Best TWAS P=6.51e-12 · Best GWAS P=1.38e-12 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RAB24 | 0.14 | 0.06 | enet | 14 | 0.09 | 4.2e-11 | 5.3 | 6.1 | 1.3e-09 | 0.18 | 0.44 | 0.56 | TRUE |
2 | GTEx | Adipose Subcutaneous | RAB24 | 0.17 | 0.08 | enet | 26 | 0.14 | 1.7e-11 | 5.3 | 6.4 | 1.4e-10 | 0.44 | 0.61 | 0.38 | FALSE |
3 | GTEx | Adipose Subcutaneous | MXD3 | 0.16 | 0.05 | enet | 13 | 0.06 | 1.7e-05 | 5.8 | 6.2 | 5.7e-10 | 0.77 | 0.02 | 0.98 | FALSE |
4 | GTEx | Adipose Visceral Omentum | MXD3 | 0.33 | 0.06 | lasso | 6 | 0.05 | 9.1e-04 | 5.9 | 5.2 | 2.5e-07 | 0.84 | 0.05 | 0.84 | FALSE |
5 | GTEx | Artery Tibial | RAB24 | 0.18 | 0.09 | lasso | 3 | 0.07 | 2.3e-06 | 5.3 | 6.5 | 1.1e-10 | 0.49 | 0.18 | 0.82 | TRUE |
6 | GTEx | Artery Tibial | MXD3 | 0.12 | 0.13 | enet | 5 | 0.12 | 7.0e-10 | 5.8 | 6.1 | 1.3e-09 | 0.89 | 0.24 | 0.76 | FALSE |
7 | GTEx | Brain Cerebellum | MXD3 | 0.28 | 0.31 | lasso | 2 | 0.30 | 1.6e-09 | 5.9 | 5.8 | 5.1e-09 | 0.87 | 0.12 | 0.86 | FALSE |
8 | GTEx | Brain Nucleus accumbens basal ganglia | MXD3 | 0.24 | 0.14 | enet | 10 | 0.25 | 2.9e-07 | 5.8 | 5.9 | 3.0e-09 | 0.83 | 0.07 | 0.76 | FALSE |
9 | GTEx | Breast Mammary Tissue | MXD3 | 0.26 | 0.08 | lasso | 5 | 0.10 | 1.3e-05 | 5.8 | 6.3 | 3.8e-10 | 0.86 | 0.00 | 0.99 | FALSE |
10 | GTEx | Breast Mammary Tissue (Female) | MXD3 | 0.23 | 0.08 | lasso | 3 | 0.09 | 1.1e-03 | 7.1 | 6.1 | 8.5e-10 | 0.82 | 0.01 | 0.88 | FALSE |
11 | GTEx | Colon Sigmoid | MXD3 | 0.35 | 0.27 | lasso | 9 | 0.29 | 6.3e-11 | 5.9 | 5.7 | 1.1e-08 | 0.90 | 0.05 | 0.95 | TRUE |
12 | GTEx | Colon Transverse | PRELID1 | 0.31 | 0.28 | lasso | 4 | 0.26 | 1.1e-12 | 5.8 | -6.0 | 2.6e-09 | -0.90 | 0.05 | 0.95 | FALSE |
13 | GTEx | Esophagus Mucosa | UIMC1 | 0.08 | 0.00 | lasso | 5 | 0.00 | 3.5e-01 | -6.1 | -6.3 | 2.4e-10 | -0.19 | 0.12 | 0.09 | TRUE |
14 | GTEx | Esophagus Mucosa | FGFR4 | 0.18 | 0.16 | enet | 8 | 0.16 | 9.2e-11 | -6.1 | -5.8 | 7.5e-09 | -0.21 | 0.47 | 0.53 | FALSE |
15 | GTEx | Esophagus Mucosa | MXD3 | 0.16 | 0.14 | lasso | 8 | 0.15 | 1.7e-10 | 5.8 | 5.8 | 6.1e-09 | 0.85 | 0.31 | 0.69 | FALSE |
16 | GTEx | Esophagus Muscularis | MXD3 | 0.27 | 0.20 | enet | 10 | 0.24 | 1.6e-14 | 5.8 | 6.0 | 1.4e-09 | 0.91 | 0.11 | 0.89 | FALSE |
17 | GTEx | Heart Atrial Appendage | MXD3 | 0.33 | 0.15 | enet | 24 | 0.16 | 1.5e-07 | 5.8 | 5.9 | 3.8e-09 | 0.76 | 0.00 | 0.99 | FALSE |
18 | GTEx | Heart Left Ventricle | MXD3 | 0.17 | 0.03 | lasso | 3 | 0.03 | 1.5e-02 | 5.9 | 5.9 | 2.9e-09 | 0.86 | 0.11 | 0.28 | FALSE |
19 | GTEx | Liver | PRELID1 | 0.22 | 0.25 | lasso | 3 | 0.24 | 2.4e-07 | 7.1 | -6.9 | 6.5e-12 | -0.98 | 0.00 | 0.99 | TRUE |
