Best TWAS P=3.02e-14 · Best GWAS P=1.24e-10 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ABHD12 | 0.10 | 0.17 | blup | 405 | 0.17 | 1.7e-20 | 5.8 | 7.0 | 2.9e-12 | -0.19 | 0.14 | 0.86 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | NINL | 0.19 | 0.17 | lasso | 20 | 0.23 | 1.2e-27 | 5.8 | 7.1 | 9.5e-13 | -0.16 | 0.13 | 0.87 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | PYGB | 0.10 | 0.05 | lasso | 3 | 0.05 | 6.9e-07 | 5.1 | -5.6 | 2.3e-08 | 0.05 | 0.10 | 0.88 | TRUE |
4 | GTEx | Adipose Visceral Omentum | ABHD12 | 0.06 | 0.00 | lasso | 8 | 0.00 | 4.6e-01 | 5.8 | 6.1 | 1.4e-09 | -0.14 | 0.12 | 0.52 | FALSE |
5 | GTEx | Artery Aorta | NINL | 0.17 | 0.18 | lasso | 6 | 0.19 | 1.5e-10 | 5.8 | 6.5 | 9.5e-11 | -0.15 | 0.13 | 0.87 | FALSE |
6 | GTEx | Artery Tibial | ABHD12 | 0.12 | 0.12 | enet | 25 | 0.15 | 7.1e-12 | 5.4 | 5.7 | 1.3e-08 | -0.07 | 0.23 | 0.77 | FALSE |
7 | GTEx | Brain Caudate basal ganglia | ABHD12 | 0.09 | 0.05 | enet | 13 | 0.04 | 2.9e-02 | 5.8 | 5.9 | 4.7e-09 | -0.15 | 0.12 | 0.64 | FALSE |
8 | GTEx | Brain Cerebellar Hemisphere | PYGB | 0.20 | 0.16 | lasso | 5 | 0.12 | 5.8e-04 | 5.5 | -5.5 | 3.8e-08 | 0.14 | 0.12 | 0.65 | FALSE |
9 | GTEx | Brain Cerebellar Hemisphere | ENTPD6 | 0.22 | 0.26 | lasso | 3 | 0.17 | 3.8e-05 | 5.5 | -5.5 | 3.1e-08 | 0.16 | 0.20 | 0.78 | FALSE |
10 | GTEx | Brain Cerebellum | ENTPD6 | 0.15 | 0.23 | enet | 8 | 0.14 | 4.6e-05 | 5.1 | -5.4 | 7.4e-08 | 0.18 | 0.28 | 0.66 | FALSE |
11 | GTEx | Brain Cortex | ABHD12 | 0.08 | 0.11 | lasso | 8 | 0.09 | 1.4e-03 | 5.9 | 5.4 | 5.6e-08 | -0.06 | 0.10 | 0.64 | FALSE |
12 | GTEx | Breast Mammary Tissue | ABHD12 | 0.08 | 0.09 | lasso | 5 | 0.09 | 3.3e-05 | 5.8 | 6.1 | 9.1e-10 | -0.14 | 0.16 | 0.77 | FALSE |
13 | GTEx | Breast Mammary Tissue (Male) | CST7 | 0.15 | 0.00 | lasso | 4 | 0.03 | 7.0e-02 | -3.6 | -5.2 | 1.7e-07 | 0.62 | 0.06 | 0.09 | FALSE |
14 | GTEx | Breast Mammary Tissue (Male) | ABHD12 | 0.06 | 0.01 | lasso | 3 | 0.02 | 1.3e-01 | 5.2 | 6.0 | 2.2e-09 | -0.13 | 0.05 | 0.17 | FALSE |
15 | GTEx | Cells Transformed fibroblasts | ABHD12 | 0.24 | 0.33 | lasso | 4 | 0.35 | 6.3e-27 | 5.9 | 5.9 | 2.8e-09 | -0.16 | 0.12 | 0.88 | FALSE |
16 | GTEx | Colon Sigmoid | ABHD12 | 0.17 | 0.17 | lasso | 15 | 0.17 | 1.0e-06 | 5.3 | 5.3 | 1.1e-07 | -0.09 | 0.19 | 0.80 | FALSE |
17 | GTEx | Esophagus Gastroesophageal Junction | ABHD12 | 0.15 | 0.14 | lasso | 13 | 0.14 | 7.0e-06 | 5.4 | 5.4 | 7.2e-08 | -0.16 | 0.14 | 0.86 | FALSE |
18 | GTEx | Esophagus Muscularis | ABHD12 | 0.10 | 0.10 | enet | 42 | 0.09 | 4.5e-06 | 5.8 | 5.3 | 1.4e-07 | -0.18 | 0.14 | 0.86 | FALSE |
19 | GTEx | Heart Atrial Appendage | ABHD12 | 0.07 | 0.06 | enet | 16 | 0.06 | 1.0e-03 | 5.9 | 5.7 | 1.4e-08 | -0.15 | 0.13 | 0.84 | FALSE |
