Best TWAS P=1.24e-10 · Best GWAS P=4.08e-11 conditioned to 0.0621
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM86B1 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.3e-02 | 4.5 | 5.6 | 2.3e-08 | -0.63 | 0.01 | 0.96 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | FAM90A25P | 0.11 | 0.08 | lasso | 3 | 0.08 | 1.4e-09 | 5.2 | 5.6 | 2.7e-08 | -0.58 | 0.00 | 1.00 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | PINX1 | 0.07 | 0.07 | enet | 7 | 0.08 | 4.9e-10 | -4.4 | 5.2 | 2.2e-07 | -0.40 | 0.83 | 0.17 | FALSE |
4 | GTEx | Adipose Subcutaneous | FDFT1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 3.4e-04 | -4.9 | 5.2 | 2.0e-07 | -0.54 | 0.16 | 0.80 | FALSE |
5 | GTEx | Adipose Subcutaneous | AF131215.2 | 0.24 | 0.15 | lasso | 7 | 0.14 | 3.5e-11 | -5.5 | 5.8 | 5.7e-09 | -0.82 | 0.44 | 0.56 | FALSE |
6 | GTEx | Adipose Subcutaneous | AF131215.9 | 0.20 | 0.12 | enet | 60 | 0.17 | 1.1e-13 | -5.5 | 5.8 | 8.6e-09 | -0.67 | 0.15 | 0.85 | FALSE |
7 | GTEx | Adipose Visceral Omentum | AF131215.2 | 0.12 | 0.08 | lasso | 6 | 0.06 | 4.6e-04 | 6.0 | 6.0 | 2.7e-09 | -0.86 | 0.15 | 0.82 | FALSE |
8 | GTEx | Adipose Visceral Omentum | AF131215.9 | 0.18 | 0.16 | lasso | 7 | 0.16 | 2.0e-08 | 6.0 | 6.1 | 1.3e-09 | -0.87 | 0.07 | 0.93 | FALSE |
9 | GTEx | Adrenal Gland | FAM86B3P | 0.16 | 0.00 | enet | 18 | 0.03 | 2.2e-02 | 4.2 | -5.1 | 2.7e-07 | 0.38 | 0.04 | 0.10 | FALSE |
10 | GTEx | Adrenal Gland | AF131215.2 | 0.20 | 0.16 | enet | 12 | 0.13 | 2.2e-05 | 6.1 | 6.2 | 4.3e-10 | -0.90 | 0.03 | 0.97 | FALSE |
11 | GTEx | Adrenal Gland | AF131215.9 | 0.18 | 0.16 | lasso | 10 | 0.18 | 3.5e-07 | 6.1 | 6.1 | 1.1e-09 | -0.87 | 0.04 | 0.95 | FALSE |
12 | GTEx | Artery Aorta | ERI1 | 0.11 | 0.08 | lasso | 5 | 0.10 | 5.1e-06 | 6.1 | -5.5 | 3.8e-08 | 0.60 | 0.00 | 1.00 | FALSE |
13 | GTEx | Artery Aorta | AF131215.2 | 0.09 | 0.09 | lasso | 7 | 0.08 | 2.0e-05 | -5.5 | 6.2 | 6.9e-10 | -0.86 | 0.10 | 0.89 | FALSE |
14 | GTEx | Artery Aorta | AF131215.9 | 0.13 | 0.05 | lasso | 6 | 0.07 | 1.3e-04 | 6.0 | 6.2 | 6.1e-10 | -0.88 | 0.09 | 0.91 | FALSE |
15 | GTEx | Artery Tibial | ERI1 | 0.05 | 0.02 | lasso | 7 | 0.01 | 3.2e-02 | 3.9 | -5.1 | 3.0e-07 | 0.61 | 0.03 | 0.95 | FALSE |
16 | GTEx | Brain Cerebellar Hemisphere | AF131215.2 | 0.15 | 0.17 | lasso | 3 | 0.09 | 3.0e-03 | -5.9 | 6.0 | 1.8e-09 | -0.86 | 0.06 | 0.78 | FALSE |
