Best TWAS P=3.53e-10 · Best GWAS P=3.15e-10 conditioned to 0.259
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | LOC100129961 | 0.17 | 0.14 | enet | 9 | 0.14 | 2.6e-17 | 6.2 | 6.1 | 1.4e-09 | 0.93 | 0.01 | 0.99 | FALSE |
2 | GTEx | Esophagus Muscularis | TMEM163 | 0.09 | 0.05 | lasso | 6 | 0.05 | 4.8e-04 | -3.8 | 5.2 | 2.3e-07 | 0.74 | 0.07 | 0.91 | FALSE |
3 | GTEx | Testis | AC016725.4 | 0.18 | 0.09 | lasso | 6 | 0.09 | 6.3e-05 | 6.2 | -6.3 | 3.5e-10 | -0.94 | 0.03 | 0.97 | TRUE |
4 | NTR | Blood | CCNT2 | 0.01 | 0.00 | blup | 370 | 0.00 | 6.7e-02 | -4.4 | -5.7 | 1.2e-08 | -0.68 | 0.16 | 0.39 | FALSE |
5 | NTR | Blood | MCM6 | 0.02 | 0.02 | lasso | 2 | 0.03 | 1.2e-08 | -5.0 | -5.2 | 2.3e-07 | -0.47 | 0.06 | 0.94 | FALSE |
6 | ROSMAP | Brain Pre-frontal Cortex | TMEM163 | 0.19 | 0.16 | lasso | 14 | 0.23 | 6.2e-29 | -2.9 | 5.2 | 2.4e-07 | 0.68 | 0.98 | 0.02 | FALSE |
7 | YFS | Blood | CCNT2 | 0.01 | 0.01 | blup | 363 | 0.01 | 6.3e-05 | -3.7 | -5.4 | 5.2e-08 | -0.70 | 0.33 | 0.53 | FALSE |
8 | YFS | Blood | MCM6 | 0.18 | 0.15 | enet | 20 | 0.20 | 8.5e-64 | -5.8 | -5.9 | 4.4e-09 | -0.46 | 0.00 | 1.00 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LCT | 0.02 | 0.02 | enet | 3 | 0.03 | 7.6e-07 | -5.8 | 5.6 | 2.3e-08 | 0.47 | 0.00 | 1.00 | FALSE |
10 | The Cancer Genome Atlas | Glioblastoma Multiforme | LCT | 0.16 | 0.08 | blup | 36 | 0.10 | 5.3e-04 | -5.0 | 5.2 | 2.3e-07 | 0.40 | 0.00 | 0.89 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ACMSD | 0.04 | 0.01 | blup | 46 | 0.02 | 2.2e-03 | -4.4 | -5.3 | 8.7e-08 | -0.87 | 0.02 | 0.85 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LCT | 0.04 | 0.02 | blup | 36 | 0.02 | 1.9e-03 | -5.0 | 5.8 | 6.7e-09 | 0.48 | 0.01 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DARS | 0.04 | 0.02 | blup | 40 | 0.01 | 2.1e-02 | -4.2 | -5.2 | 1.6e-07 | -0.42 | 0.01 | 0.72 | FALSE |
14 | The Cancer Genome Atlas | Soft Tissue Sarcoma | LCT | 0.09 | 0.04 | blup | 36 | 0.05 | 4.9e-04 | -5.8 | 5.7 | 1.2e-08 | 0.43 | 0.00 | 0.90 | FALSE |