TWAS hub - CASKIN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0241	0.0159	0.00770	-0.001	0.007	0.001	NA	0.000	0.4100	0.04500	0.2400	NA	0.2800
2	TCGA	Thyroid Carcinoma	0.0580	0.0290	0.00049	0.017	0.037	0.020	NA	0.022	0.0083	0.00015	0.0047	NA	0.0028

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Comparative height size at age 10	15.6	86.1	116.6	-10.8	-7.5
Arm predicted mass (right)	15.2	77.9	102.0	-10.1	-7.3
Arm fat-free mass (left)	15.2	77.1	100.0	-10.0	-7.4
Arm fat-free mass (right)	14.8	75.9	102.0	-10.1	-7.1
Arm predicted mass (left)	14.8	75.2	98.4	-9.9	-7.2
Hand grip strength (left)	14.6	38.6	41.3	-6.0	-6.4
Trunk fat-free mass	13.3	76.1	108.2	-10.4	-6.6
Basal metabolic rate	13.1	72.5	98.6	-9.9	-6.8
Trunk predicted mass	13.0	74.4	106.1	-10.3	-6.5
Weight	12.9	63.2	79.7	-8.9	-6.8
Standing height	12.5	123.6	169.0	-13.0	-8.8
Whole body water mass	12.5	71.5	99.8	-10.0	-6.6
Whole body fat-free mass	12.4	71.0	99.2	-10.0	-6.5
Hand grip strength (right)	11.8	32.2	36.2	-5.3	-6.0
Height	11.5	221.6	313.3	-17.7	-11.4
Waist circumference	11.1	40.6	40.7	-6.4	-6.4
Sitting height	10.9	77.6	98.2	-9.9	-7.5
Trunk fat mass	10.9	46.6	49.6	-7.0	-6.6
Whole body fat mass	10.5	44.0	46.2	-6.8	-6.5
Forced expiratory volume in 1-second (FEV1), predicted	10.1	21.0	30.1	-5.5	-3.5
Heel T-Score	9.6	76.0	81.2	8.4	9.0
Leg fat mass (left)	9.5	37.3	38.7	-6.2	-6.0
Hip circumference	9.4	40.3	52.7	-7.3	-5.3
Leg predicted mass (left)	9.2	48.6	67.2	-8.2	-5.5
Leg fat-free mass (right)	9.2	48.9	69.1	-8.3	-5.4
Leg fat-free mass (left)	9.0	47.8	66.4	-8.2	-5.4
Leg fat mass (right)	9.0	34.8	35.3	-5.9	-5.8
Leg predicted mass (right)	8.9	47.6	67.1	-8.2	-5.3
Arm fat mass (left)	6.6	27.1	30.0	-5.5	-4.9
Trunk fat percentage	6.3	25.1	29.3	-4.6	-5.4
Triglycerides	6.0	9.7	18.3	1.1	4.3
Arm fat mass (right)	5.9	24.3	26.8	-5.2	-4.7
Leg fat percentage (left)	5.9	21.2	27.5	-3.9	-5.2
Body fat percentage	5.6	22.1	27.1	-4.1	-5.2
Blood White Count	5.2	38.8	42.8	-5.9	-6.5
Leg fat percentage (right)	5.0	18.3	25.0	-3.4	-5.0
Mother’s age at death	4.9	6.1	7.2	2.7	2.3
Pack years of smoking	4.5	6.6	8.0	-2.8	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	4.4	9.9	14.5	3.8	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.0	4.7	8.5	0.9	2.9
Alcohol intake versus 10 years previously	3.7	5.5	6.8	-2.6	-2.1
Waist Hip Ratio (WHR)	3.6	16.1	28.1	-2.0	-5.3
Ever unenthusiastic/disinterested for a whole week	3.6	4.3	6.2	-2.5	-1.6
Pack years adult smoking proportion	3.5	5.3	6.6	-2.6	-2.0
Commuting to job workplace: Car/motor vehicle	3.4	3.9	7.7	2.8	0.2
Heel bone mineral density (BMD) T-score, automated (right)	3.3	7.7	10.1	3.2	2.3
BMI	3.2	18.4	18.7	-4.3	-4.3
Past tobacco smoking	3.2	5.9	10.4	3.2	1.2
Falls in the last year	3.1	4.2	7.8	-2.8	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	9.8	14.3	-3.8	-2.3
Gout (self-reported)	3.1	4.2	8.5	0.1	2.9
High blood pressure (siblings)	3.1	4.4	5.9	1.7	2.4
