Hub : Genes

FAM86B1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0230	0.0130	5.4e-03	0.021	0.011	0.004	0.011	0.012	1.1e-03	1.6e-02	9.9e-02	1.6e-02	1.3e-02
2	GTEx	Cells EBV-transformed lymphocytes	0.1740	0.0780	5.9e-03	0.038	NA	-0.009	NA	0.007	2.2e-02	NA	9.8e-01	NA	1.8e-01
3	GTEx	Muscle Skeletal	0.0869	0.0364	1.4e-03	0.022	NA	0.026	NA	0.017	2.7e-03	NA	1.2e-03	NA	7.2e-03
4	ROSMAP	Brain Pre-frontal Cortex	0.1505	0.0401	1.5e-06	0.102	0.034	0.069	0.083	0.082	4.6e-13	3.2e-05	3.4e-09	8.0e-11	1.1e-10
5	TCGA	Breast Invasive Carcinoma	0.0838	0.0336	1.7e-08	0.056	0.042	0.059	NA	0.054	1.1e-11	4.4e-09	3.9e-12	NA	2.8e-11
6	TCGA	Cervical Squamous Cell Carcinoma	0.2210	0.0870	2.4e-03	0.000	0.085	0.095	NA	0.020	3.4e-01	5.7e-05	2.1e-05	NA	3.4e-02
7	TCGA	Colon Adenocarcinoma	0.0770	0.0480	4.4e-03	0.001	-0.003	-0.003	NA	0.003	2.6e-01	5.1e-01	5.1e-01	NA	2.0e-01
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0403	0.0228	4.8e-03	0.005	0.019	0.016	NA	0.011	7.8e-02	2.9e-03	5.4e-03	NA	1.9e-02
9	TCGA	Brain Lower Grade Glioma	0.0848	0.0365	2.7e-04	0.055	0.010	0.050	NA	0.051	7.5e-07	2.1e-02	2.3e-06	NA	1.6e-06
10	TCGA	Prostate Adenocarcinoma	0.0862	0.0358	2.0e-04	0.059	0.039	0.057	NA	0.050	8.0e-07	5.9e-05	1.3e-06	NA	6.0e-06
11	TCGA	Thyroid Carcinoma	0.1370	0.0550	7.2e-05	0.025	0.039	0.041	NA	0.032	1.6e-03	1.0e-04	7.3e-05	NA	4.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.8	2.8	6.0	0.9	-0.9	-2.4	-1.5	-2.1	-0.7	-1.7	-2.1	-1.6	-0.7	-2.4
Bipolar Disorder or Schizophrenia	1.9	4.6	8.7	2.6	-1.3	-2.9	-1.6	-2.7	-0.0	-2.6	-2.3	-2.0	-1.5	-2.3
Depressed Affect (Nagel 2018)	0.4	0.9	2.8	-1.2	0.3	1.4	-0.3	0.0	1.2	0.8	1.7	-0.3	-0.7	0.6
Depression (Nagel 2018)	0.5	0.7	2.5	-1.4	-0.3	0.9	-0.3	-0.1	0.7	1.1	1.6	-0.2	-0.8	0.2
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.0	-0.8	2.2	1.0	2.1	2.0	-1.2	1.2	0.5	2.0	1.1	0.6
Neuroticism (Nagel 2018)	0.5	1.1	2.5	-1.1	1.0	1.6	0.7	0.7	1.3	0.6	1.3	0.6	0.2	1.3
Schizophrenia (2018)	1.2	2.6	7.0	2.6	-1.1	-2.1	-0.9	-1.9	0.5	-2.0	-1.3	-1.4	-1.5	-1.0
Schizophrenia vs Biploar Disorder	0.6	0.8	2.4	1.5	-1.0	-0.9	-0.3	-0.3	-1.3	-0.7	0.1	-0.3	-1.4	0.5
Worry (Nagel 2018)	0.2	0.4	1.0	-0.4	0.4	1.0	0.5	0.5	0.7	0.2	0.5	0.5	0.3	1.0
Alzheimer’s Disease (in mother)	1.0	1.1	2.5	0.6	1.2	0.5	1.5	1.3	0.6	-0.0	1.0	1.6	0.6	1.4
Alzheimer’s Disease (in father)	0.6	0.7	2.2	-0.8	0.7	0.9	-0.2	0.4	1.3	1.2	1.5	-0.1	0.1	0.2
Alzheimer’s Disease (including proxy)	0.9	1.3	3.0	-0.4	1.6	0.9	1.1	1.3	1.3	0.9	1.7	1.1	0.5	0.9
Crohns Disease (2017)	0.6	1.4	2.7	1.3	-0.9	-1.6	-1.2	-1.5	-0.6	-1.1	-1.4	-1.2	-0.5	-0.7
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	0.7	0.9	-0.1	-0.4	-0.4	0.2	0.1	0.4	-0.3	-0.0	0.5
Ulcerative Colitis (UC)	0.5	0.8	3.2	-0.1	1.8	1.3	0.1	0.1	0.7	0.9	1.5	0.2	0.1	0.9
Major Depression (MDD)	0.9	1.1	2.8	-1.0	-0.4	-0.9	-1.7	-1.0	0.6	0.9	0.6	-1.3	-1.5	-1.2
Reaction Time	0.4	0.8	4.1	-2.0	1.4	0.2	0.5	0.5	-0.7	1.0	-0.1	0.5	0.3	-0.7
Verbal and Numeric Reasoning (VNR)	1.1	2.7	5.1	-1.3	1.7	1.9	2.0	2.0	-0.4	1.2	1.9	1.8	0.4	2.3
Breast Cancer	0.3	0.7	2.4	1.6	-1.0	-0.6	-0.4	-0.7	0.6	-1.2	0.0	-0.5	-1.1	0.5
Ovarian Cancer	0.2	0.3	1.3	-0.1	0.1	0.0	0.6	0.6	1.1	0.2	-0.3	0.5	0.6	-0.3
Prostate Cancer	1.8	2.6	4.8	2.1	-1.2	-1.8	-1.4	-1.9	-1.4	-2.2	-1.8	-1.3	-1.3	-0.7
Age at First Birth	3.3	4.8	8.4	-2.3	2.4	2.8	1.6	2.1	1.0	2.9	2.9	1.6	1.5	2.2
Bipolar Disorder (2011)	0.2	0.1	0.9	0.5	-0.1	-1.0	-0.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	3.1	1.8	-0.3	-0.6	-0.0	-0.3	-1.4	-1.3	-0.6	0.0	-0.5	0.6
Coronary Artery Disease (CAD)	0.4	0.5	1.9	-0.2	-0.9	-0.8	-0.5	-0.5	-1.4	0.0	-0.2	-0.8	-0.7	-0.5
Crohns Disease (2012)	0.1	0.2	0.9	0.4	0.1	-0.9	0.1	-0.1	-0.6	-0.6	-0.8	0.0	0.0	0.2
Mean Putamen Volume	0.9	1.0	5.2	2.3	0.5	-0.4	0.7	0.4	-0.5	-1.0	-0.1	1.0	0.3	1.6
Fasting Glucose	1.4	1.7	4.3	0.1	0.7	1.0	1.3	1.7	0.6	1.6	1.5	1.4	1.0	2.1
HbA1C	1.2	1.3	5.0	0.6	0.6	0.3	1.2	1.0	2.2	-0.3	0.3	1.2	1.9	1.2
HDL Cholesterol	0.8	1.3	3.7	0.3	-0.7	-0.3	-1.4	-1.6	-0.2	-0.8	-0.9	-1.5	-1.9	-1.0
LDL Cholesterol	0.4	0.6	2.9	0.9	-0.9	-0.3	-0.1	0.2	1.7	-0.4	0.7	-0.2	-0.1	1.3
Lupus	2.2	3.4	19.4	4.4	-1.2	-1.3	-0.4	-1.6	-0.6	-3.0	-1.7	-0.3	-0.0	0.1
