Best TWAS P=5.63e-14 · Best GWAS P=1.3e-11 conditioned to 0.0652
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | BAIAP2L2 | 0.11 | 0.03 | lasso | 5 | 0.04 | 1.8e-04 | 5.4 | -6.3 | 2.2e-10 | -0.71 | 0.03 | 0.87 | FALSE |
2 | GTEx | Adipose Subcutaneous | TMEM184B | 0.08 | 0.08 | lasso | 4 | 0.07 | 1.0e-06 | 4.4 | -5.2 | 2.3e-07 | -0.59 | 0.80 | 0.16 | FALSE |
3 | GTEx | Artery Aorta | C22orf23 | 0.10 | 0.01 | enet | 24 | 0.02 | 1.6e-02 | 3.2 | 5.9 | 4.4e-09 | 0.34 | 0.25 | 0.10 | FALSE |
4 | GTEx | Artery Aorta | PLA2G6 | 0.10 | 0.02 | enet | 9 | 0.02 | 4.5e-02 | 4.2 | 6.8 | 7.5e-12 | 0.68 | 0.08 | 0.59 | FALSE |
5 | GTEx | Artery Aorta | TMEM184B | 0.17 | 0.07 | enet | 34 | 0.03 | 1.2e-02 | 6.1 | -6.7 | 2.0e-11 | -0.68 | 0.05 | 0.76 | FALSE |
6 | GTEx | Artery Aorta | AL021977.1 | 0.13 | 0.00 | enet | 17 | 0.01 | 8.7e-02 | 6.5 | -7.5 | 5.6e-14 | -0.73 | 0.03 | 0.75 | TRUE |
7 | GTEx | Brain Cortex | TMEM184B | 0.29 | 0.12 | lasso | 7 | 0.09 | 1.6e-03 | 6.1 | -6.4 | 1.3e-10 | -0.91 | 0.01 | 0.88 | FALSE |
8 | GTEx | Cells EBV-transformed lymphocytes | PLA2G6 | 0.28 | 0.17 | enet | 13 | 0.18 | 1.3e-06 | -5.9 | 6.3 | 3.7e-10 | 0.69 | 0.24 | 0.63 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | ANKRD54 | 0.11 | 0.09 | lasso | 4 | 0.09 | 5.3e-07 | -5.7 | -5.9 | 4.2e-09 | -0.19 | 0.72 | 0.13 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | PLA2G6 | 0.23 | 0.09 | lasso | 9 | 0.10 | 9.9e-08 | 5.4 | 6.1 | 8.0e-10 | 0.81 | 0.46 | 0.54 | FALSE |
11 | GTEx | Esophagus Gastroesophageal Junction | PLA2G6 | 0.28 | 0.24 | lasso | 5 | 0.23 | 1.1e-08 | -5.9 | 6.2 | 4.8e-10 | 0.64 | 0.49 | 0.44 | FALSE |
12 | GTEx | Esophagus Mucosa | PLA2G6 | 0.22 | 0.02 | lasso | 6 | 0.04 | 1.9e-03 | 5.4 | 6.1 | 8.6e-10 | 0.77 | 0.08 | 0.90 | FALSE |
13 | GTEx | Esophagus Muscularis | PLA2G6 | 0.12 | 0.00 | enet | 18 | 0.01 | 1.4e-01 | 5.4 | 5.9 | 3.0e-09 | 0.62 | 0.08 | 0.33 | FALSE |
14 | GTEx | Esophagus Muscularis | TMEM184B | 0.11 | 0.01 | enet | 10 | 0.06 | 2.7e-04 | 3.2 | -5.6 | 2.2e-08 | -0.60 | 0.25 | 0.24 | FALSE |
15 | GTEx | Muscle Skeletal | ANKRD54 | 0.15 | 0.02 | enet | 21 | 0.04 | 1.1e-04 | -5.7 | -5.6 | 1.7e-08 | -0.15 | 0.79 | 0.11 | FALSE |
16 | GTEx | Muscle Skeletal | DMC1 | 0.13 | 0.01 | enet | 17 | 0.04 | 3.3e-05 | 5.4 | 5.5 | 4.4e-08 | 0.59 | 0.04 | 0.78 | FALSE |
17 | GTEx | Nerve Tibial | PLA2G6 | 0.34 | 0.08 | lasso | 8 | 0.11 | 2.9e-08 | -5.9 | 6.2 | 5.3e-10 | 0.72 | 0.44 | 0.56 | FALSE |
18 | GTEx | Nerve Tibial | MAFF | 0.14 | 0.06 | lasso | 3 | 0.05 | 1.2e-04 | 6.7 | -6.7 | 2.7e-11 | -0.98 | 0.01 | 0.99 | FALSE |
19 | GTEx | Nerve Tibial | AL021977.1 | 0.16 | 0.05 | lasso | 3 | 0.07 | 9.3e-06 | 4.3 | -5.2 | 2.3e-07 | -0.62 | 0.34 | 0.64 | FALSE |
20 | GTEx | Skin Sun Exposed Lower leg | ANKRD54 | 0.07 | 0.04 | enet | 17 | 0.04 | 1.6e-04 | -5.7 | -5.6 | 2.0e-08 | -0.22 | 0.44 | 0.12 | FALSE |
21 | GTEx | Skin Sun Exposed Lower leg | BAIAP2L2 | 0.09 | 0.09 | lasso | 4 | 0.09 | 5.5e-08 | 5.1 | -5.5 | 3.8e-08 | -0.74 | 0.32 | 0.68 | FALSE |
22 | GTEx | Thyroid | PLA2G6 | 0.34 | 0.20 | lasso | 5 | 0.18 | 4.5e-14 | -5.9 | 6.2 | 4.3e-10 | 0.67 | 0.59 | 0.41 | FALSE |
23 | GTEx | Thyroid | TMEM184B | 0.19 | 0.16 | lasso | 7 | 0.18 | 1.0e-13 | 4.4 | -5.7 | 1.2e-08 | -0.67 | 0.99 | 0.01 | FALSE |
24 | GTEx | Thyroid | AL021977.1 | 0.20 | 0.11 | lasso | 6 | 0.12 | 2.7e-09 | 4.3 | -5.9 | 4.9e-09 | -0.66 | 0.92 | 0.08 | FALSE |
25 | ROSMAP | Brain Pre-frontal Cortex | ANKRD54 | 0.03 | 0.00 | blup | 397 | 0.01 | 2.2e-02 | 2.5 | -5.6 | 1.9e-08 | -0.28 | 0.18 | 0.06 | FALSE |
26 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ANKRD54 | 0.20 | 0.06 | lasso | 1 | 0.06 | 3.0e-07 | -5.7 | -5.7 | 1.4e-08 | -0.17 | 0.00 | 1.00 | FALSE |
27 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLA2G6 | 0.05 | 0.01 | blup | 76 | 0.01 | 7.7e-02 | 6.8 | 6.8 | 1.0e-11 | 0.83 | 0.01 | 0.84 | FALSE |
28 | The Cancer Genome Atlas | Thyroid Carcinoma | PLA2G6 | 0.03 | 0.02 | lasso | 2 | 0.03 | 6.5e-04 | 6.1 | 6.1 | 9.3e-10 | 0.81 | 0.06 | 0.43 | FALSE |