Number of children fathered	3.1	3.5	5.3	2.3	1.3
Medication: Seretide 50 evohaler	3.1	3.6	5.9	2.4	1.1
Ever smoked	3.1	5.5	8.0	-2.8	-1.7
Forced vital capacity (FVC), Best measure	2.9	10.7	14.2	-3.8	-2.7
Smoking status: Previous	2.9	4.3	7.8	-2.8	-0.9
Illnesses of father: High blood pressure	2.8	3.4	3.5	1.9	1.8
Pain all over the body in last month	2.7	2.9	4.5	-1.2	-2.1
Peak expiratory flow (PEF)	2.7	6.4	10.8	-1.4	-3.3
Health satisfaction	2.7	3.5	5.1	1.4	2.3
Chronotype (morning person)	2.6	6.0	7.1	2.7	2.2
Body mass index (BMI)	2.6	11.2	11.9	-3.5	-3.2
Impedance of arm (right)	2.6	12.0	17.1	4.1	2.6
Worrier / anxious feelings	2.5	4.7	8.3	1.1	2.9
Reason for reducing amount of alcohol drunk: Health precaution	2.5	3.0	4.6	1.1	2.1
Medication: Atorvastatin	2.5	3.1	6.2	2.5	0.2
Ovarian Cancer	2.3	3.1	4.7	1.2	2.2
Impedance of arm (left)	2.3	10.5	14.9	3.9	2.5
Tense / ‘highly strung’	2.3	3.8	6.4	1.1	2.5
Mouth/teeth dental problems: Bleeding gums	2.3	3.0	5.4	2.3	0.8
Glaucoma (self-reported)	2.3	2.7	5.2	0.3	2.3
Eye problems/disorders: None of the above	2.3	2.7	3.4	-1.9	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	4.4	-1.0	-2.1
Smoking Status	2.2	5.2	9.8	-3.1	-0.8
High blood pressure (mother)	2.2	3.1	5.0	1.1	2.2
Forced vital capacity (FVC)	2.2	8.5	10.8	-3.3	-2.5
Medication: Atenolol	2.1	2.6	5.2	-2.3	-0.1
Prostate Cancer	2.0	2.8	3.6	1.4	1.9
Worry too long after embarrassment	2.0	3.4	4.7	2.2	1.5
Qualifications: nursing, teaching	2.0	3.1	4.8	1.1	2.2
Pain experienced in last month	2.0	3.3	5.6	-2.4	-1.0
Worry (Nagel 2018)	1.9	4.0	7.9	0.3	2.8
Supplements: Glucosamine	1.9	2.5	4.7	2.2	0.6
Noisy workplace	1.9	2.3	4.5	-2.1	-0.5
Birth weight	1.9	4.1	6.0	-2.4	-1.5
Medication: Allopurinol	1.9	2.6	3.6	1.2	1.9
Diabetes (self-reported)	1.8	2.7	3.2	1.5	1.8
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	5.3	2.3	0.7
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	2.6	1.6	1.4
Illnesses of father: Heart disease	1.8	2.5	4.6	-0.7	-2.1
Eye problems/disorders: Cataract	1.8	2.1	4.0	0.5	2.0
Eye problems/disorders: Glaucoma	1.8	2.1	3.9	0.5	2.0
Sensitivity / hurt feelings	1.7	3.0	5.1	0.9	2.3
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	2.8	-1.3	-1.7
Average weekly fortified wine intake	1.7	2.0	3.1	1.8	0.9
Forced expiratory volume in 1-second (FEV1)	1.7	5.6	7.5	-2.7	-1.9
Smoking status: Current	1.7	2.8	3.4	-1.8	-1.5
Breast Cancer	1.6	3.8	4.5	-1.8	-2.1
Current tobacco smoking	1.6	2.6	3.2	-1.8	-1.4
Medication: Aspirin	1.6	2.1	2.9	1.2	1.7
Arm fat percentage (left)	1.6	6.5	7.7	-2.3	-2.8
Cholesterol lowering medication	1.6	2.3	3.4	1.8	1.1
Crohns Disease (2017)	1.5	3.4	5.2	-2.3	-1.3
High blood pressure	1.5	4.1	5.6	1.6	2.4
Chronic bronchitis/emphysema (father)	1.5	1.7	2.8	1.7	0.8
Arm fat percentage (right)	1.5	5.9	7.5	-2.1	-2.7
Back pain experienced in last month	1.5	2.2	2.5	1.6	1.4
Depressed Affect (Nagel 2018)	1.4	3.0	5.7	-2.4	-0.6