Neuroticism (2016)	5.3	7.6	36.8	-6.1	0.5	3.0	-0.0	1.5	2.2	4.4	3.1	-0.1	1.3	0.7
Primary Biliary Cirrhosis	1.0	1.5	4.1	1.6	-0.1	-1.1	-0.6	-1.4	-0.0	-2.0	-2.0	0.0	0.0	-1.4
Rheumatoid Arthritis	0.7	1.0	3.7	0.7	0.0	1.0	0.4	0.6	-0.4	0.2	1.9	0.5	-1.3	1.7
Schizophrenia (2014)	1.1	2.5	7.7	2.8	-0.4	-1.9	-0.8	-1.9	-0.4	-2.1	-1.5	-1.2	-1.6	-1.1
Triglycerides	3.9	6.4	21.7	-4.7	2.3	3.0	1.1	1.9	1.5	3.7	1.7	0.9	3.0	0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.2	1.1	0.9	0.3	0.7	0.1	0.1	-1.5	-0.4	0.5	-0.1	1.1
Ulcerative Colitis	1.0	1.5	5.3	-1.0	2.3	1.6	0.9	1.0	-0.3	1.1	1.3	0.9	0.6	1.1
Blood Eosinophil Count	0.2	1.8	3.8	0.7	-1.8	-0.9	-2.0	-1.9	-0.5	-0.9	-0.6	-1.8	-1.5	-0.8
Blood Platelet Count	0.2	2.4	4.8	0.1	-2.2	-1.3	-1.8	-1.3	-2.0	-0.4	-1.0	-1.8	-1.9	-1.8
Blood Red Count	0.1	0.7	1.4	-0.4	0.9	1.2	0.6	0.9	-0.7	1.0	0.3	0.7	0.6	1.2
Blood White Count	0.1	1.1	5.2	-0.1	0.7	0.6	-0.1	0.3	0.5	1.4	2.3	-0.1	-1.6	1.2
Heel T-Score	0.5	4.1	7.7	-0.3	2.3	1.8	2.5	2.8	0.6	2.3	1.9	2.5	1.9	1.9
BMI	0.1	0.8	2.3	-0.4	-0.4	1.4	-0.0	0.5	1.5	1.0	1.4	0.0	-0.2	1.0
Height	0.2	3.1	23.7	2.2	0.3	-1.2	0.3	-0.3	-4.9	-0.9	-1.7	0.7	0.4	-0.4
Waist Hip Ratio (WHR)	0.7	3.3	5.5	-1.3	1.3	2.0	2.3	2.3	2.3	1.2	0.6	2.1	2.3	0.9
Systolic Blood Pressure	0.2	1.2	3.2	1.2	-1.4	-1.2	-1.2	-0.8	1.8	-0.2	0.4	-1.3	-0.9	-0.3
Smoking Status	0.3	0.8	5.4	-0.8	0.9	1.0	0.5	0.5	2.3	0.1	0.2	0.4	0.2	0.1
Allergy or Eczema	0.2	0.4	1.5	1.2	-0.5	0.6	-0.1	-0.6	0.6	-1.2	-0.4	-0.2	-0.0	0.6
Cardiovascular Disease	0.6	2.0	7.5	0.9	0.1	-0.1	0.9	1.5	1.8	0.9	2.4	0.9	0.3	2.7
Hypothyroidism (self reported)	1.2	2.7	7.0	-0.3	1.2	1.5	1.1	1.7	1.7	2.6	1.9	1.2	1.5	2.2
Respiratory disease	2.2	4.8	12.2	0.5	-1.3	-1.2	-1.8	-2.3	-2.6	-2.3	-3.5	-1.9	-1.1	-3.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	4.8	0.9	0.2	0.1	1.0	1.2	1.4	-0.1	1.5	1.0	0.9	2.2
Lung FEV1/FVC ratio	1.0	5.3	20.9	-0.3	0.4	1.5	1.2	2.0	2.2	2.1	4.6	1.2	-0.8	4.2
Lung FVC	0.5	2.4	10.6	-1.2	-0.4	0.4	-0.1	0.9	-0.5	2.8	3.2	-0.1	-1.5	1.9
Neuroticism	0.2	0.5	1.5	0.4	0.9	1.0	0.4	0.2	0.9	-0.7	0.9	0.5	0.1	1.2
Chronotype (morning person)	1.8	4.1	7.0	-0.8	1.7	1.8	2.6	2.6	1.6	1.3	1.5	2.5	2.2	2.6
Hair Pigment	0.0	0.7	1.6	-1.2	1.1	0.2	-1.1	-0.7	0.6	0.4	0.3	-1.0	0.3	-1.2
Tanning	0.0	0.4	2.7	-0.3	-0.4	-0.5	-0.2	0.1	-1.6	0.8	0.3	-0.2	-0.1	-0.1
Hand grip strength (left)	0.2	0.4	2.5	0.6	0.3	-0.0	0.4	0.2	-1.6	0.3	0.5	0.5	-0.5	0.6
Number of treatments/medications taken	0.4	0.7	3.5	1.9	-0.5	-1.3	-0.3	-0.6	-0.2	-0.5	0.1	-0.3	-1.1	0.0
Average weekly spirits intake	1.9	2.4	8.9	-3.0	1.4	1.5	0.3	1.0	2.0	2.3	0.7	0.4	1.5	-0.4
Sensitivity / hurt feelings	7.4	12.6	17.8	-4.2	3.9	4.1	3.3	4.0	2.3	3.6	3.3	3.3	3.6	3.1
Frequency of depressed mood in last 2 weeks	2.7	3.8	13.3	-3.7	1.7	2.3	1.0	1.6	1.2	2.9	2.2	1.1	0.9	0.2
Hearing difficulty/problems: Yes	0.2	0.2	1.2	-0.5	-0.4	-0.2	-0.5	-0.1	1.1	0.4	-0.0	-0.5	-0.0	-0.6
Relative age of first facial hair	0.4	0.8	2.3	0.5	0.4	0.8	1.5	1.3	-0.1	0.3	0.7	1.4	-0.0	1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	0.8	0.1	1.0	0.8	0.3	0.7	-0.6	-0.0	0.7	0.4	1.0
Ever used hormone-replacement therapy (HRT)	1.4	1.8	5.2	1.1	-1.7	-1.2	-0.7	-0.9	-1.3	-1.0	-2.3	-0.7	0.5	-2.1
Ever had hysterectomy (womb removed)	3.5	3.9	9.3	3.0	-2.0	-2.2	-1.0	-1.8	-0.6	-3.0	-2.5	-1.1	-0.9	-1.7
Systolic blood pressure, automated reading	4.9	14.3	52.6	7.2	-3.2	-4.1	-2.7	-3.8	-0.7	-5.4	-3.3	-2.5	-2.4	-1.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	3.5	-0.0	1.2	0.2	0.7	0.1	-0.3	-0.3	-1.2	0.9	1.9	-0.7
Angina	0.2	0.3	0.8	0.7	-0.9	-0.7	-0.3	-0.4	-0.2	-0.9	-0.6	-0.4	-0.4	-0.2
Medication for hormone replacement therapy	1.2	1.4	4.7	1.6	-1.0	-0.8	-0.2	-0.8	-0.2	-1.7	-2.2	-0.2	0.6	-1.3
Vitamin and mineral supplements	1.1	1.5	4.5	-1.7	-0.0	1.6	0.2	1.1	0.7	2.1	2.1	0.4	0.1	0.9
Supplements: Zinc	2.0	2.2	3.2	1.3	-1.4	-1.8	-1.4	-1.6	-0.1	-1.7	-1.4	-1.5	-1.7	-1.6
Medication: Co-codamol	1.0	1.1	3.1	1.1	-1.3	-1.0	-1.0	-1.0	0.5	-1.7	-1.1	-1.1	-0.6	-0.7
Medication: Metformin	0.8	1.1	3.8	1.9	-0.3	-0.3	0.9	0.5	1.2	-1.6	0.2	1.0	0.7	1.3
Diabetes (father)	0.6	0.7	5.3	2.3	-0.5	-0.3	0.1	-0.4	0.0	-1.2	-0.1	0.1	-0.6	0.1
