Best TWAS P=1.9e-53 · Best GWAS P=3.41e-49 conditioned to 0.645
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CDK6 | 0.12 | 0.10 | lasso | 2 | 0.10 | 1.9e-12 | 14.57 | 14.6 | 4.3e-48 | 1.00 | 0.01 | 0.99 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | KRIT1 | 0.04 | 0.01 | blup | 318 | 0.02 | 1.2e-03 | 3.65 | -5.2 | 2.3e-07 | -0.23 | 0.60 | 0.02 | FALSE |
3 | GTEx | Adipose Visceral Omentum | GATAD1 | 0.12 | 0.08 | lasso | 5 | 0.06 | 7.5e-04 | 6.84 | -6.9 | 5.9e-12 | -0.46 | 0.82 | 0.05 | FALSE |
4 | GTEx | Adrenal Gland | GATAD1 | 0.40 | 0.22 | lasso | 7 | 0.25 | 2.0e-09 | 6.84 | -7.7 | 1.3e-14 | -0.47 | 0.69 | 0.05 | FALSE |
5 | GTEx | Artery Aorta | KRIT1 | 0.15 | 0.00 | enet | 24 | 0.03 | 1.3e-02 | 0.39 | -6.5 | 1.1e-10 | -0.28 | 0.12 | 0.05 | FALSE |
6 | GTEx | Artery Aorta | GATAD1 | 0.09 | 0.08 | enet | 4 | 0.07 | 7.4e-05 | 6.84 | -6.9 | 5.8e-12 | -0.42 | 0.53 | 0.03 | FALSE |
7 | GTEx | Artery Coronary | GATAD1 | 0.12 | 0.15 | lasso | 3 | 0.12 | 8.0e-05 | 7.02 | -7.2 | 5.8e-13 | -0.41 | 0.19 | 0.20 | FALSE |
8 | GTEx | Artery Tibial | GATAD1 | 0.14 | 0.04 | enet | 17 | 0.04 | 4.1e-04 | 6.84 | -6.8 | 9.2e-12 | -0.38 | 0.70 | 0.10 | FALSE |
9 | GTEx | Artery Tibial | AC007566.10 | 0.13 | 0.04 | lasso | 5 | 0.00 | 3.1e-01 | 5.33 | -6.1 | 1.1e-09 | -0.15 | 0.08 | 0.03 | FALSE |
10 | GTEx | Brain Caudate basal ganglia | GATAD1 | 0.21 | 0.09 | lasso | 4 | 0.08 | 2.3e-03 | 5.28 | -7.8 | 5.1e-15 | -0.43 | 0.09 | 0.19 | FALSE |
11 | GTEx | Breast Mammary Tissue (Female) | AC007566.10 | 0.04 | -0.01 | lasso | 2 | 0.01 | 2.0e-01 | 1.65 | -7.5 | 7.4e-14 | -0.37 | 0.02 | 0.24 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | GATAD1 | 0.23 | 0.20 | lasso | 4 | 0.22 | 1.4e-16 | 6.84 | -9.3 | 1.0e-20 | -0.58 | 0.99 | 0.01 | FALSE |
13 | GTEx | Colon Transverse | GATAD1 | 0.13 | 0.00 | enet | 16 | 0.05 | 3.0e-03 | 6.84 | -7.7 | 9.7e-15 | -0.38 | 0.21 | 0.12 | FALSE |
14 | GTEx | Esophagus Mucosa | GATAD1 | 0.16 | 0.05 | enet | 16 | 0.08 | 7.3e-06 | 6.84 | -7.6 | 4.0e-14 | -0.42 | 0.82 | 0.04 | FALSE |
15 | GTEx | Esophagus Muscularis | GATAD1 | 0.18 | 0.10 | enet | 33 | 0.13 | 1.6e-08 | 6.84 | -5.7 | 1.4e-08 | -0.32 | 0.98 | 0.00 | FALSE |
16 | GTEx | Esophagus Muscularis | FAM133B | 0.07 | 0.01 | enet | 2 | 0.01 | 1.2e-01 | -10.00 | -10.0 | 2.4e-23 | -0.46 | 0.06 | 0.45 | FALSE |
17 | GTEx | Lung | GATAD1 | 0.15 | 0.12 | lasso | 2 | 0.11 | 1.1e-08 | 6.84 | -6.8 | 8.5e-12 | -0.42 | 0.99 | 0.00 | FALSE |
18 | GTEx | Muscle Skeletal | PEX1 | 0.06 | 0.03 | lasso | 5 | 0.02 | 2.7e-03 | 5.70 | 6.1 | 1.0e-09 | 0.30 | 0.56 | 0.09 | FALSE |
