Hub : Genes

TMEM163

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0520 0.0250 5.1e-03 0.019 0.010 0.006 0.011 0.015 1.8e-03 1.8e-02 5.6e-02 1.6e-02 5.9e-03
2 GTEx Artery Coronary 0.3590 0.1550 8.2e-03 -0.008 NA 0.002 NA -0.009 8.6e-01 NA 2.6e-01 NA 9.6e-01
3 GTEx Brain Cerebellum 0.4360 0.0950 5.6e-05 0.128 NA 0.284 NA 0.225 1.3e-04 NA 5.0e-09 NA 2.9e-07
4 GTEx Esophagus Muscularis 0.0880 0.0340 8.8e-04 0.050 NA 0.050 NA 0.051 5.2e-04 NA 5.1e-04 NA 4.8e-04
5 GTEx Heart Atrial Appendage 0.3130 0.1240 5.0e-03 0.104 NA -0.002 NA 0.029 2.1e-05 NA 4.1e-01 NA 1.8e-02
6 GTEx Pituitary 0.3720 0.0940 1.2e-05 0.393 NA 0.331 NA 0.378 6.6e-11 NA 4.0e-09 NA 1.9e-10
7 GTEx Testis 0.2880 0.0670 5.4e-08 0.176 NA 0.218 NA 0.241 3.0e-08 NA 5.1e-10 NA 4.5e-11
8 GTEx Whole Blood 0.1100 0.0400 1.4e-04 0.062 NA 0.056 NA 0.058 2.1e-06 NA 7.0e-06 NA 5.0e-06
9 METSIM Adipose 0.0383 0.0165 3.2e-03 0.012 0.012 -0.001 0.011 0.006 5.1e-03 5.9e-03 4.0e-01 7.0e-03 3.6e-02
10 ROSMAP Brain Pre-frontal Cortex 0.1947 0.0361 0.0e+00 0.158 0.192 0.221 0.206 0.228 8.6e-20 4.6e-24 5.4e-28 6.3e-26 6.2e-29
11 TCGA Bladder Urothelial Carcinoma 0.0310 0.0150 8.0e-03 0.017 0.012 0.006 NA 0.004 1.2e-02 2.9e-02 9.7e-02 NA 1.4e-01
12 TCGA Breast Invasive Carcinoma 0.0593 0.0175 4.1e-15 0.087 0.077 0.078 NA 0.083 2.6e-17 1.6e-15 1.2e-15 NA 1.6e-16
13 TCGA Colon Adenocarcinoma 0.0810 0.0360 3.7e-03 0.017 0.009 0.001 NA 0.008 3.4e-02 8.9e-02 2.7e-01 NA 1.0e-01
14 TCGA Head and Neck Squamous Cell Carcinoma 0.0567 0.0219 1.1e-05 0.038 0.053 0.053 NA 0.055 4.2e-05 1.3e-06 1.2e-06 NA 8.4e-07
15 TCGA Kidney Renal Clear Cell Carcinoma 0.1731 0.0402 0.0e+00 0.207 0.154 0.198 NA 0.204 6.8e-23 5.5e-17 7.3e-22 NA 1.6e-22
16 TCGA Kidney Renal Papillary Cell Carcinoma 0.3300 0.0690 0.0e+00 0.357 0.311 0.367 NA 0.218 2.5e-21 2.7e-18 4.7e-22 NA 1.2e-12
17 TCGA Liver Hepatocellular Carcinoma 0.0930 0.0460 2.2e-03 0.059 0.072 0.084 NA 0.076 9.1e-04 2.7e-04 9.0e-05 NA 1.9e-04
18 TCGA Lung Adenocarcinoma 0.0625 0.0258 1.7e-05 0.013 0.038 0.027 NA 0.023 1.1e-02 2.6e-05 3.3e-04 NA 9.7e-04
19 TCGA Lung Squamous Cell Carcinoma 0.0408 0.0169 1.5e-04 0.000 0.016 -0.002 NA 0.002 2.9e-01 6.1e-03 6.5e-01 NA 1.9e-01
20 TCGA Prostate Adenocarcinoma 0.0708 0.0278 9.9e-06 0.070 0.037 0.065 NA 0.060 9.1e-08 9.5e-05 2.3e-07 NA 6.7e-07
21 TCGA Testicular Germ Cell Tumors 0.3370 0.1150 6.5e-03 0.020 0.082 0.061 NA 0.044 6.5e-02 7.9e-04 3.4e-03 NA 1.1e-02
22 TCGA Thyroid Carcinoma 0.1370 0.0360 6.8e-14 0.140 0.091 0.148 NA 0.181 1.7e-13 3.6e-09 2.7e-14 NA 2.4e-17

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bipolar Disorder (2018) 0.9 1.4 9.7 -1.4 0.0 0.5 -0.9 -0.6 -0.3 0.7 -1.4 -3.1 0.0 -0.2 -1.5 -0.6 -1.0 -1.6 -1.9 0.6 -1.4 -0.7 -1.3 0.1 -1.3
Bipolar Disorder or Schizophrenia 0.9 2.2 8.0 -2.8 0.0 -0.1 -0.8 0.1 -0.2 0.2 -1.2 -2.8 -1.7 -0.2 -1.8 -0.2 -1.8 -2.5 -2.0 0.2 -1.4 -0.6 -0.7 -2.3 -1.8
Depressed Affect (Nagel 2018) 2.2 4.7 8.8 2.1 0.0 1.1 2.5 2.9 2.7 -2.9 2.7 1.4 1.8 3.0 2.1 1.9 2.4 1.5 2.2 2.7 2.2 2.6 2.0 -0.4 1.4
Depression (Nagel 2018) 0.5 0.7 1.8 1.2 0.0 0.4 0.8 1.0 0.9 -1.0 1.3 1.4 0.9 1.1 0.6 0.1 0.8 0.5 0.8 1.2 0.4 1.0 0.7 -0.3 0.5
Intelligence (Savage-Jansen 2018) 2.2 6.7 12.9 2.5 0.0 1.0 2.7 2.3 2.7 -3.0 2.6 0.5 2.2 3.3 3.2 2.3 3.0 3.1 3.6 3.0 2.4 3.5 2.1 1.3 2.9
Neuroticism (Nagel 2018) 3.7 8.7 13.9 3.0 0.0 2.0 3.2 3.6 3.1 -3.5 3.2 1.9 2.8 3.7 3.2 2.6 3.4 2.6 3.6 3.4 3.2 3.6 2.9 0.1 2.5
Schizophrenia (2018) 0.7 1.5 9.4 -2.5 0.0 -0.5 -0.3 0.6 0.0 -0.3 -0.4 -1.1 -2.2 -0.2 -1.1 0.3 -1.5 -1.9 -1.1 -0.1 -0.7 -0.2 0.1 -3.1 -1.3
Schizophrenia vs Biploar Disorder 0.6 0.8 4.6 -0.1 0.0 -0.3 0.9 0.8 0.2 -1.2 1.2 1.4 -0.6 1.0 0.7 -0.1 0.0 0.3 1.3 0.9 0.8 0.5 1.4 -2.1 0.4
Worry (Nagel 2018) 5.3 11.1 16.9 3.1 0.0 2.9 3.8 3.9 3.5 -4.0 3.6 1.6 3.2 4.0 3.5 3.3 3.5 3.0 4.1 3.7 3.8 3.9 3.7 -0.3 2.9
Alzheimer’s Disease (in mother) 2.7 3.2 10.9 -0.6 0.0 -0.7 -2.6 -1.9 -2.2 2.3 -2.2 -0.4 -1.9 -1.9 -1.7 -0.8 -0.8 -1.4 -1.9 -2.9 -1.3 -1.2 -3.3 1.1 -1.8
Alzheimer’s Disease (in father) 2.3 2.5 5.7 -1.0 0.0 0.3 -2.4 -1.8 -1.8 2.2 -2.0 -0.7 -1.6 -1.7 -1.5 -1.3 -1.4 -1.6 -1.6 -1.5 -1.6 -2.1 -1.9 0.2 -1.7
Alzheimer’s Disease (including proxy) 5.4 7.9 16.6 -1.8 0.0 -0.2 -3.7 -2.8 -3.4 3.3 -3.4 -1.2 -2.8 -3.1 -3.4 -1.9 -2.4 -3.3 -3.1 -3.3 -2.4 -2.8 -4.1 0.4 -3.7
Crohns Disease (2017) 0.2 0.5 2.7 1.6 0.0 0.9 0.9 0.5 0.5 -0.5 0.8 -0.1 1.3 0.3 0.3 -0.1 0.8 0.6 0.3 -0.3 0.3 0.7 0.1 1.2 0.4
Irritable Bowel Disease (IBD) 0.3 0.7 2.1 1.4 0.0 1.1 1.0 0.7 0.4 -0.8 1.1 1.0 1.3 0.6 0.1 -0.2 0.8 0.2 0.0 0.5 0.4 1.1 0.4 1.5 -0.1
Ulcerative Colitis (UC) 0.3 0.6 2.2 0.9 0.0 0.5 0.8 0.8 0.6 -0.8 1.1 1.5 0.7 0.8 0.2 0.1 0.8 -0.2 0.1 0.9 0.4 1.2 0.4 1.1 -0.3
Major Depression (MDD) 1.2 1.4 3.6 1.0 0.0 1.2 1.2 1.0 1.4 -1.2 1.3 -0.0 1.9 1.7 1.2 1.3 0.9 0.9 1.2 1.7 1.0 0.8 1.6 -0.2 1.1
Reaction Time 0.1 0.2 1.0 0.4 0.0 0.1 0.3 0.4 0.5 0.1 1.0 -0.0 0.3 0.5 0.2 0.4 0.3 0.2 0.0 1.0 0.2 0.3 0.7 0.3 0.4
Verbal and Numeric Reasoning (VNR) 1.9 4.6 8.7 1.6 0.0 0.9 2.8 2.4 2.2 -2.9 2.3 0.6 2.2 3.0 2.4 1.6 2.2 2.1 2.6 2.7 2.1 2.7 2.3 0.1 2.1