Diabetes (mother)	0.8	1.0	2.3	0.2	-1.0	-0.2	-1.5	-1.2	0.6	0.3	0.1	-1.5	-1.3	-1.2
Severe depression (siblings)	0.3	0.3	1.4	1.2	0.3	-0.5	0.6	0.3	-0.6	-0.7	-0.0	0.6	-0.2	0.2
Pack years adult smoking proportion	0.7	1.1	5.5	2.3	0.0	-0.6	0.0	-0.7	0.9	-1.8	-1.3	0.0	0.3	-0.4
Impedance of leg (right)	4.2	20.4	88.8	-9.4	3.6	4.1	2.2	4.0	0.7	7.3	4.5	1.9	2.7	1.1
Leg fat-free mass (left)	1.7	9.2	38.4	6.2	-2.6	-2.8	-1.5	-2.5	-1.2	-4.9	-2.7	-1.2	-2.3	-0.6
Trunk fat percentage	0.9	3.4	6.8	2.6	-2.2	-1.5	-1.4	-1.8	-1.2	-2.6	-1.1	-1.4	-2.4	-1.0
Hand grip strength (right)	0.4	1.0	1.7	0.5	-1.1	-1.2	-1.3	-1.2	-1.0	-0.6	-0.7	-1.2	-1.1	-0.8
Townsend deprivation index at recruitment	0.5	0.7	2.3	-0.3	1.2	1.5	0.3	0.5	1.0	1.0	0.5	0.4	0.6	0.1
Current tobacco smoking	2.9	4.7	11.7	3.4	-1.1	-1.8	-1.4	-2.2	-0.5	-3.4	-3.1	-1.3	-1.4	-2.0
Average weekly fortified wine intake	2.2	2.5	11.2	-3.4	1.3	1.0	0.6	1.2	0.5	2.9	1.5	0.6	0.8	-0.1
Maternal smoking around birth	1.0	1.5	3.4	-0.8	1.7	1.1	1.8	1.3	0.1	0.6	-0.2	1.7	1.8	-0.2
Fed-up feelings	4.8	8.8	23.2	-4.8	2.8	3.7	1.6	2.5	2.7	4.0	3.4	1.6	1.8	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	3.3	-1.8	0.3	0.7	-0.3	-0.1	0.1	1.0	0.5	-0.3	0.2	-0.7
Relative age voice broke	1.1	1.6	3.7	-0.7	1.5	0.9	1.9	1.9	0.2	1.3	0.8	1.7	1.0	1.0
Taking other prescription medications	0.4	0.6	1.5	0.8	-0.6	-0.8	-0.6	-0.9	-0.5	-0.8	-1.0	-0.7	-0.1	-1.2
Age when periods started (menarche)	1.5	3.5	6.7	-2.5	2.6	1.9	1.9	2.0	1.9	1.8	1.3	1.9	1.4	1.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.1	0.3	1.2	0.3	1.5	1.0	1.0	-0.8	-1.1	1.4	1.8	0.4
Heel bone mineral density (BMD) T-score, automated (left)	6.5	14.8	76.2	8.7	-1.8	-3.3	-0.8	-2.7	-1.5	-6.9	-3.4	-0.7	-1.7	0.8
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	5.6	1.4	-0.8	-0.4	-1.1	-0.8	1.4	-0.1	1.3	-0.9	-2.4	0.9
Qualifications: CSEs or equivalent	1.4	1.8	3.9	-1.1	0.9	1.6	1.1	1.5	1.6	1.2	2.0	1.2	0.5	1.6
Serious illness, injury or assault to yourself	0.7	0.8	1.6	-1.1	0.9	0.4	0.9	0.8	1.1	1.0	1.3	0.7	-0.5	0.6
High blood pressure	3.0	8.4	47.8	6.9	-2.0	-3.0	-0.8	-1.7	-0.5	-4.2	-1.0	-0.7	-2.8	0.9
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.5	1.9	-0.3	-0.2	0.2	-0.5	-0.1	-1.8	-1.1	0.2	0.6	0.4
Multivitamins +/- minerals	1.5	1.9	3.4	1.5	-0.9	-1.4	-1.2	-1.8	-0.8	-1.6	-1.8	-1.3	-1.0	-1.5
Stomach or abdominal pain in last month	1.6	2.0	6.3	-2.5	1.0	1.9	-0.1	0.3	1.8	2.0	1.6	-0.2	-0.6	0.5
Supplements: Glucosamine	0.5	0.7	1.2	0.7	-1.1	-0.8	-0.4	-0.7	-0.7	-0.9	-0.9	-0.6	-0.9	-1.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.3	-0.8	0.2	-0.4	-0.5	-0.4	-0.3	0.1	-0.4	-0.7	0.1
Medication: Atenolol	1.0	1.3	4.9	2.2	-1.4	-0.7	-0.4	-0.6	-0.8	-1.4	-0.2	-0.3	-1.5	1.0
Medication: Levothyroxine sodium	5.6	9.4	21.8	-4.5	2.9	3.6	2.2	3.1	1.8	4.7	2.5	2.2	3.2	0.9
Sitting height	0.6	4.0	20.2	4.5	-0.4	-1.6	0.8	-0.1	-1.6	-3.5	-1.2	0.9	-0.3	1.9
Chronic bronchitis/emphysema (father)	1.0	1.2	3.9	-0.1	-0.3	-0.6	-0.9	-1.0	-1.0	-1.1	-1.7	-1.0	-0.7	-2.0
High blood pressure (mother)	0.7	1.0	5.4	2.3	0.1	-0.8	0.3	0.1	0.6	-0.5	0.7	0.4	-0.8	1.7
Body mass index (BMI)	4.2	18.0	61.4	7.8	-4.2	-3.6	-2.7	-4.0	-1.4	-6.6	-3.9	-2.5	-3.6	-1.9
Impedance of leg (left)	4.6	22.4	95.3	-9.8	3.9	4.1	2.7	4.5	0.8	7.4	4.4	2.4	3.2	1.1
Leg predicted mass (left)	1.7	9.0	38.7	6.2	-2.5	-2.7	-1.4	-2.5	-1.2	-4.9	-2.7	-1.2	-2.2	-0.5
Trunk fat mass	1.3	5.6	14.3	3.8	-2.7	-2.0	-1.6	-2.2	-1.7	-3.4	-1.9	-1.5	-2.6	-1.2
Waist circumference	0.6	2.3	7.2	2.7	-2.2	-1.1	-0.9	-1.2	-0.1	-2.2	-1.2	-0.8	-1.3	-1.2
Number of incorrect matches in round	0.9	1.4	6.2	-1.5	-0.5	-0.9	-0.6	-0.6	-1.2	0.5	-1.5	-0.6	1.2	-2.5
Past tobacco smoking	0.7	1.3	5.4	-2.3	0.7	0.1	0.3	0.9	-1.2	1.7	0.1	0.5	1.4	-0.5
Alcohol usually taken with meals	2.2	3.5	6.7	2.4	-1.8	-2.6	-1.3	-1.7	-2.5	-2.1	-1.8	-1.2	-1.2	-0.9
Nervous feelings	5.1	9.6	40.7	-6.4	2.1	2.8	1.8	3.0	1.4	4.6	2.9	1.6	2.1	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	5.3	-1.9	2.3	1.7	1.4	1.3	0.8	1.1	0.8	1.3	1.7	0.2
Hearing difficulty/problems with background noise	0.4	0.7	1.7	-1.3	1.0	1.1	0.6	0.9	0.8	0.8	0.4	0.6	0.4	0.7
Hair/balding pattern: Pattern 2	0.3	0.4	1.9	1.0	-0.2	-0.1	0.0	-0.4	0.1	-1.4	-1.0	-0.2	-0.2	-0.4