20 | GTEx | Heart Left Ventricle | ABHD12 | 0.15 | 0.14 | lasso | 10 | 0.12 | 4.0e-07 | 5.9 | 6.3 | 3.4e-10 | -0.18 | 0.12 | 0.88 | FALSE |
21 | GTEx | Heart Left Ventricle | NINL | 0.08 | 0.03 | enet | 11 | 0.05 | 1.1e-03 | 5.4 | 5.2 | 1.7e-07 | 0.01 | 0.31 | 0.51 | TRUE |
22 | GTEx | Liver | ABHD12 | 0.20 | 0.20 | lasso | 19 | 0.15 | 7.3e-05 | 5.8 | 5.7 | 1.1e-08 | -0.15 | 0.15 | 0.85 | FALSE |
23 | GTEx | Liver | APMAP | 0.20 | -0.01 | lasso | 9 | 0.00 | 3.8e-01 | 5.9 | 5.4 | 6.4e-08 | -0.26 | 0.10 | 0.51 | FALSE |
24 | GTEx | Lung | ABHD12 | 0.06 | 0.00 | lasso | 6 | 0.00 | 2.7e-01 | 5.9 | 6.5 | 7.9e-11 | -0.12 | 0.09 | 0.73 | FALSE |
25 | GTEx | Nerve Tibial | PYGB | 0.26 | 0.15 | enet | 11 | 0.14 | 5.7e-10 | 5.1 | -5.4 | 6.4e-08 | 0.09 | 0.86 | 0.14 | FALSE |
26 | GTEx | Nerve Tibial | ABHD12 | 0.24 | 0.44 | lasso | 11 | 0.44 | 5.1e-34 | 5.9 | -5.6 | 1.8e-08 | 0.16 | 0.14 | 0.86 | FALSE |
27 | GTEx | Pancreas | ENTPD6 | 0.11 | 0.05 | enet | 23 | 0.05 | 5.0e-03 | 5.9 | -6.2 | 4.3e-10 | 0.15 | 0.12 | 0.80 | FALSE |
28 | GTEx | Pituitary | ABHD12 | 0.27 | 0.31 | enet | 25 | 0.31 | 1.8e-08 | 5.8 | 6.5 | 8.7e-11 | -0.14 | 0.15 | 0.85 | FALSE |
29 | GTEx | Skin Not Sun Exposed Suprapubic | PYGB | 0.12 | 0.13 | enet | 13 | 0.14 | 4.2e-08 | 5.2 | -5.9 | 4.8e-09 | 0.28 | 0.34 | 0.57 | FALSE |
30 | GTEx | Skin Sun Exposed Lower leg | ABHD12 | 0.07 | 0.03 | lasso | 10 | 0.05 | 7.3e-05 | 5.1 | 6.3 | 3.7e-10 | -0.19 | 0.22 | 0.75 | FALSE |
31 | GTEx | Spleen | PYGB | 0.15 | 0.09 | lasso | 6 | 0.04 | 2.6e-02 | 5.8 | 5.3 | 1.2e-07 | -0.14 | 0.14 | 0.71 | FALSE |
32 | GTEx | Testis | ABHD12 | 0.21 | 0.18 | enet | 25 | 0.23 | 1.1e-10 | 5.9 | 6.1 | 9.7e-10 | -0.14 | 0.12 | 0.88 | FALSE |
33 | GTEx | Thyroid | ABHD12 | 0.05 | 0.04 | lasso | 5 | 0.03 | 3.9e-03 | 5.8 | -5.8 | 6.0e-09 | 0.16 | 0.14 | 0.82 | FALSE |
34 | GTEx | Thyroid | NINL | 0.13 | 0.18 | enet | 17 | 0.20 | 6.2e-15 | -3.3 | -5.7 | 1.3e-08 | 0.19 | 0.57 | 0.42 | FALSE |
35 | ROSMAP | Brain Pre-frontal Cortex | PYGB | 0.20 | 0.10 | bslmm | 414 | 0.11 | 3.2e-14 | 6.1 | -6.3 | 3.2e-10 | 0.07 | 0.02 | 0.98 | FALSE |
36 | ROSMAP | Brain Pre-frontal Cortex | ABHD12 | 0.26 | 0.35 | enet | 35 | 0.42 | 7.9e-58 | 5.4 | 6.1 | 1.2e-09 | -0.14 | 0.18 | 0.82 | FALSE |
37 | ROSMAP | Brain Pre-frontal Cortex | NINL | 0.19 | 0.19 | enet | 18 | 0.25 | 2.1e-32 | 5.8 | 5.3 | 9.3e-08 | -0.07 | 0.12 | 0.88 | FALSE |
38 | ROSMAP | Brain Pre-frontal Cortex | ENTPD6 | 0.32 | 0.10 | bslmm | 432 | 0.12 | 1.8e-15 | 5.9 | 7.6 | 3.0e-14 | -0.70 | 0.06 | 0.94 | TRUE |
39 | YFS | Blood | ABHD12 | 0.15 | 0.35 | bslmm | 390 | 0.34 | 2.2e-118 | 5.9 | 6.2 | 6.5e-10 | -0.16 | 0.11 | 0.89 | TRUE |
40 | YFS | Blood | NINL | 0.04 | 0.03 | lasso | 8 | 0.03 | 2.8e-10 | 6.2 | 6.1 | 1.3e-09 | -0.07 | 0.02 | 0.98 | FALSE |
