[Hub]/) : Traits : Arm predicted mass (left) :

chr2:217,456,567-220,226,393

Best TWAS P=6.01e-16 · Best GWAS P=8.47e-29 conditioned to 2.01e-12

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous BCS1L 0.06 0.01 enet 9 0.04 2.3e-04 -2.8 5.8 9.1e-09 -0.04 0.07 0.24 FALSE
2 GTEx Adipose Visceral Omentum PNKD 0.11 0.00 enet 31 0.00 2.3e-01 -6.0 6.3 3.9e-10 0.06 0.01 0.92 TRUE
3 GTEx Adipose Visceral Omentum TMBIM1 0.17 0.03 enet 31 0.03 1.1e-02 -4.7 5.4 8.3e-08 0.09 0.02 0.96 FALSE
4 GTEx Adrenal Gland PNKD 0.20 0.16 lasso 5 0.19 1.6e-07 -5.1 5.5 4.1e-08 0.07 0.04 0.96 FALSE
5 GTEx Brain Cerebellar Hemisphere RP11-378A13.1 0.53 0.57 enet 24 0.60 3.3e-19 -4.8 5.3 1.2e-07 0.07 0.05 0.94 FALSE
6 GTEx Brain Hypothalamus RP11-378A13.1 0.37 0.44 enet 17 0.45 5.6e-12 -4.8 5.5 3.9e-08 0.10 0.01 0.99 FALSE
7 GTEx Lung PNKD 0.13 0.04 enet 10 0.03 3.7e-03 -5.6 5.5 4.8e-08 0.08 0.02 0.98 FALSE
8 GTEx Pancreas PNKD 0.12 0.10 lasso 3 0.08 3.6e-04 -6.0 5.6 2.6e-08 0.05 0.00 0.97 FALSE
9 GTEx Pituitary PNKD 0.29 0.23 enet 21 0.24 8.9e-07 -6.0 5.6 1.9e-08 0.09 0.01 0.99 FALSE
10 GTEx Skin Not Sun Exposed Suprapubic PNKD 0.28 0.28 enet 9 0.26 9.7e-15 -5.0 5.2 1.7e-07 0.08 0.17 0.83 FALSE
11 GTEx Skin Sun Exposed Lower leg PNKD 0.27 0.29 lasso 8 0.34 3.9e-29 -5.1 5.2 2.2e-07 0.08 0.18 0.82 FALSE
12 GTEx Small Intestine Terminal Ileum RP11-378A13.1 0.39 0.17 enet 15 0.14 4.5e-04 -4.8 5.3 1.5e-07 0.06 0.03 0.92 FALSE
13 GTEx Spleen RP11-378A13.1 0.37 0.41 enet 27 0.41 1.2e-11 -4.1 5.1 3.1e-07 0.07 0.02 0.97 FALSE
14 GTEx Testis RP11-378A13.1 0.37 0.18 enet 22 0.22 2.7e-10 -3.9 5.1 2.8e-07 0.09 0.46 0.54 FALSE
15 GTEx Thyroid PNKD 0.13 0.12 enet 13 0.14 6.3e-11 -6.0 5.3 9.6e-08 0.07 0.00 1.00 FALSE
16 GTEx Thyroid RP11-378A13.1 0.31 0.34 enet 34 0.38 3.7e-30 -4.7 5.2 2.3e-07 0.10 0.11 0.89 FALSE
17 METSIM Adipose PNKD 0.07 0.08 lasso 7 0.08 4.8e-12 -6.0 5.9 3.9e-09 0.07 0.00 1.00 FALSE
18 ROSMAP Brain Pre-frontal Cortex DIRC3 0.12 0.07 bslmm 697 0.08 2.7e-10 -6.7 7.2 8.7e-13 0.00 1.00 0.00 TRUE
19 YFS Blood PNKD 0.08 0.07 lasso 6 0.09 2.9e-27 -4.1 5.5 3.7e-08 0.05 0.05 0.95 FALSE
20 The Cancer Genome Atlas Breast Invasive Carcinoma TMBIM1 0.04 0.01 blup 49 0.02 4.8e-05 -4.8 5.3 1.1e-07 0.09 0.10 0.86 FALSE
21 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DIRC3 0.12 0.01 blup 275 0.02 3.3e-03 -1.4 6.3 2.7e-10 -0.51 0.05 0.51 TRUE
22 The Cancer Genome Atlas Thyroid Carcinoma DIRC3 0.08 0.06 lasso 5 0.07 2.7e-07 -8.6 8.1 6.0e-16 -0.56 0.98 0.01 TRUE