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.4	1.5	0.9
Medication: Omeprazole	1.4	1.6	1.8	1.4	1.2
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.2	2.1	0.3
Osteoporosis (self-reported)	1.4	1.8	3.6	1.9	-0.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	1.4	1.2	1.1
Multivitamins +/- minerals	1.3	1.7	2.8	1.7	0.8
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.9	0.7	1.7
Prospective memory result	1.3	1.5	2.9	0.5	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	2.4	-1.6	1.0
Hypertension (Self-reported)	1.3	3.5	4.6	1.6	2.1
Medication: Gliclazide	1.3	1.5	2.3	-1.5	-0.8
Number of self-reported non-cancer illnesses	1.3	2.3	2.7	1.4	1.6
Fractured/broken bones in last 5 years	1.3	1.7	2.8	-1.7	-0.8
Average weekly spirits intake	1.2	1.5	2.9	-1.7	-0.4
Family relationship satisfaction	1.2	1.5	3.0	0.1	1.7
Medication for cholesterol	1.2	1.8	2.1	-1.5	-1.2
Irritability	1.2	2.0	3.6	-1.9	-0.5
Unable to work because of sickness or disability	1.2	1.6	3.0	-1.7	-0.3
Alzheimer’s Disease (in father)	1.1	1.2	2.3	0.4	1.5
Cardiovascular Disease	1.1	3.5	5.3	1.3	2.3
Ever had hysterectomy (womb removed)	1.1	1.2	2.2	-0.4	-1.5
Serious illness, injury or assault to yourself	1.1	1.3	1.5	-1.2	-1.0
Allergy	1.1	2.6	4.2	-1.0	-2.0
Breastfed as a baby	1.1	1.3	1.3	1.2	1.2
Blood clot in the leg (DVT)	1.1	1.4	2.5	0.6	1.6
Headache pain in last month	1.1	1.8	2.5	1.6	1.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	1.8	1.3	1.0
Alzheimer’s Disease (including proxy)	1.0	1.4	1.7	1.0	1.3
HbA1C	1.0	1.1	2.0	-0.3	1.4
Respiratory disease	1.0	2.3	4.1	2.0	0.7
Diabetes (father)	1.0	1.2	2.4	1.5	-0.1
Qualifications: CSEs or equivalent	1.0	1.3	1.4	-1.2	-1.0
Number of live births	1.0	1.4	2.8	1.7	0.1
Shortness of breath walking on level ground	1.0	1.1	1.6	-0.8	1.3
Heart disease (mother)	1.0	1.2	2.4	-0.3	-1.5
Friendships satisfaction	1.0	1.3	1.8	1.4	0.9
Financial situation satisfaction	1.0	1.2	1.8	0.8	1.3
Number of treatments/medications taken	0.9	1.6	1.8	1.2	1.4
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.9	1.4	0.5
Vitamin and mineral supplements	0.9	1.2	1.3	-1.0	-1.1
Diabetes (mother)	0.9	1.2	2.1	0.5	1.4
Severe depression (siblings)	0.9	1.0	1.6	-0.7	1.3
Hair/balding pattern: Pattern 2	0.9	1.1	2.1	-1.4	-0.5
Depression (self-reported)	0.9	1.0	2.0	0.1	1.4
Loud music exposure frequency	0.9	1.0	1.3	-1.1	-0.8
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.8	1.3	-0.7
Comparative body size at age 10	0.9	2.4	4.0	-2.0	-0.8
Medication for pain relief, constipation, heartburn	0.9	1.5	2.8	-0.5	-1.7
Commuting to job workplace: Public transport	0.9	1.1	1.8	-1.3	0.7
Heart attack/myocardial infarction (self-reported)	0.9	1.1	1.9	0.5	1.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.2	0.4	1.5
Impedance of whole body	0.9	4.3	8.4	2.9	0.5
Lung FEV1/FVC ratio	0.8	4.0	5.4	-2.3	-1.6
Medication for hormone replacement therapy	0.8	0.9	1.4	1.2	0.6
Had menopause	0.8	1.0	1.7	0.5	-1.3