Breast Cancer 3.4 8.2 17.1 -2.9 0.0 -4.1 -3.2 -2.5 -2.8 3.3 -2.9 -0.6 -3.1 -3.5 -2.9 -2.1 -2.7 -2.6 -3.2 -3.5 -3.1 -2.8 -3.7 -0.4 -2.7
Ovarian Cancer 1.2 1.6 4.2 -2.0 0.0 -1.2 -1.3 -0.8 -1.4 1.4 -1.1 0.5 -1.2 -1.1 -1.1 -1.6 -1.5 -1.4 -0.8 -1.2 -1.2 -1.4 -1.5 -1.3 -1.3
Prostate Cancer 0.0 0.1 0.4 -0.6 0.0 0.6 0.0 0.1 -0.2 0.1 0.0 0.2 0.1 -0.0 -0.2 -0.6 -0.3 -0.2 0.3 0.0 0.2 0.0 -0.1 0.1 -0.2
Age at First Birth 0.3 0.5 2.2 -0.2 0.0 -1.5 -0.7 -0.2 -0.2 0.7 -1.0 0.1 -1.5 -0.4 0.1 -0.1 0.6 0.1 -0.0 -0.8 -0.5 0.1 -1.4 1.0 0.1
Bipolar Disorder (2011) 1.4 1.3 5.0 -0.9 0.0 0.4 -1.1 -0.5 -1.4 1.1 -1.5 -2.2 -0.9 -1.0 -1.4 -0.7 -0.9 -1.3 -1.9 -0.4 -0.7 -0.6 -1.8 -0.1 -1.4
Body Mass Index (BMI) (2010) 3.4 4.7 11.5 2.1 0.0 2.4 2.2 1.7 1.7 -1.9 2.0 1.5 3.4 2.7 2.4 1.3 2.3 2.2 2.3 2.8 2.6 2.7 2.1 1.2 2.0
Coronary Artery Disease (CAD) 0.9 1.1 4.7 -1.0 0.0 1.8 1.1 0.8 1.2 -1.5 0.6 1.4 0.2 1.0 0.7 0.0 -0.2 0.1 0.7 1.1 1.0 0.1 2.2 -1.7 0.6
Crohns Disease (2012) 0.1 0.2 1.2 1.1 0.0 1.0 0.7 0.5 0.2 -0.4 0.8 0.0 0.6 0.2 -0.1 0.1 0.5 0.1 -0.0 -0.1 0.1 0.6 0.2 0.3 -0.2
Mean Putamen Volume 0.2 0.3 2.0 0.6 0.0 -1.2 -0.2 0.4 0.0 0.3 -0.1 -1.4 0.0 0.0 -0.2 -0.1 0.4 -0.2 -0.6 -0.2 -0.4 0.3 -0.7 -0.0 -0.2
Fasting Glucose 2.5 3.0 7.6 2.4 0.0 -0.5 1.7 2.0 1.9 -1.6 1.7 -1.5 0.5 1.7 2.5 2.4 2.8 1.9 2.0 0.1 1.2 1.6 0.7 1.6 2.5
HbA1C 1.1 1.2 2.8 0.5 0.0 -1.2 1.3 1.7 1.0 -1.0 1.3 0.9 0.7 1.0 1.5 1.3 1.2 1.1 1.7 0.6 1.2 1.0 0.6 0.2 1.3
HDL Cholesterol 4.4 7.4 13.2 -2.5 0.0 -1.3 -3.2 -2.3 -3.1 3.3 -2.5 -0.5 -3.3 -3.6 -3.4 -3.2 -3.1 -2.9 -3.0 -2.5 -2.1 -2.9 -3.0 -1.3 -2.9
LDL Cholesterol 3.0 4.8 13.6 -3.7 0.0 -0.2 -1.9 -1.9 -2.6 1.5 -2.5 -0.2 -1.8 -1.5 -3.0 -1.9 -3.1 -3.5 -2.5 0.1 -2.0 -2.2 -1.2 -1.7 -3.0
Lupus 1.8 2.7 5.4 2.0 0.0 1.0 1.9 1.3 2.3 -1.9 1.9 -0.1 1.2 2.3 2.1 0.9 2.1 2.2 1.8 1.3 0.5 1.8 1.7 0.3 2.1
Neuroticism (2016) 5.4 7.8 14.1 3.2 0.0 1.4 2.5 3.7 1.7 -3.4 2.9 0.8 2.9 3.3 3.3 1.9 3.3 3.1 3.8 2.8 3.3 3.1 2.9 -0.6 3.0
Primary Biliary Cirrhosis 2.7 3.9 12.9 1.9 0.0 1.2 2.4 3.6 2.4 -2.1 2.9 1.4 1.2 2.4 2.0 1.5 2.5 1.2 2.0 0.8 2.4 2.8 0.5 -0.5 0.9
Rheumatoid Arthritis 0.6 0.8 5.1 -0.6 0.0 -1.2 0.2 1.2 -0.4 0.2 0.8 -1.1 -1.1 -0.2 -0.6 -0.7 -0.6 -0.9 -0.2 -0.9 -0.8 -0.1 -1.0 -2.2 -0.9
Schizophrenia (2014) 1.5 3.4 13.2 -3.6 0.0 -1.2 -0.9 0.4 -0.7 0.0 -1.0 -1.7 -3.2 -0.8 -2.1 -0.5 -2.5 -2.8 -2.2 -0.4 -1.2 -0.8 -0.7 -3.6 -2.0
Triglycerides 0.1 0.2 1.2 -0.5 0.0 1.1 0.4 0.4 0.0 0.0 0.3 -0.8 0.3 0.0 0.0 -0.1 -0.3 -0.1 0.1 -0.4 -0.3 0.0 -0.6 -0.2 0.1
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.3 -1.1 0.0 1.4 -0.4 0.3 -0.5 0.8 -0.4 -0.2 1.4 0.2 -1.0 -1.0 -0.8 -1.5 -1.2 0.6 -0.6 -0.4 -0.6 -0.7 -1.4
Ulcerative Colitis 0.5 0.7 2.4 1.4 0.0 0.4 0.7 1.1 0.5 -0.7 1.1 1.5 0.6 0.6 0.5 0.9 1.3 0.5 0.4 0.2 0.5 1.3 0.2 1.4 0.1
Blood Eosinophil Count 0.9 6.7 18.7 -4.3 0.0 -1.7 -2.5 -2.3 -2.6 1.9 -3.3 -2.1 -1.7 -2.0 -3.2 -1.7 -4.1 -3.1 -2.8 -0.9 -2.1 -3.5 -1.7 -2.3 -2.6
Blood Platelet Count 0.2 2.7 6.8 1.3 0.0 1.7 2.2 2.6 0.8 -1.8 2.5 1.0 1.7 1.8 0.8 1.4 1.0 0.9 1.6 2.2 2.1 1.7 1.6 -1.9 0.6
Blood Red Count 6.0 57.6 91.7 6.8 0.0 5.7 9.6 8.2 8.2 -8.5 9.4 3.9 8.4 8.6 8.4 8.3 7.4 7.5 8.5 7.0 8.3 8.0 8.8 0.9 7.7
Blood White Count 0.1 0.6 1.8 -1.1 0.0 0.2 -0.5 -0.1 -0.7 1.0 -0.8 -0.9 -0.5 -0.5 -0.8 1.1 -1.3 -0.6 -0.6 0.0 -0.2 -1.2 -0.1 -1.4 -0.3
Heel T-Score 0.3 2.1 6.1 1.7 0.0 1.1 1.3 1.3 1.4 -1.5 1.0 0.3 1.4 1.5 1.7 1.6 2.2 1.6 1.1 1.1 1.3 1.9 1.0 2.5 1.3
BMI 1.8 10.4 15.7 3.7 0.0 2.6 3.6 3.3 3.5 -3.1 4.0 0.9 3.7 3.8 3.6 3.6 3.5 3.4 3.7 3.0 3.4 3.2 3.3 0.8 3.4
Height 0.2 3.7 8.4 -2.2 0.0 -1.3 -2.2 -2.9 -2.3 2.1 -2.7 2.9 -0.5 -1.2 -2.0 -2.3 -2.0 -1.8 -2.1 0.2 -1.9 -2.0 -1.4 -0.1 -1.8
Waist Hip Ratio (WHR) 1.2 5.6 19.2 -4.4 0.0 -3.0 -1.3 -1.6 -1.5 1.2 -2.4 -1.8 -2.7 -2.1 -2.4 -1.8 -3.5 -2.2 -2.0 -1.2 -3.0 -3.2 -0.9 -3.5 -1.4
Systolic Blood Pressure 2.2 11.1 18.2 3.7 0.0 3.9 4.1 3.6 3.7 -3.6 4.3 0.6 3.6 3.7 3.3 3.5 3.3 3.1 2.8 3.2 3.5 3.6 3.7 1.0 3.4
Smoking Status 4.5 10.7 19.1 -4.0 0.0 -2.4 -3.1 -3.1 -3.6 3.2 -3.2 0.8 -2.6 -3.2 -3.9 -3.8 -4.4 -4.0 -3.9 -1.8 -4.0 -4.1 -2.9 -2.5 -3.7
Allergy or Eczema 0.3 0.7 6.5 0.0 0.0 -2.5 -1.1 -0.6 -0.9 0.7 -1.0 -0.8 -1.7 -0.5 -0.3 0.4 -0.2 0.3 -0.1 -0.7 -0.0 -0.4 -0.9 -0.4 0.2
Cardiovascular Disease 0.3 0.8 2.7 1.3 0.0 0.7 0.5 -0.1 0.4 -0.5 0.4 -0.6 0.5 0.1 0.6 1.1 0.9 1.4 0.5 1.2 1.1 1.1 1.2 1.6 1.5
Hypothyroidism (self reported) 0.5 1.2 4.5 -2.1 0.0 -0.8 -0.5 -0.2 -0.8 0.3 -0.7 -1.1 -0.5 -0.8 -1.6 -0.6 -1.7 -1.9 -1.1 -0.5 -0.7 -0.9 -0.1 -1.5 -1.8
Respiratory disease 0.8 1.8 5.8 -0.1 0.0 -2.4 -1.0 -0.0 -1.5 1.1 -0.6 -1.9 -1.5 -1.4 -1.9 0.4 -1.1 -1.7 -1.6 -1.1 -0.2 -0.8 -1.6 -1.7 -2.0
Type 2 Diabetes (T2D) (2018) 2.9 5.4 8.4 -2.6 0.0 -2.0 -2.5 -1.9 -2.5 2.5 -2.5 -0.9 -2.1 -2.9 -2.7 -2.7 -2.5 -2.8 -2.8 -2.2 -2.6 -2.3 -2.2 -0.6 -2.9
Lung FEV1/FVC ratio 0.3 1.4 4.6 -1.6 0.0 -0.1 -0.8 -0.4 -0.9 0.9 -0.5 0.3 -1.1 -1.1 -1.5 -1.3 -1.2 -2.1 -1.3 -0.9 -1.3 -1.1 -1.1 -1.6 -2.1
Lung FVC 4.1 20.9 31.1 -5.4 0.0 -4.4 -4.9 -3.0 -4.0 3.9 -4.9 -4.4 -5.4 -4.3 -5.4 -4.7 -5.0 -5.6 -5.0 -3.9 -4.9 -4.8 -4.7 -3.5 -5.2
Neuroticism 2.0 4.8 8.5 2.3 0.0 1.3 2.6 2.7 2.7 -2.9 2.3 0.9 1.8 2.7 2.2 2.3 2.6 1.6 2.1 2.7 2.5 2.5 2.3 -0.1 1.6
