TWAS hub - SPG7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1370	0.0340	3.5e-11	0.061	0.100	0.092	0.100	0.097	6.7e-08	3.2e-12	2.5e-11	3.9e-12	8.0e-12
2	GTEx	Brain Frontal Cortex BA9	0.1849	0.0803	8.1e-03	0.026	NA	0.013	NA	0.067	6.7e-02	NA	1.4e-01	NA	7.6e-03
3	GTEx	Brain Hypothalamus	0.4300	0.1230	1.0e-03	0.056	NA	0.245	NA	0.178	2.0e-02	NA	1.9e-06	NA	5.9e-05
4	GTEx	Colon Sigmoid	0.1290	0.0600	6.0e-03	-0.006	NA	-0.008	NA	-0.007	6.3e-01	NA	7.9e-01	NA	7.2e-01
5	GTEx	Muscle Skeletal	0.2358	0.0464	0.0e+00	0.218	NA	0.218	NA	0.234	4.4e-21	NA	3.9e-21	NA	8.8e-23
6	GTEx	Skin Sun Exposed Lower leg	0.0920	0.0360	1.0e-03	0.050	NA	0.026	NA	0.030	5.4e-05	NA	3.1e-03	NA	1.6e-03
7	GTEx	Whole Blood	0.0590	0.0260	2.0e-03	0.053	NA	0.028	NA	0.046	1.2e-05	NA	1.1e-03	NA	3.9e-05
8	METSIM	Adipose	0.1669	0.0444	5.8e-14	0.071	0.118	0.150	0.134	0.137	7.2e-11	3.6e-17	8.6e-22	1.5e-19	6.3e-20
9	YFS	Blood	0.0829	0.0189	0.0e+00	0.112	0.104	0.108	0.109	0.110	1.1e-34	3.0e-32	2.0e-33	9.5e-34	6.8e-34
10	TCGA	Bladder Urothelial Carcinoma	0.0460	0.0320	3.3e-03	0.031	0.028	0.015	NA	0.028	1.1e-03	1.9e-03	1.7e-02	NA	1.8e-03
11	TCGA	Breast Invasive Carcinoma	0.0347	0.0175	3.1e-05	0.026	0.018	0.023	NA	0.024	3.4e-06	8.7e-05	1.3e-05	NA	8.0e-06
12	TCGA	Colon Adenocarcinoma	0.1330	0.0730	4.2e-03	0.006	0.032	0.031	NA	0.013	1.4e-01	5.8e-03	6.5e-03	NA	5.5e-02
13	TCGA	Head and Neck Squamous Cell Carcinoma	0.0460	0.0229	2.7e-04	0.007	0.028	0.019	NA	0.018	4.4e-02	3.7e-04	2.6e-03	NA	3.9e-03
14	TCGA	Kidney Renal Clear Cell Carcinoma	0.0501	0.0236	1.9e-05	0.052	0.046	0.046	NA	0.051	1.5e-06	6.4e-06	5.5e-06	NA	1.9e-06
15	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0880	0.0530	4.0e-03	0.058	0.017	0.009	NA	0.017	3.0e-04	3.5e-02	8.9e-02	NA	3.4e-02
16	TCGA	Brain Lower Grade Glioma	0.0257	0.0164	2.1e-03	0.021	0.027	0.020	NA	0.024	1.7e-03	4.1e-04	2.2e-03	NA	8.2e-04
17	TCGA	Pancreatic Adenocarcinoma	0.1150	0.0610	4.1e-04	0.090	0.082	0.068	NA	0.082	1.3e-04	2.5e-04	8.3e-04	NA	2.5e-04
18	TCGA	Prostate Adenocarcinoma	0.0710	0.0389	8.2e-05	0.027	0.037	0.041	NA	0.028	7.3e-04	8.4e-05	3.7e-05	NA	5.5e-04
19	TCGA	Thyroid Carcinoma	0.1010	0.0360	1.6e-09	0.094	0.100	0.103	NA	0.106	1.9e-09	5.8e-10	3.1e-10	NA	1.8e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Tanning	126.8	1547.6	4277.2	24.9	-14.1	61.0	-45.4	37.2	-16.1	-0.3	44.5	54.4	-17.4	-26.5	-65.4	-52.2	-19.1	-56.5	6.3	-15.1	-49.7	-43.8
Hair Pigment	92.0	2622.4	10201.0	-46.1	-11.6	-101.0	34.7	-42.9	23.5	4.2	-38.9	-65.2	25.5	38.7	93.3	64.5	27.6	73.2	-1.8	21.3	56.1	57.0
Coronary Artery Disease (CAD)	10.6	12.7	20.0	-4.5	-2.5	-1.9	-1.9	-3.3	-4.2	-4.4	-2.6	-2.0	-4.3	-3.9	-3.6	-3.5	-4.2	-3.3	-4.3	-4.4	-2.4	-4.2
Past tobacco smoking	5.2	9.6	21.9	2.8	2.8	0.2	3.0	1.2	3.6	3.0	-1.6	0.1	3.1	2.9	4.1	3.9	3.2	4.0	2.6	4.0	3.3	4.7
Schizophrenia (2014)	5.0	11.0	28.4	-0.8	-3.7	-0.5	-4.2	0.6	-2.9	-1.8	1.8	2.3	-2.7	-4.0	-4.3	-5.0	-2.6	-5.2	-1.1	-2.7	-5.3	-4.3
Trunk predicted mass	5.0	28.3	52.0	-6.8	-2.0	-1.9	-2.8	-6.9	-6.7	-7.2	-3.9	-6.0	-6.4	-4.9	-4.1	-3.7	-6.5	-3.2	-7.1	-6.8	-1.9	-5.6
Basal cell carcinoma (self-reported)	5.0	5.9	19.5	-1.1	1.1	-3.1	3.2	-2.9	0.8	-0.6	-2.3	-4.0	0.6	1.8	4.4	3.4	0.7	3.0	-1.1	0.8	2.7	2.5
Leg fat-free mass (left)	4.9	26.1	45.0	-5.0	-2.2	-1.4	-2.4	-5.7	-6.6	-6.7	-3.9	-4.3	-6.4	-5.3	-5.3	-4.3	-6.4	-4.3	-6.5	-6.5	-2.9	-5.9
Leg predicted mass (left)	4.9	25.8	44.2	-5.0	-2.2	-1.4	-2.3	-5.6	-6.5	-6.7	-3.8	-4.3	-6.3	-5.3	-5.3	-4.3	-6.4	-4.3	-6.5	-6.5	-2.9	-5.9
Bipolar Disorder or Schizophrenia	4.8	11.7	28.8	-1.9	-4.3	-1.7	-5.4	0.3	-3.0	-1.8	2.3	2.1	-2.7	-4.2	-3.5	-5.1	-2.7	-4.7	-1.2	-2.8	-5.1	-4.2
Diabetes (self-reported)	4.8	7.4	11.2	-2.2	-2.5	-3.0	-1.6	-2.7	-3.3	-3.2	-2.7	-2.0	-2.9	-3.2	-3.2	-2.2	-2.8	-2.3	-3.0	-3.3	-1.2	-3.0
Trunk fat-free mass	4.8	27.7	50.8	-6.7	-1.9	-1.9	-2.8	-6.9	-6.6	-7.1	-3.9	-6.0	-6.3	-4.8	-4.1	-3.6	-6.4	-3.1	-7.0	-6.7	-1.8	-5.5
Basal metabolic rate	4.8	26.6	47.5	-5.6	-1.8	-1.6	-2.5	-6.1	-6.6	-6.9	-3.9	-5.0	-6.3	-5.1	-4.9	-4.1	-6.4	-3.8	-6.8	-6.7	-2.6	-5.8
Whole body fat-free mass	4.7	27.1	49.6	-6.2	-1.9	-1.8	-2.5	-6.5	-6.6	-7.0	-4.0	-5.5	-6.3	-5.0	-4.5	-3.8	-6.5	-3.5	-7.0	-6.7	-2.2	-5.6
Whole body water mass	4.7	26.9	49.4	-6.0	-2.0	-1.8	-2.4	-6.5	-6.6	-7.0	-4.0	-5.5	-6.3	-5.1	-4.5	-3.8	-6.4	-3.5	-6.9	-6.6	-2.1	-5.5
Waist circumference	4.4	16.2	34.7	-3.0	-0.9	-0.9	-1.9	-2.9	-5.0	-4.7	-1.9	-1.5	-4.9	-4.2	-5.9	-4.8	-4.9	-4.6	-4.2	-5.0	-4.1	-5.4
Ever smoked	4.4	7.7	15.9	-3.0	-1.6	-0.7	-0.7	-2.6	-3.4	-3.4	0.1	-1.8	-3.1	-2.8	-2.8	-2.6	-3.2	-3.3	-3.4	-3.8	-2.2	-4.0
Arm fat-free mass (left)	4.4	22.4	41.6	-5.6	-1.3	-2.1	-2.2	-6.2	-6.0	-6.5	-3.9	-5.4	-5.7	-4.3	-3.9	-3.2	-5.8	-2.8	-6.4	-6.1	-1.7	-4.9
Arm predicted mass (left)	4.4	22.3	41.6	-5.7	-1.1	-1.9	-1.9	-6.2	-5.9	-6.5	-3.9	-5.4	-5.7	-4.3	-3.9	-3.1	-5.8	-2.8	-6.4	-6.1	-1.6	-4.9
Leg fat-free mass (right)	4.2	22.6	40.4	-4.7	-2.1	-1.6	-2.0	-5.6	-6.1	-6.4	-3.8	-4.4	-5.9	-4.9	-4.7	-3.7	-6.0	-3.7	-6.3	-6.0	-2.4	-5.3
Leg predicted mass (right)	4.2	22.3	40.2	-4.7	-2.0	-1.5	-1.8	-5.6	-6.1	-6.3	-3.9	-4.5	-5.9	-4.9	-4.6	-3.5	-5.9	-3.6	-6.3	-6.0	-2.2	-5.2
Smoking Status	4.1	9.9	27.8	-1.9	-1.6	-1.3	-2.1	-0.1	-3.7	-2.5	2.4	1.2	-3.0	-3.1	-4.0	-4.5	-3.3	-4.6	-1.9	-4.0	-3.9	-5.3
Weight	3.9	19.0	32.5	-3.5	-1.1	-1.0	-2.3	-4.0	-5.6	-5.5	-2.6	-2.7	-5.4	-4.5	-5.5	-4.6	-5.5	-4.2	-5.1	-5.7	-3.5	-5.6
Arm fat-free mass (right)	3.8	19.6	39.6	-5.4	-0.3	-1.9	-0.9	-6.2	-5.6	-6.2	-4.3	-5.7	-5.3	-3.7	-3.3	-2.3	-5.4	-2.1	-6.3	-5.7	-0.7	-4.2
Medication: Blood pressure	3.8	6.7	15.3	-3.8	-1.5	-2.3	1.5	-3.9	-2.8	-3.4	-3.9	-3.5	-2.7	-2.0	-0.8	-0.9	-2.7	-1.1	-3.3	-2.6	-0.3	-1.8
Arm predicted mass (right)	3.8	19.6	39.2	-5.2	-0.7	-2.0	-1.1	-6.0	-5.6	-6.1	-4.4	-5.4	-5.3	-3.9	-3.5	-2.5	-5.3	-2.3	-6.3	-5.8	-0.8	-4.4
Bipolar Disorder (2018)	3.7	5.9	23.1	-0.5	-2.8	0.1	-4.8	1.5	-1.5	-0.3	2.5	2.9	-1.3	-2.4	-2.3	-3.8	-1.3	-2.9	0.3	-1.4	-3.8	-2.7
