.08 | 0.09 | blup | 80 | 0.09 | 1.7e-06 | 5.7 | 5.6 | 2.4e-08 | 0.82 | 0.06 | 0.94 | FALSE |
46 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ENTPD6 | 0.07 | 0.07 | lasso | 1 | 0.04 | 9.2e-03 | 5.3 | -5.3 | 1.3e-07 | -0.77 | 0.03 | 0.68 | FALSE |
47 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ABHD12 | 0.03 | 0.02 | lasso | 4 | 0.03 | 5.8e-04 | -5.1 | 5.3 | 9.5e-08 | 0.71 | 0.07 | 0.74 | FALSE |
48 | The Cancer Genome Atlas | Thyroid Carcinoma | ENTPD6 | 0.16 | 0.14 | lasso | 4 | 0.13 | 1.2e-12 | 5.3 | -5.2 | 2.0e-07 | -0.76 | 0.04 | 0.96 | FALSE |
49 | The Cancer Genome Atlas | Thyroid Carcinoma | NINL | 0.08 | 0.14 | lasso | 11 | 0.13 | 2.9e-12 | 5.7 | -5.5 | 3.4e-08 | -0.80 | 0.03 | 0.97 | FALSE |
50 | The Cancer Genome Atlas | Thyroid Carcinoma | PYGB | 0.10 | 0.08 | lasso | 7 | 0.07 | 1.4e-07 | 4.7 | -5.5 | 4.9e-08 | -0.44 | 0.47 | 0.53 | FALSE |