17 | GTEx | Breast Mammary Tissue | AF131215.2 | 0.16 | 0.15 | lasso | 6 | 0.12 | 1.1e-06 | -5.5 | 5.6 | 2.3e-08 | -0.80 | 0.45 | 0.52 | FALSE |
18 | GTEx | Breast Mammary Tissue | AF131215.9 | 0.10 | 0.10 | lasso | 8 | 0.12 | 8.7e-07 | -5.0 | 5.7 | 1.0e-08 | -0.79 | 0.27 | 0.72 | FALSE |
19 | GTEx | Breast Mammary Tissue (Female) | AF131215.9 | 0.04 | -0.01 | enet | 6 | 0.02 | 7.3e-02 | -4.3 | 5.5 | 3.8e-08 | -0.65 | 0.08 | 0.13 | FALSE |
20 | GTEx | Cells EBV-transformed lymphocytes | AF131215.2 | 0.20 | 0.10 | enet | 14 | 0.11 | 1.5e-04 | -5.9 | 5.9 | 4.2e-09 | -0.85 | 0.15 | 0.82 | FALSE |
21 | GTEx | Cells EBV-transformed lymphocytes | AF131215.9 | 0.20 | 0.15 | enet | 19 | 0.13 | 5.6e-05 | -5.9 | 5.9 | 3.6e-09 | -0.79 | 0.18 | 0.75 | FALSE |
22 | GTEx | Cells Transformed fibroblasts | ERI1 | 0.34 | 0.35 | lasso | 7 | 0.35 | 1.9e-27 | 6.1 | -6.2 | 5.9e-10 | 0.59 | 0.00 | 1.00 | FALSE |
23 | GTEx | Colon Sigmoid | AF131215.2 | 0.10 | 0.00 | enet | 7 | 0.02 | 5.0e-02 | 5.4 | 5.2 | 1.7e-07 | -0.76 | 0.12 | 0.53 | FALSE |
24 | GTEx | Colon Sigmoid | AF131215.9 | 0.11 | 0.17 | enet | 5 | 0.09 | 4.9e-04 | -5.9 | 5.8 | 6.7e-09 | -0.87 | 0.10 | 0.76 | FALSE |
25 | GTEx | Colon Transverse | AF131215.2 | 0.15 | 0.09 | enet | 32 | 0.07 | 3.1e-04 | 6.0 | 5.2 | 1.7e-07 | -0.78 | 0.11 | 0.86 | FALSE |
26 | GTEx | Colon Transverse | AF131215.9 | 0.12 | 0.14 | enet | 18 | 0.12 | 4.0e-06 | -5.9 | 5.8 | 7.6e-09 | -0.88 | 0.11 | 0.89 | FALSE |
27 | GTEx | Esophagus Mucosa | AF131215.2 | 0.15 | 0.14 | enet | 15 | 0.18 | 4.3e-12 | -5.1 | 5.6 | 2.2e-08 | -0.84 | 0.69 | 0.31 | FALSE |
28 | GTEx | Esophagus Mucosa | AF131215.9 | 0.18 | 0.16 | lasso | 14 | 0.19 | 1.6e-12 | 5.7 | 6.2 | 5.8e-10 | -0.89 | 0.07 | 0.93 | FALSE |
29 | GTEx | Esophagus Muscularis | ERI1 | 0.12 | 0.09 | enet | 13 | 0.08 | 7.7e-06 | 5.5 | -5.3 | 1.2e-07 | 0.61 | 0.05 | 0.95 | FALSE |
30 | GTEx | Esophagus Muscularis | AF131215.2 | 0.10 | 0.08 | lasso | 5 | 0.09 | 2.3e-06 | -5.1 | 5.2 | 2.0e-07 | -0.81 | 0.72 | 0.26 | FALSE |
31 | GTEx | Esophagus Muscularis | FAM85A | 0.10 | 0.01 | enet | 20 | 0.04 | 2.7e-03 | -4.1 | 5.3 | 9.4e-08 | -0.53 | 0.06 | 0.86 | FALSE |