Had menopause	2.8	3.5	6.2	1.5	-2.5	-1.9	-1.7	-1.6	-1.9	-1.2	-1.5	-1.7	-2.3	-2.3
Had other major operations	1.0	1.3	5.0	2.2	-0.7	-1.1	-0.4	-0.8	-0.1	-1.3	-1.0	-0.5	-1.6	-1.1
Forced vital capacity (FVC)	1.2	4.6	10.7	-3.3	1.8	1.6	1.5	2.4	1.4	2.7	2.7	1.5	0.9	2.5
Heel bone mineral density (BMD) T-score, automated (right)	6.7	15.5	82.4	9.1	-1.7	-3.2	-0.5	-2.6	-0.2	-7.2	-3.6	-0.4	-1.2	0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.2	0.6	0.3	0.5	0.9	0.9	0.3	0.1	1.5	0.9	-0.5	1.4
Qualifications: None of the above	0.8	1.7	4.6	0.9	-1.6	-0.0	-1.6	-1.7	-0.5	-1.1	-0.6	-1.6	-2.1	-0.9
Financial difficulties in last 2 years	0.9	1.2	2.1	0.4	-1.0	-1.2	-1.4	-1.3	-0.5	-1.1	-1.1	-1.4	-0.5	-1.3
Mouth/teeth dental problems	3.8	5.9	12.7	-3.6	2.6	3.4	2.0	2.5	-0.3	3.3	2.1	2.0	2.0	0.7
Heart attack	0.6	0.7	1.2	0.1	-1.1	-0.7	-1.0	-1.1	-0.9	-0.9	-0.6	-1.0	-1.0	-0.6
Allergy	1.8	4.0	11.5	-3.3	1.1	1.5	0.8	1.8	2.2	3.4	2.7	0.9	0.5	1.1
Pain all over the body in last month	0.9	0.9	2.7	1.6	0.2	0.7	1.2	0.9	0.3	-0.7	0.9	1.3	-0.1	1.3
Diabetes (self-reported)	0.4	0.6	2.9	1.7	-0.6	-0.8	0.3	0.0	0.5	-1.2	-0.0	0.3	0.6	0.7
Hayfever/allergic rhinitis (self-reported)	4.0	5.3	10.2	-1.4	3.0	2.5	2.6	2.4	1.7	1.9	1.1	2.5	3.2	2.0
Medication: Ramipril	1.4	1.9	8.0	2.8	-0.7	-1.9	-0.8	-1.2	0.1	-2.1	-0.8	-0.6	-0.7	-0.2
Medication: Simvastatin	0.4	0.7	2.7	1.3	-0.6	-1.4	-0.2	-0.5	-1.6	-0.4	-0.4	-0.1	-0.1	-0.4
Fluid intelligence score	1.2	2.6	4.5	-1.6	1.5	1.4	1.8	2.1	0.7	1.6	1.9	1.5	1.0	1.9
Illnesses of siblings	0.4	0.5	1.7	-1.3	0.7	0.5	0.4	0.5	1.0	0.4	-0.0	0.3	1.1	-0.3
Neuroticism score	9.5	19.8	63.8	-8.0	4.0	4.8	2.7	4.2	2.8	6.4	4.6	2.6	3.1	1.8
Weight	2.0	9.6	30.8	5.5	-3.2	-2.7	-2.0	-2.9	-1.6	-4.7	-2.8	-1.8	-2.7	-1.4
Impedance of arm (right)	4.7	21.9	81.3	-9.0	3.7	4.4	2.4	4.0	1.9	7.3	5.7	2.1	2.2	2.4
Arm fat percentage (right)	2.0	8.0	23.1	4.8	-3.1	-2.2	-1.9	-2.9	-1.2	-4.3	-2.1	-1.9	-3.2	-1.1
Trunk fat-free mass	0.9	5.2	20.6	4.5	-1.8	-2.2	-0.9	-1.8	-1.6	-3.3	-2.8	-0.7	-1.1	-1.2
Hip circumference	2.2	9.5	30.1	5.5	-3.3	-2.9	-2.1	-2.8	-1.4	-4.7	-2.5	-1.9	-2.8	-1.2
Time employed in main current job	1.0	1.2	6.0	-2.5	0.5	0.3	-0.0	0.4	0.7	2.0	0.4	-0.2	0.2	-1.3
Alcohol intake versus 10 years previously	0.2	0.3	1.2	-0.6	-0.1	1.1	-0.1	-0.0	-0.4	0.5	0.3	-0.0	1.0	-0.1
Father’s age at death	2.2	3.0	12.1	-3.4	0.7	1.9	0.2	1.1	0.6	3.5	1.5	0.1	1.0	-0.4
Worrier / anxious feelings	11.3	21.4	67.4	-8.2	3.6	5.1	2.9	4.5	1.9	7.2	4.8	2.8	3.2	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.6	-1.9	1.3	1.6	0.8	0.9	0.2	1.4	1.4	0.7	0.3	0.3
Falls in the last year	0.3	0.4	0.9	0.7	0.8	0.1	0.9	0.8	-0.2	-0.3	-0.3	0.8	0.9	0.8
Hair/balding pattern: Pattern 3	0.2	0.3	1.9	-0.5	-0.1	-0.7	0.2	0.4	-0.2	0.1	-0.6	0.3	1.4	-0.4
Number of live births	0.7	1.0	4.1	0.7	-0.7	-0.6	-1.1	-1.2	0.5	-0.7	-0.0	-1.2	-2.0	-0.9
Forced expiratory volume in 1-second (FEV1)	2.8	9.3	25.8	-5.1	2.2	2.3	1.8	3.2	1.6	4.1	4.3	1.8	1.0	3.3
Pulse rate	0.4	0.6	2.4	-0.6	1.0	-0.2	-0.1	-0.3	-1.5	-0.3	-1.1	-0.1	0.9	-0.8
Happiness	0.1	0.1	0.6	-0.2	-0.2	-0.4	0.3	0.3	0.8	-0.3	-0.1	0.2	0.4	0.5
Noisy workplace	1.1	1.4	2.6	-0.4	-1.0	-1.2	-1.6	-1.5	-0.8	-0.1	-0.7	-1.5	-1.4	-1.5
Qualifications: A levels/AS levels or equivalent	1.8	4.0	9.6	-2.8	1.3	1.5	0.7	1.5	2.7	3.1	2.9	0.6	0.7	1.7
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.7	8.1	-2.8	1.9	1.8	1.1	1.2	1.2	2.5	1.3	1.1	1.3	-0.0
Mouth/teeth dental problems: Dentures	3.7	6.2	17.8	4.2	-1.9	-2.5	-1.7	-2.5	-2.2	-3.7	-2.6	-1.6	-1.9	-1.0
Asthma	3.6	7.2	15.7	2.9	-1.7	-2.1	-1.9	-2.8	-2.7	-3.8	-4.0	-1.9	-0.9	-3.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	3.4	-0.9	0.4	0.7	0.2	0.2	1.9	1.1	1.0	0.1	-0.6	-0.0
Medication: Cholesterol lowering	0.3	0.5	2.5	0.8	0.1	-0.0	0.8	0.6	-0.4	-0.0	0.8	0.9	0.4	1.6
Depression (self-reported)	0.7	0.9	3.2	-1.8	0.3	0.9	-0.1	0.1	-1.2	1.2	-0.3	0.1	0.0	-1.6
Medication: Lansoprazole	0.1	0.1	0.3	-0.6	0.2	0.3	-0.2	-0.3	0.0	-0.0	-0.2	-0.2	-0.0	-0.6
Prospective memory result	0.7	0.8	1.6	0.7	-1.3	-0.6	-1.0	-0.9	0.4	-1.2	-1.2	-0.9	-0.5	-0.8
Lung cancer (father)	1.2	1.4	2.8	-0.0	-1.2	-1.6	-1.4	-1.4	0.7	-0.7	-0.4	-1.6	-1.7	-1.1
