[Hub]/) : Traits : Arm fat-free mass (left) :

chr10:101,548,177-103,428,898

Best TWAS P=5.18e-27 · Best GWAS P=4.06e-25 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex SEC31B 0.13 0.21 lasso 3 0.20 4.1e-24 -5.3 5.3 1.1e-07 0.05 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous SEC31B 0.32 0.39 lasso 5 0.38 5.1e-33 -5.3 5.2 1.6e-07 0.05 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous RP11-179B2.2 0.15 0.08 lasso 6 0.08 3.2e-07 8.4 9.0 1.6e-19 0.90 0.02 0.98 FALSE
4 GTEx Adipose Visceral Omentum SEC31B 0.18 0.28 lasso 10 0.27 1.5e-14 -4.7 5.1 2.7e-07 0.07 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum RP11-179B2.2 0.13 0.02 lasso 3 0.03 6.5e-03 10.3 9.9 3.6e-23 0.99 0.00 0.99 FALSE
6 GTEx Artery Aorta RP11-179B2.2 0.16 0.11 lasso 2 0.09 7.6e-06 10.3 10.2 2.0e-24 0.98 0.00 1.00 FALSE
7 GTEx Artery Tibial RP11-179B2.2 0.11 0.09 lasso 4 0.08 8.8e-07 10.3 10.2 3.0e-24 0.96 0.00 1.00 FALSE
8 GTEx Brain Cerebellum RP11-179B2.2 0.37 0.21 lasso 4 0.20 1.4e-06 10.4 10.8 5.2e-27 0.96 0.00 0.99 TRUE
9 GTEx Brain Frontal Cortex BA9 RP11-179B2.2 0.22 0.15 lasso 2 0.11 7.2e-04 10.4 9.8 1.4e-22 0.98 0.00 0.97 FALSE
10 GTEx Breast Mammary Tissue SEC31B 0.17 0.26 lasso 5 0.25 2.9e-13 -5.3 5.1 3.0e-07 0.05 1.00 0.00 FALSE
11 GTEx Breast Mammary Tissue RP11-179B2.2 0.11 0.09 lasso 2 0.07 1.8e-04 10.3 9.7 4.8e-22 0.96 0.01 0.99 FALSE
12 GTEx Breast Mammary Tissue (Male) SEC31B 0.13 0.08 lasso 4 0.10 3.0e-03 -5.3 5.3 1.3e-07 0.05 0.27 0.04 FALSE
13 GTEx Breast Mammary Tissue (Male) RP11-179B2.2 0.16 -0.01 enet 4 -0.01 7.1e-01 -9.4 9.7 4.8e-22 0.77 0.04 0.45 FALSE
14 GTEx Breast Mammary Tissue (Female) RP11-179B2.2 0.19 0.00 lasso 3 -0.01 5.1e-01 8.4 6.0 1.7e-09 0.65 0.03 0.45 FALSE
15 GTEx Colon Transverse SEC31B 0.28 0.12 lasso 3 0.09 3.3e-05 -5.3 5.3 1.4e-07 0.07 0.98 0.00 FALSE
16 GTEx Esophagus Gastroesophageal Junction SEC31B 0.15 0.21 lasso 4 0.20 8.0e-08 -5.3 5.3 1.3e-07 0.05 0.96 0.00 FALSE
17 GTEx Esophagus Mucosa SEC31B 0.14 0.18 lasso 4 0.17 2.0e-11 -5.3 5.3 1.3e-07 0.05 1.00 0.00 FALSE
18 GTEx Esophagus Mucosa HIF1AN 0.14 0.08 lasso 7 0.09 2.2e-06 -5.4 5.3 1.2e-07 0.09 0.98 0.00 FALSE
19 GTEx Esophagus Muscularis SEC31B 0.18 0.19 lasso 4 0.20 4.5e-12 -5.3 5.3 1.5e-07 0.05 1.00 0.00 FALSE