Chronotype (morning person) 1.0 2.3 9.9 3.1 0.0 0.8 1.3 0.7 0.9 -0.9 1.5 0.3 1.7 1.4 1.9 1.6 2.5 1.7 1.9 1.0 1.3 2.0 1.0 1.4 1.0
Hair Pigment 3.1 89.4 158.8 -6.9 0.0 -4.7 -10.8 -10.4 -12.6 11.0 -9.8 -2.5 -8.1 -11.3 -11.2 -11.2 -10.1 -10.4 -10.8 -9.2 -9.4 -10.4 -10.0 -2.9 -11.5
Tanning 0.0 0.4 3.0 -0.3 0.0 -1.7 0.4 0.2 0.1 -0.2 -0.1 0.7 -0.3 -0.2 0.6 0.9 0.5 0.7 0.8 -1.1 0.8 0.2 0.3 0.6 0.5
Hand grip strength (left) 5.5 14.6 32.3 -5.3 0.0 -1.6 -5.2 -4.2 -4.3 3.9 -5.7 -1.2 -3.9 -3.6 -4.0 -3.8 -4.5 -3.8 -4.1 -2.5 -3.5 -4.7 -3.6 -1.4 -3.5
Number of treatments/medications taken 0.4 0.7 5.3 0.8 0.0 0.3 -0.3 -0.8 -0.3 0.5 -0.4 0.3 0.8 -0.6 0.3 1.4 0.5 1.0 0.4 0.7 1.4 0.8 0.4 2.3 1.0
Average weekly spirits intake 0.8 1.0 2.6 -0.2 0.0 -0.6 -1.1 -1.2 -0.7 0.9 -1.0 -1.1 -0.4 -0.8 -1.0 -0.4 -0.8 -1.1 -1.6 -1.2 -1.6 -1.3 -0.9 0.4 -1.1
Sensitivity / hurt feelings 0.9 1.5 5.0 0.8 0.0 0.9 1.6 0.8 1.3 -1.6 1.1 0.9 1.8 1.7 1.2 0.4 0.8 0.8 1.3 2.2 1.0 1.0 1.7 -0.1 0.9
Frequency of depressed mood in last 2 weeks 0.4 0.5 2.1 -0.1 0.0 -0.1 0.6 0.7 0.5 -0.8 0.3 1.0 1.1 1.2 0.1 0.1 -0.2 -0.1 0.0 1.3 0.4 -0.1 1.2 -1.5 0.2
Hearing difficulty/problems: Yes 0.1 0.2 1.1 -0.4 0.0 -0.7 -0.2 -0.3 -0.1 0.1 -0.4 -0.3 0.2 0.0 -0.1 -1.1 -0.1 0.0 -0.2 0.4 -0.6 0.1 0.0 0.7 0.3
Relative age of first facial hair 3.4 7.0 12.4 -3.5 0.0 -2.7 -3.3 -2.4 -2.4 3.3 -3.2 -1.6 -3.2 -2.8 -2.3 -2.3 -2.8 -2.1 -2.2 -3.2 -3.0 -3.1 -3.4 -0.7 -1.7
Other serious medical condition/disability diagnosed by doctor 2.6 3.4 8.2 -1.5 0.0 -1.5 -1.7 -1.7 -1.6 1.7 -1.9 -1.6 -1.8 -1.7 -2.2 -2.1 -1.8 -2.4 -2.4 -1.0 -2.9 -1.9 -2.0 -1.1 -2.3
Ever used hormone-replacement therapy (HRT) 0.8 1.0 3.3 -1.0 0.0 0.4 -1.0 -0.3 -0.7 1.2 -0.8 -1.8 -1.3 -1.3 -0.9 -0.1 -0.9 -0.8 -1.0 -1.7 -1.0 -0.9 -1.2 -0.6 -0.5
Ever had hysterectomy (womb removed) 0.4 0.5 1.4 -0.3 0.0 -0.6 -0.1 -0.3 -0.6 0.6 0.0 1.1 -0.5 -0.9 -0.9 -0.4 -0.7 -1.0 -0.5 -0.7 -0.6 -0.6 -0.7 -1.2 -1.0
Systolic blood pressure, automated reading 5.3 15.3 24.0 4.2 0.0 4.9 4.6 3.6 4.1 -4.2 4.9 1.4 4.9 4.5 3.8 4.1 3.8 3.4 3.6 3.8 4.3 4.1 4.7 1.2 3.5
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.0 -0.2 0.0 0.7 -0.7 -0.6 -1.0 0.8 -0.5 -0.4 -0.1 -0.6 -0.9 -1.0 -0.7 -0.6 -1.0 0.1 -0.5 -0.9 -0.4 -0.4 -0.9
Angina 0.2 0.3 0.9 0.7 0.0 0.1 0.4 0.5 0.3 -0.3 0.7 -0.5 -0.4 0.1 0.3 1.0 0.4 0.4 0.4 0.8 0.9 0.7 0.4 -0.3 0.5
Medication for hormone replacement therapy 2.1 2.3 4.0 -1.7 0.0 0.0 -1.7 -1.3 -1.8 1.7 -1.6 -1.5 -1.2 -1.5 -1.8 -1.6 -1.7 -2.0 -2.0 -1.1 -1.4 -1.5 -1.5 -1.2 -1.9
Vitamin and mineral supplements 2.0 2.7 6.3 1.1 0.0 2.0 2.3 1.9 2.4 -2.5 1.9 0.5 2.5 2.4 1.5 1.0 1.4 0.9 1.5 1.4 1.0 1.8 1.7 0.0 0.9
Supplements: Zinc 0.5 0.6 2.4 -0.5 0.0 -0.5 -0.6 -0.9 -0.4 0.3 -0.6 1.5 -1.4 -1.3 -0.6 0.2 -0.6 -0.3 -0.7 -0.1 0.3 -0.5 0.3 1.6 -0.2
Medication: Co-codamol 0.1 0.1 0.4 -0.4 0.0 0.5 -0.0 -0.1 0.1 -0.1 -0.1 0.6 -0.2 0.1 0.0 -0.1 -0.0 -0.2 -0.4 0.3 -0.4 -0.1 0.6 0.1 -0.1
Medication: Metformin 2.6 3.7 8.0 -1.4 0.0 -1.8 -2.1 -1.9 -2.5 2.5 -1.8 -0.7 -1.5 -2.8 -2.3 -1.6 -2.2 -2.1 -1.8 -2.1 -1.9 -2.3 -1.7 -0.3 -2.3
Diabetes (father) 4.0 5.0 11.3 -2.4 0.0 -0.4 -2.2 -2.2 -2.7 1.7 -2.6 -1.0 -0.7 -1.8 -3.1 -3.0 -2.6 -3.4 -3.2 -0.6 -2.5 -1.8 -1.8 -1.0 -3.3
Diabetes (mother) 1.0 1.2 4.0 0.7 0.0 -0.3 -1.1 -0.7 -1.5 1.2 -0.2 -0.4 -1.0 -1.8 -1.3 -1.9 -0.4 -1.3 -1.2 -1.3 -0.6 -0.6 -1.2 -0.4 -2.0
Severe depression (siblings) 0.7 0.8 2.7 0.7 0.0 0.5 1.1 1.3 0.9 -1.2 1.6 -0.7 -0.0 0.9 0.9 1.6 0.9 0.5 1.1 -0.2 0.7 1.1 0.7 0.3 0.6
Pack years adult smoking proportion 2.6 3.9 9.7 3.1 0.0 1.6 2.0 1.0 1.3 -2.0 2.3 1.5 2.0 1.7 2.0 1.8 2.3 2.3 2.0 2.4 1.7 2.3 2.6 1.8 1.8
Impedance of leg (right) 0.3 1.3 5.1 -1.1 0.0 0.4 1.6 1.4 0.9 -2.0 1.2 1.5 -0.1 1.1 0.5 0.6 -0.2 -0.2 1.1 1.3 1.3 0.9 1.2 -2.2 -0.1
Leg fat-free mass (left) 0.1 0.7 3.4 1.6 0.0 0.6 -0.3 -1.1 -0.4 0.8 -0.4 1.4 1.8 0.4 0.2 0.1 0.6 0.6 0.3 1.0 0.3 -0.1 0.4 1.4 0.4
Trunk fat percentage 3.9 15.8 26.7 3.5 0.0 3.6 5.2 3.7 4.4 -4.3 4.9 1.8 5.2 4.9 3.8 4.6 3.4 3.3 4.4 4.7 4.0 3.9 4.7 -0.3 3.6
Hand grip strength (right) 6.3 17.1 33.2 -5.5 0.0 -1.3 -5.3 -4.4 -4.5 4.0 -5.8 -0.7 -3.5 -4.0 -4.8 -4.2 -5.0 -4.7 -5.2 -3.3 -3.8 -4.8 -4.2 -0.8 -4.2
Townsend deprivation index at recruitment 0.4 0.5 1.7 -1.3 0.0 0.1 0.1 -0.9 0.2 -0.2 -0.9 -0.8 0.4 0.2 0.2 0.4 -1.0 0.6 0.5 1.2 -0.2 -0.8 1.2 0.7 1.3
Current tobacco smoking 1.3 2.2 4.6 -1.7 0.0 -0.5 -1.3 -1.8 -1.9 1.1 -1.7 1.2 -0.8 -1.6 -1.7 -2.1 -2.0 -1.7 -1.8 -0.2 -1.5 -1.7 -0.9 -0.4 -1.7
Average weekly fortified wine intake 0.4 0.5 2.8 0.2 0.0 1.0 0.3 1.1 -0.0 -0.6 0.7 0.9 -0.7 -0.1 0.1 -0.9 0.3 -0.3 0.3 0.2 0.9 0.4 -0.3 -1.7 -0.7
Maternal smoking around birth 0.6 0.9 3.3 -1.8 0.0 -1.4 -0.1 -0.8 0.3 -0.3 -0.7 -0.4 -0.9 0.0 -1.1 -0.4 -1.6 -1.1 -1.1 1.1 -1.8 -1.1 0.9 -0.5 -0.3
Fed-up feelings 2.0 3.7 7.8 1.2 0.0 0.6 2.6 2.5 2.4 -2.8 2.3 0.7 1.8 2.7 1.9 1.1 1.7 1.4 1.9 2.8 1.6 2.0 2.2 -1.3 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 3.4 1.0 0.0 1.0 0.9 0.6 0.7 -1.0 0.8 1.1 1.1 0.8 0.4 0.6 0.6 0.6 0.2 1.9 1.0 1.0 1.2 0.9 0.6
Relative age voice broke 0.4 0.7 3.4 -1.8 0.0 -1.8 -1.0 -0.6 -0.2 0.8 -1.0 -0.2 -1.3 -0.4 -0.2 -0.0 -0.6 -0.2 -0.3 -0.9 -0.7 -0.7 -0.9 -0.1 0.2