Chronic bronchitis/emphysema (mother)	3.6	4.2	16.6	0.2	-1.7	1.4	-2.5	1.3	-1.1	-0.5	2.0	2.3	-1.5	-1.9	-2.3	-3.5	-1.5	-2.7	0.3	-1.0	-4.1	-2.1
Leg pain on walking	3.6	4.5	14.5	-0.8	-1.0	-1.5	-1.0	-0.6	-2.3	-1.8	0.3	0.5	-2.3	-2.3	-3.8	-3.1	-2.1	-3.1	-1.3	-2.0	-3.0	-2.7
Other serious medical condition/disability diagnosed by doctor	3.5	4.6	12.0	-2.4	-2.8	-1.6	-3.5	-1.0	-2.0	-2.0	0.8	-0.2	-2.2	-2.1	-1.9	-2.2	-2.1	-2.8	-1.9	-1.9	-2.4	-2.5
Hair/balding pattern: Pattern 3	3.4	5.1	10.5	3.1	3.0	0.1	2.6	0.8	2.4	2.2	0.2	-0.2	2.6	2.9	3.2	2.5	2.6	2.2	1.9	2.3	1.5	2.5
Arm fat mass (right)	3.4	13.8	27.5	-1.8	-1.6	-1.3	-2.4	-2.2	-4.7	-4.0	-1.1	-0.7	-4.4	-4.2	-5.2	-4.7	-4.4	-4.3	-3.6	-4.7	-4.1	-5.2
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.0	15.3	-2.2	-0.1	1.3	-1.1	-2.9	-3.6	-3.5	-1.9	-2.1	-3.4	-2.4	-2.9	-2.7	-3.5	-1.5	-3.0	-3.9	-1.2	-3.2
Schizophrenia (2018)	3.3	6.9	13.6	-2.0	-3.3	-2.4	-3.0	-0.8	-2.7	-2.0	0.9	0.4	-2.5	-3.4	-2.7	-3.5	-2.4	-3.7	-1.7	-2.5	-3.6	-3.3
Diabetes diagnosed by doctor	3.3	5.4	9.5	-1.7	-1.8	-2.5	-1.3	-2.2	-2.9	-2.7	-1.9	-1.4	-2.4	-3.0	-3.1	-2.2	-2.4	-2.1	-2.4	-2.9	-1.0	-2.8
Age started oral contraceptive pill	3.3	4.2	8.5	1.2	1.6	0.5	0.9	0.9	2.8	2.0	0.5	-0.0	2.6	2.9	2.6	2.9	2.5	2.3	1.5	2.7	1.7	2.8
Smoking status: Previous	3.1	4.6	10.6	-2.2	-2.0	0.3	-2.5	-0.6	-2.4	-1.9	1.8	0.1	-1.9	-1.7	-2.8	-2.8	-2.0	-2.6	-1.4	-2.7	-2.4	-3.2
Age at First Birth	3.0	4.4	14.4	-0.0	1.3	-1.5	0.6	-1.2	1.5	0.8	-0.7	-2.2	1.8	1.8	3.8	2.9	1.9	3.5	0.6	1.7	3.3	3.1
Number of children fathered	2.9	3.3	8.3	-2.1	-2.2	0.3	-2.9	-0.6	-1.9	-1.3	1.0	0.1	-1.7	-2.2	-2.5	-2.2	-1.6	-2.1	-1.3	-1.7	-1.6	-2.3
Hand grip strength (right)	2.8	7.6	24.1	-3.2	0.9	0.0	0.5	-4.8	-2.6	-3.5	-4.2	-4.9	-2.5	-1.4	-1.3	0.9	-2.5	-0.2	-4.3	-2.7	2.0	-1.3
Illnesses of siblings	2.8	3.9	7.5	2.7	2.6	1.5	2.0	2.0	2.2	2.5	1.8	1.9	1.9	1.3	1.3	1.0	2.0	0.8	2.6	2.6	0.6	2.1
Birth weight	2.8	6.1	9.9	-3.0	-2.7	-1.7	-1.7	-1.6	-3.1	-2.7	0.0	-0.4	-3.0	-2.6	-2.5	-3.1	-3.1	-2.1	-2.2	-3.1	-2.2	-3.1
Shortness of breath walking on level ground	2.8	3.4	12.5	0.3	0.3	0.2	-0.0	1.1	-1.4	-0.9	0.9	2.2	-1.6	-1.5	-2.7	-3.3	-1.7	-2.9	0.2	-1.3	-3.5	-2.4
Mouth/teeth dental problems: Loose teeth	2.8	3.3	10.3	-1.5	-2.1	-0.3	-2.1	0.1	-1.6	-1.4	0.6	0.8	-1.8	-1.7	-1.5	-2.4	-1.8	-3.2	-1.1	-1.5	-2.9	-2.5
Arm fat mass (left)	2.8	11.5	23.6	-1.5	-1.2	-0.8	-1.9	-2.1	-4.3	-3.8	-1.4	-0.8	-4.1	-3.8	-4.9	-4.2	-4.1	-3.9	-3.5	-4.3	-3.5	-4.7
Medication: Lisinopril	2.8	3.7	13.5	-3.4	-0.5	-1.0	-0.2	-3.2	-1.5	-2.3	-3.7	-3.4	-1.3	-0.2	0.4	0.1	-1.4	1.2	-2.1	-1.9	0.9	-0.4
Leg fat mass (right)	2.7	10.6	20.8	-1.9	-0.4	-1.2	-1.7	-2.0	-4.2	-3.6	-1.3	-0.8	-3.9	-3.4	-4.6	-4.2	-4.0	-3.7	-3.2	-4.2	-3.5	-4.6
Type 2 Diabetes (T2D) (2018)	2.6	4.9	10.0	-1.7	-2.0	-2.3	-2.0	-1.4	-2.9	-2.2	-1.4	-0.6	-2.3	-2.6	-2.7	-2.4	-2.2	-2.1	-1.9	-3.2	-1.3	-3.1
Number of live births	2.6	3.7	7.2	-1.4	-2.1	-0.1	-2.1	-0.3	-2.0	-1.6	1.4	0.6	-1.8	-2.6	-2.7	-2.5	-2.0	-2.2	-1.7	-1.9	-2.0	-2.6
Friendships satisfaction	2.6	3.2	9.7	2.1	0.9	0.3	-0.8	3.1	1.9	2.3	1.9	2.9	1.8	1.6	0.9	-0.5	1.9	-0.1	3.0	1.7	-1.3	0.8
Leg fat mass (left)	2.6	10.1	19.8	-1.8	-0.3	-1.4	-1.4	-2.0	-4.1	-3.5	-1.2	-0.8	-3.9	-3.4	-4.4	-4.1	-3.9	-3.5	-3.1	-4.2	-3.4	-4.5
Trunk fat mass	2.5	10.8	27.4	-0.7	-0.4	0.5	-1.9	-1.5	-4.1	-3.4	-0.9	-0.1	-3.8	-3.6	-5.2	-4.6	-3.9	-3.9	-2.9	-4.2	-3.9	-4.7
Peak expiratory flow (PEF)	2.5	5.7	20.7	-2.0	0.3	1.5	0.5	-4.2	-2.4	-3.2	-3.3	-4.5	-1.9	-0.9	0.0	1.3	-2.1	0.9	-3.8	-2.4	2.2	-0.7
Whole body fat mass	2.5	10.4	23.1	-1.1	-0.5	-0.3	-1.8	-1.7	-4.2	-3.5	-1.1	-0.4	-3.8	-3.5	-4.8	-4.4	-3.9	-3.7	-3.0	-4.2	-3.7	-4.6
Relative age of first facial hair	2.4	5.0	29.2	-3.5	-2.0	-5.4	-0.0	-3.1	-1.0	-2.0	-2.6	-3.6	-1.1	-0.2	1.9	1.0	-1.1	1.3	-1.9	-1.3	0.7	0.1
High blood pressure (mother)	2.4	3.4	10.9	-1.7	0.9	-0.5	2.4	-2.5	0.2	-0.9	-3.3	-3.0	0.1	0.6	2.8	2.0	0.0	2.6	-1.1	0.1	2.2	1.7
Back pain experienced in last month	2.4	3.4	12.6	-0.2	-2.5	-0.9	-2.0	0.5	-1.3	-0.8	3.5	1.4	-1.3	-2.3	-1.2	-2.8	-1.3	-2.3	-0.2	-1.1	-3.0	-1.8
Systolic Blood Pressure	2.3	11.4	21.3	-4.6	-2.3	-2.6	-0.0	-2.7	-4.3	-3.8	-2.3	-1.4	-4.1	-3.9	-2.1	-3.7	-4.2	-3.2	-3.4	-4.2	-3.4	-4.2
Medication: Metformin	2.3	3.2	7.2	-1.6	-0.3	-1.5	0.6	-2.7	-2.2	-2.2	-2.6	-2.3	-1.7	-2.1	-1.2	-0.8	-1.6	-0.6	-2.5	-2.3	0.3	-1.6
Happiness	2.3	2.8	6.2	2.3	1.5	-0.2	-1.0	2.3	1.8	2.1	2.1	2.0	1.9	2.4	0.7	0.3	2.0	0.5	2.5	1.3	-0.0	0.9
Smoking status: Current	2.3	3.6	10.6	-1.0	0.1	-1.1	-0.3	-0.1	-2.3	-1.6	0.8	0.7	-2.0	-1.8	-2.5	-2.8	-2.2	-2.9	-1.2	-2.5	-2.3	-3.2
Triglycerides	2.2	3.7	6.8	-0.4	-2.2	-0.4	-2.2	-1.0	-2.0	-1.7	0.1	-0.1	-2.1	-2.3	-2.4	-2.4	-2.0	-2.4	-1.7	-2.2	-2.4	-2.6
Sitting height	2.2	15.6	29.8	-4.0	-1.5	1.6	-3.8	-4.5	-5.1	-5.5	-1.3	-3.5	-5.0	-3.2	-3.7	-3.6	-5.2	-2.8	-5.0	-5.1	-2.4	-4.4
Impedance of leg (left)	2.2	10.9	21.1	4.1	3.8	3.6	1.4	4.0	3.8	4.1	2.9	3.5	3.6	3.3	2.1	1.2	3.5	2.8	4.6	3.4	1.0	3.1
Had menopause	2.2	2.7	8.8	-2.5	-3.0	-2.3	-0.8	-0.7	-1.5	-1.5	1.0	0.0	-1.5	-1.5	-1.5	-1.7	-1.6	-1.7	-1.4	-1.4	-1.6	-1.8
Arm fat percentage (right)	2.2	8.5	22.8	0.1	-1.4	-0.4	-2.2	-0.0	-3.1	-2.2	0.4	1.4	-2.9	-3.1	-4.8	-4.5	-2.9	-4.3	-1.6	-3.1	-4.5	-4.3
Standing height	2.2	21.7	41.5	-5.1	-0.2	2.2	-2.4	-5.7	-5.9	-6.4	-2.6	-4.7	-5.9	-4.2	-5.0	-4.3	-6.1	-2.8	-5.7	-6.1	-2.1	-5.0
Neck or shoulder pain in last month	2.2	3.1	5.8	-0.8	-2.4	-1.6	-0.7	-1.2	-2.3	-1.9	0.9	-0.4	-2.0	-2.3	-2.0	-1.9	-2.0	-1.5	-1.9	-2.3	-1.3	-2.2
Financial situation satisfaction	2.2	2.7	9.2	1.8	0.2	1.2	-1.7	3.0	1.5	1.9	2.4	3.0	1.3	1.6	-0.1	-0.2	1.4	-0.4	2.3	1.1	-0.6	0.3
Impedance of whole body	2.2	11.1	24.2	4.9	2.9	4.7	1.1	4.5	3.8	4.0	3.0	4.2	3.3	2.9	1.0	0.8	3.3	1.9	4.6	3.6	0.4	2.8
Mean Putamen Volume	2.1	2.4	6.0	-1.4	-1.2	-1.8	-0.5	-0.6	-1.8	-1.3	-0.3	0.2	-1.7	-1.8	-1.5	-2.4	-1.6	-2.0	-1.0	-1.7	-2.1	-2.0
Type 2 Diabetes (T2D) (2012)	2.1	2.4	6.5	-0.2	-1.0	1.0	-1.1	-0.3	-1.7	-1.2	-1.6	-0.2	-1.3	-1.4	-2.3	-1.9	-1.4	-1.9	-1.3	-2.2	-2.0	-2.5