20 | GTEx | Lung | MXD3 | 0.20 | 0.12 | lasso | 10 | 0.12 | 1.8e-09 | 5.8 | 6.0 | 1.9e-09 | 0.85 | 0.16 | 0.84 | FALSE |
21 | GTEx | Nerve Tibial | FGFR4 | 0.44 | 0.48 | lasso | 7 | 0.47 | 2.1e-37 | -6.1 | -6.0 | 2.0e-09 | -0.19 | 0.47 | 0.53 | FALSE |
22 | GTEx | Nerve Tibial | RAB24 | 0.27 | 0.08 | enet | 32 | 0.17 | 6.3e-12 | 2.1 | 6.6 | 5.2e-11 | 0.52 | 0.34 | 0.61 | FALSE |
23 | GTEx | Nerve Tibial | MXD3 | 0.26 | 0.17 | lasso | 7 | 0.28 | 6.9e-20 | 5.8 | 6.2 | 4.2e-10 | 0.87 | 0.06 | 0.94 | FALSE |
24 | GTEx | Pituitary | MXD3 | 0.25 | 0.20 | lasso | 6 | 0.16 | 7.5e-05 | 5.0 | 5.6 | 2.6e-08 | 0.74 | 0.05 | 0.88 | FALSE |
25 | GTEx | Skin Not Sun Exposed Suprapubic | MXD3 | 0.22 | 0.18 | lasso | 3 | 0.17 | 1.8e-09 | 5.9 | 6.4 | 1.4e-10 | 0.94 | 0.02 | 0.98 | FALSE |
26 | GTEx | Skin Sun Exposed Lower leg | PRELID1 | 0.06 | 0.02 | enet | 5 | 0.03 | 3.4e-03 | 5.8 | -5.7 | 9.5e-09 | -0.92 | 0.01 | 0.98 | FALSE |
27 | GTEx | Skin Sun Exposed Lower leg | MXD3 | 0.19 | 0.14 | lasso | 6 | 0.12 | 4.2e-10 | 7.1 | 6.5 | 7.8e-11 | 0.91 | 0.00 | 1.00 | FALSE |
28 | GTEx | Small Intestine Terminal Ileum | PRELID1 | 0.47 | 0.16 | enet | 10 | 0.13 | 7.6e-04 | 7.1 | -6.5 | 6.5e-11 | -0.94 | 0.00 | 0.95 | FALSE |
29 | GTEx | Thyroid | MXD3 | 0.31 | 0.17 | lasso | 8 | 0.24 | 1.1e-18 | 5.8 | 6.6 | 4.7e-11 | 0.91 | 0.00 | 1.00 | FALSE |
30 | METSIM | Adipose | MXD3 | 0.18 | 0.18 | lasso | 3 | 0.21 | 1.3e-30 | 5.8 | 6.1 | 9.7e-10 | 0.86 | 0.70 | 0.30 | FALSE |
31 | METSIM | Adipose | RAB24 | 0.05 | 0.02 | lasso | 4 | 0.02 | 1.2e-03 | 5.3 | 5.1 | 2.9e-07 | 0.22 | 0.13 | 0.76 | FALSE |
32 | The Cancer Genome Atlas | Colon Adenocarcinoma | RAB24 | 0.08 | 0.04 | enet | 7 | 0.06 | 3.4e-04 | -3.0 | 6.2 | 7.2e-10 | 0.57 | 0.04 | 0.10 | FALSE |
33 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LMAN2 | 0.04 | 0.00 | blup | 46 | 0.00 | 1.6e-01 | 7.1 | -5.3 | 1.4e-07 | -0.77 | 0.00 | 0.91 | TRUE |
34 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PRELID1 | 0.24 | 0.11 | lasso | 5 | 0.10 | 1.2e-11 | 6.1 | -6.0 | 1.5e-09 | -0.88 | 0.34 | 0.66 | TRUE |
35 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PRELID1 | 0.33 | 0.08 | enet | 4 | 0.08 | 2.7e-05 | 5.8 | -6.0 | 1.8e-09 | -0.90 | 0.14 | 0.73 | FALSE |
36 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PRELID1 | 0.08 | 0.10 | lasso | 4 | 0.07 | 2.9e-04 | 5.4 | -5.6 | 1.8e-08 | -0.83 | 0.02 | 0.92 | FALSE |
37 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MXD3 | 0.04 | 0.02 | blup | 40 | 0.03 | 2.8e-04 | 5.8 | 5.2 | 2.3e-07 | 0.84 | 0.10 | 0.77 | TRUE |