Taking other prescription medications 0.8 1.2 5.4 -1.3 0.0 -2.3 -1.2 -1.6 -0.9 0.9 -1.7 -1.3 -1.6 -1.2 -1.1 0.7 -1.2 -0.7 -0.6 -0.5 -0.7 -1.2 -0.3 0.1 -0.5
Age when periods started (menarche) 0.2 0.6 2.4 -1.6 0.0 -1.0 0.5 -0.1 0.2 -1.2 -0.5 0.1 -0.1 0.7 -0.6 -0.9 -0.7 -0.7 -0.4 1.2 -0.6 -0.2 0.8 -1.3 -0.6
Bilateral oophorectomy (both ovaries removed) 4.4 5.1 8.8 2.2 0.0 2.3 3.0 2.5 2.1 -2.8 2.8 2.0 2.8 2.9 1.9 2.0 2.1 1.0 2.1 2.8 2.4 2.7 2.6 -0.7 0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 6.8 0.8 0.0 2.0 1.7 1.1 1.7 -1.7 1.5 1.4 2.6 2.0 0.9 0.8 0.9 1.1 0.5 1.9 0.8 1.5 2.0 1.5 1.5
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 2.1 0.1 0.0 -0.7 -0.6 -0.6 0.1 0.5 -0.6 -0.1 -0.5 -0.2 -0.7 -0.4 -0.0 -0.7 -1.4 -0.1 -1.4 -0.5 -0.2 0.6 -0.6
Qualifications: CSEs or equivalent 0.6 0.8 4.3 -2.1 0.0 -0.5 -0.7 -1.2 -0.3 0.6 -1.4 0.5 -0.4 -0.6 -0.7 -0.2 -1.6 -0.9 -0.6 0.3 -1.0 -1.2 -0.0 0.1 -0.4
Serious illness, injury or assault to yourself 0.2 0.2 1.1 0.2 0.0 0.6 0.4 -0.0 0.2 -0.2 0.5 0.1 0.8 0.6 -0.1 0.3 -0.2 -0.2 -0.0 1.0 -0.2 -0.1 0.8 -0.2 -0.1
High blood pressure 3.4 9.4 14.4 3.6 0.0 3.5 3.1 1.8 2.8 -2.8 3.0 0.9 3.2 2.4 2.9 3.4 3.4 3.6 2.8 3.2 3.7 3.8 3.5 3.2 3.6
Hayfever, allergic rhinitis or eczema 1.1 2.5 7.1 -1.1 0.0 -2.7 -2.1 -1.5 -1.9 1.6 -1.9 -1.3 -2.4 -1.4 -1.4 -0.9 -1.3 -1.1 -1.3 -1.4 -1.4 -1.7 -1.5 -1.7 -1.3
Multivitamins +/- minerals 1.7 2.2 5.3 -0.7 0.0 -2.0 -1.7 -1.1 -2.1 2.0 -1.1 -0.8 -2.3 -2.1 -1.4 -1.1 -1.2 -1.1 -1.5 -1.5 -1.1 -1.3 -1.8 -1.0 -1.3
Stomach or abdominal pain in last month 1.8 2.2 6.6 -0.4 0.0 -1.2 -2.0 -1.6 -2.5 2.1 -1.5 -0.3 -1.7 -2.1 -1.4 -1.3 -1.0 -1.0 -1.2 -1.5 -0.3 -1.1 -2.6 -0.4 -1.7
Supplements: Glucosamine 0.3 0.4 2.5 0.5 0.0 -1.2 -0.4 -0.4 -0.2 0.6 -0.2 -0.3 -1.1 -0.9 0.0 0.5 0.2 0.2 -0.6 -1.6 -0.3 -0.2 -0.6 0.5 0.0
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.8 0.9 0.0 0.4 0.1 -0.1 -0.1 -0.2 0.7 0.1 -0.3 0.1 0.2 -0.2 0.3 0.0 -0.1 -0.2 -0.1 0.0 0.6 -0.4 -0.3
Medication: Atenolol 0.8 1.0 4.0 1.1 0.0 0.9 1.2 0.3 0.8 -1.0 0.9 -0.0 1.1 0.7 0.8 1.2 1.0 0.7 0.8 2.0 1.1 1.0 1.7 0.7 0.7
Medication: Levothyroxine sodium 0.6 1.0 3.2 -1.8 0.0 -1.4 -0.3 0.2 -0.1 0.1 -0.1 -1.8 -0.5 -0.4 -1.2 -0.1 -1.2 -1.6 -1.1 -0.7 -1.0 -0.6 -0.3 -1.7 -1.3
Sitting height 0.1 1.0 4.0 1.3 0.0 1.2 -0.3 -1.4 -0.2 0.5 -0.3 1.7 2.0 0.5 0.9 -0.6 0.8 1.3 1.1 1.3 0.5 -0.0 0.2 1.6 0.9
Chronic bronchitis/emphysema (father) 0.8 0.9 4.0 1.7 0.0 0.9 1.4 1.1 0.4 -1.2 2.0 0.1 1.1 0.7 0.3 -0.0 0.7 0.3 0.4 1.2 0.4 1.2 1.1 -0.3 -0.2
High blood pressure (mother) 1.8 2.6 8.1 2.8 0.0 1.9 1.6 1.3 1.7 -1.3 1.8 0.1 1.1 1.3 1.4 2.8 2.1 1.6 0.9 1.3 1.9 1.7 1.6 0.8 1.3
Body mass index (BMI) 1.5 6.4 14.5 3.2 0.0 2.7 3.0 2.2 2.6 -2.2 3.3 0.6 3.8 2.9 2.3 2.7 2.5 2.3 2.3 2.7 2.3 2.5 3.0 0.6 2.4
Impedance of leg (left) 0.2 1.0 3.9 -1.5 0.0 0.5 1.4 1.2 0.8 -1.7 1.1 1.4 -0.4 0.8 0.4 0.6 -0.5 -0.1 1.0 0.9 1.0 0.7 0.8 -2.0 0.2
Leg predicted mass (left) 0.1 0.7 3.5 1.6 0.0 0.7 -0.3 -1.1 -0.4 0.8 -0.4 1.4 1.9 0.4 0.1 0.2 0.6 0.6 0.3 1.0 0.3 -0.1 0.5 1.4 0.4
Trunk fat mass 2.3 9.8 20.6 3.1 0.0 3.0 3.9 2.5 3.2 -3.1 3.7 1.9 4.5 3.9 3.0 3.5 2.7 2.7 3.5 3.9 3.1 2.9 3.8 0.1 2.9
Waist circumference 0.7 2.4 5.8 1.3 0.0 1.6 2.0 1.2 1.5 -1.4 2.1 0.5 2.4 2.0 1.1 1.7 0.9 1.1 1.3 2.3 1.3 1.2 2.3 -1.0 1.5
Number of incorrect matches in round 5.2 8.6 20.2 -4.5 0.0 -0.3 -3.2 -2.3 -2.7 2.7 -3.4 -3.9 -3.6 -3.0 -3.0 -3.0 -3.9 -2.9 -3.0 -2.0 -2.9 -3.4 -2.4 -2.3 -2.2
Past tobacco smoking 4.3 8.0 12.7 3.2 0.0 3.2 2.9 2.4 2.9 -3.6 2.6 0.5 2.4 3.4 3.1 2.4 3.1 3.2 3.5 2.6 3.1 3.4 3.3 1.1 2.9
Alcohol usually taken with meals 1.0 1.6 4.4 -0.5 0.0 -1.2 -1.5 -0.7 -1.8 1.6 -1.2 -0.7 -1.6 -1.6 -1.3 -0.7 -0.9 -1.2 -1.2 -2.1 -0.7 -0.9 -1.8 -0.6 -1.5
Nervous feelings 4.9 9.2 16.6 2.9 0.0 2.7 3.0 2.7 2.7 -3.1 2.9 2.5 3.7 3.9 3.6 2.0 3.1 3.4 3.6 4.1 3.1 3.2 3.5 0.5 3.2
Frequency of tenseness / restlessness in last 2 weeks 3.5 5.5 9.4 2.3 0.0 2.0 2.7 2.9 2.5 -2.8 2.7 1.7 2.8 2.6 1.9 2.5 2.3 1.4 1.8 3.0 3.1 3.0 2.6 0.6 1.3
Hearing difficulty/problems with background noise 0.3 0.6 2.5 -0.7 0.0 -0.0 -0.3 -0.1 -0.6 0.6 0.1 -0.8 0.3 -0.2 -1.0 -1.6 -0.8 -1.2 -1.1 -0.0 -0.9 -0.4 -0.5 -1.0 -1.0
Hair/balding pattern: Pattern 2 0.2 0.3 1.1 -0.3 0.0 0.1 -0.2 -0.6 -0.1 0.2 -0.2 0.3 0.2 -0.6 -0.5 -1.0 -0.3 -0.8 -0.9 -0.8 -0.8 -0.1 -0.5 0.5 -0.8
Had menopause 0.5 0.7 2.3 -0.1 0.0 0.2 -1.1 -0.5 -0.6 1.2 -0.5 -1.5 -1.1 -1.3 -0.3 -0.3 -0.2 -0.3 -0.6 -1.5 -0.7 -1.0 -1.2 0.4 -0.5
Had other major operations 0.2 0.2 1.0 -0.8 0.0 -0.7 -0.6 -0.0 0.4 0.6 -0.6 -1.0 -0.6 -0.1 0.0 0.3 -0.2 -0.0 -0.2 -0.4 -0.6 -0.2 -0.4 0.1 0.6
Forced vital capacity (FVC) 3.9 15.0 22.9 -4.6 0.0 -4.1 -4.3 -3.4 -3.6 3.5 -4.8 -1.5 -3.9 -3.5 -4.6 -4.2 -4.2 -4.6 -4.5 -2.9 -4.3 -4.3 -4.0 -2.0 -4.5
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 5.8 1.2 0.0 2.4 1.4 0.7 1.4 -1.3 1.2 0.6 2.4 2.0 1.1 0.2 1.4 1.4 0.8 1.7 0.5 1.6 1.7 1.6 1.6
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 3.2 -0.2 0.0 1.8 0.1 -0.1 -0.9 -0.4 0.2 1.0 0.0 -0.4 -0.5 -1.6 -0.6 -0.9 -0.4 1.0 0.1 0.5 0.4 -0.7 -1.1