Wheeze or whistling in the chest in last year	2.1	3.7	14.1	-0.5	-0.9	-1.1	-1.7	1.3	-1.6	-0.9	2.1	2.3	-1.5	-2.0	-1.8	-3.8	-1.6	-2.1	0.6	-1.4	-3.5	-2.3
Eye problems/disorders: None of the above	2.1	2.4	5.8	1.5	1.1	-1.0	2.4	1.7	1.5	1.5	1.7	1.3	1.6	1.4	1.8	1.1	1.5	1.5	1.8	1.7	1.1	1.7
Comparative height size at age 10	2.1	11.7	25.6	-4.5	-1.4	0.4	-1.0	-5.1	-4.4	-4.8	-2.6	-4.5	-4.1	-3.6	-1.4	-2.3	-4.2	-1.0	-4.6	-4.2	-0.6	-2.9
Mood swings	2.1	3.8	10.1	-1.4	-2.1	-0.6	-3.1	-0.0	-2.0	-1.8	0.8	0.8	-2.0	-2.0	-1.1	-2.9	-2.2	-2.3	-0.9	-1.9	-3.2	-2.5
Lupus	2.0	3.1	7.4	-1.5	-1.6	-1.0	-1.6	-1.2	-2.1	-1.6	-1.1	-0.5	-1.7	-2.7	-2.2	-2.0	-1.8	-1.8	-1.6	-2.1	-1.5	-2.3
Medication: Omeprazole	2.0	2.3	8.5	-0.5	-2.0	-1.0	-2.9	0.9	-0.9	-0.3	2.6	1.7	-0.8	-0.9	-2.1	-2.1	-0.9	-1.5	0.1	-0.8	-1.8	-1.5
Bipolar Disorder (2011)	1.9	1.8	6.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.1	0.0	-2.4	-2.6	-1.1	-2.5	-0.5	-1.4	-2.5	-2.3
Height	1.9	36.2	69.2	-6.3	-0.6	4.4	-4.1	-6.8	-7.4	-8.3	-2.4	-5.5	-7.8	-5.7	-6.3	-5.4	-8.0	-4.1	-7.6	-7.6	-2.7	-6.4
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	4.3	-1.0	-0.7	-0.1	-0.7	-1.3	-1.8	-1.6	-0.9	-0.5	-1.8	-2.1	-1.8	-1.4	-1.8	-1.7	-1.8	-1.7	-1.2	-1.8
Medication for hormone replacement therapy	1.9	2.1	6.2	-1.2	-0.7	-0.3	0.2	-0.8	-1.5	-1.5	-1.1	-0.2	-1.5	-1.1	-2.5	-1.9	-1.5	-2.0	-1.2	-1.7	-1.8	-2.1
Supplements: Zinc	1.9	2.1	7.0	-0.4	-1.2	1.2	-1.4	1.2	-1.1	-0.1	0.7	2.2	-1.0	-1.0	-1.2	-2.5	-1.0	-2.5	0.3	-0.5	-2.6	-1.7
Diabetes (mother)	1.9	2.4	6.8	0.1	-1.1	-0.3	-2.4	0.9	-1.4	-0.3	0.1	1.6	-1.0	-1.4	-2.6	-2.6	-0.9	-2.3	0.1	-1.4	-2.3	-2.2
Time employed in main current job	1.9	2.1	7.1	-1.1	-1.6	-0.0	-1.8	0.5	-1.5	-0.5	1.7	1.2	-1.0	-1.5	-1.2	-2.7	-1.0	-1.5	0.1	-1.5	-2.2	-2.0
Length of working week for main job	1.9	2.1	6.3	2.5	1.4	0.9	2.1	0.8	1.6	1.5	-0.4	0.4	1.4	0.7	1.5	1.8	1.4	0.7	1.0	2.1	0.8	1.9
Had other major operations	1.8	2.2	6.6	2.0	1.5	2.6	-0.4	2.0	1.1	1.8	2.1	2.1	1.5	0.9	-0.2	-0.1	1.4	0.7	2.1	1.1	-0.2	0.7
Hip circumference	1.8	7.8	16.0	-2.2	-0.4	0.1	-1.0	-2.6	-3.5	-3.4	-2.0	-1.7	-3.2	-2.7	-4.0	-3.1	-3.3	-2.9	-3.1	-3.6	-2.5	-3.6
Medication: Blood pressure	1.8	3.4	12.6	-2.8	2.8	-1.6	3.5	-2.3	0.3	-1.0	-3.0	-2.9	0.0	1.3	1.1	1.5	-0.0	0.9	-0.8	0.5	1.3	1.1
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	7.5	0.4	-1.2	-1.2	-2.7	1.9	-0.1	0.4	2.7	2.5	-0.2	-0.3	-1.5	-1.7	-0.3	-1.4	1.0	0.1	-2.0	-0.8
Alcohol drinker status: Previous	1.8	2.1	8.3	0.9	-1.4	-0.8	-2.8	1.9	0.6	1.1	2.9	2.4	0.7	-0.3	-0.4	-1.0	0.7	-0.4	1.6	0.7	-1.7	0.1
Breast Cancer	1.7	4.0	11.9	-2.9	-3.5	-2.4	-1.3	-2.2	-2.3	-2.5	-0.8	-1.6	-2.3	-1.8	-0.7	-0.8	-2.4	-0.4	-2.6	-2.2	0.1	-1.5
Ever used hormone-replacement therapy (HRT)	1.7	2.2	4.0	-1.7	-1.7	-1.8	-0.7	-1.4	-1.5	-1.8	-0.1	-1.1	-1.4	-1.1	-1.9	-1.0	-1.5	-1.4	-1.8	-2.0	-0.9	-2.0
Systolic blood pressure, automated reading	1.7	4.9	9.1	-3.0	-1.3	-1.8	-1.0	-1.0	-2.8	-2.2	-1.2	0.0	-2.5	-2.8	-1.6	-3.0	-2.6	-2.0	-1.8	-2.8	-2.7	-3.0
Angina	1.7	2.3	7.5	-1.1	-2.5	-2.7	-1.0	-0.5	-1.8	-1.0	0.6	0.4	-1.5	-2.0	-1.4	-1.8	-1.4	-1.4	-0.9	-1.7	-1.1	-1.7
Medication: Atenolol	1.7	2.1	9.1	-3.0	-0.7	-1.2	0.5	-2.6	-0.9	-1.6	-1.2	-2.8	-0.8	-0.1	0.6	1.0	-0.8	-0.1	-2.0	-1.1	1.2	-0.4
Body mass index (BMI)	1.7	7.2	13.8	-1.5	-1.2	-2.1	-1.4	-1.7	-3.4	-2.9	-1.6	-0.7	-3.1	-3.0	-3.5	-3.0	-3.1	-3.2	-2.9	-3.4	-2.7	-3.7
Number of incorrect matches in round	1.7	2.8	13.1	0.6	-1.9	1.0	-2.9	2.5	0.7	1.4	3.6	2.8	0.8	-0.2	0.8	-1.1	0.8	-0.9	1.6	0.7	-1.9	-0.4
Forced vital capacity (FVC)	1.7	6.4	17.6	-2.4	0.5	2.5	-0.2	-4.2	-2.6	-3.7	-3.0	-4.2	-2.7	-1.4	-1.1	0.1	-2.9	0.4	-3.8	-2.7	1.5	-1.1
Father’s age at death	1.7	2.3	4.4	-1.9	-1.4	-0.7	-1.2	-2.0	-1.7	-2.1	-0.9	-1.6	-2.0	-1.8	-0.5	-0.9	-1.9	-0.7	-2.0	-1.9	-0.3	-1.3
Impedance of arm (left)	1.7	7.8	22.7	4.5	1.6	4.8	0.9	4.2	2.8	3.1	2.9	4.4	2.2	1.5	-0.4	-0.2	2.2	0.2	3.7	2.9	-0.7	1.6
Birth weight of first child	1.7	3.1	6.1	-2.3	-1.6	-1.2	-0.7	-1.6	-2.5	-2.3	-0.2	-0.7	-2.1	-1.6	-1.4	-2.3	-2.2	-0.9	-1.5	-2.4	-1.4	-2.0
Worry too long after embarrassment	1.7	2.8	9.1	0.6	0.7	-1.6	1.7	-0.8	0.9	0.6	-1.2	-1.7	1.2	2.0	3.0	2.7	1.1	2.6	0.1	1.3	2.2	2.2
Emphysema/chronic bronchitis	1.7	1.9	6.8	1.8	0.3	0.6	-0.6	2.2	0.7	0.9	2.5	2.6	0.3	0.0	-1.5	-1.3	0.3	-1.6	1.6	0.8	-1.9	-0.5
Long-standing illness, disability or infirmity	1.7	2.6	7.9	-1.0	-1.3	-2.6	-1.8	0.1	-1.2	-1.0	1.0	0.9	-1.3	-1.3	-1.4	-2.7	-1.2	-2.3	-0.3	-1.2	-2.8	-1.9
Pain type(s) experienced in last month: Hip pain	1.7	2.1	5.5	-1.5	-2.3	-1.4	-1.9	-1.0	-1.9	-1.7	0.6	-0.4	-1.8	-2.0	-0.6	-1.6	-1.8	-0.1	-1.2	-1.6	-0.6	-1.2
Verbal and Numeric Reasoning (VNR)	1.6	3.9	9.9	-1.2	2.6	-0.6	3.1	-2.4	0.1	-0.9	-2.7	-2.9	-0.0	0.8	2.3	2.0	0.0	3.1	-1.0	0.0	3.0	1.9
Blood Red Count	1.6	15.5	45.0	5.2	3.3	2.4	2.5	1.6	4.5	3.8	-2.8	0.1	4.3	3.4	0.9	6.2	4.5	3.7	1.9	4.7	6.7	4.9
High blood pressure	1.6	4.4	16.6	-3.4	0.5	-2.0	2.6	-3.6	-0.9	-2.1	-3.6	-4.1	-0.9	0.1	1.1	1.3	-1.0	1.2	-2.0	-0.8	1.7	0.5
Angina (self-reported)	1.6	2.1	7.7	-1.0	-2.4	-2.8	-0.7	-0.6	-1.8	-1.0	0.4	0.1	-1.4	-1.8	-1.2	-1.5	-1.3	-1.2	-0.9	-1.7	-0.9	-1.6
Hypertension (Self-reported)	1.6	4.4	16.8	-3.0	1.1	-1.5	3.2	-3.5	-0.7	-2.0	-3.6	-4.1	-0.8	0.3	1.1	1.5	-0.9	1.4	-1.9	-0.5	1.9	0.8
Arm fat percentage (left)	1.6	6.5	19.1	0.4	-0.7	-0.3	-1.2	-0.1	-2.9	-2.0	-0.1	1.2	-2.7	-2.8	-4.4	-3.8	-2.7	-3.7	-1.7	-2.8	-3.7	-3.7
Mineral and other dietary supplements	1.6	2.2	7.2	0.1	2.3	0.9	1.9	-0.8	0.9	0.5	-1.4	-1.5	1.2	1.3	0.8	2.3	1.2	2.0	-0.1	0.7	2.7	1.6
Impedance of leg (right)	1.5	7.1	15.2	3.1	3.1	3.7	0.5	3.3	3.0	3.3	2.5	3.0	2.8	2.6	1.5	0.5	2.7	1.9	3.9	2.6	0.4	2.2
Trunk fat percentage	1.5	5.9	20.8	1.4	0.4	1.4	-1.3	0.6	-2.4	-1.5	0.3	1.9	-2.2	-2.4	-4.6	-4.0	-2.2	-3.3	-0.9	-2.4	-3.8	-3.4
Stomach or abdominal pain in last month	1.5	1.8	6.7	1.3	-1.2	-1.2	-0.8	2.2	0.8	1.4	2.1	2.6	0.5	-0.6	-0.1	-1.1	0.7	-1.1	1.6	1.1	-1.8	0.2
Medication: Ramipril	1.5	2.0	4.0	-2.0	-0.0	-1.1	0.6	-1.4	-1.6	-1.7	-1.8	-0.8	-1.7	-1.3	-1.4	-1.3	-1.7	-1.5	-1.3	-1.4	-1.3	-1.5