Illnesses of mother	1.6	2.0	3.7	0.4	-1.7	-1.4	-1.5	-1.4	-0.6	-1.9	-1.4	-1.6	-1.1	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.7	19.4	-4.4	1.5	2.0	1.2	2.8	1.9	3.8	4.4	1.2	0.2	3.3
Pulse wave Arterial Stiffness index	0.9	1.0	2.4	1.1	-0.9	-1.6	-0.6	-0.9	-0.4	-1.5	-1.5	-0.5	-0.3	-0.7
Impedance of arm (left)	4.3	19.9	71.2	-8.4	4.0	4.1	2.6	4.1	2.1	6.6	5.1	2.4	2.6	2.4
Arm fat mass (right)	2.9	12.1	36.3	6.0	-3.7	-2.9	-2.3	-3.4	-1.8	-5.2	-3.1	-2.1	-3.3	-1.6
Trunk predicted mass	0.9	5.2	20.3	4.5	-1.7	-2.2	-0.9	-1.8	-1.6	-3.4	-2.8	-0.7	-1.1	-1.2
Standing height	0.5	4.5	18.4	-4.3	1.6	1.5	1.1	2.1	-0.6	3.5	2.0	1.2	1.4	0.9
Length of working week for main job	1.4	1.5	2.7	1.3	-0.9	-1.5	-0.8	-1.4	-1.5	-1.3	-1.7	-0.8	-0.5	-1.3
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.7	-0.0	-0.3	-0.1	-0.1	0.3	-0.3	-0.2	-0.2	0.1	0.1
Breastfed as a baby	0.2	0.3	0.7	-0.7	-0.4	-0.8	-0.7	-0.6	0.1	-0.0	-0.5	-0.8	-0.1	-0.1
Tense / ‘highly strung’	3.9	6.4	22.9	-4.8	1.7	2.5	1.2	2.3	0.5	4.4	2.6	1.2	2.1	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	7.6	-2.8	1.7	1.8	0.6	1.0	1.1	1.5	1.6	0.7	0.4	1.1
Hair/balding pattern: Pattern 4	0.4	1.1	3.4	-1.1	0.6	0.9	0.5	0.9	1.2	1.8	1.6	0.5	0.1	0.8
Birth weight of first child	0.8	1.4	5.0	-2.2	0.9	1.2	0.7	1.0	0.4	2.2	1.1	0.6	-0.0	-0.4
Peak expiratory flow (PEF)	4.2	9.7	27.6	-5.2	2.3	2.5	2.0	3.5	0.8	4.5	4.3	2.0	1.3	2.5
Pulse wave reflection index	0.7	0.9	2.2	1.5	-1.3	-1.4	-0.5	-0.6	0.6	-1.1	-1.2	-0.4	-0.6	-0.3
Ever highly irritable/argumentative for 2 days	2.0	2.4	6.9	-1.2	-1.6	-1.0	-1.7	-1.5	-0.6	-0.5	-2.3	-1.8	0.3	-2.6
Loud music exposure frequency	0.5	0.5	1.2	0.5	-0.2	-0.2	-1.1	-1.0	0.2	-0.8	-1.1	-1.0	-0.2	-0.6
Qualifications: O levels/GCSEs or equivalent	3.3	5.3	9.4	-3.1	2.4	1.3	2.4	2.8	1.3	2.8	2.3	2.3	2.1	1.9
Mouth/teeth dental problems: Bleeding gums	3.3	4.2	11.2	3.4	-1.8	-2.6	-1.4	-2.2	0.6	-3.0	-2.4	-1.3	-0.9	-1.1
Blood clot in the leg (DVT)	1.2	1.5	6.1	2.5	-0.6	-1.2	0.3	-0.2	-1.3	-2.3	-1.0	0.2	-0.1	0.9
Medication: Paracetamol	0.5	0.8	2.5	-1.4	0.1	0.7	-0.2	0.1	0.9	1.6	1.4	-0.4	-0.5	-0.2
Headache pain in last month	1.0	1.8	4.8	-2.2	1.4	1.2	1.4	1.4	0.7	1.4	1.4	1.3	0.4	1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	4.4	-2.1	0.7	0.7	-0.4	-0.1	-0.1	0.4	-0.6	-0.6	0.2	-1.6
Glaucoma (self-reported)	0.5	0.6	2.3	0.8	0.0	0.1	-0.5	-0.9	-0.6	-0.8	-1.5	-0.4	0.5	-0.9
Gout (self-reported)	0.2	0.3	1.6	0.3	0.1	-1.2	0.0	0.0	-0.8	-0.2	-0.5	0.1	-0.3	-0.6
Hypothyroidism/myxoedema (self-reported)	7.6	14.8	36.1	-5.5	3.2	4.2	2.6	4.0	3.0	6.0	3.8	2.6	3.7	1.6
Medication: Amlodipine	0.5	0.8	5.3	2.3	-0.1	-0.4	-0.7	-0.6	0.6	-0.3	0.6	-0.6	-0.7	0.7
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.8	0.6	-0.2	-0.9	0.2	-0.1	-1.1	-1.0	-2.0	0.1	0.8	-2.0
Birth weight	0.3	0.6	2.8	1.0	0.2	-0.6	-0.4	-0.5	-0.5	-1.7	-1.0	-0.3	0.1	0.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.7	-0.5	-0.5	0.1	0.9	0.9	-0.1	0.8	-0.3	0.9	1.6	0.1
High blood pressure (siblings)	0.3	0.5	2.2	1.5	-0.5	-0.3	-0.4	-0.5	-0.6	-0.6	0.2	-0.4	-1.2	0.4
Forced vital capacity (FVC), Best measure	1.1	3.9	10.1	-2.8	1.2	1.1	1.1	2.2	1.4	2.5	3.2	1.1	0.0	2.7
Body fat percentage	1.4	5.7	11.6	3.4	-2.8	-2.0	-1.8	-2.4	-1.5	-3.4	-1.7	-1.8	-2.8	-1.4
Leg fat percentage (right)	2.1	7.6	14.8	3.9	-3.3	-2.2	-2.4	-2.9	-1.6	-3.6	-1.9	-2.4	-3.2	-1.8
Arm fat-free mass (right)	1.6	8.2	30.9	5.6	-2.6	-2.7	-1.3	-2.2	-1.7	-4.3	-3.3	-1.1	-1.6	-1.5
Exposure to tobacco smoke outside home	0.3	0.4	1.5	-0.5	-0.6	-0.9	-0.7	-0.4	-0.5	0.0	0.1	-0.8	-1.2	-0.6
Comparative body size at age 10	4.8	13.3	43.0	6.6	-2.9	-3.3	-2.6	-3.8	-2.6	-5.1	-3.3	-2.4	-3.3	-1.6
Number of full brothers	0.5	0.6	2.0	1.4	-0.4	-0.3	-0.4	-0.9	-0.4	-1.4	-0.3	-0.4	-0.9	0.3
Worry too long after embarrassment	4.8	8.0	21.9	-4.7	3.1	2.9	2.3	3.0	1.0	3.7	3.0	2.2	1.8	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.6	-0.9	0.8	0.2	-0.3	-0.4	-0.3	-0.1	-1.0	-0.2	-0.0	-1.3
Wheeze or whistling in the chest in last year	3.8	6.8	12.6	3.4	-2.5	-2.2	-2.3	-2.8	-1.2	-3.5	-2.9	-2.2	-2.7	-2.2
Number of children fathered	1.4	1.6	3.7	1.9	0.9	-0.0	1.7	1.1	0.4	-0.8	-0.7	1.6	1.8	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.4	-1.4	-0.0	0.1	-0.4	0.1	0.8	1.5	1.6	-0.4	-0.1	0.5