Qualifications: A levels/AS levels or equivalent	0.8	1.8	2.7	1.6	1.0
Mean time to correctly identify matches	0.8	1.4	1.7	-1.1	1.3
Pulse rate, automated reading	0.8	2.6	4.3	1.0	2.1
Mood swings	0.8	1.4	2.6	-1.6	-0.4
Commuting to job workplace: Walk	0.8	0.8	1.0	-0.8	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.7	-0.5	-1.3
Average weekly champagne plus white wine intake	0.8	1.1	2.1	-0.4	1.4
Commuting to job workplace: Cycle	0.8	1.0	1.8	0.4	1.4
Heart disease (siblings)	0.8	1.0	2.0	-1.4	-0.3
Neuroticism (Nagel 2018)	0.7	1.6	1.7	-1.2	1.3
Mean Putamen Volume	0.7	0.8	0.9	0.9	-0.9
Rheumatoid Arthritis	0.7	1.0	1.2	-0.8	1.1
Relative age of first facial hair	0.7	1.4	1.4	1.1	1.2
Taking other prescription medications	0.7	1.1	1.4	1.2	0.9
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.2	0.1	1.8
Nervous feelings	0.7	1.2	2.4	0.3	1.5
Mouth/teeth dental problems	0.7	1.1	2.2	-1.5	-0.1
Suffer from ‘nerves’	0.7	1.1	2.2	-0.1	1.5
Leg pain on walking	0.7	0.8	1.7	-0.2	1.3
Medication: Aspirin	0.7	0.9	1.2	0.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.7	1.6	0.4
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.2	-1.1	-0.6
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.7	-0.0	-1.3
Irritable Bowel Disease (IBD)	0.6	1.5	1.8	-1.4	-1.1
LDL Cholesterol	0.6	1.0	1.2	-0.9	1.1
Neuroticism (2016)	0.6	0.8	1.4	-0.4	1.2
Maternal smoking around birth	0.6	0.9	1.1	-1.0	0.8
Relative age voice broke	0.6	1.0	1.9	1.4	0.1
Heart attack	0.6	0.8	1.5	0.4	1.2
Fluid intelligence score	0.6	1.3	2.2	1.5	-0.6
Pulse rate	0.6	1.0	2.0	-0.0	1.4
Medication: Cholesterol lowering	0.6	0.9	1.5	-1.2	0.6
Illnesses of mother	0.6	0.7	1.4	-0.2	-1.2
Exposure to tobacco smoke at home	0.6	0.7	1.2	-0.4	-1.1
Knee pain experienced in last month	0.6	0.9	1.0	-0.9	-1.0
Asthma (self-reported)	0.6	1.1	2.0	1.4	0.5
Ever depressed for a whole week	0.6	0.7	1.0	-1.0	-0.7
Myopia	0.6	0.9	1.2	-0.8	-1.1
Vascular/heart problems diagnosed by doctor	0.6	1.5	1.8	-1.1	-1.3
HDL Cholesterol	0.5	0.8	1.5	-0.4	-1.2
Hypothyroidism (self reported)	0.5	1.1	1.1	-1.0	1.0
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.5	0.6	1.2
Lung FVC	0.5	2.5	4.1	2.0	0.9
Fed-up feelings	0.5	1.0	1.8	-1.3	-0.4
Qualifications: None of the above	0.5	1.2	1.3	-1.0	-1.1
Financial difficulties in last 2 years	0.5	0.6	1.0	-1.0	0.5
Father’s age at death	0.5	0.7	1.3	1.2	-0.2
Lung cancer (father)	0.5	0.6	1.1	0.3	1.1
Length of working week for main job	0.5	0.5	0.9	-1.0	-0.4
Pulse wave reflection index	0.5	0.6	1.3	0.1	-1.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.3	1.1	-0.5
Medication: Amlodipine	0.5	0.7	1.1	-1.1	-0.6
Wheeze or whistling in the chest in last year	0.5	0.8	1.4	0.5	-1.2
Age at first live birth	0.5	0.9	1.8	1.3	0.3
Emphysema/chronic bronchitis	0.5	0.6	0.9	0.4	1.0
Chest pain or discomfort	0.5	0.7	1.4	0.1	-1.2
Had major operations	0.5	0.5	1.1	-1.0	0.0
Ever had bowel cancer screening	0.5	0.5	1.1	1.0	-0.2