Impedance of arm (right)	1.5	6.8	22.9	3.5	-0.3	4.2	-1.5	4.2	1.9	2.6	3.9	4.8	1.5	0.6	-1.1	-1.8	1.4	-1.0	3.5	1.9	-2.4	0.3
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	14.4	-1.7	0.3	2.7	0.2	-3.7	-2.2	-3.1	-3.3	-3.8	-2.2	-1.1	-0.5	0.8	-2.3	0.8	-3.5	-2.3	2.1	-0.7
Hair/balding pattern: Pattern 4	1.5	3.5	11.0	-1.8	0.1	-2.4	3.3	-2.8	-0.8	-1.4	-2.2	-3.1	-0.5	-0.1	1.9	1.8	-0.4	1.8	-1.7	-0.6	2.8	0.9
High blood pressure (siblings)	1.5	2.2	5.7	-2.1	-1.1	-0.9	0.1	-2.2	-1.5	-2.0	-2.1	-2.4	-1.3	-0.5	-0.1	0.2	-1.4	0.0	-2.3	-1.8	0.7	-1.0
Pulse wave peak to peak time	1.5	1.7	4.5	-1.0	-0.1	0.1	-0.1	-1.1	-1.5	-1.5	-0.7	-0.6	-1.7	-1.3	-1.7	-1.3	-1.6	-2.1	-1.6	-1.3	-1.4	-1.6
Knee pain experienced in last month	1.5	2.3	9.4	0.0	-2.7	-1.3	-3.1	0.1	-1.5	-1.0	0.6	0.6	-1.2	-1.7	-2.0	-1.8	-1.3	-0.9	-0.7	-1.6	-1.2	-1.8
Illnesses of father: High blood pressure	1.5	1.8	6.2	-2.3	1.5	-0.1	1.4	-1.9	-0.2	-1.0	-2.5	-2.3	-0.4	0.5	1.3	1.4	-0.4	0.5	-1.4	-0.5	1.4	0.3
Vascular/heart problems diagnosed by doctor	1.5	4.0	13.9	3.5	-0.5	1.9	-2.5	3.4	1.0	2.2	3.3	3.7	1.2	0.1	-0.6	-1.0	1.2	-0.6	2.0	0.8	-1.3	-0.3
Blood Platelet Count	1.4	16.5	25.5	3.9	4.7	0.7	3.7	3.2	4.8	4.7	4.1	1.7	5.0	4.8	4.8	3.3	5.0	3.8	4.9	4.5	1.9	4.4
Heel T-Score	1.4	11.2	43.3	-2.2	2.0	-0.1	1.5	-5.3	-3.1	-4.0	-6.6	-5.2	-3.3	-2.1	-3.1	-0.2	-3.2	-1.7	-4.6	-3.3	1.2	-2.3
Hand grip strength (left)	1.4	3.6	15.0	-2.1	1.8	0.6	0.7	-3.3	-1.4	-2.0	-3.1	-3.9	-1.2	-0.3	-0.2	1.2	-1.2	0.6	-2.6	-1.6	2.1	-0.4
Vitamin and mineral supplements	1.4	1.8	5.9	-0.2	1.4	1.1	1.8	-1.2	0.9	0.2	-1.4	-1.9	0.8	0.9	0.7	1.9	0.9	2.0	-0.2	0.8	2.4	1.8
Current tobacco smoking	1.4	2.3	6.8	-1.0	0.6	-1.2	0.2	-0.2	-1.9	-1.3	0.5	0.3	-1.6	-1.5	-1.6	-2.1	-1.8	-2.4	-1.0	-2.0	-1.8	-2.6
Pain all over the body in last month	1.4	1.5	4.9	0.5	0.4	1.1	-0.6	1.7	-0.1	0.2	1.0	2.2	-0.4	0.1	-1.6	-1.9	-0.4	-2.0	0.9	-0.0	-2.2	-1.1
Asthma	1.4	2.8	11.7	0.0	-0.5	-0.5	-2.4	1.4	-0.5	-0.2	2.4	2.0	-0.8	-1.2	-1.8	-2.9	-0.9	-2.2	0.8	-0.3	-3.4	-1.5
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.5	1.2	2.1	0.8	1.2	1.4	1.7	1.5	0.2	0.8	1.7	1.9	1.1	1.0	1.7	0.1	1.8	1.6	0.0	1.1
Body fat percentage	1.4	5.7	18.4	1.0	0.3	0.5	-1.2	0.5	-2.4	-1.5	0.4	1.8	-2.2	-2.3	-4.3	-3.9	-2.2	-3.3	-0.9	-2.5	-3.8	-3.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.5	1.8	0.8	0.8	-0.6	2.0	1.9	1.7	0.7	1.6	1.4	1.6	0.8	0.8	1.4	-0.2	1.6	2.1	-0.0	1.3
Age at first live birth	1.4	2.6	8.9	-0.4	-0.6	-0.2	-0.4	-1.3	0.8	0.3	-2.0	-2.1	1.0	0.9	3.0	2.3	1.1	2.4	-0.3	0.9	3.0	2.1
Health satisfaction	1.4	1.8	7.8	0.8	-0.1	0.5	-1.8	1.6	-0.2	0.2	1.0	2.2	-0.4	-0.4	-1.1	-2.3	-0.3	-1.8	1.1	-0.3	-2.8	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	6.2	2.2	-0.5	-0.7	-1.3	2.2	0.7	1.4	2.0	2.5	0.9	0.3	-0.1	-0.6	0.9	-0.2	1.6	0.8	-1.0	0.1
Number of self-reported non-cancer illnesses	1.4	2.5	7.0	-1.3	-1.8	-1.1	-1.9	-0.4	-1.5	-1.4	-0.1	0.0	-1.7	-1.6	-1.8	-2.2	-1.8	-1.7	-1.0	-1.5	-2.6	-1.9
Mother’s age at death	1.4	1.8	5.5	-1.9	0.6	-1.7	1.5	-2.0	-0.5	-1.2	-2.3	-2.2	-0.7	0.1	0.4	1.2	-0.7	0.6	-1.6	-0.4	1.5	0.3
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.8	-0.6	-2.0	-0.8	-1.6	0.1	-1.1	-0.7	1.1	0.6	-1.2	-1.6	-0.9	-2.0	-1.2	-2.1	-0.4	-1.0	-2.2	-1.7
Body Mass Index (BMI) (2010)	1.3	1.7	3.1	-1.3	-0.6	-1.4	0.4	-1.0	-1.5	-1.6	-0.8	-0.5	-1.5	-1.8	-0.7	-1.5	-1.6	-1.4	-1.3	-1.5	-1.6	-1.5
HbA1C	1.3	1.5	8.3	-0.4	-0.5	0.5	-2.9	-0.1	-1.0	-0.8	-0.1	0.4	-1.2	-0.7	-1.8	-1.5	-1.0	-1.4	-0.6	-1.3	-1.8	-1.4
Rheumatoid Arthritis	1.3	1.9	6.3	-0.1	-1.0	0.2	-1.6	0.6	-1.1	-0.5	1.1	1.3	-1.0	-0.9	-2.2	-2.3	-1.1	-1.7	-0.0	-1.1	-2.5	-1.8
Sensitivity / hurt feelings	1.3	2.2	5.2	-2.1	-1.1	-1.4	-0.1	-2.2	-1.8	-2.0	-1.2	-2.3	-1.5	-1.2	-0.5	-0.3	-1.5	-0.8	-2.1	-1.7	0.1	-1.3
Leg fat percentage (right)	1.3	4.8	12.5	-0.5	0.0	-0.6	-1.5	-0.1	-2.5	-1.7	0.1	0.9	-2.2	-2.1	-3.4	-3.5	-2.2	-3.1	-1.2	-2.5	-3.4	-3.3
Illnesses of siblings: Diabetes	1.3	1.6	6.4	-0.2	-0.8	-0.8	-1.9	-0.0	-1.1	-0.8	0.1	0.5	-1.0	-0.8	-1.8	-1.8	-1.1	-1.7	-0.4	-1.1	-2.5	-1.7
Commuting to job workplace: Walk	1.3	1.4	3.6	-1.2	0.3	-1.1	-0.2	-1.7	-1.4	-1.8	-0.9	-1.4	-1.4	-0.9	-0.6	-0.3	-1.5	0.3	-1.9	-1.6	0.4	-0.8
Ever taken oral contraceptive pill	1.3	1.4	3.2	1.5	1.0	1.6	-0.3	1.2	1.4	1.5	0.8	1.1	1.2	1.3	1.1	0.5	1.1	0.4	1.8	1.7	-0.1	1.2
Blood Eosinophil Count	1.2	9.4	18.7	3.4	2.0	0.4	0.5	4.1	4.1	4.2	3.5	3.4	3.7	3.4	2.0	1.7	3.6	1.3	4.3	3.9	0.2	2.8
Waist Hip Ratio (WHR)	1.2	5.5	11.0	-2.2	-0.2	-0.9	-1.5	-1.9	-3.1	-3.2	-0.7	-1.0	-3.2	-2.6	-3.2	-2.5	-3.3	-1.7	-2.7	-2.9	-1.4	-2.7
Taking other prescription medications	1.2	1.9	7.0	-1.1	-1.3	-1.3	-2.6	0.2	-1.0	-0.3	1.3	0.7	-0.7	-0.9	-1.8	-2.1	-0.7	-1.7	-0.1	-1.1	-2.2	-1.6
Hearing difficulty/problems with background noise	1.2	1.9	5.2	-0.7	-0.8	-0.3	-0.9	0.7	-1.0	-0.8	1.8	1.2	-1.2	-0.4	-2.1	-2.3	-1.3	-2.1	-0.1	-1.0	-2.3	-1.8
Fluid intelligence score	1.2	2.4	6.0	-1.0	1.8	-0.8	2.4	-2.0	0.1	-0.7	-2.1	-2.4	0.1	0.7	1.9	1.7	0.1	2.3	-0.8	-0.1	2.5	1.3
Alcohol intake frequency.	1.2	2.7	10.4	1.5	-0.9	-0.5	-1.2	2.9	1.3	2.1	2.3	3.2	1.3	-0.2	-0.2	-0.7	1.4	-1.3	2.1	1.5	-2.1	0.1
Overall health rating	1.2	2.5	9.2	1.3	-0.7	-1.0	-2.1	2.2	0.7	1.1	2.8	2.3	0.6	0.3	-1.2	-1.9	0.6	-1.5	1.7	0.5	-3.0	-0.7
Chest pain or discomfort	1.2	1.8	5.8	1.2	0.9	0.9	-0.2	2.0	0.3	0.7	1.4	2.4	-0.1	0.5	-1.7	-1.9	0.0	-1.7	1.6	0.2	-2.4	-0.8
Supplements: Vitamin C	1.2	1.4	3.4	-0.4	-1.0	-0.3	-1.4	0.1	-1.4	-0.9	-0.1	0.9	-1.3	-1.3	-0.6	-1.5	-1.3	-1.7	-0.8	-1.4	-1.7	-1.8
Asthma (self-reported)	1.2	2.5	9.9	0.3	-0.4	-0.2	-2.4	1.5	-0.2	0.0	2.5	2.1	-0.5	-0.9	-1.7	-2.7	-0.6	-2.0	1.0	-0.0	-3.1	-1.2
Risk taking	1.2	1.7	7.6	0.7	-1.0	-0.7	-0.2	1.0	-0.8	-0.6	0.9	1.7	-1.1	-1.3	-1.9	-2.2	-1.2	-1.6	0.3	-0.5	-2.8	-1.3
Pain experienced in last month	1.2	2.0	4.8	0.2	2.1	1.6	2.2	-0.1	1.3	0.9	-1.8	-0.9	1.2	1.6	0.7	2.0	1.2	1.5	0.5	1.1	1.9	1.5
Worry (Nagel 2018)	1.1	2.2	6.3	-2.4	-1.0	-2.1	-0.1	-2.3	-1.4	-2.1	-1.9	-2.5	-1.1	-0.8	-0.2	-0.3	-1.3	0.1	-1.9	-1.3	-0.3	-0.7
