Best TWAS P=6.98e-11 · Best GWAS P=6.02e-10 conditioned to 0.000954
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | METTL21A | 0.10 | 0.02 | lasso | 4 | 0.02 | 1.6e-02 | -4.7 | 5.3 | 1.1e-07 | 0.32 | 0.23 | 0.07 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CREB1 | 0.15 | 0.00 | enet | 7 | 0.00 | 2.8e-01 | -4.7 | -6.5 | 7.0e-11 | -0.50 | 0.14 | 0.43 | TRUE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | NDUFS1 | 0.16 | 0.09 | enet | 22 | 0.03 | 2.4e-02 | -4.5 | 5.2 | 2.5e-07 | 0.01 | 0.03 | 0.93 | FALSE |
| 4 | GTEx | Esophagus Mucosa | METTL21A | 0.10 | 0.10 | enet | 9 | 0.12 | 1.8e-08 | -4.7 | 5.4 | 5.1e-08 | 0.57 | 0.76 | 0.23 | FALSE |
| 5 | GTEx | Nerve Tibial | AC007383.4 | 0.14 | 0.06 | lasso | 6 | 0.05 | 3.0e-04 | -4.8 | 5.3 | 9.4e-08 | 0.01 | 0.03 | 0.96 | TRUE |
| 6 | GTEx | Testis | NDUFS1 | 0.15 | 0.08 | lasso | 6 | 0.08 | 2.1e-04 | -4.6 | 5.2 | 2.5e-07 | 0.02 | 0.05 | 0.85 | FALSE |
| 7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CREB1 | 0.03 | 0.01 | blup | 64 | 0.01 | 2.5e-02 | -5.2 | -5.2 | 1.6e-07 | -0.49 | 0.13 | 0.36 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FAM119A | 0.04 | 0.02 | blup | 51 | 0.03 | 1.0e-06 | -4.6 | 5.5 | 3.2e-08 | 0.64 | 0.03 | 0.95 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CREB1 | 0.11 | 0.02 | enet | 7 | 0.02 | 1.7e-03 | 4.9 | -5.4 | 7.4e-08 | -0.70 | 0.01 | 0.86 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM119A | 0.09 | 0.12 | lasso | 2 | 0.12 | 4.4e-12 | -4.7 | 5.3 | 1.2e-07 | 0.50 | 0.03 | 0.96 | FALSE |