Qualifications: None of the above 0.5 1.1 4.9 0.1 0.0 1.1 0.9 -0.1 0.9 -1.0 0.7 1.2 1.8 0.8 0.5 0.7 -0.1 0.7 0.5 2.1 1.2 0.4 2.2 1.0 1.0
Financial difficulties in last 2 years 0.8 1.0 4.4 -0.5 0.0 -0.3 -0.9 -0.7 -1.1 0.5 -1.1 -0.7 -0.7 -1.0 -1.8 -0.4 -0.9 -1.9 -1.8 0.1 -1.0 -0.4 -0.4 -0.4 -2.1
Mouth/teeth dental problems 2.8 4.3 7.5 -1.8 0.0 -2.0 -2.3 -1.5 -1.9 2.3 -2.5 -2.2 -2.0 -1.8 -1.9 -2.3 -1.8 -2.0 -2.2 -2.2 -2.4 -2.4 -2.7 -1.8 -2.1
Heart attack 0.1 0.1 1.1 -0.2 0.0 0.3 0.4 -0.4 0.3 -0.3 -0.0 -0.1 0.2 0.2 -0.1 0.6 -0.4 -0.0 -0.2 0.3 0.2 -0.0 1.1 -0.4 0.3
Allergy 0.8 1.7 4.1 0.5 0.0 2.0 1.8 1.4 1.8 -1.4 1.6 1.6 1.9 1.4 1.2 0.1 1.1 0.7 1.0 1.3 0.5 1.2 1.5 1.3 1.0
Pain all over the body in last month 5.4 5.8 9.8 2.9 0.0 2.0 3.1 2.5 2.4 -2.9 3.0 -0.2 2.9 2.9 1.9 3.1 2.4 1.4 1.7 3.0 2.7 2.8 2.9 -0.4 1.0
Diabetes (self-reported) 1.9 2.9 5.8 -1.3 0.0 -0.6 -1.7 -1.4 -1.9 2.1 -1.5 -0.4 -0.8 -2.1 -2.2 -2.4 -1.8 -2.2 -2.1 -1.5 -2.2 -1.8 -1.7 -0.0 -2.3
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 1.0 0.5 0.0 0.3 0.0 0.4 -0.2 -0.1 0.6 0.0 0.2 0.0 -0.3 0.7 0.2 -0.5 -0.5 0.3 1.0 0.1 0.5 0.2 -0.9
Medication: Ramipril 4.3 5.5 10.6 3.1 0.0 0.2 2.3 2.1 2.4 -2.1 2.4 0.7 1.9 2.0 2.7 3.1 3.2 2.8 3.3 1.8 2.6 2.9 1.9 1.7 2.5
Medication: Simvastatin 0.2 0.3 2.3 -1.5 0.0 -0.1 -0.1 -0.6 0.1 0.2 -0.6 -0.8 -0.3 -0.9 -0.5 0.3 -1.1 -0.2 -0.2 0.1 -0.4 -0.4 -0.1 0.5 0.5
Fluid intelligence score 0.1 0.2 1.2 0.4 0.0 -0.1 0.5 -0.2 -0.3 -0.4 0.0 -0.4 1.1 0.5 0.1 -0.9 -0.1 0.2 0.4 0.7 -0.2 0.1 0.3 -0.1 0.1
Illnesses of siblings 3.4 4.7 8.4 -2.3 0.0 -1.7 -2.4 -2.1 -2.7 2.0 -2.6 0.6 -2.6 -2.4 -2.1 -2.9 -2.4 -2.0 -1.9 -2.6 -1.9 -2.7 -2.0 -1.3 -2.2
Neuroticism score 2.5 5.3 10.4 2.0 0.0 1.4 2.4 2.3 2.7 -2.7 2.0 1.2 2.3 3.0 2.5 2.0 2.5 2.1 2.5 3.2 2.9 2.4 2.6 0.4 2.4
Weight 0.6 2.9 9.8 2.3 0.0 1.8 1.6 0.6 1.3 -1.0 1.7 1.9 3.1 1.9 1.5 1.6 1.6 1.6 1.6 2.3 1.6 1.4 2.1 0.7 1.7
Impedance of arm (right) 0.4 2.1 5.2 -0.1 0.0 -0.2 2.2 1.9 1.9 -2.2 1.5 0.3 0.6 2.3 1.4 1.4 0.8 0.7 1.7 2.0 0.8 1.3 1.2 -2.0 0.8
Arm fat percentage (right) 2.6 10.2 18.8 3.3 0.0 2.8 4.3 3.3 3.6 -3.4 4.3 0.3 4.2 4.0 3.0 3.8 2.9 2.6 3.1 3.5 2.7 3.2 3.7 -0.5 2.9
Trunk fat-free mass 0.5 2.7 8.2 0.2 0.0 -0.4 -2.6 -2.9 -2.5 2.5 -2.3 1.6 -0.1 -1.8 -1.5 -1.9 -0.9 -0.6 -1.5 -0.7 -1.1 -1.7 -1.4 1.6 -1.0
Hip circumference 1.5 6.3 15.0 3.3 0.0 3.1 2.7 1.6 2.0 -2.2 3.0 1.7 3.9 3.2 2.2 2.0 2.4 2.1 2.4 3.3 2.5 2.5 2.9 0.3 2.0
Time employed in main current job 0.5 0.5 2.1 0.4 0.0 -0.1 1.3 0.7 0.3 -1.2 0.7 0.8 0.1 0.4 -0.1 0.5 0.2 -0.1 0.2 1.4 0.9 0.7 1.1 -1.2 -0.5
Alcohol intake versus 10 years previously 0.2 0.4 1.1 -0.9 0.0 -0.7 0.6 0.4 1.0 -0.6 0.7 0.1 -0.5 0.5 0.4 0.2 -0.4 0.0 0.7 1.0 -0.6 -0.3 1.0 -0.5 0.4
Father’s age at death 0.2 0.3 2.3 -0.1 0.0 0.4 -0.5 -0.1 -0.1 0.1 -0.7 1.5 -0.5 0.2 0.2 -0.6 0.1 -0.4 0.1 0.3 0.1 -0.1 -0.1 -1.2 -0.7
Worrier / anxious feelings 2.7 5.1 10.5 2.3 0.0 1.8 1.9 1.7 2.2 -2.0 1.8 1.0 2.3 2.4 2.4 2.6 2.5 2.4 2.2 3.2 3.0 2.6 2.9 1.8 2.4
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 3.4 0.8 0.0 -0.6 0.7 0.6 1.0 -0.8 0.8 1.1 0.5 0.9 0.7 1.9 0.7 0.7 1.1 1.6 1.1 1.1 1.3 0.1 0.9
Falls in the last year 0.5 0.6 2.4 -0.2 0.0 -1.5 -0.8 -1.2 -1.0 1.0 -0.6 0.3 -0.5 -0.4 -0.8 -0.9 -0.7 -0.4 -1.0 -0.4 -1.0 -1.0 -0.9 -0.4 -0.3
Hair/balding pattern: Pattern 3 1.7 2.6 4.5 1.8 0.0 0.7 2.1 2.0 2.0 -2.0 2.0 0.5 1.7 1.6 1.7 1.7 1.8 1.7 1.6 1.2 1.2 2.0 1.2 0.7 1.7
Number of live births 0.2 0.3 2.2 0.8 0.0 0.6 0.2 0.1 -0.1 0.1 0.3 1.5 0.6 0.0 0.3 -0.3 0.3 0.6 0.4 0.4 0.6 0.4 -0.0 1.0 0.4
Forced expiratory volume in 1-second (FEV1) 3.3 11.1 17.6 -4.2 0.0 -3.5 -3.6 -2.5 -2.8 2.9 -3.9 -1.5 -3.5 -2.8 -3.9 -3.7 -3.6 -4.1 -3.9 -2.5 -4.0 -3.6 -3.5 -2.1 -3.9
Pulse rate 0.8 1.3 3.4 0.6 0.0 1.7 1.0 0.3 0.7 -0.7 0.5 1.4 1.3 0.9 1.5 1.4 0.6 1.5 1.9 0.7 1.5 0.5 1.1 0.7 1.6
Happiness 0.1 0.1 1.1 -0.3 0.0 -0.9 0.0 -0.2 -0.4 -0.1 -0.3 0.2 -0.3 -0.2 -0.2 -1.1 -0.4 -0.1 -0.1 0.4 -0.4 -0.2 0.3 -0.1 0.0
Noisy workplace 2.1 2.5 4.7 1.4 0.0 1.7 1.4 1.2 1.7 -1.4 1.5 0.9 1.5 2.2 1.7 1.9 1.7 1.9 1.8 2.2 1.6 1.4 1.6 0.5 2.0
Qualifications: A levels/AS levels or equivalent 0.3 0.6 5.2 2.3 0.0 0.1 -0.1 0.3 -0.6 0.0 0.5 0.5 -0.1 -0.5 0.4 -0.6 1.3 0.3 0.7 -1.3 0.2 0.8 -1.0 0.3 -0.8
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 9.7 -1.0 0.0 0.5 -1.2 -1.3 -1.3 0.8 -1.5 -0.5 0.3 -0.0 -1.2 -2.9 -1.3 -1.8 -1.7 -0.3 -3.1 -1.8 -0.8 -1.5 -1.8
Mouth/teeth dental problems: Dentures 4.5 7.6 9.9 2.9 0.0 3.1 2.9 2.1 2.6 -2.7 3.0 2.8 3.1 3.0 3.0 3.1 2.8 2.7 3.1 3.0 3.2 2.7 3.1 1.5 2.4
Asthma 0.2 0.4 2.4 0.7 0.0 -0.5 -0.1 0.3 -0.6 0.2 0.1 -1.1 -0.3 -0.3 -0.6 1.5 -0.1 -0.2 -0.3 -0.0 1.4 0.3 -0.5 -0.5 -0.3
Medication: Ibuprofen (e.g. Nurofen) 5.1 6.5 10.8 -2.5 0.0 -1.6 -2.8 -2.1 -3.3 3.0 -2.7 -0.5 -2.1 -3.2 -3.2 -3.3 -2.7 -3.0 -3.1 -2.4 -1.4 -2.1 -3.1 -0.1 -3.0
Medication: Cholesterol lowering 0.8 1.2 3.5 -1.1 0.0 -1.1 -1.3 -1.8 -0.8 1.4 -1.9 -1.7 -0.8 -1.6 -0.6 0.2 -0.9 -0.2 -0.7 -1.2 -1.1 -1.1 -0.7 1.1 0.1
Depression (self-reported) 1.9 2.3 6.1 0.7 0.0 1.3 1.2 1.8 1.8 -1.3 1.3 1.0 0.1 1.4 2.0 2.5 1.7 1.7 2.4 0.1 2.4 1.3 1.1 0.0 1.8