20 GTEx Esophagus Muscularis RP11-179B2.2 0.15 0.16 lasso 3 0.16 8.1e-10 10.1 10.1 9.2e-24 0.98 0.01 0.99 FALSE
21 GTEx Heart Left Ventricle RP11-179B2.2 0.15 0.18 enet 2 0.14 4.8e-08 10.4 10.4 4.2e-25 1.00 0.00 1.00 FALSE
22 GTEx Lung RP11-179B2.2 0.18 0.12 lasso 3 0.12 1.7e-09 10.4 9.9 4.2e-23 0.99 0.00 1.00 FALSE
23 GTEx Muscle Skeletal HIF1AN 0.05 0.06 lasso 1 0.05 1.6e-05 -5.3 -5.3 1.1e-07 -0.06 0.94 0.00 FALSE
24 GTEx Nerve Tibial SEC31B 0.42 0.42 lasso 9 0.43 1.4e-32 -5.3 5.1 3.0e-07 0.06 1.00 0.00 FALSE
25 GTEx Nerve Tibial RP11-179B2.2 0.15 0.08 lasso 2 0.12 6.4e-09 10.1 8.1 4.8e-16 0.88 0.01 0.99 FALSE
26 GTEx Pancreas SEC31B 0.24 0.19 lasso 5 0.17 9.9e-08 -5.3 5.2 2.6e-07 0.06 0.97 0.00 FALSE
27 GTEx Prostate SEC31B 0.18 0.14 lasso 2 0.12 6.7e-04 -5.2 5.2 1.5e-07 0.05 0.38 0.05 FALSE
28 GTEx Skin Not Sun Exposed Suprapubic SEC31B 0.15 0.16 lasso 4 0.15 8.3e-09 -5.3 5.3 1.3e-07 0.05 0.99 0.00 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic HIF1AN 0.13 0.03 lasso 5 0.02 3.4e-02 -5.4 5.5 4.6e-08 0.04 0.26 0.03 FALSE
30 GTEx Skin Not Sun Exposed Suprapubic RP11-179B2.2 0.27 0.15 enet 36 0.15 2.0e-08 10.4 8.9 6.1e-19 0.75 0.00 1.00 FALSE
31 GTEx Skin Sun Exposed Lower leg SEC31B 0.20 0.34 lasso 4 0.34 8.3e-29 -5.3 5.1 2.8e-07 0.06 1.00 0.00 FALSE
32 GTEx Skin Sun Exposed Lower leg HIF1AN 0.07 0.05 lasso 8 0.03 2.2e-03 -5.5 5.3 1.2e-07 0.06 0.93 0.00 FALSE
33 GTEx Skin Sun Exposed Lower leg RP11-179B2.2 0.12 0.09 lasso 2 0.08 1.7e-07 8.3 8.0 1.1e-15 0.86 0.06 0.94 FALSE
34 GTEx Spleen SEC31B 0.21 0.12 lasso 3 0.05 2.3e-02 -5.3 5.4 6.7e-08 0.05 0.28 0.09 FALSE
35 GTEx Testis SEC31B 0.11 0.11 lasso 5 0.08 2.5e-04 -5.3 5.3 9.6e-08 0.05 0.84 0.01 FALSE
36 GTEx Testis HIF1AN 0.12 0.08 lasso 3 0.06 1.6e-03 -5.5 5.6 2.7e-08 0.08 0.34 0.04 TRUE
37 GTEx Thyroid RP11-179B2.2 0.18 0.12 lasso 7 0.11 8.3e-09 8.4 9.1 1.2e-19 0.91 0.04 0.96 FALSE
38 GTEx Uterus SEC31B 0.40 0.14 lasso 18 0.05 3.1e-02 -5.4 5.2 2.1e-07 0.02 0.36 0.04 FALSE
39 GTEx Whole Blood HIF1AN 0.15 0.12 enet 7 0.12 8.7e-11 -5.5 5.4 6.2e-08 0.06 1.00 0.00 FALSE
40 METSIM Adipose MRPL43 0.05 0.04 bslmm 422 0.04 1.9e-06 -4.2 6.9 5.1e-12 0.46 0.94 0.02 FALSE
41 NTR Blood HIF1AN 0.02 0.03 lasso 2 0.02 1.4e-07 -5.3 5.4 8.3e-08 0.05 1.00 0.00 FALSE
