[Hub]/) : Traits : Arm fat-free mass (left) : ← →

chr12:14,220,891-15,812,575

Best TWAS P=1.41e-12 · Best GWAS P=1.17e-11 conditioned to 0.0158

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	ROSMAP	Brain Pre-frontal Cortex	WBP11	0.10	0.05	lasso	4	0.06	1.2e-08	-5.8	7.1	1.4e-12	-0.72	0.09	0.91	TRUE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	WBP11	0.03	0.03	blup	57	0.02	2.3e-03	-6.4	6.7	2.2e-11	-0.90	0.01	0.94	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf60	0.16	0.16	enet	10	0.18	1.3e-17	5.3	6.6	5.5e-11	-0.61	0.92	0.08	FALSE
13	GTEx	Heart Left Ventricle	H2AFJ	0.16	0.07	lasso	8	0.05	1.1e-03	-6.4	-6.3	2.4e-10	0.85	0.04	0.96	FALSE
41	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C12orf60	0.10	0.01	blup	56	0.07	1.6e-05	4.7	6.2	4.4e-10	-0.49	0.08	0.16	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	RP11-174G6.5	0.23	0.13	lasso	4	0.11	8.9e-04	-6.1	6.2	5.7e-10	-0.48	0.16	0.29	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C12orf60	0.12	0.07	enet	8	0.07	5.4e-05	5.3	6.2	7.3e-10	-0.64	0.07	0.83	FALSE
25	YFS	Blood	H2AFJ	0.05	0.02	bslmm	360	0.03	2.9e-10	-6.4	-6.0	2.3e-09	0.68	0.02	0.98	FALSE
19	GTEx	Thyroid	C12orf60	0.16	0.10	enet	9	0.12	8.1e-10	4.7	6.0	2.4e-09	-0.37	0.97	0.03	FALSE
3	GTEx	Artery Tibial	WBP11	0.09	0.06	lasso	2	0.06	3.8e-05	-5.8	5.9	2.8e-09	-0.48	0.58	0.37	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C12orf60	0.28	0.25	lasso	4	0.24	2.0e-29	5.2	5.9	4.6e-09	-0.49	0.94	0.06	FALSE
6	GTEx	Brain Cortex	C12orf60	0.44	0.28	lasso	3	0.29	1.2e-08	5.3	5.9	4.8e-09	-0.42	0.62	0.22	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C12orf60	0.05	0.05	lasso	3	0.04	1.1e-05	5.3	5.7	1.1e-08	-0.43	0.78	0.19	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	C12orf60	0.14	0.14	lasso	4	0.13	2.2e-14	5.3	5.7	1.3e-08	-0.43	0.92	0.08	FALSE
46	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ERP27	0.13	0.02	blup	74	0.06	1.4e-02	-5.4	5.7	1.3e-08	-0.20	0.02	0.77	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	C12orf60	0.07	0.05	enet	7	0.05	1.5e-06	5.3	5.6	1.9e-08	-0.42	0.79	0.20	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	ERP27	0.15	0.28	lasso	6	0.28	8.3e-33	-5.5	5.6	2.2e-08	-0.23	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ERP27	0.17	0.24	enet	13	0.25	6.7e-28	-5.3	5.6	2.2e-08	-0.27	0.02	0.98	FALSE
12	GTEx	Heart Left Ventricle	C12orf60	0.24	0.23	lasso	5	0.26	7.1e-14	5.2	5.6	2.5e-08	-0.42	0.92	0.08	FALSE
43	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERP27	0.14	0.12	lasso	5	0.11	2.9e-05	-5.5	5.6	2.7e-08	-0.23	0.01	0.98	FALSE
30	The Cancer Genome Atlas	Esophageal Carcinoma	ERP27	0.10	0.12	blup	75	0.08	1.5e-03	-5.2	5.5	3.1e-08	-0.21	0.02	0.88	FALSE
14	GTEx	Liver	H2AFJ	0.18	0.11	lasso	8	0.04	2.7e-02	-6.4	-5.5	3.4e-08	0.79	0.05	0.70	FALSE
47	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ERP27	0.10	0.05	lasso	1	0.08	8.9e-04	-5.5	5.5	3.4e-08	-0.23	0.02	0.96	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ERP27	0.09	0.14	lasso	2	0.12	1.7e-06	-5.5	5.5	3.8e-08	-0.24	0.02	0.98	FALSE