Medication: Lansoprazole 0.1 0.1 1.3 -0.0 0.0 1.1 0.2 0.2 0.0 -0.2 0.3 -0.3 0.1 -0.1 -0.2 0.2 -0.3 -0.3 -0.2 0.1 0.3 -0.1 0.6 -0.9 -0.2
Prospective memory result 1.0 1.2 5.3 -0.2 0.0 0.4 -1.8 -1.1 -0.7 1.8 -1.3 0.2 -0.9 -1.3 -0.5 -0.1 -0.3 -0.1 -0.8 -2.3 -0.9 -1.2 -2.2 0.5 -0.3
Lung cancer (father) 1.9 2.2 6.5 0.8 0.0 1.4 2.0 2.5 1.3 -1.9 2.2 1.5 0.8 1.4 1.0 1.9 0.9 0.8 1.3 1.4 2.3 1.8 1.0 -0.7 1.1
Illnesses of mother 0.5 0.6 4.4 -2.1 0.0 -0.4 -0.2 -0.2 -0.7 0.0 -0.2 1.1 -0.4 -0.2 -0.5 -1.2 -1.5 -0.6 0.4 0.5 -0.0 -0.7 0.5 -0.7 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 3.0 9.4 16.9 -3.8 0.0 -2.9 -3.3 -2.5 -2.7 2.6 -3.5 -1.0 -2.7 -2.5 -3.9 -3.8 -3.5 -4.1 -3.9 -1.7 -3.4 -3.2 -2.8 -1.9 -3.9
Pulse wave Arterial Stiffness index 1.4 1.6 4.9 0.8 0.0 1.7 1.7 0.8 1.3 -1.7 1.2 -0.7 1.6 1.4 1.2 0.8 1.0 1.2 1.0 1.9 1.2 1.1 2.2 -0.1 1.2
Impedance of arm (left) 0.4 2.0 5.3 -0.5 0.0 -0.2 2.2 1.7 1.9 -2.3 1.2 0.3 0.4 2.2 1.4 1.4 0.6 0.6 1.8 2.0 1.0 1.2 1.4 -2.0 0.8
Arm fat mass (right) 1.8 7.2 16.2 3.1 0.0 2.6 3.3 2.2 2.7 -2.5 3.4 1.1 4.0 3.2 2.5 3.0 2.4 2.4 2.7 3.2 2.5 2.5 3.2 0.1 2.5
Trunk predicted mass 0.5 2.7 8.4 0.2 0.0 -0.5 -2.6 -2.9 -2.6 2.6 -2.3 1.6 -0.2 -1.9 -1.5 -1.9 -0.9 -0.7 -1.6 -0.9 -1.1 -1.7 -1.4 1.6 -1.0
Standing height 0.3 2.7 9.9 -1.1 0.0 -1.2 -2.2 -2.9 -2.2 2.0 -2.8 3.1 -0.4 -1.2 -1.2 -1.7 -1.3 -0.7 -0.8 0.1 -0.8 -1.7 -1.3 0.6 -1.0
Length of working week for main job 1.6 1.7 4.8 -1.0 0.0 -1.5 -1.8 -1.3 -1.4 2.0 -1.7 -0.2 -0.6 -1.4 -1.4 -0.7 -1.0 -0.8 -1.4 -1.4 -1.2 -1.3 -2.2 1.4 -0.7
Exposure to tobacco smoke at home 0.4 0.4 5.0 -0.7 0.0 -0.7 0.6 0.8 0.5 -0.5 0.6 -0.6 -0.3 0.4 -0.1 0.3 -0.4 -0.7 -0.0 0.6 0.1 -0.2 0.3 -2.2 -0.2
Breastfed as a baby 0.5 0.6 3.0 -1.1 0.0 -1.7 -0.6 -0.1 -0.7 0.4 -0.8 0.5 -0.8 -0.4 -0.6 -0.1 -0.7 -0.9 -0.3 -0.6 -0.4 -0.8 -0.6 -1.2 -1.1
Tense / ‘highly strung’ 2.7 4.4 8.7 1.4 0.0 1.5 2.4 2.0 1.8 -2.4 2.1 0.9 2.1 2.5 2.3 1.8 1.8 2.4 2.4 3.0 2.7 2.3 2.7 -0.5 2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 3.3 5.1 9.6 2.2 0.0 2.1 2.1 1.7 2.0 -2.3 1.8 2.3 2.7 2.8 2.4 1.4 2.4 2.0 2.4 3.1 2.9 2.8 2.8 0.9 1.9
Hair/balding pattern: Pattern 4 0.1 0.3 1.9 0.7 0.0 1.4 -0.6 -0.2 -0.4 0.7 -0.7 -0.3 0.8 0.3 0.4 -0.6 0.6 0.4 0.5 0.3 0.1 -0.2 -0.5 0.8 0.1
Birth weight of first child 0.4 0.7 5.1 0.2 0.0 -0.5 0.5 0.1 0.5 -0.8 -0.0 2.3 0.6 0.7 1.0 0.9 0.8 1.1 1.1 0.2 0.8 0.2 0.8 -0.0 1.0
Peak expiratory flow (PEF) 0.7 1.5 4.8 -1.3 0.0 -1.8 -0.9 -0.1 -0.7 0.5 -1.1 -0.4 -1.1 -0.5 -1.8 -1.3 -1.0 -2.1 -1.6 -0.7 -1.6 -0.9 -1.6 -1.0 -2.2
Pulse wave reflection index 0.3 0.4 1.5 -0.9 0.0 0.2 -0.6 -0.6 -0.5 0.1 -0.6 -1.1 -0.6 -0.4 -0.9 -0.6 -0.7 -0.9 -1.2 -0.1 -0.7 -0.3 0.1 -0.1 -1.0
Ever highly irritable/argumentative for 2 days 0.5 0.5 1.4 -0.3 0.0 -0.2 -1.1 -0.7 -1.1 0.9 -1.0 0.4 -0.6 -0.9 -0.6 -0.6 -0.2 -0.7 -0.8 -1.0 -0.3 -0.6 -1.2 0.6 -0.9
Loud music exposure frequency 0.6 0.6 2.7 0.0 0.0 -0.5 0.8 0.3 0.6 -0.8 0.7 -0.4 0.5 1.0 0.8 -0.2 0.1 0.4 0.9 1.5 -0.1 0.3 1.6 -1.6 0.5
Qualifications: O levels/GCSEs or equivalent 0.7 1.0 4.8 2.2 0.0 -0.8 0.9 1.4 0.2 -0.5 1.3 0.2 -0.7 0.4 1.0 0.4 1.6 0.9 1.6 -1.2 -0.1 1.1 -1.0 -0.9 0.1
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.6 -1.3 0.0 -0.4 -0.5 -0.4 0.2 0.0 -0.6 -1.0 -0.2 -0.3 -0.5 0.2 -0.8 -0.1 -0.3 -0.7 -0.8 -0.3 -0.2 0.7 0.6
Blood clot in the leg (DVT) 0.3 0.3 1.5 -0.0 0.0 1.2 -0.0 -0.3 -0.1 -0.3 0.1 0.5 0.9 0.6 0.2 -0.0 -0.2 0.4 0.7 1.2 0.8 0.6 0.7 0.3 0.6
Medication: Paracetamol 0.6 0.9 2.7 -1.2 0.0 -0.8 -0.3 0.7 -0.3 0.7 0.6 -0.8 -0.4 -0.1 -1.5 -1.2 -1.3 -1.6 -1.3 -0.1 -1.0 -0.7 -1.1 -1.5 -1.1
Headache pain in last month 0.1 0.3 1.2 -0.5 0.0 -1.1 -0.5 -0.4 -0.7 0.8 -0.3 -0.2 0.2 -0.4 -0.6 -0.1 -0.5 -0.8 -0.1 -0.5 -0.2 -0.5 -0.2 -0.0 -0.7
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.5 -0.2 0.0 0.3 -0.2 0.7 -0.4 0.2 0.4 0.4 -0.3 0.2 -0.5 -0.6 -0.3 -1.0 -0.4 -0.7 -0.2 -0.4 -0.9 -1.2 -1.2
Glaucoma (self-reported) 0.3 0.4 2.2 -0.3 0.0 -0.8 0.6 0.5 0.6 -0.5 0.2 0.5 0.1 0.9 0.3 1.5 0.1 0.0 0.8 0.7 0.4 0.1 0.6 -1.1 0.4
Gout (self-reported) 0.6 0.8 3.1 -0.2 0.0 0.0 -1.1 -1.5 -1.4 1.0 -1.5 1.0 0.5 -1.0 -0.3 -1.6 -0.6 -0.0 -0.2 -0.2 -0.7 -0.7 -0.5 1.8 -0.2
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 5.7 -2.4 0.0 -1.5 -0.6 0.2 -0.8 0.5 -0.5 -1.1 -0.6 -0.7 -1.7 -0.6 -1.8 -2.1 -1.4 -0.9 -1.1 -1.0 -1.1 -1.9 -1.9
Medication: Amlodipine 0.1 0.2 0.9 -0.4 0.0 0.5 0.0 -0.6 0.2 -0.1 -0.4 0.0 0.0 -0.8 -0.5 0.0 -0.6 -0.4 -0.3 0.5 -0.0 -0.1 0.5 1.0 -0.2
Medication: Ventolin 100micrograms inhaler 0.8 1.0 4.7 -0.1 0.0 -0.7 -0.3 -0.0 -1.2 0.3 -0.3 -1.9 0.1 -0.4 -1.4 -0.2 -0.7 -1.5 -1.0 0.3 -0.1 -0.8 -0.7 -2.2 -2.0
Birth weight 2.7 5.8 12.4 -2.2 0.0 -0.7 -3.0 -2.8 -2.4 3.0 -2.9 -0.7 -2.4 -2.5 -2.3 -2.1 -2.6 -2.1 -2.5 -3.0 -3.1 -3.5 -2.9 -1.0 -1.8
Chronic bronchitis/emphysema (mother) 0.5 0.5 3.5 -0.2 0.0 0.1 0.8 0.7 1.1 -1.1 0.5 0.4 0.4 0.9 0.2 0.6 0.3 -0.2 0.3 1.9 0.7 0.5 0.7 -0.9 -0.3
High blood pressure (siblings) 5.7 8.3 13.2 2.5 0.0 2.1 3.2 2.9 3.6 -3.1 3.1 0.5 3.1 3.4 3.1 3.4 3.0 2.9 3.0 3.0 2.9 3.4 3.0 1.1 3.3
Forced vital capacity (FVC), Best measure 2.5 9.0 15.3 -3.7 0.0 -2.8 -3.3 -2.8 -2.8 2.5 -3.7 -0.4 -2.5 -2.3 -3.8 -3.7 -3.6 -3.9 -3.7 -1.4 -3.3 -3.3 -2.6 -1.7 -3.7