Age at first live birth	1.4	2.6	8.4	-2.9	1.4	1.7	1.0	1.5	-0.3	2.3	1.6	1.0	1.3	1.0
Pulse wave peak to peak time	1.0	1.2	3.1	-1.6	1.0	1.6	0.5	0.9	0.1	1.8	1.5	0.4	0.3	0.4
Health satisfaction	0.9	1.2	5.0	2.2	-0.8	-1.3	-0.0	-0.3	0.8	-1.3	0.5	0.0	-1.5	1.0
Shortness of breath walking on level ground	1.6	1.9	3.6	1.5	-1.9	-1.3	-1.4	-1.5	-1.3	-1.1	-1.1	-1.3	-1.4	-1.0
Qualifications: College or University degree	0.2	0.5	2.1	-1.4	0.6	0.5	0.6	0.7	0.5	0.5	-0.2	0.6	1.2	0.2
Eye problems/disorders: None of the above	0.3	0.4	1.5	-0.2	-0.1	-0.8	0.4	0.7	0.1	0.7	1.2	0.4	0.4	0.8
Mouth/teeth dental problems: Loose teeth	3.7	4.4	8.8	2.1	-2.4	-3.0	-1.9	-2.2	-1.4	-2.3	-2.1	-1.9	-1.3	-2.0
Emphysema/chronic bronchitis	8.0	9.0	17.2	3.8	-2.3	-3.1	-1.9	-2.9	-3.0	-4.2	-3.5	-1.9	-3.2	-2.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	0.5	0.8	0.7	0.9	0.8	0.0	-0.1	-0.7	1.0	1.1	0.4
Neck or shoulder pain in last month	0.1	0.2	0.4	-0.2	0.6	-0.2	0.6	0.5	0.1	-0.6	-0.6	0.3	0.4	-0.2
Medication: Blood pressure	1.2	2.2	12.8	3.6	-1.2	-1.7	-0.2	-0.7	-0.2	-1.4	0.2	-0.1	-1.9	0.9
Angina (self-reported)	0.6	0.7	1.7	0.9	-1.2	-1.1	-0.7	-0.8	-0.1	-1.3	-0.8	-0.8	-0.6	-0.4
Migraine (self-reported)	0.2	0.3	1.2	-0.2	-1.1	-0.8	-0.6	-0.3	-0.4	0.4	0.1	-0.6	-0.6	0.2
Medication: Ibuprofen	0.6	0.7	3.9	-0.8	0.6	0.4	0.2	0.2	2.0	1.1	0.7	0.1	-0.8	-0.5
Medication: Allopurinol	0.5	0.7	1.4	1.0	0.5	-0.6	1.0	0.5	-0.9	-1.1	-1.2	1.0	0.8	-0.1
Medication: Omeprazole	0.2	0.3	1.1	1.1	-0.3	-0.1	-0.3	-0.5	-0.2	-0.8	-0.3	-0.3	-0.8	0.2
Medication: Seretide 50 evohaler	0.2	0.2	0.9	0.9	0.3	0.1	0.5	0.3	0.3	-0.5	-0.1	0.4	0.2	0.3
Mean time to correctly identify matches	0.6	1.2	3.9	-0.8	-0.4	-1.1	-1.0	-1.0	-2.0	0.0	-0.8	-1.0	-1.0	-1.7
Heart disease (mother)	1.3	1.6	4.2	-0.8	1.0	2.1	1.2	1.1	0.2	1.7	1.3	1.2	0.4	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	7.7	-2.8	1.6	1.3	-0.1	-0.1	-0.7	1.0	-0.2	-0.1	1.0	-0.8
Whole body fat mass	1.9	8.0	20.2	4.5	-3.1	-2.5	-1.9	-2.7	-1.9	-4.1	-2.3	-1.8	-3.0	-1.6
Leg fat mass (right)	2.6	10.3	29.1	5.4	-3.5	-2.8	-2.3	-3.1	-1.6	-4.8	-2.5	-2.2	-3.3	-1.4
Arm predicted mass (right)	1.9	9.8	33.5	5.8	-2.8	-3.1	-1.5	-2.5	-2.2	-4.6	-3.6	-1.3	-1.9	-1.8
Pulse rate, automated reading	0.7	2.2	6.2	1.0	1.2	-1.4	-0.2	-0.9	-2.1	-1.8	-2.5	-0.0	1.5	-1.6
Alcohol intake frequency.	0.1	0.2	1.6	-0.1	0.0	-0.0	0.2	0.3	-1.3	0.3	0.1	0.3	0.9	0.0
Comparative height size at age 10	0.4	2.0	8.4	1.1	-0.2	-1.6	-1.1	-1.4	-2.9	-1.1	-1.3	-0.9	-1.0	-1.3
Number of full sisters	1.1	1.3	5.5	2.3	0.0	-0.1	0.2	-0.5	-0.7	-2.3	-1.4	0.2	-1.0	0.1
Suffer from ‘nerves’	2.9	4.5	17.2	-4.1	1.8	2.3	1.0	1.9	1.3	3.2	2.4	0.9	0.8	0.8
Overall health rating	1.9	4.0	19.7	4.4	-0.5	-1.5	-0.0	-1.2	0.1	-3.9	-1.8	-0.0	-1.1	0.2
Chest pain or discomfort	0.7	0.9	3.8	-1.0	-0.6	-0.5	-1.3	-0.9	-0.4	0.1	0.0	-1.3	-1.9	-0.9
Had major operations	0.1	0.1	0.2	0.1	-0.1	-0.3	0.4	0.5	0.5	0.1	0.2	0.3	-0.5	0.1
Age at last live birth	2.3	3.3	8.8	-3.0	1.4	2.3	0.7	1.3	1.3	2.9	2.1	0.8	1.1	1.2
Family relationship satisfaction	0.5	0.6	2.0	-1.4	-0.9	0.2	-0.8	-0.1	0.9	0.6	1.1	-0.8	-0.6	0.0
Leg pain on walking	2.0	2.5	6.9	2.6	-1.6	-2.2	-1.0	-1.4	-1.2	-2.0	-1.0	-1.1	-1.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	3.5	-0.1	1.5	1.2	1.8	1.9	1.4	0.6	1.3	1.8	1.7	1.7
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.2	1.1	0.7	-0.0	0.8	0.6	0.9	-0.9	0.0	0.8	-0.1	0.9
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	3.2	1.4	-0.6	-0.8	0.1	-0.3	-1.1	-1.8	-1.7	-0.0	0.3	-0.2
Medication: Aspirin	3.1	4.1	7.1	2.4	-1.5	-2.0	-1.6	-2.3	-2.7	-2.5	-2.4	-1.5	-1.0	-1.7
Supplements: Vitamin C	0.6	0.7	3.6	1.9	-0.2	-1.1	0.4	-0.4	0.4	-1.2	-0.8	0.2	0.3	0.2
Knee pain experienced in last month	1.2	1.9	8.0	2.8	-0.1	-1.2	0.0	-0.7	-0.5	-2.8	-1.7	-0.2	-0.6	0.1
Hypertension (Self-reported)	3.4	9.4	46.9	6.8	-2.4	-3.4	-1.2	-2.2	-0.7	-4.4	-1.1	-1.2	-3.3	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	0.4	-0.9	-0.8	-1.0	-0.9	-0.2	-0.1	0.2	-1.1	-1.0	-0.3
Illnesses of father: Heart disease	0.6	0.8	2.5	0.7	0.9	0.5	1.6	1.3	-0.2	0.0	-0.5	1.5	0.8	0.2