18	GTEx	Skin Sun Exposed Lower leg	C12orf60	0.09	0.06	enet	11	0.05	4.0e-05	5.2	5.5	3.9e-08	-0.44	0.78	0.16	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERP27	0.04	0.09	lasso	5	0.09	2.8e-17	-5.5	5.5	4.2e-08	-0.24	0.01	0.99	FALSE
9	GTEx	Brain Putamen basal ganglia	C12orf60	0.33	0.32	lasso	3	0.29	1.5e-07	5.4	5.5	4.4e-08	-0.37	0.32	0.25	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	ERP27	0.37	0.54	enet	18	0.55	2.3e-63	-5.5	5.4	5.5e-08	-0.23	0.01	0.99	FALSE
21	METSIM	Adipose	MGP	0.04	0.04	bslmm	359	0.04	6.2e-07	-4.6	5.4	5.8e-08	-0.37	0.98	0.02	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C12orf60	0.17	0.03	blup	56	0.07	2.9e-06	4.7	5.4	6.9e-08	-0.63	0.05	0.85	FALSE
2	GTEx	Artery Aorta	ARHGDIB	0.10	0.06	enet	10	0.08	5.4e-05	-5.4	5.4	7.2e-08	-0.25	0.70	0.09	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ERP27	0.10	0.18	lasso	6	0.18	1.2e-19	-5.4	5.4	8.2e-08	-0.26	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	C12orf60	0.05	0.03	lasso	1	0.01	1.2e-02	5.4	5.3	8.6e-08	-0.36	0.10	0.10	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	C12orf60	0.15	0.16	lasso	2	0.13	1.6e-07	5.3	5.3	9.8e-08	-0.36	0.92	0.06	FALSE
4	GTEx	Brain Caudate basal ganglia	C12orf60	0.39	0.34	lasso	3	0.32	5.4e-10	5.2	5.3	1.0e-07	-0.37	0.86	0.11	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf60	0.10	0.04	enet	7	0.05	2.0e-06	-4.5	5.3	1.1e-07	-0.49	0.29	0.49	FALSE
42	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ERP27	0.04	0.05	enet	12	0.04	1.0e-03	-5.2	5.3	1.3e-07	-0.26	0.02	0.95	FALSE
10	GTEx	Breast Mammary Tissue (Female)	C12orf60	0.19	0.17	lasso	3	0.12	2.6e-04	5.2	5.3	1.4e-07	-0.36	0.14	0.23	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ERP27	0.07	0.03	enet	17	0.04	1.6e-04	-5.3	5.3	1.5e-07	-0.21	0.02	0.96	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	ERP27	0.13	0.14	lasso	5	0.13	8.3e-14	-5.2	5.2	1.5e-07	-0.26	0.02	0.98	FALSE
24	YFS	Blood	ERP27	0.30	0.41	enet	31	0.42	3.1e-152	-5.2	5.2	2.0e-07	-0.25	0.96	0.04	FALSE
31	The Cancer Genome Atlas	Glioblastoma Multiforme	ERP27	0.18	0.07	blup	76	0.11	2.7e-04	-5.4	5.2	2.0e-07	-0.19	0.02	0.93	FALSE
16	GTEx	Nerve Tibial	C12orf60	0.39	0.27	enet	11	0.30	9.6e-22	5.2	5.2	2.1e-07	-0.37	0.94	0.06	FALSE
11	GTEx	Cells Transformed fibroblasts	C12orf60	0.10	0.10	lasso	2	0.09	1.8e-07	4.7	5.2	2.2e-07	-0.36	0.95	0.05	FALSE
20	METSIM	Adipose	C12orf60	0.14	0.10	lasso	4	0.08	1.2e-12	5.2	5.2	2.2e-07	-0.37	0.93	0.07	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	C12orf60	0.26	0.29	lasso	5	0.29	1.9e-37	5.3	5.2	2.2e-07	-0.33	0.92	0.08	FALSE
5	GTEx	Brain Cerebellum	C12orf60	0.19	0.17	lasso	3	0.13	1.2e-04	5.2	5.1	2.8e-07	-0.35	0.17	0.08	FALSE
7	GTEx	Brain Hypothalamus	C12orf60	0.28	0.27	lasso	4	0.19	3.8e-05	5.2	5.1	2.9e-07	-0.36	0.23	0.12	FALSE
15	GTEx	Muscle Skeletal	WBP11	0.08	0.08	lasso	5	0.08	2.4e-08	-5.1	5.1	2.9e-07	-0.45	0.74	0.25	FALSE