TWAS
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Models
Genes
Traits
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Traits
:
Arm fat mass (left)
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chr16:1,381,714-2,713,729
Best TWAS P=1.95e-08 · Best GWAS P=2.19e-09 conditioned to 0.742
1.4M
1.6M
1.8M
2M
2.2M
2.4M
2.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Thyroid Carcinoma
SLC9A3R2
0.06
0.03
lasso
5
0.03
3.7e-04
-4.7
5.6
1.9e-08
-0.59
0.17
0.31
TRUE
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
CASKIN1
0.02
0.00
blup
38
0.01
4.5e-02
4.2
-5.5
4.3e-08
0.45
0.03
0.04
TRUE
1
CommonMind
Brain Pre-frontal Cortex
SLC9A3R2
0.15
0.09
enet
7
0.10
7.8e-12
-4.7
5.3
1.1e-07
-0.58
0.04
0.96
FALSE
2
ROSMAP
Brain Pre-frontal Cortex
SLC9A3R2
0.16
0.11
lasso
6
0.12
6.3e-15
-5.7
5.2
1.5e-07
-0.61
0.01
0.99
FALSE
4
The Cancer Genome Atlas
Thyroid Carcinoma
MLST8
0.09
0.07
enet
8
0.09
9.9e-09
4.7
5.1
2.7e-07
-0.29
0.00
0.99
FALSE