Wears glasses or contact lenses	0.5	0.5	0.9	1.0	0.4
Medication: Blood pressure	0.5	1.0	1.2	1.0	1.1
High cholesterol (Self-reported)	0.5	0.9	1.7	-0.0	1.3
Reaction Time	0.4	0.7	1.1	-0.5	1.1
Blood Eosinophil Count	0.4	3.4	6.8	-2.6	-0.2
Allergy or Eczema	0.4	1.0	1.9	0.1	1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.7	0.8	-0.3
Medication: Metformin	0.4	0.5	1.0	1.0	-0.0
Alcohol usually taken with meals	0.4	0.6	1.2	-0.1	-1.1
Medication: Ramipril	0.4	0.5	1.0	-0.0	1.0
Neuroticism score	0.4	0.8	1.5	0.1	1.2
Asthma	0.4	0.7	1.3	1.1	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	0.6	0.8	0.7
Birth weight of first child	0.4	0.8	1.4	-1.2	-0.4
Medication: Paracetamol	0.4	0.7	1.4	-0.2	1.2
Qualifications: College or University degree	0.4	1.3	1.5	1.0	1.2
Average weekly red wine intake	0.4	0.6	1.2	0.2	-1.1
Diabetes diagnosed by doctor	0.4	0.6	1.0	0.5	1.0
Miserableness	0.4	0.6	1.2	-1.1	0.3
Ever taken oral contraceptive pill	0.4	0.5	0.6	0.6	0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	0.8	0.6
Medication: Bendroflumethiazide	0.4	0.6	0.7	-0.7	0.8
Medication: Paracetamol	0.4	0.6	1.1	0.3	1.0
Alcohol drinker status: Never	0.4	0.5	0.9	-0.9	-0.3
Average weekly beer plus cider intake	0.4	0.6	0.6	-0.7	-0.8
Supplements: Calcium	0.4	0.5	0.7	-0.5	-0.8
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	1.0	-0.4
Intelligence (Savage-Jansen 2018)	0.3	0.8	0.8	0.9	-0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.6	0.0	-1.3
Age at First Birth	0.3	0.4	0.6	0.4	-0.8
Primary Biliary Cirrhosis	0.3	0.4	0.7	-0.8	-0.4
Blood Red Count	0.3	2.9	3.1	1.6	-1.8
Neuroticism	0.3	0.8	1.0	-0.8	1.0
Stomach or abdominal pain in last month	0.3	0.4	0.6	0.8	0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.7	0.1	0.8
Impedance of leg (left)	0.3	1.3	2.5	0.4	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	-0.2	0.9
Illnesses of siblings	0.3	0.4	0.5	-0.7	-0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	0.6	-0.5	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.9	-0.4	0.9
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.2	-0.8
Pulse wave peak to peak time	0.3	0.4	0.4	-0.7	-0.6
Neck or shoulder pain in last month	0.3	0.5	0.9	1.0	0.1
Migraine (self-reported)	0.3	0.4	0.7	0.8	0.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.4	0.5	0.7
Loneliness, isolation	0.3	0.4	0.6	-0.8	0.5
Risk taking	0.3	0.5	0.8	-0.4	-0.9
Diastolic blood pressure, automated reading	0.3	0.8	1.6	1.3	0.2
Lupus	0.2	0.3	0.7	-0.8	-0.1
Medication: Co-codamol	0.2	0.2	0.4	0.6	0.1
Impedance of leg (right)	0.2	1.1	1.4	1.0	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.3	-0.5	-0.4
Hearing difficulty/problems with background noise	0.2	0.3	0.5	0.1	0.7
Medication: Simvastatin	0.2	0.3	0.6	-0.8	0.3
Time employed in main current job	0.2	0.3	0.5	-0.0	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.2	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.4	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.4	-0.7	0.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	0.3	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	-0.0	0.7
