[Hub]/) : Traits : Arm fat-free mass (left) :

chr1:77,547,831-79,699,821

Best TWAS P=2.8e-18 · Best GWAS P=1.95e-34 conditioned to 1.98e-17

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Cells EBV-transformed lymphocytes NEXN 0.23 0.10 lasso 3 0.08 1.4e-03 -6.8 -7.3 2.1e-13 -0.13 0.21 0.04 FALSE
2 GTEx Cells Transformed fibroblasts PTGFR 0.12 0.04 enet 17 0.04 4.7e-04 4.0 -6.3 2.6e-10 -0.26 0.97 0.00 FALSE
3 GTEx Lung GIPC2 0.15 0.09 enet 17 0.12 2.5e-09 -7.1 7.8 6.8e-15 0.19 1.00 0.00 FALSE
4 GTEx Nerve Tibial DNAJB4 0.08 0.07 lasso 3 0.07 1.3e-05 -7.1 -7.1 1.2e-12 -0.14 0.82 0.01 FALSE
5 GTEx Pancreas GIPC2 0.41 0.13 enet 29 0.14 1.1e-06 -6.6 6.7 2.8e-11 0.31 0.65 0.10 FALSE
6 GTEx Skin Sun Exposed Lower leg DNAJB4 0.07 0.05 lasso 5 0.05 6.5e-05 -7.1 -6.7 1.8e-11 -0.11 0.60 0.01 FALSE
7 GTEx Spleen GIPC2 0.43 0.07 enet 19 0.22 2.9e-06 -7.5 8.1 6.3e-16 0.22 0.83 0.02 FALSE
8 METSIM Adipose DNAJB4 0.04 0.04 lasso 4 0.03 2.1e-05 -6.9 -7.5 4.8e-14 -0.26 0.70 0.01 FALSE
9 ROSMAP Brain Pre-frontal Cortex DNAJB4 0.08 0.09 lasso 2 0.09 1.3e-11 -7.0 -7.0 2.0e-12 -0.18 1.00 0.00 FALSE
10 ROSMAP Brain Pre-frontal Cortex FAM73A 0.09 0.04 enet 19 0.06 9.6e-09 -2.3 6.4 1.9e-10 0.33 0.99 0.01 TRUE
11 YFS Blood NEXN 0.02 0.01 blup 367 0.02 1.2e-06 -6.3 5.8 8.6e-09 0.09 0.59 0.01 FALSE
12 The Cancer Genome Atlas Bladder Urothelial Carcinoma DNAJB4 0.05 0.03 lasso 3 0.02 3.3e-03 -6.6 -7.3 2.6e-13 -0.20 0.30 0.09 FALSE
13 The Cancer Genome Atlas Breast Invasive Carcinoma GIPC2 0.02 0.02 lasso 2 0.02 8.3e-05 -6.4 6.6 4.0e-11 0.24 0.56 0.02 FALSE
14 The Cancer Genome Atlas Colon Adenocarcinoma GIPC2 0.04 0.01 blup 65 0.00 2.5e-01 -6.8 8.7 2.8e-18 0.28 0.07 0.06 TRUE
15 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma USP33 0.07 0.02 blup 42 0.01 7.7e-03 -1.8 -5.2 1.9e-07 -0.21 0.06 0.03 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GIPC2 0.10 0.06 enet 13 0.06 1.5e-07 -6.7 7.3 2.3e-13 0.37 0.96 0.00 FALSE
17 The Cancer Genome Atlas Brain Lower Grade Glioma DNAJB4 0.08 0.07 lasso 1 0.06 9.3e-08 -6.6 -6.7 3.0e-11 -0.19 0.97 0.00 FALSE
18 The Cancer Genome Atlas Brain Lower Grade Glioma GIPC2 0.02 0.02 lasso 3 0.02 1.0e-03 -7.6 7.6 2.2e-14 0.22 0.37 0.02 FALSE
19 The Cancer Genome Atlas Lung Adenocarcinoma DNAJB4 0.04 0.04 lasso 2 0.04 1.2e-05 8.6 -8.6 6.9e-18 -0.45 0.00 1.00 FALSE
20 The Cancer Genome Atlas Prostate Adenocarcinoma GIPC2 0.10 0.11 blup 64 0.13 1.1e-13 -7.0 5.7 1.5e-08 0.13 1.00 0.00 FALSE
21 The Cancer Genome Atlas Testicular Germ Cell Tumors DNAJB4 0.24 0.14 lasso 1 0.11 1.1e-04 -6.6 -6.7 3.0e-11 -0.19 0.10 0.20 FALSE
22 The Cancer Genome Atlas Thyroid Carcinoma GIPC2 0.07 0.05 blup 64 0.06 1.5e-06 -7.2 7.5 9.0e-14 0.28 0.67 0.02 FALSE