BMI	1.1	6.2	12.0	-1.5	-0.7	-1.6	-1.8	-1.9	-3.0	-2.5	-2.8	-1.1	-2.6	-2.6	-3.5	-2.2	-2.5	-3.2	-2.9	-3.0	-2.1	-3.3
Maternal smoking around birth	1.1	1.6	5.2	-0.1	-0.1	1.2	-0.5	-0.3	-1.5	-1.5	0.0	0.0	-1.9	-1.2	-2.3	-1.4	-1.9	-1.0	-1.2	-1.8	-0.8	-1.8
Pulse rate	1.1	1.8	4.1	1.9	0.9	0.9	0.9	1.6	1.4	2.0	1.0	1.4	1.7	0.6	1.1	1.2	1.6	1.2	1.5	1.4	0.8	1.0
Exposure to tobacco smoke at home	1.1	1.2	4.7	1.1	0.3	1.2	0.4	2.0	0.4	0.6	2.1	2.2	0.3	0.3	-0.9	-1.0	0.2	-1.0	0.8	0.3	-1.8	-0.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.9	1.8	0.8	2.0	-1.1	1.6	1.6	1.5	1.3	1.3	1.4	1.2	0.9	1.1	1.3	1.2	1.3	1.4	0.6	1.3
Medication: Seretide 50 evohaler	1.1	1.2	2.5	0.8	1.3	1.3	0.1	1.6	1.2	1.3	1.3	1.4	1.0	0.7	0.1	-0.3	1.1	-1.4	1.3	1.2	-1.3	0.1
Ever had bowel cancer screening	1.1	1.3	4.5	-0.7	-0.8	0.4	-1.1	1.3	0.0	0.6	1.7	1.7	0.3	-0.2	-1.0	-1.4	0.3	-1.9	0.7	-0.2	-2.1	-1.3
Osteoarthritis (self-reported)	1.1	1.4	9.5	0.8	-3.1	-1.7	-1.9	-0.5	-0.7	-1.0	0.1	-0.2	-0.9	-1.2	-1.3	-0.9	-0.9	-0.3	-0.8	-0.6	-0.8	-0.5
Wears glasses or contact lenses	1.1	1.3	2.7	1.3	0.0	-1.0	0.5	1.0	1.2	1.2	1.6	0.8	1.6	1.6	1.5	0.7	1.5	0.9	1.4	1.0	0.1	0.9
Alzheimer’s Disease (including proxy)	1.0	1.4	7.1	0.5	-2.7	-0.3	-1.0	-0.5	-1.4	-1.2	-0.2	0.3	-1.2	-1.9	-1.3	-1.0	-1.4	-0.9	-1.0	-0.7	-1.1	-1.0
HDL Cholesterol	1.0	1.7	4.5	0.3	1.5	0.3	0.8	0.6	1.3	0.9	0.0	-0.0	1.2	1.8	1.5	1.7	1.2	2.1	1.0	1.2	2.1	1.8
Average weekly fortified wine intake	1.0	1.2	6.3	-0.6	0.2	-1.5	0.4	-0.3	1.0	1.0	-0.3	-0.7	1.3	0.5	2.5	1.4	1.4	0.7	0.6	1.2	1.1	1.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.7	-1.6	-1.7	0.6	-1.1	-1.3	-1.5	-1.4	-0.1	-1.1	-1.3	-1.2	-0.1	-0.6	-1.2	-0.6	-1.4	-1.2	-0.3	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	4.3	0.7	-0.6	-0.9	-2.0	1.7	-0.5	0.1	1.7	2.1	-0.3	0.1	-1.3	-1.9	-0.4	-1.7	0.7	-0.6	-2.1	-1.6
Medication: Lansoprazole	1.0	1.1	6.2	1.2	-0.5	-0.6	-0.6	1.2	-0.3	0.2	1.2	1.6	-0.3	-0.4	-1.0	-1.7	-0.4	-0.9	0.9	-0.3	-2.5	-0.9
Loud music exposure frequency	1.0	1.1	2.5	0.8	0.1	-1.4	-0.6	1.2	1.0	1.6	1.2	0.9	1.6	0.4	0.8	0.1	1.6	1.0	1.6	0.9	0.5	0.9
Forced vital capacity (FVC), Best measure	1.0	3.7	9.9	-1.5	0.2	2.1	-0.0	-3.1	-2.0	-2.8	-2.2	-3.1	-2.3	-1.1	-0.5	0.0	-2.3	0.1	-3.0	-2.1	0.9	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.5	-1.4	-1.5	0.4	-1.6	-1.2	-0.9	-1.3	-1.3	-1.4	-1.1	0.2	-0.7	-0.0	-1.0	-0.8	-1.5	-1.1	0.0	-0.9
Pulse rate, automated reading	1.0	3.2	6.7	1.5	0.8	0.8	0.9	2.2	2.0	2.6	1.1	2.0	2.4	0.7	2.0	1.5	2.4	1.3	2.1	2.4	1.2	1.9
Medication for cholesterol	1.0	1.4	6.0	2.4	-1.5	0.6	-2.2	1.3	0.7	1.2	1.9	1.1	0.8	-0.1	0.9	0.7	0.9	1.1	0.6	0.7	0.8	0.8
Average weekly champagne plus white wine intake	1.0	1.4	6.5	0.6	1.3	0.4	2.5	-0.4	0.8	0.5	-0.9	-0.9	0.8	1.2	1.4	1.6	0.8	1.6	0.5	1.0	1.5	1.5
Leg fat percentage (left)	1.0	3.6	9.5	-0.0	0.3	-0.9	-1.0	0.1	-2.1	-1.4	0.2	1.0	-1.8	-1.7	-3.0	-3.1	-1.9	-2.6	-1.0	-2.2	-3.0	-2.9
Heart disease (siblings)	1.0	1.2	3.7	-1.8	-1.4	-1.9	-0.7	-0.3	-1.2	-0.8	1.6	-0.1	-0.6	-0.6	-0.8	-1.2	-0.8	-0.4	-0.5	-1.6	-0.6	-1.5
Respiratory disease	0.9	2.0	7.8	1.2	0.8	-0.2	-1.9	1.8	0.8	0.8	2.8	2.1	0.6	0.2	-0.9	-1.8	0.4	-0.8	1.8	1.0	-2.4	-0.1
Average weekly spirits intake	0.9	1.1	2.3	-1.3	-0.4	-0.6	0.6	-1.4	-1.4	-1.4	0.2	-1.1	-1.4	-1.4	-0.6	-0.5	-1.4	-0.6	-1.5	-1.1	-0.2	-0.8
Multivitamins +/- minerals	0.9	1.1	4.0	1.0	-0.6	-0.6	-0.6	1.6	0.1	0.6	2.0	1.9	0.1	0.2	-0.1	-1.2	0.0	-1.3	1.0	0.0	-1.9	-0.9
Chronic bronchitis/emphysema (father)	0.9	1.0	5.7	0.2	-0.1	0.3	0.6	1.4	-0.2	0.4	2.4	1.7	0.0	-0.7	-1.4	-1.2	-0.0	-1.1	0.6	-0.2	-1.2	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	3.1	0.1	-1.7	-0.9	-0.7	0.5	-1.3	-1.1	1.1	1.1	-1.2	-0.8	-1.8	-1.6	-1.3	-1.3	-0.8	-1.3	-1.3	-1.7
Allergy	0.9	2.1	7.4	-2.7	-0.7	-0.4	0.5	-2.2	-1.4	-1.6	-2.0	-2.2	-1.3	-0.9	-0.3	0.4	-1.2	-0.5	-2.0	-1.3	1.2	-0.7
Alcohol intake versus 10 years previously	0.9	1.4	5.4	-0.6	-2.0	-2.3	-1.6	-0.1	-0.6	-0.5	2.1	0.4	-0.9	-1.1	-0.5	-1.1	-0.9	-1.4	-0.5	-0.5	-1.2	-0.9
Family relationship satisfaction	0.9	1.1	3.8	0.4	0.5	0.6	-0.5	1.5	0.6	1.2	1.6	1.4	1.1	1.6	1.2	-0.3	1.1	1.2	1.9	0.1	0.2	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	4.5	-1.0	-0.4	0.4	0.4	-1.8	-0.2	-0.9	-1.0	-2.1	-0.4	-0.9	1.2	1.3	-0.3	0.7	-1.3	0.3	1.6	0.9
Medication: Aspirin	0.9	1.2	4.3	-1.8	0.6	-2.1	1.6	-1.5	-0.4	-0.8	-1.5	-1.7	-0.3	0.7	0.6	0.7	-0.4	0.7	-0.7	-0.6	0.6	0.0
Cardiovascular Disease	0.8	2.6	10.0	-2.6	1.5	-1.7	2.9	-2.1	-1.0	-1.5	-3.2	-2.4	-0.9	0.0	0.4	0.4	-1.0	0.2	-1.2	-0.8	0.5	-0.2
Number of treatments/medications taken	0.8	1.4	15.5	-1.8	-0.7	-3.9	-0.5	-0.7	-0.6	-0.6	0.2	-0.6	-0.4	-0.3	-0.2	-1.2	-0.4	-0.9	-0.2	-0.7	-1.4	-0.8
Severe depression (siblings)	0.8	0.9	5.7	-0.1	-0.7	1.0	-2.4	0.6	-0.8	-0.1	1.8	0.9	-0.4	-0.4	-0.6	-1.0	-0.4	-0.7	0.1	-1.0	-0.8	-1.2
Pack years adult smoking proportion	0.8	1.2	5.4	0.2	0.3	-0.8	-0.4	0.6	-0.9	-0.5	0.6	1.1	-1.1	-1.1	-2.3	-1.7	-1.1	-1.7	-0.1	-0.6	-1.3	-1.2
Townsend deprivation index at recruitment	0.8	1.2	4.2	-0.2	-2.1	-1.2	-0.5	-0.0	-0.8	-0.7	0.4	0.6	-1.0	-1.5	-1.7	-1.3	-0.9	-1.1	-0.4	-0.9	-1.4	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	4.7	-1.1	0.6	-0.9	-1.3	-2.1	-1.4	-1.7	-2.2	-2.1	-1.3	-1.0	-0.1	-0.2	-1.2	-0.8	-1.8	-1.4	0.5	-1.1
Heart attack	0.8	1.0	3.1	-1.8	-1.3	-0.8	-1.3	-0.6	-1.4	-0.7	0.2	-0.0	-1.0	-1.2	-0.8	-1.3	-0.8	-0.4	-0.5	-1.3	-0.1	-0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.9	7.3	-1.7	0.5	-0.8	-0.1	-2.7	-0.9	-1.6	-2.0	-2.7	-1.1	-0.0	0.5	0.6	-1.1	1.2	-1.6	-0.9	1.4	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.9	-1.2	-1.0	0.8	-1.2	-0.1	-1.0	-0.8	0.4	0.2	-0.9	-0.6	-1.4	-1.1	-0.9	-1.2	-0.6	-1.1	-0.5	-1.3
Mouth/teeth dental problems: Dentures	0.8	1.3	2.6	-0.9	-0.8	-1.6	-0.4	-0.9	-1.4	-1.3	-0.3	-0.7	-1.1	-1.3	-1.5	-0.8	-1.2	-1.3	-1.3	-1.3	-1.2	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.7	-1.0	0.2	2.1	0.4	-2.5	-1.5	-2.1	-2.6	-2.6	-1.7	-0.5	0.0	0.8	-1.7	0.6	-2.5	-1.6	1.6	-0.4