Number of full brothers	0.2	0.3	0.5	0.7	-0.2
Angina (self-reported)	0.2	0.3	0.3	0.4	0.6
Medication: Ibuprofen	0.2	0.3	0.5	-0.0	0.7
Alcohol intake frequency.	0.2	0.4	0.5	-0.4	-0.7
Age at last live birth	0.2	0.4	0.5	0.5	0.7
Supplements: Vitamin C	0.2	0.3	0.3	0.6	0.5
Illnesses of siblings: Diabetes	0.2	0.3	0.6	0.0	-0.8
Long-standing illness, disability or infirmity	0.2	0.3	0.7	0.1	0.8
Guilty feelings	0.2	0.3	0.6	0.1	-0.8
Medication: Lisinopril	0.2	0.3	0.5	0.7	0.3
Number of operations (self-reported)	0.2	0.4	0.7	-0.0	0.8
Age started oral contraceptive pill	0.2	0.3	0.4	-0.6	-0.5
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.5	-0.3
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.2	-0.4
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.4	0.1
Crohns Disease (2012)	0.1	0.1	0.2	0.1	-0.4
Systolic Blood Pressure	0.1	0.4	0.7	0.9	-0.1
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.5	-0.2
Systolic blood pressure, automated reading	0.1	0.2	0.3	0.5	-0.4
Supplements: Zinc	0.1	0.1	0.2	-0.2	-0.4
Townsend deprivation index at recruitment	0.1	0.1	0.1	-0.4	0.2
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.2	0.4
Had other major operations	0.1	0.1	0.1	-0.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.2	-0.5	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.5	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	0.4	-0.0
Medication: Blood pressure	0.1	0.2	0.3	-0.3	0.5
Number of full sisters	0.1	0.1	0.2	-0.2	-0.4
Overall health rating	0.1	0.2	0.3	-0.6	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.3	0.3
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.2	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	-0.3	-0.3
Hearing aid user	0.1	0.1	0.1	-0.3	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.2	0.4
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	0.0	0.0
Depression (Nagel 2018)	0.0	0.1	0.1	-0.2	-0.3
Schizophrenia (2018)	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.3	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.1	-0.0	-0.3
Schizophrenia (2014)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.4	0.9	-0.9	0.1
Hair Pigment	0.0	0.2	0.3	0.5	-0.3
Tanning	0.0	0.3	0.6	0.8	0.1
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.2	0.1
Angina	0.0	0.0	0.1	-0.1	0.2
Age when periods started (menarche)	0.0	0.1	0.1	0.4	-0.1
Number of incorrect matches in round	0.0	0.1	0.1	0.2	0.3
Happiness	0.0	0.0	0.0	0.1	0.2
Medication: Lansoprazole	0.0	0.0	0.1	0.3	0.1
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	0.0	0.3
Mineral and other dietary supplements	0.0	0.0	0.1	-0.3	0.2
Breast cancer (self-reported)	0.0	0.0	0.0	-0.1	-0.1

Hub : Genes

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Models

Trait associations