41 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ABHD12 | 0.04 | 0.00 | blup | 77 | 0.02 | 6.6e-03 | 5.8 | 5.3 | 1.1e-07 | -0.17 | 0.04 | 0.53 | FALSE |
42 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PYGB | 0.08 | 0.02 | enet | 7 | 0.03 | 1.7e-07 | 5.7 | -5.7 | 1.4e-08 | 0.06 | 0.15 | 0.85 | FALSE |
43 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PYGB | 0.08 | 0.04 | blup | 74 | 0.06 | 1.0e-03 | 5.8 | -6.1 | 1.0e-09 | 0.14 | 0.07 | 0.74 | TRUE |
44 | The Cancer Genome Atlas | Colon Adenocarcinoma | NINL | 0.20 | 0.06 | lasso | 4 | 0.08 | 2.7e-05 | 5.2 | 6.0 | 1.5e-09 | -0.04 | 0.01 | 0.98 | FALSE |
45 | The Cancer Genome Atlas | Glioblastoma Multiforme | ABHD12 | 0.14 | 0.10 | lasso | 5 | 0.13 | 1.1e-04 | 5.3 | 5.6 | 2.6e-08 | -0.15 | 0.06 | 0.89 | FALSE |
46 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ABHD12 | 0.04 | 0.03 | blup | 77 | 0.04 | 4.0e-05 | 5.9 | 5.7 | 1.6e-08 | -0.16 | 0.05 | 0.94 | FALSE |
47 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ABHD12 | 0.03 | 0.01 | blup | 77 | 0.01 | 8.7e-03 | 4.5 | 6.0 | 2.1e-09 | -0.14 | 0.06 | 0.74 | FALSE |
48 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ENTPD6 | 0.29 | 0.17 | lasso | 4 | 0.18 | 1.0e-10 | 4.5 | -5.2 | 2.1e-07 | 0.10 | 0.41 | 0.58 | FALSE |
49 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ABHD12 | 0.04 | 0.06 | blup | 77 | 0.06 | 2.2e-07 | 5.9 | 6.0 | 1.8e-09 | -0.15 | 0.06 | 0.94 | FALSE |
50 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABHD12 | 0.07 | 0.05 | blup | 77 | 0.05 | 2.4e-03 | 5.8 | 5.6 | 2.2e-08 | -0.15 | 0.05 | 0.83 | FALSE |
51 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ABHD12 | 0.08 | 0.09 | blup | 80 | 0.09 | 1.7e-06 | 5.8 | 5.7 | 1.4e-08 | -0.12 | 0.06 | 0.94 | FALSE |
52 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ENTPD6 | 0.07 | 0.07 | lasso | 1 | 0.04 | 9.2e-03 | 5.5 | -5.5 | 4.5e-08 | 0.15 | 0.08 | 0.18 | FALSE |
53 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ABHD12 | 0.03 | 0.02 | lasso | 4 | 0.03 | 5.8e-04 | -5.1 | 5.4 | 8.0e-08 | -0.17 | 0.07 | 0.74 | FALSE |
54 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PYGB | 0.21 | 0.13 | enet | 5 | 0.17 | 2.0e-17 | 4.5 | -5.4 | 6.2e-08 | 0.09 | 0.94 | 0.06 | FALSE |
55 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | NINL | 0.11 | 0.03 | blup | 81 | 0.07 | 2.1e-03 | -5.2 | -5.2 | 2.1e-07 | 0.16 | 0.04 | 0.55 | FALSE |
56 | The Cancer Genome Atlas | Thyroid Carcinoma | ENTPD6 | 0.16 | 0.14 | lasso | 4 | 0.13 | 1.2e-12 | 5.5 | -5.4 | 5.9e-08 | 0.16 | 0.31 | 0.69 | FALSE |
57 | The Cancer Genome Atlas | Thyroid Carcinoma | NINL | 0.08 | 0.14 | lasso | 11 | 0.13 | 2.9e-12 | 5.9 | -5.7 | 1.2e-08 | 0.16 | 0.04 | 0.96 | FALSE |
58 | The Cancer Genome Atlas | Thyroid Carcinoma | PYGB | 0.10 | 0.08 | lasso | 7 | 0.07 | 1.4e-07 | 5.0 | -5.8 | 5.0e-09 | 0.10 | 0.35 | 0.65 | FALSE |