19 | GTEx | Muscle Skeletal | GATAD1 | 0.05 | 0.00 | enet | 13 | 0.01 | 2.4e-02 | 2.90 | -6.8 | 1.4e-11 | -0.38 | 0.48 | 0.02 | FALSE |
20 | GTEx | Nerve Tibial | GATAD1 | 0.30 | 0.19 | lasso | 5 | 0.23 | 1.8e-16 | 6.84 | -5.2 | 2.2e-07 | -0.35 | 1.00 | 0.00 | FALSE |
21 | GTEx | Pancreas | GATAD1 | 0.12 | 0.13 | lasso | 2 | 0.14 | 2.0e-06 | 6.84 | -6.2 | 4.8e-10 | -0.40 | 0.21 | 0.37 | FALSE |
22 | GTEx | Pituitary | KRIT1 | 0.21 | -0.01 | enet | 14 | 0.20 | 1.1e-05 | 0.04 | -5.2 | 2.2e-07 | -0.09 | 0.28 | 0.07 | TRUE |
23 | GTEx | Skin Not Sun Exposed Suprapubic | GATAD1 | 0.22 | 0.27 | lasso | 4 | 0.26 | 1.1e-14 | 6.84 | -7.0 | 2.7e-12 | -0.42 | 1.00 | 0.00 | FALSE |
24 | GTEx | Skin Sun Exposed Lower leg | PEX1 | 0.18 | 0.06 | enet | 41 | 0.03 | 1.5e-03 | -7.93 | -8.3 | 1.2e-16 | -0.39 | 0.20 | 0.18 | FALSE |
25 | GTEx | Skin Sun Exposed Lower leg | GATAD1 | 0.30 | 0.10 | enet | 14 | 0.16 | 7.0e-13 | 6.84 | -6.8 | 1.2e-11 | -0.39 | 1.00 | 0.00 | FALSE |
26 | GTEx | Spleen | PEX1 | 0.18 | 0.00 | enet | 38 | 0.05 | 2.4e-02 | 3.58 | -7.2 | 5.5e-13 | -0.32 | 0.08 | 0.06 | FALSE |
27 | GTEx | Stomach | GATAD1 | 0.30 | 0.13 | lasso | 5 | 0.15 | 8.6e-08 | 6.84 | -7.0 | 2.5e-12 | -0.46 | 0.98 | 0.00 | FALSE |
28 | GTEx | Testis | CDK6 | 0.10 | 0.10 | lasso | 3 | 0.09 | 8.0e-05 | 14.62 | -15.4 | 1.9e-53 | -0.92 | 0.03 | 0.95 | TRUE |
29 | GTEx | Thyroid | GATAD1 | 0.18 | 0.06 | lasso | 4 | 0.06 | 3.3e-05 | 6.84 | -6.7 | 1.9e-11 | -0.43 | 0.94 | 0.04 | FALSE |
30 | METSIM | Adipose | GATAD1 | 0.10 | 0.05 | lasso | 7 | 0.06 | 9.4e-10 | 2.90 | -5.2 | 2.1e-07 | -0.40 | 1.00 | 0.00 | FALSE |
31 | ROSMAP | Brain Pre-frontal Cortex | KRIT1 | 0.04 | 0.03 | bslmm | 311 | 0.01 | 9.0e-03 | 3.59 | 6.9 | 4.0e-12 | 0.49 | 0.75 | 0.05 | FALSE |
32 | ROSMAP | Brain Pre-frontal Cortex | GATAD1 | 0.17 | 0.15 | lasso | 4 | 0.16 | 6.0e-20 | 6.84 | -7.0 | 3.3e-12 | -0.43 | 1.00 | 0.00 | FALSE |
33 | YFS | Blood | CYP51A1 | 0.03 | 0.06 | blup | 288 | 0.05 | 1.2e-16 | 3.68 | -5.3 | 1.4e-07 | -0.31 | 1.00 | 0.00 | FALSE |
34 | YFS | Blood | GATAD1 | 0.01 | 0.01 | blup | 297 | 0.01 | 5.1e-04 | 6.84 | -9.0 | 1.9e-19 | -0.55 | 0.73 | 0.10 | FALSE |
35 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GATAD1 | 0.06 | 0.04 | lasso | 6 | 0.04 | 2.2e-09 | 6.57 | -6.2 | 7.5e-10 | -0.31 | 0.88 | 0.12 | FALSE |
36 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GATAD1 | 0.04 | 0.04 | lasso | 2 | 0.03 | 2.8e-04 | 6.57 | -6.3 | 2.6e-10 | -0.36 | 0.16 | 0.06 | FALSE |