Pulse wave Arterial Stiffness index	0.8	1.0	3.3	0.7	0.0	0.0	-0.2	0.6	1.1	1.1	0.5	0.2	1.2	1.0	1.4	1.0	1.1	1.8	1.1	0.8	1.3	1.2
Number of full brothers	0.8	0.9	3.9	0.5	-0.9	-0.2	-1.5	0.6	-0.3	0.2	1.4	1.1	-0.3	-1.2	-2.0	-1.3	-0.2	-1.1	0.4	-0.1	-1.2	-0.8
Breast cancer (self-reported)	0.8	0.9	2.3	1.4	1.2	0.9	0.7	0.6	1.1	1.4	0.4	0.3	1.5	0.7	0.6	1.1	1.4	0.8	0.5	0.7	1.1	0.6
Osteoporosis (self-reported)	0.8	1.0	2.7	1.0	0.6	0.8	0.2	1.6	0.8	1.2	0.4	1.6	1.0	0.9	0.3	0.7	0.9	1.3	1.1	1.1	0.7	1.1
Hearing aid user	0.8	0.9	1.7	0.1	0.2	-1.2	-0.5	0.6	1.3	1.1	1.1	0.1	1.2	1.2	0.9	0.7	1.3	1.1	1.0	1.2	0.7	1.3
Medication: Bendroflumethiazide	0.8	1.2	5.8	-2.4	0.3	-0.7	0.8	-1.5	-0.6	-1.3	-2.1	-1.6	-1.1	-0.3	-0.1	-0.6	-1.0	-0.7	-1.1	-0.7	-0.8	-0.4
Pack years of smoking	0.8	1.1	4.2	0.2	0.2	-1.3	-0.5	0.6	-0.8	-0.5	0.7	1.1	-1.0	-1.1	-2.0	-1.7	-1.0	-1.6	-0.1	-0.6	-1.3	-1.2
Prostate Cancer	0.7	0.9	2.8	1.2	-0.5	-0.5	0.4	1.2	0.8	1.0	1.7	1.1	0.8	1.0	1.0	0.4	0.6	1.2	1.5	0.8	0.1	0.9
Allergy or Eczema	0.7	1.8	4.5	2.0	0.0	-0.1	-0.8	1.8	1.4	1.6	1.8	1.8	1.5	1.2	0.6	-0.1	1.4	1.4	2.1	1.2	-0.8	1.2
Hearing difficulty/problems: Yes	0.7	1.0	4.0	0.1	1.2	0.9	-0.2	1.1	0.1	0.4	2.0	1.2	0.3	0.8	-1.7	-1.2	0.2	-1.4	0.7	-0.1	-1.2	-1.0
Qualifications: None of the above	0.7	1.6	4.4	-0.9	-0.4	-0.4	-0.2	0.8	-1.1	-0.6	2.1	1.3	-0.6	-1.2	-1.8	-1.8	-0.7	-1.8	-0.5	-1.0	-2.0	-1.9
Worrier / anxious feelings	0.7	1.3	3.1	-1.5	-1.0	-1.3	0.1	-1.6	-1.2	-1.6	-0.5	-1.5	-1.2	-0.8	-0.6	-0.4	-1.3	-0.3	-1.8	-1.3	-0.1	-1.0
Blood clot in the leg (DVT)	0.7	0.9	3.4	1.4	0.4	0.3	1.8	-0.2	0.5	0.1	-0.5	-0.7	0.6	0.3	1.1	1.6	0.5	1.3	-0.4	0.6	1.6	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	5.4	0.5	-1.6	-0.5	-2.3	0.4	-0.2	-0.0	0.4	0.6	-0.0	-0.1	0.4	-1.3	-0.1	0.2	0.4	-0.5	-1.7	-0.5
Age at last live birth	0.7	1.0	3.8	1.0	-1.3	0.9	-0.8	0.6	0.9	1.2	0.4	0.4	1.2	0.8	1.9	0.9	1.3	0.7	0.8	1.0	0.5	0.9
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.2	0.6	-0.2	1.5	0.3	1.4	1.0	1.3	1.2	1.3	1.0	0.4	-0.2	0.5	1.1	-0.2	0.9	1.2	0.7	0.5
Illnesses of father: Heart disease	0.7	0.9	2.3	-1.5	-1.3	-1.3	-0.4	-1.3	-1.2	-1.0	-0.6	-1.0	-0.9	-0.9	-0.1	-0.3	-0.9	0.1	-1.2	-1.2	0.5	-0.6
Qualifications: nursing, teaching	0.7	1.1	3.9	-0.9	-0.1	-1.4	-0.2	-1.8	-0.9	-1.4	-1.4	-2.0	-1.0	0.0	0.3	0.1	-1.1	0.3	-1.4	-1.3	0.3	-0.5
Medication: Gliclazide	0.7	0.8	2.8	-0.0	-0.4	-1.7	-0.1	-0.4	-1.1	-0.8	-0.7	0.1	-0.9	-1.3	-1.1	-1.3	-0.9	-0.6	-0.4	-1.1	-1.0	-1.2
Commuting to job workplace: Public transport	0.7	0.8	2.9	0.5	1.3	-1.5	0.1	0.2	1.0	0.8	-0.2	-0.3	1.2	1.7	0.9	0.7	1.1	1.0	0.7	0.4	0.5	0.6
Medication: Paracetamol	0.7	1.0	8.2	-0.6	-1.3	-2.9	-0.7	0.2	-0.2	-0.0	1.8	0.7	-0.2	-0.9	-0.1	-1.2	-0.2	-1.0	0.2	-0.4	-1.1	-0.8
Myopia	0.7	1.0	5.0	0.8	0.3	1.3	0.4	1.4	1.1	1.0	2.2	1.1	0.7	0.3	1.3	0.6	0.7	0.3	0.9	1.1	0.6	0.8
Intelligence (Savage-Jansen 2018)	0.6	1.7	6.2	-1.0	1.8	-0.6	1.5	-2.0	-0.3	-1.5	-2.5	-2.4	-0.7	0.6	0.9	0.9	-0.8	1.2	-1.2	-0.4	1.2	0.7
Major Depression (MDD)	0.6	0.7	2.7	0.4	0.2	0.0	0.8	0.1	-0.7	-0.9	0.1	0.7	-1.5	0.0	-0.2	-1.6	-1.4	-1.6	-0.2	0.0	0.0	-0.8
Ovarian Cancer	0.6	0.8	2.4	0.7	0.1	0.4	0.2	0.6	1.2	1.0	0.9	0.4	0.7	0.9	1.1	1.3	0.8	0.7	0.8	1.6	0.4	1.5
Crohns Disease (2012)	0.6	1.0	3.7	0.3	1.9	1.1	0.3	1.6	0.9	1.1	1.0	1.7	0.7	0.0	-0.7	-0.6	0.7	0.5	1.7	0.0	0.0	0.6
Hypothyroidism (self reported)	0.6	1.3	3.6	1.2	0.4	1.2	-1.5	1.6	0.9	1.2	1.9	1.4	1.1	1.4	0.6	0.1	1.1	0.4	1.6	0.8	0.0	0.6
Lung FVC	0.6	2.9	10.4	0.2	2.1	3.1	1.6	-0.6	1.0	0.3	-0.5	-1.2	0.8	1.7	1.8	2.4	0.8	2.5	0.0	0.9	3.2	2.0
Diabetes (father)	0.6	0.7	1.9	-0.5	-0.5	-1.0	-1.0	-0.2	-1.0	-0.7	0.4	0.2	-1.0	-1.2	-0.2	-1.4	-0.9	-0.4	-0.5	-1.4	-0.7	-1.1
Serious illness, injury or assault to yourself	0.6	0.7	6.0	-1.5	-0.4	-2.5	0.1	0.3	-0.5	0.2	1.0	0.5	0.1	-0.6	-0.5	-0.3	0.2	-1.1	-0.3	-0.4	-0.1	-0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.7	-0.0	-0.5	0.2	-0.4	0.2	-1.0	-0.6	1.2	0.7	-0.8	-1.1	-1.0	-1.3	-0.9	-0.6	-0.4	-1.0	-1.3	-1.1
Nervous feelings	0.6	1.1	2.4	-1.6	-1.3	-0.7	-0.7	-0.9	-1.0	-1.1	-0.4	-1.0	-0.7	-0.8	-1.2	-1.0	-0.7	-1.3	-0.9	-0.8	-1.5	-1.2
Mouth/teeth dental problems	0.6	0.9	4.5	0.4	0.5	0.4	0.7	-0.1	0.8	0.5	-0.1	-0.2	0.6	0.9	1.6	1.4	0.7	1.7	0.1	0.6	2.1	1.3
Medication: Simvastatin	0.6	0.9	2.5	-1.0	-0.5	-1.2	-0.3	-0.1	-1.1	-0.5	-1.1	0.2	-0.9	-0.5	-0.9	-1.1	-0.8	-1.5	-0.5	-1.3	-1.0	-1.6
Neuroticism score	0.6	1.2	3.8	-1.5	-1.2	-2.0	-0.4	-1.4	-1.1	-1.5	-0.6	-1.5	-1.0	-0.6	-0.0	-0.4	-1.1	-0.7	-1.4	-0.9	-0.8	-0.8
Illnesses of mother	0.6	0.7	5.1	0.2	-0.3	-0.7	-1.5	0.5	-0.7	0.1	2.3	0.9	-0.6	-0.7	-0.4	-0.8	-0.5	-0.8	-0.1	-0.6	-0.5	-0.9
Pulse wave reflection index	0.6	0.7	2.2	-1.5	-0.4	0.0	0.1	-1.3	-0.5	-0.8	-1.1	-1.5	-0.4	0.5	0.8	0.5	-0.4	0.9	-0.5	-0.5	1.3	0.2
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	3.2	0.3	0.3	-0.2	-0.8	-0.8	0.5	0.1	-1.1	-1.1	0.1	0.9	0.7	1.6	0.1	1.8	0.1	0.8	1.8	1.5
Headache pain in last month	0.6	1.0	7.5	0.2	-0.7	-2.7	0.6	0.7	-0.1	0.2	2.3	1.0	-0.0	-0.4	0.8	-1.0	-0.1	-0.6	0.5	0.1	-1.5	-0.3
Medication: Amlodipine	0.6	0.8	5.0	-1.8	-0.1	-1.3	1.4	-0.7	-0.6	-0.7	-2.2	-0.6	-0.6	-0.6	0.3	-0.2	-0.5	-0.4	-0.5	-0.1	-0.2	-0.0
Exposure to tobacco smoke outside home	0.6	0.9	4.6	1.0	0.3	1.6	-1.2	1.0	-0.6	-0.2	1.0	1.1	-0.4	-0.2	-2.2	-1.0	-0.5	-0.1	0.0	-0.7	-0.4	-0.9
Comparative body size at age 10	0.6	1.7	4.4	-1.4	-2.1	-2.0	-0.8	-1.5	-0.3	-0.6	-0.8	-1.9	-0.3	0.1	1.4	2.0	-0.2	1.1	-1.6	-0.1	2.1	0.7
Suffer from ‘nerves’	0.6	0.9	4.2	-0.9	-0.1	-1.3	0.7	-1.5	-0.1	-0.6	-1.5	-2.1	0.3	-0.1	1.0	1.2	0.4	0.1	-1.0	0.3	0.9	0.5
High cholesterol (Self-reported)	0.6	1.0	3.2	-0.6	0.1	-0.4	0.3	0.7	-0.8	-0.2	-0.4	1.1	-0.7	-0.8	-1.8	-1.7	-0.6	-1.7	0.2	-0.9	-1.5	-1.6
Commuting to job workplace: Cycle	0.6	0.7	3.9	-0.7	0.4	0.9	1.3	-1.4	-0.0	-0.7	-0.5	-2.0	-0.2	0.7	0.9	1.0	-0.2	0.6	-0.8	-0.3	0.8	0.3
Supplements: Calcium	0.6	0.6	2.9	0.6	-0.0	0.7	-1.1	1.0	-0.5	0.1	0.8	1.7	-0.4	-0.5	-0.9	-0.9	-0.4	-1.0	-0.0	-0.3	-0.9	-1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.5	-1.6	-1.2	-0.8	-1.1	-0.6	-1.2	-0.6	0.0	-0.1	-0.8	-1.0	-0.9	-1.1	-0.6	-0.2	-0.4	-1.1	0.1	-0.8