32 | GTEx | Esophagus Muscularis | AF131215.9 | 0.14 | 0.17 | enet | 16 | 0.17 | 1.6e-10 | -5.9 | 6.3 | 2.7e-10 | -0.86 | 0.15 | 0.85 | FALSE |
33 | GTEx | Heart Atrial Appendage | AF131215.2 | 0.39 | 0.13 | enet | 26 | 0.21 | 6.6e-10 | -5.1 | 5.4 | 7.4e-08 | -0.75 | 0.63 | 0.37 | FALSE |
34 | GTEx | Heart Left Ventricle | AF131215.2 | 0.05 | 0.01 | enet | 11 | 0.01 | 1.5e-01 | 5.9 | 6.1 | 1.3e-09 | -0.86 | 0.08 | 0.82 | FALSE |
35 | GTEx | Heart Left Ventricle | AF131215.9 | 0.07 | 0.10 | enet | 8 | 0.10 | 9.4e-06 | -5.9 | 6.3 | 2.3e-10 | -0.87 | 0.11 | 0.88 | FALSE |
36 | GTEx | Lung | AF131215.2 | 0.12 | 0.08 | lasso | 5 | 0.08 | 1.0e-06 | -5.9 | 6.1 | 8.9e-10 | -0.86 | 0.18 | 0.82 | FALSE |
37 | GTEx | Lung | AF131215.9 | 0.15 | 0.18 | lasso | 4 | 0.15 | 1.5e-11 | -5.9 | 6.0 | 1.7e-09 | -0.86 | 0.17 | 0.83 | FALSE |
38 | GTEx | Nerve Tibial | AF131215.2 | 0.19 | 0.18 | lasso | 12 | 0.23 | 3.5e-16 | -5.1 | 6.1 | 9.5e-10 | -0.89 | 0.25 | 0.75 | FALSE |
39 | GTEx | Nerve Tibial | AF131215.9 | 0.17 | 0.17 | lasso | 4 | 0.18 | 5.0e-13 | -5.9 | 5.8 | 6.1e-09 | -0.86 | 0.20 | 0.80 | FALSE |
40 | GTEx | Pancreas | AF131215.2 | 0.16 | 0.16 | enet | 17 | 0.15 | 9.1e-07 | -5.9 | 6.2 | 4.5e-10 | -0.88 | 0.12 | 0.87 | FALSE |
41 | GTEx | Pancreas | AF131215.9 | 0.25 | 0.24 | enet | 14 | 0.22 | 1.0e-09 | 6.0 | 6.4 | 1.2e-10 | -0.90 | 0.07 | 0.93 | TRUE |
42 | GTEx | Prostate | AF131215.2 | 0.18 | 0.02 | lasso | 6 | 0.02 | 9.6e-02 | 4.1 | 5.9 | 2.8e-09 | -0.74 | 0.08 | 0.53 | FALSE |
43 | GTEx | Skin Not Sun Exposed Suprapubic | AF131215.2 | 0.16 | 0.11 | enet | 21 | 0.20 | 3.9e-11 | -5.1 | 5.6 | 2.2e-08 | -0.87 | 0.11 | 0.89 | FALSE |
44 | GTEx | Skin Not Sun Exposed Suprapubic | AF131215.9 | 0.17 | 0.14 | lasso | 8 | 0.19 | 9.4e-11 | -5.9 | 5.8 | 6.7e-09 | -0.86 | 0.13 | 0.87 | FALSE |
45 | GTEx | Skin Sun Exposed Lower leg | AF131215.2 | 0.14 | 0.11 | lasso | 9 | 0.16 | 4.3e-13 | -5.1 | 5.8 | 5.5e-09 | -0.85 | 0.53 | 0.47 | FALSE |
46 | GTEx | Skin Sun Exposed Lower leg | FAM85A | 0.09 | 0.04 | enet | 28 | 0.04 | 1.4e-04 | -4.1 | 5.3 | 1.5e-07 | -0.45 | 0.09 | 0.81 | FALSE |
47 | GTEx | Skin Sun Exposed Lower leg | AF131215.9 | 0.19 | 0.17 | enet | 29 | 0.21 | 3.9e-17 | -5.9 | 6.3 | 3.7e-10 | -0.86 | 0.20 | 0.80 | FALSE |
48 | GTEx | Spleen | AF131215.2 | 0.16 | 0.08 | enet | 14 | 0.06 | 1.1e-02 | -5.9 | 5.6 | 2.7e-08 | -0.88 | 0.04 | 0.89 | FALSE |
