Best TWAS P=5.61e-10 · Best GWAS P=4.77e-09 conditioned to 0.0251
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | PLA2G6 | 0.10 | 0.02 | enet | 9 | 0.02 | 4.5e-02 | 4.2 | 6.2 | 5.6e-10 | 0.68 | 0.10 | 0.48 | TRUE |
2 | GTEx | Artery Aorta | TMEM184B | 0.17 | 0.07 | enet | 34 | 0.03 | 1.2e-02 | 5.1 | -5.2 | 1.6e-07 | -0.68 | 0.07 | 0.68 | FALSE |
3 | GTEx | Artery Aorta | AL021977.1 | 0.13 | 0.00 | enet | 17 | 0.01 | 8.7e-02 | 5.2 | -6.0 | 2.2e-09 | -0.73 | 0.05 | 0.63 | FALSE |
4 | GTEx | Brain Cortex | TMEM184B | 0.29 | 0.12 | lasso | 7 | 0.09 | 1.6e-03 | 5.1 | -5.5 | 4.8e-08 | -0.91 | 0.02 | 0.83 | FALSE |
5 | GTEx | Cells EBV-transformed lymphocytes | PLA2G6 | 0.28 | 0.17 | enet | 13 | 0.18 | 1.3e-06 | -4.8 | 5.3 | 1.2e-07 | 0.69 | 0.25 | 0.61 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | PLA2G6 | 0.23 | 0.09 | lasso | 9 | 0.10 | 9.9e-08 | 5.0 | 5.4 | 5.5e-08 | 0.81 | 0.34 | 0.66 | FALSE |
7 | GTEx | Esophagus Gastroesophageal Junction | PLA2G6 | 0.28 | 0.24 | lasso | 5 | 0.23 | 1.1e-08 | -4.8 | 5.1 | 2.9e-07 | 0.64 | 0.49 | 0.43 | FALSE |
8 | GTEx | Esophagus Mucosa | PLA2G6 | 0.22 | 0.02 | lasso | 6 | 0.04 | 1.9e-03 | 5.0 | 5.5 | 4.3e-08 | 0.77 | 0.13 | 0.85 | FALSE |
9 | GTEx | Esophagus Muscularis | TMEM184B | 0.11 | 0.01 | enet | 10 | 0.06 | 2.7e-04 | 2.9 | -5.2 | 2.0e-07 | -0.60 | 0.25 | 0.26 | FALSE |
10 | GTEx | Muscle Skeletal | DMC1 | 0.13 | 0.01 | enet | 17 | 0.04 | 3.3e-05 | 4.6 | 5.2 | 1.9e-07 | 0.59 | 0.07 | 0.62 | FALSE |
11 | GTEx | Nerve Tibial | PLA2G6 | 0.34 | 0.08 | lasso | 8 | 0.11 | 2.9e-08 | -4.8 | 5.3 | 1.4e-07 | 0.72 | 0.38 | 0.61 | FALSE |
12 | GTEx | Nerve Tibial | MAFF | 0.14 | 0.06 | lasso | 3 | 0.05 | 1.2e-04 | 5.6 | -5.6 | 2.2e-08 | -0.98 | 0.02 | 0.97 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | BAIAP2L2 | 0.09 | 0.09 | lasso | 4 | 0.09 | 5.5e-08 | 4.8 | -5.2 | 1.8e-07 | -0.74 | 0.17 | 0.83 | FALSE |
14 | GTEx | Thyroid | PLA2G6 | 0.34 | 0.20 | lasso | 5 | 0.18 | 4.5e-14 | -4.8 | 5.1 | 2.8e-07 | 0.67 | 0.66 | 0.34 | FALSE |
15 | GTEx | Thyroid | TMEM184B | 0.19 | 0.16 | lasso | 7 | 0.18 | 1.0e-13 | 4.3 | -5.4 | 5.4e-08 | -0.67 | 0.75 | 0.24 | FALSE |
16 | GTEx | Thyroid | AL021977.1 | 0.20 | 0.11 | lasso | 6 | 0.12 | 2.7e-09 | 4.2 | -5.4 | 6.7e-08 | -0.66 | 0.72 | 0.27 | FALSE |
17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLA2G6 | 0.05 | 0.01 | blup | 76 | 0.01 | 7.7e-02 | 5.9 | 5.5 | 3.6e-08 | 0.83 | 0.01 | 0.84 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | PLA2G6 | 0.03 | 0.02 | lasso | 2 | 0.03 | 6.5e-04 | 5.1 | 5.1 | 2.6e-07 | 0.81 | 0.06 | 0.46 | FALSE |