Best TWAS P=8.68e-19 · Best GWAS P=2.74e-26 conditioned to 1.77e-09
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | UBN1 | 0.18 | 0.15 | lasso | 4 | 0.14 | 6.8e-08 | 6.1 | -5.5 | 4.8e-08 | -0.04 | 0.13 | 0.87 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | ZNF500 | 0.27 | 0.13 | enet | 13 | 0.12 | 4.4e-04 | 2.5 | 5.4 | 6.4e-08 | 0.00 | 0.21 | 0.45 | TRUE |
3 | GTEx | Brain Cerebellum | SLX4 | 0.33 | 0.14 | lasso | 3 | 0.10 | 6.8e-04 | 5.2 | -5.3 | 8.6e-08 | -0.01 | 0.16 | 0.05 | FALSE |
4 | GTEx | Brain Frontal Cortex BA9 | NLRC3 | 0.50 | 0.18 | enet | 30 | 0.33 | 1.6e-09 | 2.7 | -5.7 | 1.2e-08 | 0.03 | 0.44 | 0.06 | TRUE |
5 | GTEx | Brain Hippocampus | CLUAP1 | 0.37 | 0.10 | lasso | 5 | 0.09 | 4.9e-03 | 4.5 | 5.4 | 5.7e-08 | 0.02 | 0.17 | 0.06 | FALSE |
6 | GTEx | Esophagus Mucosa | UBN1 | 0.12 | 0.06 | lasso | 3 | 0.08 | 5.1e-06 | 5.6 | -5.9 | 4.6e-09 | -0.05 | 0.11 | 0.89 | FALSE |
7 | GTEx | Esophagus Muscularis | UBN1 | 0.18 | 0.19 | lasso | 4 | 0.19 | 9.1e-12 | 6.1 | -5.9 | 3.0e-09 | -0.04 | 0.26 | 0.74 | FALSE |
8 | GTEx | Lung | ZSCAN32 | 0.08 | 0.02 | lasso | 3 | 0.02 | 6.3e-03 | 5.2 | 5.3 | 1.1e-07 | 0.04 | 0.05 | 0.55 | FALSE |
9 | GTEx | Muscle Skeletal | ZNF500 | 0.06 | 0.00 | enet | 15 | 0.00 | 2.8e-01 | 2.5 | 5.2 | 2.6e-07 | 0.05 | 0.06 | 0.14 | FALSE |
10 | GTEx | Nerve Tibial | UBN1 | 0.14 | 0.12 | lasso | 4 | 0.11 | 5.6e-08 | 6.0 | -6.0 | 1.4e-09 | -0.04 | 0.25 | 0.74 | TRUE |
11 | GTEx | Skin Not Sun Exposed Suprapubic | UBN1 | 0.22 | 0.16 | lasso | 4 | 0.14 | 2.5e-08 | 5.6 | -5.1 | 2.9e-07 | -0.04 | 0.35 | 0.64 | FALSE |
12 | GTEx | Skin Sun Exposed Lower leg | CLUAP1 | 0.34 | 0.25 | lasso | 6 | 0.27 | 1.1e-22 | 5.2 | 5.3 | 1.1e-07 | 0.04 | 1.00 | 0.00 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | PPL | 0.10 | 0.04 | lasso | 6 | 0.02 | 5.7e-03 | 5.6 | 5.4 | 7.3e-08 | 0.05 | 0.08 | 0.70 | FALSE |
14 | GTEx | Skin Sun Exposed Lower leg | UBN1 | 0.16 | 0.15 | lasso | 5 | 0.17 | 9.5e-14 | 6.1 | -5.7 | 1.6e-08 | -0.05 | 0.27 | 0.73 | FALSE |
15 | ROSMAP | Brain Pre-frontal Cortex | RP11-462G12.1 | 0.11 | 0.07 | enet | 18 | 0.06 | 1.1e-08 | -10.2 | -8.8 | 8.7e-19 | 0.86 | 0.00 | 1.00 | TRUE |
16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NLRC3 | 0.05 | 0.01 | blup | 39 | 0.02 | 9.8e-03 | 5.2 | -5.2 | 2.5e-07 | -0.09 | 0.00 | 0.87 | FALSE |
17 | The Cancer Genome Atlas | Colon Adenocarcinoma | UBN1 | 0.05 | 0.04 | enet | 7 | 0.05 | 4.2e-04 | -5.8 | 5.3 | 1.3e-07 | 0.06 | 0.02 | 0.76 | FALSE |
18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ROGDI | 0.03 | 0.04 | lasso | 3 | 0.03 | 1.6e-04 | 5.5 | -5.4 | 6.1e-08 | 0.01 | 0.02 | 0.95 | FALSE |
19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ROGDI | 0.05 | 0.02 | lasso | 2 | 0.03 | 6.0e-04 | -4.3 | -5.3 | 8.6e-08 | -0.05 | 0.05 | 0.11 | FALSE |