49 | GTEx | Spleen | AF131215.9 | 0.34 | 0.23 | enet | 16 | 0.15 | 1.2e-04 | 6.4 | 5.4 | 6.4e-08 | -0.88 | 0.02 | 0.97 | FALSE |
50 | GTEx | Testis | AF131215.2 | 0.28 | 0.18 | enet | 41 | 0.17 | 8.0e-08 | -5.1 | 5.9 | 4.7e-09 | -0.65 | 0.79 | 0.21 | FALSE |
51 | GTEx | Thyroid | AF131215.2 | 0.11 | 0.15 | enet | 17 | 0.18 | 1.2e-13 | -5.1 | 6.3 | 3.0e-10 | -0.87 | 0.36 | 0.64 | FALSE |
52 | GTEx | Thyroid | AF131215.9 | 0.11 | 0.08 | enet | 16 | 0.17 | 4.7e-13 | -5.9 | 5.9 | 4.0e-09 | -0.86 | 0.17 | 0.83 | FALSE |
53 | GTEx | Uterus | AF131215.2 | 0.17 | 0.07 | enet | 13 | 0.09 | 7.1e-03 | 6.1 | 6.2 | 8.0e-10 | -0.87 | 0.05 | 0.82 | FALSE |
54 | GTEx | Vagina | AF131215.9 | 0.21 | 0.11 | lasso | 9 | 0.08 | 6.3e-03 | 6.4 | 6.4 | 2.1e-10 | -0.92 | 0.04 | 0.92 | FALSE |
55 | NTR | Blood | MSRA | 0.02 | 0.01 | blup | 833 | 0.01 | 2.3e-05 | 4.2 | -5.6 | 2.0e-08 | 0.61 | 0.35 | 0.64 | FALSE |
56 | ROSMAP | Brain Pre-frontal Cortex | XKR6 | 0.11 | 0.10 | enet | 23 | 0.13 | 1.2e-16 | -5.1 | 6.2 | 6.9e-10 | -0.81 | 0.32 | 0.68 | FALSE |
57 | ROSMAP | Brain Pre-frontal Cortex | FAM66A | 0.23 | 0.26 | enet | 29 | 0.30 | 4.7e-39 | 5.5 | 5.8 | 4.9e-09 | -0.60 | 0.00 | 1.00 | FALSE |
58 | ROSMAP | Brain Pre-frontal Cortex | AF131215.3 | 0.08 | 0.10 | lasso | 7 | 0.12 | 8.3e-16 | 6.1 | 6.3 | 3.1e-10 | -0.86 | 0.04 | 0.96 | FALSE |
59 | ROSMAP | Brain Pre-frontal Cortex | RP11-481A20.11 | 0.06 | 0.04 | blup | 286 | 0.04 | 2.2e-06 | 5.2 | 5.1 | 2.8e-07 | -0.61 | 0.01 | 0.98 | FALSE |
60 | ROSMAP | Brain Pre-frontal Cortex | AF131215.2 | 0.49 | 0.57 | lasso | 7 | 0.57 | 9.0e-89 | -5.9 | 6.0 | 1.8e-09 | -0.87 | 0.16 | 0.84 | FALSE |
61 | ROSMAP | Brain Pre-frontal Cortex | FAM85A | 0.11 | 0.07 | enet | 23 | 0.11 | 4.3e-14 | 5.5 | 5.4 | 6.1e-08 | -0.60 | 0.00 | 1.00 | FALSE |
62 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ERI1 | 0.05 | 0.01 | blup | 72 | 0.01 | 5.0e-02 | 6.1 | -6.2 | 5.7e-10 | 0.50 | 0.00 | 0.88 | FALSE |
63 | The Cancer Genome Atlas | Lung Adenocarcinoma | ERI1 | 0.06 | 0.04 | blup | 72 | 0.04 | 1.5e-05 | 5.0 | -5.2 | 2.6e-07 | 0.53 | 0.03 | 0.96 | FALSE |
64 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ZNF705D | 0.23 | 0.20 | lasso | 3 | 0.24 | 4.7e-09 | 5.5 | -5.3 | 1.0e-07 | 0.55 | 0.00 | 1.00 | FALSE |