Illnesses of siblings: Diabetes	0.4	0.5	1.8	1.3	-0.7	-1.1	-0.1	0.1	0.0	-0.6	0.5	-0.1	-0.8	0.9
Smoking status: Previous	0.4	0.6	1.5	1.0	-0.3	0.1	0.1	-0.2	1.2	-0.5	1.1	-0.1	-1.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.6	-1.6	0.0	0.5	0.2	1.0	2.2	1.1	1.3	0.2	0.1	1.6
Whole body fat-free mass	1.3	7.6	30.4	5.5	-2.2	-2.6	-1.2	-2.2	-1.6	-4.3	-3.0	-1.0	-1.7	-1.0
Leg fat-free mass (right)	1.6	8.6	36.9	6.1	-2.4	-2.8	-1.2	-2.3	-1.1	-4.8	-2.8	-1.0	-2.0	-0.6
Arm fat percentage (left)	2.2	8.8	26.5	5.1	-3.1	-2.5	-1.9	-2.9	-1.2	-4.5	-2.3	-1.9	-3.1	-1.2
Average weekly red wine intake	0.9	1.3	2.8	0.7	-1.5	-0.9	-1.4	-1.3	-0.9	0.6	0.9	-1.3	-1.7	-0.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.5	-0.7	0.7	1.4	0.4	0.9	1.2	1.4	1.6	0.4	0.1	1.9
Mood swings	3.8	6.9	19.2	-4.4	1.7	3.0	1.8	2.7	2.3	3.6	3.0	1.9	1.5	1.4
Loneliness, isolation	0.5	0.7	2.9	-1.7	1.6	0.8	0.4	0.5	-0.4	0.6	0.2	0.4	0.5	0.1
Long-standing illness, disability or infirmity	0.4	0.7	2.0	1.4	-1.2	-0.9	0.1	-0.2	0.4	-1.4	-0.9	0.1	0.1	-0.1
Ever had bowel cancer screening	0.5	0.5	1.7	-1.0	0.5	1.3	0.4	0.4	-0.3	1.2	0.1	0.5	0.9	-0.5
Diabetes diagnosed by doctor	0.7	1.1	5.7	2.4	-0.8	-1.0	0.3	0.0	0.8	-1.6	0.2	0.3	0.0	1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	6.9	2.4	-0.8	-2.0	-0.7	-1.4	0.1	-2.6	-2.3	-0.9	-0.8	-0.4
Friendships satisfaction	0.4	0.5	2.1	0.4	-0.1	0.4	0.1	0.1	1.5	-0.7	0.7	0.0	-0.6	1.2
Qualifications: nursing, teaching	2.8	4.4	9.1	-0.5	3.0	1.5	2.7	2.3	1.4	1.1	1.6	2.6	2.1	2.5
Commuting to job workplace: Walk	0.2	0.2	1.1	-0.1	-0.3	-0.2	0.1	-0.1	0.6	-0.2	-0.8	0.0	1.0	-0.0
Eye problems/disorders: Cataract	0.6	0.7	2.1	-0.6	1.2	1.5	0.3	0.4	-0.1	0.8	0.9	0.4	-1.1	0.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	3.5	-1.9	0.6	0.5	0.4	1.4	1.6	1.7	1.8	0.3	0.2	1.2
Medication for cholesterol	3.5	5.3	10.0	-3.2	3.2	2.7	2.3	2.4	0.7	2.6	1.7	2.3	1.3	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	4.5	1.2	-1.0	-0.7	-0.7	-0.9	0.7	-2.1	-1.6	-0.9	0.1	0.1
Back pain experienced in last month	0.5	0.7	2.4	0.9	-0.7	-0.8	-0.6	-0.8	-0.4	-1.5	-0.9	-0.7	-1.1	-0.2
Mineral and other dietary supplements	2.0	2.8	12.0	-3.5	0.5	1.6	0.3	1.4	0.9	2.8	1.7	0.4	1.2	0.4
Breast cancer (self-reported)	0.7	0.9	2.4	0.9	-1.2	-0.5	-0.9	-1.2	0.1	-1.0	-1.6	-1.0	-0.4	-0.6
Asthma (self-reported)	3.8	7.6	15.4	3.1	-2.0	-2.4	-1.9	-2.9	-2.6	-3.9	-3.9	-2.0	-1.0	-3.1
Osteoporosis (self-reported)	0.7	0.9	4.5	-2.1	0.3	0.3	0.6	0.8	-1.5	1.2	0.5	0.4	0.5	-0.4
Osteoarthritis (self-reported)	0.9	1.1	4.6	1.2	-0.5	-1.1	0.1	-0.5	0.1	-1.7	-2.2	-0.2	0.1	-1.3
Medication: Aspirin	2.9	3.8	6.4	2.4	-1.4	-2.0	-1.4	-2.2	-2.5	-2.4	-2.2	-1.4	-1.2	-1.7
Medication: Gliclazide	0.5	0.6	2.8	1.7	-0.5	-0.7	0.4	-0.1	-1.1	-1.0	-0.0	0.5	0.1	0.5
Illnesses of father: None of the above (group 1)	0.7	0.8	6.1	-2.5	0.4	0.1	-0.9	-0.4	0.4	0.8	0.3	-0.8	0.4	-0.2
Smoking status: Current	2.4	3.9	11.3	3.4	-1.0	-1.4	-1.0	-1.8	-0.0	-3.3	-2.9	-0.9	-1.1	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.5	7.4	20.0	-4.1	1.7	2.7	1.3	2.6	0.9	4.5	4.0	1.4	0.6	2.5
Whole body water mass	1.3	7.4	30.2	5.5	-2.2	-2.5	-1.2	-2.2	-1.6	-4.2	-2.9	-0.9	-1.7	-1.0
Leg predicted mass (right)	1.6	8.3	36.9	6.1	-2.4	-2.7	-1.1	-2.2	-1.0	-4.8	-2.7	-0.9	-1.9	-0.4
Arm fat mass (left)	2.5	10.4	35.1	5.9	-3.3	-2.6	-1.9	-3.0	-1.5	-5.0	-2.8	-1.8	-3.0	-1.3
Number of self-reported non-cancer illnesses	0.1	0.1	0.7	0.8	-0.3	-0.4	0.0	-0.0	0.1	0.1	-0.0	-0.0	-0.2	-0.2
Average weekly champagne plus white wine intake	0.2	0.3	1.1	0.4	-0.3	-0.4	0.6	0.6	-0.0	-0.1	0.5	0.5	-0.2	1.1
Miserableness	3.7	6.5	29.8	-5.5	1.8	1.9	0.8	2.0	1.8	4.1	2.9	0.7	1.1	-0.1
Guilty feelings	4.4	6.6	23.8	-4.9	2.6	2.7	1.4	2.2	1.2	3.8	2.3	1.4	2.1	0.4
Wears glasses or contact lenses	0.4	0.4	2.0	-1.4	-0.4	-0.5	-0.2	0.1	-0.9	0.9	0.5	-0.3	-0.6	-0.5
Ever taken oral contraceptive pill	0.4	0.4	2.3	-0.8	0.2	-0.0	0.5	0.5	1.0	-0.1	0.5	0.4	0.1	1.5
Hearing aid user	3.9	4.4	7.3	0.3	2.1	1.9	2.7	2.7	2.0	1.2	1.7	2.5	2.2	2.5
Mother’s age at death	0.7	0.8	2.5	-1.6	0.9	0.1	0.5	0.8	-1.0	1.6	0.2	0.6	1.0	-0.6
Financial situation satisfaction	2.1	2.6	4.5	1.0	-2.1	-2.1	-1.9	-1.8	-1.5	-1.3	-0.5	-1.7	-2.0	-1.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.3	-1.1	1.1	0.4	1.1	0.8	-0.4	0.5	-0.6	1.0	1.5	-0.2
