Best TWAS P=4.23e-08 · Best GWAS P=1.07e-07 conditioned to 0.00771
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MEI1 | 0.09 | 0.10 | blup | 343 | 0.10 | 3.1e-12 | 4.0 | 5.2 | 1.6e-07 | -0.60 | 0.36 | 0.57 | FALSE |
| 2 | GTEx | Artery Tibial | ACO2 | 0.06 | 0.02 | enet | 15 | 0.06 | 1.2e-05 | 4.5 | 5.4 | 7.0e-08 | -0.60 | 0.09 | 0.89 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | CYP2D7P1 | 0.32 | 0.00 | lasso | 8 | 0.02 | 9.7e-02 | 3.7 | -5.5 | 4.2e-08 | 0.29 | 0.01 | 0.03 | TRUE |
| 4 | GTEx | Nerve Tibial | ACO2 | 0.06 | 0.05 | lasso | 5 | 0.04 | 8.5e-04 | 4.7 | 5.4 | 5.8e-08 | -0.48 | 0.06 | 0.91 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | POLR3H | 0.04 | 0.04 | blup | 22 | 0.04 | 6.8e-05 | 4.7 | -5.2 | 1.5e-07 | 0.32 | 0.04 | 0.92 | FALSE |