Best TWAS P=1.18e-12 · Best GWAS P=1.24e-12 conditioned to 0.00172
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CTU2 | 0.10 | 0.07 | lasso | 5 | 0.08 | 4.0e-10 | -4.6 | 5.5 | 4.5e-08 | -0.43 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | SPG7 | 0.14 | 0.06 | blup | 445 | 0.10 | 3.2e-12 | 5.8 | -5.6 | 1.7e-08 | -0.02 | 0.01 | 0.99 | FALSE |
3 | GTEx | Artery Aorta | RPL13 | 0.19 | 0.20 | lasso | 5 | 0.17 | 1.7e-09 | 5.4 | -6.1 | 1.4e-09 | 0.05 | 0.02 | 0.98 | FALSE |
4 | GTEx | Breast Mammary Tissue | RPL13 | 0.09 | 0.05 | enet | 7 | 0.04 | 5.3e-03 | 6.3 | -6.1 | 8.8e-10 | 0.00 | 0.02 | 0.94 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | RPL13 | 0.10 | 0.08 | enet | 8 | 0.09 | 3.7e-07 | 5.0 | -6.1 | 1.2e-09 | 0.09 | 0.03 | 0.97 | FALSE |
6 | GTEx | Colon Sigmoid | RPL13 | 0.17 | 0.18 | lasso | 1 | 0.16 | 3.1e-06 | 5.4 | -5.4 | 6.4e-08 | 0.08 | 0.02 | 0.98 | FALSE |
7 | GTEx | Colon Sigmoid | CDK10 | 0.37 | 0.12 | lasso | 8 | 0.22 | 2.2e-08 | 3.8 | -5.6 | 2.3e-08 | -0.21 | 0.52 | 0.16 | FALSE |
8 | GTEx | Colon Sigmoid | RP11-104N10.1 | 0.14 | 0.00 | lasso | 2 | 0.02 | 8.3e-02 | -5.3 | -5.5 | 4.6e-08 | -0.17 | 0.10 | 0.19 | FALSE |
9 | GTEx | Colon Transverse | RPL13 | 0.23 | 0.17 | lasso | 4 | 0.16 | 3.7e-08 | 6.2 | -7.1 | 1.2e-12 | 0.01 | 0.01 | 0.99 | TRUE |
10 | GTEx | Esophagus Muscularis | RPL13 | 0.17 | 0.12 | lasso | 3 | 0.11 | 2.4e-07 | 6.2 | -6.4 | 1.4e-10 | 0.06 | 0.01 | 0.99 | FALSE |
11 | GTEx | Muscle Skeletal | RPL13 | 0.10 | 0.09 | lasso | 5 | 0.10 | 3.3e-10 | 5.4 | -5.7 | 9.7e-09 | 0.08 | 0.02 | 0.98 | FALSE |
12 | GTEx | Muscle Skeletal | SPG7 | 0.24 | 0.22 | lasso | 5 | 0.23 | 8.9e-23 | -5.1 | -6.2 | 6.8e-10 | -0.11 | 0.74 | 0.26 | FALSE |
13 | GTEx | Nerve Tibial | RPL13 | 0.10 | 0.07 | lasso | 3 | 0.07 | 2.0e-05 | 5.8 | -5.4 | 6.2e-08 | 0.09 | 0.04 | 0.96 | FALSE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | RPL13 | 0.16 | 0.15 | lasso | 4 | 0.15 | 2.0e-08 | 5.8 | -5.9 | 3.7e-09 | 0.09 | 0.04 | 0.96 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-104N10.1 | 0.11 | 0.04 | lasso | 4 | 0.03 | 5.2e-03 | -5.3 | -5.2 | 1.7e-07 | -0.13 | 0.14 | 0.48 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | RPL13 | 0.11 | 0.13 | enet | 7 | 0.12 | 1.7e-10 | 5.2 | -5.4 | 8.6e-08 | 0.06 | 0.09 | 0.91 | FALSE |