Commuting to job workplace: Public transport	1.1	1.3	5.2	-2.3	-0.5	0.2	-1.0	-0.1	-1.0	2.0	0.8	-0.9	-0.8	-0.9
Eye problems/disorders: Glaucoma	1.3	1.6	5.4	1.4	-0.4	-0.6	-0.7	-1.3	-1.2	-1.5	-2.3	-0.7	0.0	-1.6
Medication: Blood pressure	6.8	13.0	31.2	5.6	-3.9	-3.9	-3.2	-3.7	-1.1	-4.9	-2.4	-3.1	-3.7	-1.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.8	1.7	-0.1	-1.2	0.4	-0.4	-1.5	-1.5	-1.3	0.1	-0.5	-0.7
Supplements: Fish oil (including cod liver oil)	3.5	4.6	14.5	3.8	-1.2	-2.1	-1.2	-2.3	-1.7	-3.2	-1.4	-1.3	-2.5	-0.7
High cholesterol (Self-reported)	0.1	0.1	0.3	0.6	-0.4	-0.2	-0.1	0.0	-0.6	0.3	0.1	-0.1	0.1	-0.0
Medication: Bendroflumethiazide	4.5	6.9	25.8	5.1	-2.5	-3.1	-1.7	-2.2	-0.4	-3.3	-1.0	-1.7	-3.4	-0.1
Medication: Paracetamol	0.3	0.4	1.4	-0.7	0.5	0.5	-0.2	-0.1	0.5	1.0	1.2	-0.3	-0.9	-0.2
Medication: Lisinopril	1.5	2.0	4.3	1.5	-1.5	-2.1	-1.1	-1.4	1.0	-1.8	-1.5	-1.1	-1.1	-0.9
Medication: Atorvastatin	0.8	1.0	2.8	0.5	-1.7	-0.9	-1.4	-1.1	0.0	-0.4	-0.1	-1.5	-1.2	-0.1
Illnesses of father: High blood pressure	2.4	3.0	9.1	2.6	-2.3	-1.4	-1.4	-1.5	-0.3	-1.6	0.5	-1.5	-3.0	0.8
Alcohol drinker status: Never	0.3	0.3	1.8	-1.1	0.2	0.0	0.0	0.2	-0.1	0.6	-0.0	-0.0	1.3	-0.4
Ever smoked	0.4	0.6	1.7	1.3	-0.6	0.2	-0.6	-0.9	1.0	-1.2	-0.6	-0.8	-0.7	-0.3
Basal metabolic rate	1.5	8.1	31.9	5.7	-2.5	-2.7	-1.4	-2.4	-1.5	-4.5	-3.0	-1.1	-1.9	-1.0
Leg fat percentage (left)	2.1	7.6	16.1	4.0	-3.3	-2.3	-2.2	-2.8	-1.7	-3.9	-2.3	-2.1	-2.7	-1.9
Arm fat-free mass (left)	1.5	7.8	29.3	5.4	-2.5	-2.5	-1.3	-2.2	-1.8	-4.2	-3.2	-1.1	-1.7	-1.3
Number of operations (self-reported)	1.3	1.9	5.9	2.4	-0.8	-2.1	-0.0	-0.6	0.3	-2.3	-1.8	-0.3	-1.1	-0.6
Average weekly beer plus cider intake	3.2	4.7	13.9	-3.7	1.9	2.6	1.5	2.2	1.4	3.2	1.8	1.3	1.6	0.3
Irritability	7.0	11.8	51.3	-7.2	2.4	3.7	1.2	2.7	2.7	5.2	3.1	1.1	2.3	0.5
Risk taking	1.6	2.3	8.0	2.8	-1.7	-1.8	-0.7	-1.1	-0.8	-2.5	-1.6	-0.5	-0.6	-0.1
Ever had prostate specific antigen (PSA) test	1.5	1.7	5.3	0.3	1.3	2.3	1.2	1.0	0.9	1.0	1.2	1.3	0.9	1.8
Fractured/broken bones in last 5 years	0.5	0.6	2.6	-1.5	-0.1	-0.3	-0.0	0.5	-0.6	1.6	0.5	0.2	0.8	-0.5
Age started oral contraceptive pill	0.5	0.6	2.3	-1.5	0.5	1.0	-0.1	0.1	-0.6	1.3	-0.5	-0.0	0.6	-0.9
Diastolic blood pressure, automated reading	6.8	21.0	64.9	8.1	-3.9	-5.6	-2.7	-4.2	-2.0	-7.0	-4.7	-2.6	-2.7	-2.2
Ever depressed for a whole week	1.5	1.8	3.1	-1.7	1.5	1.8	1.1	1.5	1.3	1.6	1.2	1.1	1.2	0.3
Unable to work because of sickness or disability	1.5	2.0	5.2	1.7	-0.1	-0.7	-1.2	-1.8	-0.4	-2.2	-1.0	-1.2	-2.3	-0.9
Commuting to job workplace: Cycle	0.5	0.6	1.3	0.9	0.6	-0.0	1.2	0.8	-1.1	0.1	0.4	1.1	0.3	0.8
Myopia	0.2	0.3	0.7	-0.8	-0.4	-0.6	0.0	0.6	0.5	0.8	0.4	0.1	0.5	0.2
Vascular/heart problems diagnosed by doctor	2.7	7.5	38.3	-6.2	2.2	3.1	0.9	1.7	0.9	3.9	0.9	0.9	2.7	-0.6
Cholesterol lowering medication	0.3	0.4	1.3	0.3	-1.1	-0.8	-0.7	-0.1	-0.2	0.7	0.2	-0.8	0.1	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.2	0.5	-0.4	-0.6	-0.4	-0.5	0.0	-1.1	-0.6	-0.4	-0.6	-0.3
Pain experienced in last month	0.6	0.9	2.6	-1.1	-0.9	-0.1	-1.2	-0.8	-0.9	1.2	-0.3	-1.0	0.3	-1.6
Supplements: Calcium	0.4	0.4	1.5	0.4	-0.1	-0.5	-0.3	-0.7	-1.1	0.0	-0.7	-0.3	0.1	-1.2
Basal cell carcinoma (self-reported)	0.4	0.4	2.0	1.0	-0.3	-0.2	0.0	-0.2	1.4	-1.1	-0.5	-0.0	-0.0	0.2
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.3	0.2	-1.1	-0.7	-1.1	-1.2	-0.9	-0.9	-0.7	-1.0	-1.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	7.4	2.7	-0.2	-1.1	0.5	-0.1	-1.3	-2.3	-1.0	0.4	-0.2	1.1
Heart disease (siblings)	0.2	0.3	0.8	-0.7	0.4	0.9	-0.2	-0.1	-0.7	0.8	-0.1	-0.1	0.3	0.0
Alcohol drinker status: Previous	0.2	0.3	1.0	-0.3	0.9	-0.1	0.4	0.4	-1.0	0.5	0.5	0.4	-0.2	0.0
Pack years of smoking	0.5	0.7	3.7	1.9	0.4	-0.1	0.4	-0.1	1.2	-1.2	-0.7	0.4	0.6	0.1
Impedance of whole body	4.7	23.8	97.6	-9.9	4.1	4.3	2.8	4.5	1.4	7.4	5.0	2.5	3.1	1.8
Leg fat mass (left)	2.6	10.1	30.3	5.5	-3.5	-2.8	-2.0	-2.9	-1.8	-4.8	-2.7	-1.9	-3.0	-1.5
Arm predicted mass (left)	1.8	8.9	31.2	5.6	-2.8	-2.8	-1.6	-2.6	-1.9	-4.3	-3.3	-1.4	-1.9	-1.6