Body fat percentage 3.7 14.6 25.6 3.4 0.0 3.6 5.1 3.8 4.3 -4.2 5.0 1.6 5.0 4.7 3.6 4.3 3.2 3.1 4.1 4.3 3.6 3.8 4.6 -0.5 3.4
Leg fat percentage (right) 3.0 11.0 21.8 3.2 0.0 3.5 4.4 3.5 3.6 -3.7 4.7 1.4 4.3 3.9 3.0 3.6 2.9 2.5 3.2 3.5 3.2 3.5 4.0 -0.7 2.7
Arm fat-free mass (right) 0.1 0.7 3.8 0.9 0.0 0.4 -1.0 -1.4 -1.1 1.3 -0.8 1.9 0.8 -0.7 -0.2 -0.5 0.1 0.5 0.1 0.3 0.4 -0.4 -0.1 1.6 0.3
Exposure to tobacco smoke outside home 0.1 0.2 1.3 -0.8 0.0 -0.0 0.2 -0.1 -0.2 0.1 0.0 -1.1 -0.1 0.1 -0.1 -0.2 -0.6 -0.2 -0.0 -0.5 -0.3 -0.3 -0.3 -0.9 0.3
Comparative body size at age 10 0.3 0.8 4.6 0.5 0.0 -0.5 -0.8 0.6 -0.6 1.1 0.0 -0.1 -0.9 -0.6 -0.8 -0.0 0.3 -0.8 -0.5 -2.1 -1.0 -0.2 -2.1 0.0 -1.1
Number of full brothers 0.2 0.2 1.5 0.2 0.0 -1.2 0.2 -0.2 0.5 -0.5 0.1 -0.9 0.2 0.2 0.4 0.1 0.3 0.2 0.2 0.6 -0.5 0.0 0.5 0.8 0.3
Worry too long after embarrassment 1.6 2.7 7.3 0.9 0.0 1.5 1.6 1.0 1.5 -1.9 1.0 1.2 2.1 2.1 1.8 1.3 1.4 1.3 2.1 2.7 2.3 1.4 2.3 0.6 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 5.2 0.9 0.0 0.1 0.7 0.9 1.0 -1.0 0.3 0.8 0.8 1.9 2.1 1.2 1.6 2.0 2.3 1.6 1.9 1.3 1.5 0.5 2.1
Wheeze or whistling in the chest in last year 0.4 0.7 5.0 0.1 0.0 0.7 0.8 0.1 0.2 -0.8 0.5 0.1 0.8 0.5 -0.0 1.2 0.0 0.1 0.6 2.2 1.3 0.6 1.7 -0.3 0.1
Number of children fathered 0.6 0.7 2.7 -0.5 0.0 -0.4 0.1 0.0 0.0 0.0 0.6 -0.0 -0.7 -0.3 -1.3 -0.6 -0.7 -1.5 -1.6 -0.2 -1.6 -0.4 -0.0 -1.3 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.8 -0.1 0.0 0.5 0.0 0.0 0.2 -0.5 -0.2 -0.4 -0.1 -0.1 0.5 1.0 0.3 0.4 0.9 0.8 1.3 0.5 0.4 0.7 0.2
Age at first live birth 1.0 1.8 4.8 -1.5 0.0 -1.9 -1.3 -1.1 -0.7 1.4 -1.7 -0.3 -2.2 -1.7 -0.5 -1.3 -1.0 -0.6 -0.7 -2.0 -2.1 -1.7 -1.4 -0.6 -0.4
Pulse wave peak to peak time 1.4 1.6 4.7 -0.7 0.0 -1.8 -1.8 -0.9 -1.3 1.7 -1.3 1.0 -1.4 -1.3 -1.2 -0.8 -0.9 -1.1 -0.9 -1.8 -1.2 -1.1 -2.2 0.2 -1.2
Health satisfaction 0.2 0.3 1.0 -0.9 0.0 -0.4 -0.2 -0.5 -0.2 0.2 -0.5 -0.7 -0.1 -0.5 -0.6 -0.2 -0.9 -0.6 -0.7 0.3 -1.0 -0.5 0.2 0.1 -0.2
Shortness of breath walking on level ground 0.5 0.5 1.8 0.4 0.0 -0.5 0.6 0.7 0.7 -0.4 1.0 1.3 -0.1 0.7 0.7 1.2 0.4 0.8 0.5 0.7 0.6 0.1 0.8 -0.8 1.4
Qualifications: College or University degree 0.3 1.0 5.4 0.5 0.0 -1.5 -1.2 0.3 -1.0 1.1 -0.7 -0.7 -1.7 -1.0 -0.4 -0.6 0.4 -0.5 -0.5 -2.3 -0.0 -0.1 -1.8 -0.7 -1.0
Eye problems/disorders: None of the above 0.3 0.4 1.5 0.7 0.0 -1.0 0.7 1.2 -0.3 -0.0 1.2 0.2 0.1 -0.0 0.4 0.0 0.8 0.3 0.4 -0.4 0.6 0.7 -0.6 -0.7 -0.3
Mouth/teeth dental problems: Loose teeth 0.3 0.3 1.3 -0.8 0.0 -1.2 0.7 0.9 0.8 -0.5 0.3 -0.8 -0.6 0.0 0.2 0.5 0.2 -0.2 0.3 0.4 0.3 0.5 0.3 -0.6 0.2
Emphysema/chronic bronchitis 1.4 1.6 10.4 -0.8 0.0 -1.6 -0.1 0.5 -0.5 -0.2 0.1 -0.7 -1.3 -0.8 -1.6 -0.2 -1.3 -2.2 -1.0 0.3 -0.7 -0.6 -0.3 -3.2 -2.5
Medication for pain relief, constipation, heartburn 1.8 3.1 7.0 1.9 0.0 2.3 1.9 0.9 1.8 -2.5 1.3 0.6 1.9 2.3 2.0 1.9 1.9 1.7 1.9 1.8 1.2 1.5 2.6 0.6 1.3
Neck or shoulder pain in last month 0.5 0.7 2.7 -0.3 0.0 -0.1 -1.1 -1.4 -1.2 0.8 -1.4 0.6 0.1 -0.7 -0.5 -1.6 -0.5 -0.5 0.3 0.2 -0.8 -0.6 -0.7 0.9 -0.8
Medication: Blood pressure 0.6 1.0 2.2 1.2 0.0 0.5 0.8 -0.1 0.8 -0.8 0.5 0.4 1.1 0.5 0.9 1.0 0.9 1.5 0.9 1.5 1.1 1.1 1.3 1.4 1.4
Angina (self-reported) 0.2 0.3 1.2 0.7 0.0 0.1 0.4 0.4 0.3 -0.3 0.6 -0.6 -0.6 0.0 0.4 1.1 0.5 0.6 0.4 0.6 0.9 0.7 0.5 -0.1 0.6
Migraine (self-reported) 2.7 3.4 8.3 -2.2 0.0 -1.4 -1.9 -2.4 -1.8 2.1 -2.3 -0.1 -0.5 -1.5 -1.8 -2.4 -2.1 -1.8 -1.6 -1.7 -2.9 -2.7 -1.3 -0.9 -1.7
Medication: Ibuprofen 5.3 6.3 12.1 -2.7 0.0 -1.2 -2.7 -2.0 -3.2 2.8 -2.6 0.2 -1.9 -3.0 -3.3 -3.5 -2.9 -3.2 -3.3 -2.0 -1.5 -2.1 -2.8 -0.3 -3.1
Medication: Allopurinol 0.5 0.6 2.7 0.1 0.0 -0.2 -1.2 -1.4 -1.1 1.0 -1.4 0.5 0.2 -0.7 -0.1 -1.0 -0.4 0.1 -0.1 0.2 -0.7 -0.6 -0.4 1.6 -0.1
Medication: Omeprazole 0.7 0.8 3.2 -0.3 0.0 -0.3 -1.2 -1.3 -0.7 1.5 -0.9 -1.5 -0.9 -0.5 -0.2 -0.8 -0.2 0.2 -0.6 -0.7 -1.8 -1.1 -1.2 0.4 0.4
Medication: Seretide 50 evohaler 0.3 0.4 2.3 0.7 0.0 -0.4 -0.3 0.3 -0.5 0.2 0.1 -1.5 -0.9 -0.5 -0.4 1.2 0.0 0.1 -0.2 -1.0 0.7 0.1 -0.8 -0.5 -0.1
Mean time to correctly identify matches 0.3 0.7 2.1 1.0 0.0 1.1 0.8 0.9 0.8 -0.3 1.4 0.6 0.8 0.7 0.7 0.8 0.8 0.8 0.6 1.0 0.6 0.8 0.9 0.6 0.8
Heart disease (mother) 0.4 0.5 1.8 0.7 0.0 -0.6 0.6 0.1 0.8 -0.4 0.1 -1.3 0.6 0.6 1.0 0.8 0.8 1.2 0.9 0.2 -0.1 0.5 0.4 0.1 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.9 -1.7 0.0 -0.6 -0.3 -0.2 -0.5 0.2 -0.7 -0.8 -1.5 -0.9 -0.6 -0.9 -1.1 -0.6 -0.4 -0.5 -0.6 -0.6 -0.2 -1.0 -0.5
Whole body fat mass 2.2 9.3 19.9 3.2 0.0 3.1 3.7 2.5 3.0 -2.8 3.8 1.8 4.5 3.6 2.9 3.5 2.7 2.6 3.2 3.6 3.2 2.9 3.6 0.1 2.7
Leg fat mass (right) 2.2 8.4 17.7 3.3 0.0 3.2 3.5 2.4 2.8 -2.7 3.7 1.8 4.2 3.4 2.6 3.1 2.6 2.4 2.9 3.3 3.0 2.9 3.5 0.0 2.4
Arm predicted mass (right) 0.2 0.9 4.0 0.9 0.0 0.3 -1.3 -1.8 -1.4 1.6 -1.0 2.0 0.8 -1.0 -0.4 -0.7 -0.1 0.3 -0.1 -0.0 0.2 -0.6 -0.2 1.7 0.1
Pulse rate, automated reading 3.0 9.7 20.6 2.3 0.0 3.6 3.9 2.5 2.7 -3.4 3.3 3.5 3.8 3.5 2.8 3.2 1.8 2.4 3.5 4.4 3.5 2.6 4.5 -0.9 2.5
Alcohol intake frequency. 0.7 1.5 5.7 0.1 0.0 1.3 1.3 0.8 1.4 -1.3 1.0 1.1 1.7 1.5 1.2 0.5 0.5 1.0 1.3 2.4 0.8 0.9 1.8 1.5 1.2