17 | GTEx | Skin Sun Exposed Lower leg | SPG7 | 0.09 | 0.05 | lasso | 2 | 0.03 | 1.5e-03 | 6.2 | -6.0 | 2.1e-09 | 0.08 | 0.02 | 0.98 | FALSE |
18 | GTEx | Testis | RPL13 | 0.25 | 0.22 | lasso | 5 | 0.21 | 1.6e-09 | 5.4 | -5.4 | 5.4e-08 | 0.09 | 0.03 | 0.97 | FALSE |
19 | GTEx | Testis | RP5-1142A6.2 | 0.21 | 0.13 | lasso | 4 | 0.12 | 7.2e-06 | -5.7 | -6.6 | 4.5e-11 | 0.60 | 0.15 | 0.35 | TRUE |
20 | GTEx | Thyroid | RPL13 | 0.13 | 0.05 | enet | 10 | 0.06 | 1.4e-05 | 5.9 | -6.8 | 8.3e-12 | -0.02 | 0.02 | 0.98 | FALSE |
21 | GTEx | Whole Blood | SPG7 | 0.06 | 0.05 | lasso | 3 | 0.05 | 3.9e-05 | 5.8 | -6.5 | 1.1e-10 | 0.01 | 0.05 | 0.92 | FALSE |
22 | GTEx | Whole Blood | CTD-2555A7.3 | 0.10 | 0.00 | lasso | 5 | 0.01 | 1.0e-01 | 2.8 | 5.6 | 2.7e-08 | -0.19 | 0.11 | 0.27 | TRUE |
23 | METSIM | Adipose | RPL13 | 0.05 | 0.05 | enet | 5 | 0.05 | 1.0e-07 | 5.9 | -5.9 | 4.2e-09 | 0.07 | 0.02 | 0.98 | FALSE |
24 | NTR | Blood | RPL13 | 0.02 | 0.01 | bslmm | 365 | 0.01 | 5.9e-05 | 6.2 | 5.2 | 2.4e-07 | -0.12 | 0.01 | 0.99 | FALSE |
25 | YFS | Blood | SPG7 | 0.08 | 0.11 | lasso | 6 | 0.11 | 6.9e-34 | -5.2 | -5.4 | 8.5e-08 | -0.18 | 0.69 | 0.30 | FALSE |
26 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SPG7 | 0.05 | 0.03 | lasso | 3 | 0.03 | 1.8e-03 | 5.8 | -5.7 | 1.4e-08 | 0.08 | 0.02 | 0.84 | FALSE |
27 | The Cancer Genome Atlas | Esophageal Carcinoma | RPL13 | 0.14 | 0.07 | lasso | 3 | 0.04 | 2.6e-02 | 5.8 | -6.0 | 2.6e-09 | 0.07 | 0.01 | 0.81 | FALSE |
28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SPG7 | 0.05 | 0.05 | lasso | 5 | 0.05 | 1.9e-06 | 5.8 | -5.8 | 7.0e-09 | 0.08 | 0.04 | 0.96 | FALSE |
29 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SPG7 | 0.03 | 0.02 | blup | 58 | 0.03 | 4.1e-04 | 5.0 | -6.4 | 1.7e-10 | -0.01 | 0.03 | 0.72 | FALSE |
30 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RPL13 | 0.03 | 0.01 | blup | 41 | 0.02 | 8.5e-03 | 5.6 | -6.4 | 1.9e-10 | 0.01 | 0.02 | 0.72 | FALSE |
31 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SPG7 | 0.11 | 0.09 | lasso | 2 | 0.08 | 2.5e-04 | 6.1 | -6.1 | 9.1e-10 | 0.07 | 0.02 | 0.96 | FALSE |
32 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CDK10 | 0.20 | 0.02 | enet | 15 | 0.08 | 5.3e-04 | 3.0 | -5.2 | 2.5e-07 | -0.08 | 0.00 | 0.00 | TRUE |
33 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RPL13 | 0.04 | 0.03 | blup | 41 | 0.03 | 2.2e-03 | 5.4 | -6.5 | 1.1e-10 | 0.06 | 0.02 | 0.86 | FALSE |