Alzheimer’s Disease (in mother)	0.5	0.5	3.5	1.1	-1.2	0.8	-0.5	0.1	-0.5	-0.3	-0.1	0.4	-0.5	-1.0	-1.9	-0.1	-0.5	-1.0	-0.5	0.3	-0.3	-0.3
LDL Cholesterol	0.5	0.7	2.1	0.1	-1.3	-0.3	-0.7	0.7	-0.4	-0.3	0.7	1.1	-0.8	-1.0	-1.0	-1.4	-0.9	-1.1	0.0	-0.3	-1.3	-0.7
Lung FEV1/FVC ratio	0.5	2.7	6.7	-1.0	-0.7	0.1	0.2	-1.1	-2.2	-1.8	-2.2	-0.7	-2.0	-1.3	-2.0	-0.7	-2.1	-1.7	-2.1	-2.6	-0.3	-2.5
Ever had hysterectomy (womb removed)	0.5	0.6	2.7	-0.2	0.6	-0.2	-0.7	0.9	0.8	0.7	1.6	1.0	0.8	0.5	-1.1	-0.3	0.6	-0.5	0.9	0.6	-1.0	-0.2
Medication: Co-codamol	0.5	0.6	3.2	-0.3	-1.8	-1.3	-1.2	-0.7	-0.8	-0.7	-0.1	-0.5	-0.6	-1.1	0.2	-0.7	-0.6	-0.3	-0.5	-0.5	-0.3	-0.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.6	-0.9	0.8	0.1	1.2	-0.3	-0.8	-0.5	0.2	0.1	-0.5	-0.5	-1.6	-0.6	-0.6	-1.1	-0.4	-0.7	-0.6	-1.0
Hayfever, allergic rhinitis or eczema	0.5	1.0	4.4	2.1	0.1	0.6	-0.2	1.3	1.2	1.3	0.8	1.3	1.1	1.0	0.3	0.1	1.0	0.6	1.5	1.0	-0.5	0.8
Falls in the last year	0.5	0.7	2.7	-0.5	-1.6	-0.3	-1.6	-0.8	-1.0	-1.0	-0.5	-0.3	-0.9	-1.3	-0.1	-0.4	-0.9	-0.4	-0.8	-0.6	-0.4	-0.4
Breastfed as a baby	0.5	0.6	2.2	1.5	0.3	0.5	0.1	1.1	0.3	0.6	0.4	1.4	0.4	0.2	-0.7	-0.2	0.4	-1.4	0.5	0.5	-0.9	-0.4
Tense / ‘highly strung’	0.5	0.8	1.9	-1.4	-0.7	-0.7	-0.7	-0.9	-1.1	-1.3	-0.8	-0.9	-1.0	-0.9	-0.5	-0.5	-1.1	-0.6	-1.2	-0.8	-0.6	-0.7
Medication: Paracetamol	0.5	0.9	4.3	-0.3	-0.7	-2.1	-0.6	0.9	0.2	0.5	1.9	1.4	0.2	-0.5	-0.2	-1.3	0.3	-0.6	1.0	0.1	-1.3	-0.3
Gout (self-reported)	0.5	0.7	2.0	-0.7	0.1	-0.6	-1.1	-0.4	-1.0	-0.4	0.9	-0.3	-0.5	-0.5	-1.2	-1.1	-0.4	-1.1	-0.5	-1.4	-0.4	-1.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	5.7	1.0	-0.8	0.4	-2.4	1.4	0.2	0.7	2.1	1.4	0.4	0.4	-0.1	-0.8	0.3	-0.7	1.0	0.1	-1.0	-0.4
Medication: Ibuprofen	0.5	0.6	2.3	-0.9	0.6	-1.5	-0.7	-0.7	-0.7	-0.7	0.5	-0.8	-0.6	-0.0	-0.9	-1.0	-0.7	-0.3	-0.3	-0.9	-0.6	-0.8
Heart disease (mother)	0.5	0.6	2.2	-1.5	-0.2	-0.0	1.0	-1.3	-0.4	-0.8	-1.4	-1.4	-0.2	-0.3	0.3	0.4	-0.1	0.7	-0.7	-0.5	0.7	0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	3.3	1.7	0.9	0.9	1.8	0.1	0.4	0.4	-0.1	0.1	0.3	-0.1	0.7	0.5	0.2	0.9	0.3	0.4	0.6	0.6
Medication: Aspirin	0.5	0.7	3.6	-1.5	0.5	-1.9	1.3	-1.0	-0.2	-0.4	-1.1	-1.2	-0.1	0.8	0.2	0.6	-0.1	0.4	-0.5	-0.4	0.5	-0.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.1	-1.1	1.0	-0.5	0.7	-1.2	-0.1	-0.1	0.0	-1.4	0.4	0.6	1.3	0.6	0.4	0.7	-0.3	0.1	1.1	0.5
Tinnitus: Yes, now most or all of the time	0.5	0.5	2.9	0.5	-0.6	0.0	-0.3	0.2	0.6	0.8	0.6	-0.2	1.2	0.8	1.7	0.9	1.1	0.6	0.4	0.3	0.7	0.3
Number of operations (self-reported)	0.5	0.7	7.6	0.5	-0.2	0.8	-2.8	0.4	0.3	0.4	1.4	0.6	0.3	0.4	-1.0	-0.5	0.2	-0.5	0.2	-0.1	-0.9	-0.5
Average weekly beer plus cider intake	0.5	0.7	2.6	0.1	1.6	-0.4	1.3	-0.7	0.7	0.4	0.3	-1.3	1.0	1.1	-0.1	1.2	1.0	0.3	0.2	0.8	0.7	0.7
Depression (Nagel 2018)	0.4	0.7	2.3	0.7	0.7	-0.1	0.6	0.7	1.0	0.7	1.1	0.3	1.1	1.5	0.9	0.7	0.9	0.8	0.9	0.7	0.4	0.7
Irritable Bowel Disease (IBD)	0.4	0.9	2.2	-1.5	0.2	-0.7	-1.0	-0.3	-1.0	-0.9	0.4	0.2	-1.0	-0.8	-0.7	-1.3	-1.1	-1.1	-0.5	-1.0	-1.2	-1.2
Neuroticism	0.4	0.9	7.9	-1.6	-1.1	-2.8	-0.5	-0.9	-0.5	-0.8	0.0	-1.0	-0.3	-0.2	0.3	-0.4	-0.4	-0.1	-0.4	-0.3	-1.2	-0.2
Relative age voice broke	0.4	0.6	6.8	-0.6	-0.3	-2.6	-0.4	-0.5	0.2	0.1	-0.2	-1.1	0.2	0.8	1.1	0.7	0.2	0.9	-0.1	-0.3	-0.0	0.2
Age when periods started (menarche)	0.4	1.1	4.6	0.1	-1.3	-0.1	0.4	-1.2	-1.1	-1.1	-1.2	-1.1	-1.1	-2.1	-0.5	-0.0	-1.1	-0.4	-1.7	-0.8	0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.8	-0.5	1.0	0.1	-0.7	-1.5	-1.0	-1.2	-2.0	-1.6	-0.7	-0.3	0.1	0.1	-0.8	-0.3	-1.2	-1.0	0.7	-0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.6	1.3	-0.2	0.4	-1.0	1.1	0.8	0.8	0.9	1.1	0.6	0.6	-0.0	-0.4	0.5	0.6	1.1	0.2	-1.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.6	-0.9	0.6	-1.3	-0.7	-0.7	-0.6	-0.6	0.4	-0.8	-0.5	0.1	-0.8	-1.0	-0.6	-0.2	-0.1	-0.8	-0.8	-0.7
Lung cancer (father)	0.4	0.4	1.2	0.3	0.0	0.9	0.0	-0.3	-0.7	-0.7	0.0	-0.2	-0.6	-0.6	-1.1	-0.6	-0.8	-0.9	-0.6	-0.7	-0.8	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.3	0.4	0.3	0.8	-1.5	1.0	0.4	0.6	1.5	1.1	0.3	0.2	-0.4	-0.3	0.4	-1.0	0.7	0.8	-0.7	0.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	-0.3	0.2	-0.4	-1.0	-0.3	-0.4	-0.5	-0.4	-0.2	-0.5	-0.9	-0.6	-1.2	-0.5	-1.0	-0.2	-0.4	-1.2	-0.7
Medication for pain relief, constipation, heartburn	0.4	0.7	5.8	0.2	-0.0	2.4	0.9	-0.8	-0.5	-0.6	-1.0	-0.8	-0.6	-1.0	0.3	0.6	-0.6	-0.2	-1.2	-0.2	0.8	0.0
Mean time to correctly identify matches	0.4	0.8	2.8	-0.2	-0.2	-0.5	-0.2	1.3	0.4	0.8	1.6	1.7	0.6	0.2	1.0	-1.0	0.5	0.0	1.4	0.6	-1.4	0.1
Loneliness, isolation	0.4	0.6	2.4	-0.1	-0.2	0.5	0.8	-0.6	0.4	-0.1	0.1	-1.1	0.4	1.1	0.7	1.6	0.4	0.9	-0.4	0.4	1.4	0.8
Eye problems/disorders: Cataract	0.4	0.5	2.3	-0.3	-0.1	1.5	-0.7	-1.2	0.0	-0.5	-1.5	-1.2	-0.3	0.2	-0.1	0.4	-0.3	0.1	-0.7	-0.1	0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	4.5	-0.0	-1.1	0.6	-2.1	0.6	-0.2	0.4	1.2	0.9	0.0	-0.4	-0.5	-0.8	-0.0	-0.4	0.6	0.2	-1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.7	7.4	-0.2	-0.4	2.7	0.2	-0.4	-0.8	-0.8	-0.9	0.0	-1.1	-0.6	-0.6	-0.5	-1.1	-0.1	-0.6	-0.5	-0.4	-0.2
Miserableness	0.4	0.7	5.3	0.0	0.2	1.9	-2.3	0.1	-0.3	-0.4	0.5	0.2	-0.5	-0.1	-0.8	-0.6	-0.5	-0.9	-0.2	-0.2	-0.8	-0.5
Medication: Atorvastatin	0.4	0.5	0.9	-0.0	0.2	-0.3	-0.0	-0.9	-0.9	-0.9	-0.9	-0.6	-0.8	-0.8	-0.6	-0.9	-0.9	-0.2	-0.5	-0.6	-0.8	-0.5
Fractured/broken bones in last 5 years	0.4	0.5	1.7	0.5	0.3	1.3	-0.8	1.1	0.4	1.0	0.9	1.1	0.8	0.8	0.5	-0.2	0.8	0.2	0.7	0.4	-0.1	0.2
Alzheimer’s Disease (in father)	0.3	0.4	1.8	0.3	-1.3	-0.8	-0.6	0.7	-0.0	0.0	0.8	0.8	0.2	-0.4	1.0	-0.3	0.1	0.0	0.5	0.3	-0.7	0.0
Crohns Disease (2017)	0.3	0.7	2.3	-1.4	0.6	-0.3	-1.0	0.3	-0.7	-0.3	1.0	0.9	-0.6	-0.6	-1.1	-1.5	-0.6	-0.8	0.2	-0.5	-1.1	-0.8
Fasting Glucose	0.3	0.4	1.4	0.3	0.5	0.9	-0.3	0.4	-0.7	-0.3	0.2	0.8	-0.1	-0.9	0.0	-1.2	-0.5	-0.6	0.2	-0.7	-0.9	-1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.2	-0.7	0.0	0.3	-1.1	-0.8	0.2	-0.2	-0.3	-1.1	0.1	0.3	-1.1	0.4	0.1	-0.5	-0.7	0.0	0.1	-0.1