42 NTR Blood SEC31B 0.03 0.03 lasso 4 0.03 1.1e-10 -5.3 5.2 1.6e-07 0.06 1.00 0.00 FALSE
43 ROSMAP Brain Pre-frontal Cortex MRPL43 0.10 0.08 bslmm 411 0.09 1.2e-11 -4.2 -5.6 2.5e-08 -0.56 1.00 0.00 FALSE
44 The Cancer Genome Atlas Colon Adenocarcinoma HIF1AN 0.07 0.03 blup 40 0.05 4.9e-04 -5.3 5.4 8.5e-08 0.05 0.03 0.84 FALSE
45 The Cancer Genome Atlas Colon Adenocarcinoma MRPL43 0.07 0.02 blup 52 0.00 1.7e-01 9.7 -9.1 6.8e-20 -0.80 0.01 0.82 FALSE
46 The Cancer Genome Atlas Colon Adenocarcinoma SEC31B 0.06 0.07 blup 51 0.08 2.9e-05 -4.7 5.2 1.8e-07 0.06 0.04 0.95 FALSE
47 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MRPL43 0.03 0.02 blup 52 0.03 3.0e-04 -4.2 -6.3 3.5e-10 -0.68 0.10 0.51 FALSE
48 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SEC31B 0.05 0.05 blup 51 0.05 1.3e-06 -5.3 5.3 1.1e-07 0.05 0.03 0.97 FALSE
49 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SEC31B 0.05 0.05 blup 51 0.05 8.9e-07 -5.3 5.2 1.7e-07 0.06 0.03 0.97 FALSE
50 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SEMA4G 0.04 0.01 blup 52 0.02 1.2e-03 8.3 8.4 2.9e-17 0.83 0.01 0.79 FALSE
51 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SEC31B 0.14 0.10 lasso 7 0.10 1.6e-06 -5.4 5.4 7.3e-08 0.05 0.03 0.97 FALSE
52 The Cancer Genome Atlas Brain Lower Grade Glioma NDUFB8 0.02 0.01 blup 38 0.01 1.6e-02 -4.7 -5.3 1.3e-07 -0.06 0.03 0.59 FALSE
53 The Cancer Genome Atlas Brain Lower Grade Glioma SEC31B 0.06 0.06 blup 51 0.06 1.1e-07 -5.2 5.4 6.8e-08 0.05 0.03 0.97 FALSE
54 The Cancer Genome Atlas Brain Lower Grade Glioma SEMA4G 0.03 0.01 blup 52 0.01 4.2e-02 10.1 7.6 2.6e-14 0.83 0.00 0.90 FALSE
55 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SEC31B 0.11 0.12 enet 15 0.13 1.5e-14 -5.4 5.1 3.0e-07 0.06 0.03 0.97 FALSE
56 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MRPL43 0.06 0.04 blup 51 0.04 7.4e-04 -4.2 -5.1 2.7e-07 -0.52 0.55 0.08 FALSE
57 The Cancer Genome Atlas Pancreatic Adenocarcinoma SEC31B 0.15 0.14 lasso 12 0.15 8.5e-07 -5.2 5.3 1.3e-07 0.06 0.04 0.96 FALSE
58 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FAM178A 0.14 0.08 lasso 2 0.08 5.9e-04 -7.9 -7.0 2.5e-12 -0.54 0.07 0.13 FALSE
59 The Cancer Genome Atlas Thyroid Carcinoma SEMA4G 0.07 0.08 blup 52 0.08 5.1e-08 -4.2 6.7 1.7e-11 0.75 0.04 0.96 FALSE