Supplements: Glucosamine	0.3	0.4	1.2	-0.2	-0.9	0.6	-0.8	0.1	-0.3	-0.3	-0.4	0.4	-0.8	-0.6	-0.4	-0.9	-0.7	-0.8	-0.2	-0.1	-1.1	-0.3
Glaucoma (self-reported)	0.3	0.4	1.2	-0.4	-0.1	1.1	-0.5	-0.3	-0.7	-0.3	-0.7	-0.1	-0.4	-0.7	-0.3	-0.3	-0.3	-0.8	-0.9	-0.9	-0.1	-0.9
Qualifications: College or University degree	0.3	0.8	3.7	-0.8	1.0	0.2	0.7	-1.5	0.2	-0.2	-0.5	-1.9	0.2	0.8	1.7	0.8	0.3	0.7	-0.5	-0.0	1.2	0.7
Migraine (self-reported)	0.3	0.4	1.2	0.3	-0.9	-0.9	-0.1	0.7	-0.5	0.0	0.1	1.1	-0.4	-0.9	-0.5	-1.1	-0.4	-0.5	0.0	-0.7	-0.7	-0.8
Medication: Allopurinol	0.3	0.4	1.4	-0.4	-0.6	0.2	-1.2	-0.5	-0.7	-0.7	0.5	-0.8	-0.6	-0.5	0.2	-0.5	-0.4	-0.9	-0.8	-0.8	-0.2	-0.7
Had major operations	0.3	0.3	1.7	0.0	-1.2	-0.5	-1.3	-0.4	-0.1	0.1	0.7	-0.2	-0.1	-0.6	-0.5	-0.6	-0.0	-0.8	-0.1	-0.1	-0.6	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	3.3	1.8	-0.2	0.4	-0.6	0.8	0.6	0.5	0.3	0.6	0.3	-0.0	-0.2	0.3	0.3	-0.4	0.5	1.0	-0.3	0.4
Ever had prostate specific antigen (PSA) test	0.3	0.4	2.5	-0.9	-1.0	-1.6	-0.1	-0.5	-0.3	-0.5	0.1	-0.6	-0.4	-0.5	0.7	-0.4	-0.3	-0.5	-0.4	-0.0	-0.7	-0.1
Diastolic blood pressure, automated reading	0.3	1.1	4.4	-1.4	2.1	-0.2	0.9	-0.8	0.6	-0.0	-1.5	-1.3	0.6	0.7	1.5	0.9	0.4	1.3	0.1	0.6	1.0	1.0
Ever depressed for a whole week	0.3	0.4	2.9	-0.2	0.6	1.7	-0.4	0.1	0.5	0.2	0.3	-0.0	0.1	1.0	0.1	0.6	0.2	-0.0	0.4	0.9	0.0	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	2.3	0.6	-0.1	0.0	1.5	-0.5	-0.2	-0.5	-0.3	-0.9	0.0	-0.2	0.5	1.1	-0.1	0.8	-0.9	-0.1	1.1	0.3
Depressed Affect (Nagel 2018)	0.2	0.4	1.7	-0.7	-0.2	-0.1	-1.0	-0.1	-0.3	-0.8	1.0	-0.1	-0.6	-0.1	-0.4	-0.9	-0.6	-0.7	-0.2	-0.4	-1.3	-0.6
Neuroticism (Nagel 2018)	0.2	0.5	2.2	-1.2	0.1	-1.4	0.4	-0.9	-0.1	-0.7	-0.3	-1.5	0.0	0.6	0.7	0.2	-0.1	0.4	-0.4	0.0	-0.2	0.3
Schizophrenia vs Biploar Disorder	0.2	0.2	1.1	0.5	0.8	-0.5	1.1	0.3	-0.2	-0.2	0.0	0.2	-0.4	-0.0	-0.1	-0.4	-0.4	-0.4	-0.1	-0.4	-0.6	-0.4
Ulcerative Colitis (UC)	0.2	0.4	1.0	-0.7	0.0	-0.7	-0.3	-0.2	-0.6	-0.8	0.2	0.1	-0.7	-0.4	-0.3	-0.8	-0.9	-0.9	-0.5	-0.7	-0.9	-1.0
Reaction Time	0.2	0.3	1.2	-0.3	0.1	-0.4	-0.3	0.9	0.2	0.6	0.5	1.1	0.4	-0.0	1.0	-0.7	0.3	0.2	0.9	0.4	-0.8	0.2
Neuroticism (2016)	0.2	0.2	1.8	-0.1	1.3	-0.5	1.1	0.5	0.1	0.1	0.1	0.4	0.2	0.6	0.3	0.1	0.1	0.1	0.5	0.3	-0.0	0.2
Primary Biliary Cirrhosis	0.2	0.3	2.5	1.2	0.2	1.6	0.1	0.4	-0.1	0.0	-0.6	0.3	-0.0	0.0	-0.9	-0.1	0.0	-0.1	0.1	-0.1	0.1	-0.1
Chronotype (morning person)	0.2	0.5	1.5	-1.0	-1.1	0.4	-0.9	-0.9	-0.3	-0.5	-0.8	-1.2	-0.2	-0.6	0.6	0.6	-0.3	0.2	-1.1	-0.4	0.6	-0.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	1.0	0.4	0.4	0.4	-0.2	0.4	0.3	0.2	0.6	0.2	0.5	1.0	0.2	0.5	0.4	0.7	0.3	0.3	0.8	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	1.7	0.2	0.5	0.4	-0.4	0.7	0.2	0.2	1.3	0.5	0.3	0.6	-0.4	-0.3	0.2	0.1	0.3	-0.1	-0.3	-0.3
Qualifications: CSEs or equivalent	0.2	0.3	2.2	1.5	-0.4	1.2	-0.3	0.6	0.1	0.2	-0.6	0.8	0.0	-0.4	-0.5	0.3	-0.1	-0.3	-0.1	0.3	0.0	-0.1
Medication: Levothyroxine sodium	0.2	0.4	3.4	0.5	-0.6	-1.0	-1.8	0.4	0.3	0.4	0.6	0.3	0.3	0.2	-0.2	-0.1	0.4	-0.7	0.3	0.1	-0.5	-0.2
Alcohol usually taken with meals	0.2	0.4	1.2	0.1	-0.7	0.0	0.2	-0.7	-0.8	-0.9	-0.5	-0.4	-0.8	-1.1	0.3	-0.4	-0.9	0.1	-0.7	-0.5	-0.1	-0.2
Hair/balding pattern: Pattern 2	0.2	0.3	3.0	-1.7	-0.7	0.0	-1.1	-0.4	-0.1	-0.2	-0.2	-0.4	-0.2	-0.2	-0.6	0.3	-0.0	-0.2	-0.4	-0.1	0.0	0.0
Noisy workplace	0.2	0.2	0.9	-0.9	-0.3	-0.5	-0.5	-0.2	0.2	0.2	-0.7	-0.4	0.1	0.1	-0.7	0.2	0.3	-0.8	-0.1	0.2	0.2	-0.2
Medication: Cholesterol lowering	0.2	0.3	3.6	0.4	-0.1	-1.9	1.2	0.1	-0.0	0.3	-0.4	-0.0	0.2	-0.3	0.1	-0.3	0.3	-0.3	0.3	-0.1	-0.1	-0.2
Depression (self-reported)	0.2	0.2	2.6	-0.2	-0.2	0.6	-1.6	0.1	-0.0	-0.2	0.8	0.0	-0.2	-0.0	0.3	-0.1	-0.3	0.1	-0.0	0.3	-0.4	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.0	-0.0	0.4	0.0	-1.0	0.8	0.3	0.5	0.6	0.8	0.4	0.4	0.0	-0.3	0.3	0.5	0.8	0.3	-0.2	0.3
Guilty feelings	0.2	0.3	0.8	-0.4	-0.3	-0.3	0.3	-0.5	-0.6	-0.9	-0.0	-0.3	-0.9	-0.4	-0.5	-0.6	-0.9	-0.8	-0.7	-0.1	-0.8	-0.2
Eye problems/disorders: Glaucoma	0.2	0.3	0.9	-0.0	-1.0	0.8	-0.8	0.1	-0.5	-0.1	-0.7	0.1	-0.2	-0.7	0.3	-0.0	-0.2	-0.2	-0.7	-0.7	0.4	-0.6
Alcohol drinker status: Never	0.2	0.2	2.3	-0.1	0.7	0.8	1.5	0.1	0.3	-0.1	-0.8	-0.2	0.1	0.1	-0.4	0.4	0.0	0.2	-0.1	0.3	-0.1	0.3
Irritability	0.2	0.4	2.4	-0.3	0.4	-1.6	0.8	0.0	0.2	0.1	0.5	-0.1	0.4	0.8	1.2	0.0	0.3	0.7	0.6	0.2	-0.2	0.4
Unable to work because of sickness or disability	0.2	0.3	1.3	-0.4	-0.7	-1.1	-0.1	0.2	-0.0	-0.2	-0.3	0.3	-0.1	-0.2	-1.0	-0.2	-0.1	-1.0	-0.4	-0.1	-0.4	-0.6
Cholesterol lowering medication	0.2	0.3	0.9	-0.4	0.5	-0.2	-0.2	0.3	-0.6	-0.3	-0.8	0.7	-0.6	0.0	-0.5	-0.9	-0.6	-0.8	0.1	-0.6	-0.9	-0.8
Ulcerative Colitis	0.1	0.2	0.7	-0.0	0.2	-0.1	0.3	0.8	0.2	0.2	0.8	0.8	-0.0	0.0	-0.5	-0.6	-0.2	-0.5	0.4	0.0	0.0	-0.4
Blood White Count	0.1	0.9	4.2	2.1	-0.1	1.7	-0.3	0.2	0.5	0.3	0.5	0.0	0.5	0.0	-1.3	1.5	0.5	-1.1	-1.1	0.3	1.1	-0.3
Fed-up feelings	0.1	0.3	1.4	0.3	-1.1	-1.2	-0.4	-0.2	-0.2	-0.5	0.5	-0.5	-0.3	-0.5	-0.2	0.2	-0.4	0.1	-0.6	-0.1	0.3	-0.0
Financial difficulties in last 2 years	0.1	0.2	0.8	-0.2	0.5	0.2	0.2	0.6	0.6	0.4	-0.2	0.4	0.2	0.7	-0.9	0.5	0.3	-0.3	0.3	0.5	0.4	0.3
Prospective memory result	0.1	0.2	0.8	-0.1	0.2	-0.1	0.1	-0.5	-0.1	-0.1	-0.4	-0.9	0.3	0.3	-0.7	0.6	0.2	0.7	-0.2	-0.2	0.5	0.0
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.4	0.3	0.4	0.3	-0.7	0.7	0.2	0.4	-0.3	0.6	0.3	0.7	-0.4	-0.3	0.3	-0.1	0.7	0.1	-0.5	-0.1
Number of full sisters	0.1	0.2	0.9	-0.1	-0.3	0.3	1.0	0.0	0.2	-0.4	0.7	-0.0	-0.2	-0.4	-0.1	-0.3	-0.4	-0.1	0.0	0.4	-0.8	0.2
Average weekly red wine intake	0.1	0.1	0.4	0.3	-0.2	0.2	-0.4	0.1	-0.4	-0.1	0.2	0.2	-0.0	0.2	-0.3	-0.3	-0.2	0.6	0.1	-0.5	0.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.6	-0.0	-0.6	0.8	-0.6	0.4	0.1	0.3	0.7	0.3	0.2	0.6	-0.0	-0.1	0.2	-0.1	0.2	-0.2	-0.4	-0.3

Hub : Genes

SPG7

Models

Trait associations