Comparative height size at age 10 0.1 0.7 7.3 1.5 0.0 1.3 0.0 -0.3 -0.5 0.3 0.5 2.7 1.3 0.1 0.2 -0.2 0.6 0.2 0.4 0.5 0.8 0.3 0.1 0.7 -0.3
Number of full sisters 0.5 0.6 1.8 -0.1 0.0 -0.3 -0.6 -1.3 -0.8 1.1 -0.4 -0.4 -0.4 -1.1 -0.9 -0.8 -1.0 -0.6 -1.2 -0.4 -1.2 -1.1 0.1 -0.1 -0.5
Suffer from ‘nerves’ 3.9 6.1 10.6 2.4 0.0 1.4 2.4 2.4 2.5 -2.4 2.1 1.1 2.0 2.7 3.2 3.2 3.0 3.1 3.1 1.6 3.0 2.8 2.7 0.9 3.0
Overall health rating 0.5 1.2 6.0 0.6 0.0 0.3 1.6 0.5 1.2 -1.3 1.2 -0.7 1.2 1.2 0.6 1.2 0.4 0.6 0.7 2.5 0.3 0.9 2.0 -0.1 0.9
Chest pain or discomfort 0.2 0.2 0.7 -0.3 0.0 -0.5 0.3 0.4 -0.1 -0.3 0.3 0.4 0.4 0.3 -0.5 0.7 -0.3 -0.6 -0.4 0.8 0.7 0.4 0.3 -0.7 -0.5
Had major operations 0.1 0.1 0.5 -0.2 0.0 -0.2 -0.2 -0.2 0.1 0.5 -0.3 -0.7 -0.3 -0.3 0.2 0.1 0.1 0.1 0.2 -0.3 0.1 0.2 0.2 0.3 0.2
Age at last live birth 1.2 1.7 4.4 -1.8 0.0 -2.0 -1.7 -1.4 -0.8 1.5 -1.9 -0.2 -2.1 -1.4 -0.5 -0.8 -1.1 -0.4 -0.8 -1.9 -1.4 -1.9 -1.1 -0.2 -0.0
Family relationship satisfaction 1.1 1.4 3.1 -1.7 0.0 -0.4 -0.9 -0.5 -0.8 0.6 -1.2 -0.9 -1.1 -0.9 -1.6 -0.9 -1.6 -1.8 -1.7 -0.6 -1.6 -1.1 -0.5 -1.3 -1.5
Leg pain on walking 1.3 1.7 3.0 1.4 0.0 0.7 1.5 1.4 1.3 -1.7 1.7 1.0 1.5 1.7 1.3 0.7 1.5 1.0 1.3 1.2 1.2 1.7 1.4 0.5 1.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 2.7 -0.2 0.0 -1.6 0.0 -0.1 0.1 0.0 -0.0 -0.0 0.0 0.2 0.0 0.4 0.1 0.0 -0.0 0.4 0.1 -0.1 0.2 0.1 0.2
Commuting to job workplace: Car/motor vehicle 0.5 0.6 5.1 -0.5 0.0 0.6 -0.2 0.2 -0.4 -0.0 0.3 2.2 -0.5 -0.0 -0.5 -1.1 -0.5 -1.0 -0.3 -0.1 -0.4 -0.3 0.0 -1.6 -1.0
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 2.1 -0.6 0.0 -0.8 -0.1 -0.3 -0.6 0.4 -0.2 0.1 -1.2 -1.5 -0.2 -0.2 -0.6 0.2 0.1 -0.9 0.5 -0.4 -0.6 0.1 0.1
Medication: Aspirin 0.2 0.2 0.9 0.2 0.0 -0.8 -0.2 0.2 -0.2 0.8 0.1 0.3 -0.3 -0.9 0.4 0.7 0.1 0.7 0.5 -0.3 0.8 0.2 -0.3 -0.2 0.7
Supplements: Vitamin C 0.4 0.5 3.6 -0.1 0.0 -0.7 -0.6 -0.9 -0.4 0.0 -0.8 1.5 -0.2 -0.3 -0.2 0.2 0.0 0.2 -0.5 1.4 0.3 -0.0 1.0 1.9 0.2
Knee pain experienced in last month 0.6 1.0 3.3 1.4 0.0 -1.4 -1.2 -1.1 -0.6 1.5 -0.6 -0.1 -1.3 -1.3 0.0 0.4 0.8 0.3 -0.4 -1.8 -0.1 -0.5 -1.2 1.5 -0.2
Hypertension (Self-reported) 3.1 8.5 15.8 3.5 0.0 4.0 2.8 1.4 2.4 -2.5 2.7 0.8 3.3 2.2 2.7 2.9 3.1 3.5 2.5 3.3 3.6 3.5 3.4 3.3 3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.8 -0.6 0.0 -0.2 -0.3 -0.3 -0.2 0.4 -0.1 -0.2 -1.1 -0.4 -0.1 0.1 -0.6 -0.0 -0.0 -0.3 -0.8 -0.8 -0.1 -1.4 0.1
Illnesses of father: Heart disease 3.3 4.6 8.6 2.2 0.0 1.8 2.2 1.9 2.2 -2.3 1.8 2.0 2.9 2.6 2.2 2.4 2.4 2.1 2.3 1.8 2.2 2.6 2.3 1.6 2.0
Illnesses of siblings: Diabetes 0.2 0.3 1.0 0.5 0.0 -0.1 0.2 1.0 0.4 -0.1 0.8 -0.7 0.4 0.5 0.4 0.0 0.7 0.1 0.6 -0.1 -0.1 0.8 -0.9 0.3 -0.0
Smoking status: Previous 2.8 4.1 6.8 -2.4 0.0 -2.5 -1.9 -1.4 -2.0 2.6 -1.7 -1.1 -1.5 -2.5 -2.4 -1.5 -2.3 -2.6 -2.6 -1.5 -2.1 -2.2 -2.2 -1.0 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.2 6.9 -1.4 0.0 -1.5 -1.9 -2.6 -2.3 1.9 -2.2 2.2 -1.2 -2.0 -2.0 -2.4 -2.0 -1.8 -1.9 -0.4 -1.6 -1.8 -1.3 -0.5 -1.9
Whole body fat-free mass 0.2 1.2 4.6 0.8 0.0 0.1 -1.7 -2.1 -1.6 1.9 -1.5 1.5 0.6 -1.0 -0.8 -0.9 -0.3 -0.0 -0.7 -0.1 -0.4 -1.0 -0.6 1.7 -0.3
Leg fat-free mass (right) 0.1 0.7 3.1 1.2 0.0 0.4 -1.0 -1.6 -0.8 1.4 -0.9 1.1 1.3 -0.3 -0.2 -0.2 0.1 0.4 -0.1 0.5 -0.2 -0.7 -0.2 1.8 0.3
Arm fat percentage (left) 2.7 10.7 19.1 3.3 0.0 2.8 4.4 3.3 3.7 -3.5 4.3 0.5 4.3 4.0 3.1 3.8 2.9 2.7 3.4 3.5 2.9 3.2 3.8 -0.5 3.0
Average weekly red wine intake 0.3 0.4 2.6 0.3 0.0 -1.6 -0.2 -0.1 -0.5 0.2 -0.3 -0.1 -0.8 -1.0 -0.6 -0.6 0.1 -0.6 -0.3 -0.7 0.2 0.2 -0.6 0.6 -0.9
Handedness (chirality/laterality): Left-handed 0.7 0.9 5.6 0.1 0.0 -0.9 0.6 0.6 1.0 -0.6 0.5 -2.4 -0.2 1.1 1.2 0.9 0.8 1.2 1.4 0.3 -0.3 0.6 0.1 0.5 1.5
Mood swings 1.7 3.0 6.1 1.5 0.0 0.7 1.7 1.7 2.3 -1.9 1.8 1.2 1.7 2.5 1.9 1.7 1.9 1.8 1.5 2.2 1.6 2.0 1.4 1.3 2.2
Loneliness, isolation 0.1 0.2 0.8 0.1 0.0 -0.2 -0.0 0.1 0.4 -0.5 -0.2 -0.0 0.4 0.5 0.4 0.6 0.4 0.5 0.4 0.6 0.4 0.4 -0.0 0.9 0.5
Long-standing illness, disability or infirmity 0.1 0.2 0.8 -0.4 0.0 -0.2 0.2 0.1 0.3 -0.2 -0.0 -0.9 0.3 0.2 -0.4 0.6 -0.4 -0.6 -0.4 0.7 -0.2 -0.1 0.6 -0.8 -0.5
Ever had bowel cancer screening 0.2 0.2 1.0 0.3 0.0 0.3 0.2 0.5 0.5 -0.1 0.4 0.1 -0.8 0.2 0.6 1.0 0.5 0.5 0.5 -0.8 0.3 -0.0 0.2 -0.4 0.6
Diabetes diagnosed by doctor 1.1 1.7 3.6 -1.2 0.0 -0.4 -1.2 -1.0 -1.3 1.5 -1.1 -0.7 -0.5 -1.7 -1.7 -1.9 -1.4 -1.8 -1.7 -1.1 -1.8 -1.3 -1.3 -0.2 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 2.8 -0.8 0.0 -0.4 -0.4 0.1 -0.6 0.3 -0.6 -0.3 -1.0 -0.9 -0.9 -1.1 -0.8 -1.4 -0.8 -0.6 -1.5 -0.8 -0.9 -1.4 -1.7
Friendships satisfaction 0.3 0.4 2.7 -0.4 0.0 -1.0 0.6 0.9 0.2 -0.8 0.4 -1.6 -0.9 0.2 -0.2 -0.1 -0.4 -0.0 0.0 0.3 -0.1 0.2 0.2 -1.3 0.2
Qualifications: nursing, teaching 1.2 1.9 5.5 -0.6 0.0 -0.3 -1.7 -1.3 -1.3 1.5 -1.2 -1.1 -0.5 -0.7 -1.3 -1.9 -0.8 -1.7 -1.4 -1.7 -2.4 -1.5 -1.8 -0.6 -2.1
Commuting to job workplace: Walk 0.4 0.4 5.5 0.4 0.0 -0.8 -0.0 0.3 -0.2 0.0 -0.2 -2.4 0.3 0.0 0.2 -0.8 0.3 -0.2 0.3 -0.2 -0.2 -0.0 -0.7 -0.6 -0.7
Eye problems/disorders: Cataract 1.5 1.7 3.8 -1.0 0.0 1.0 -1.1 -1.4 -1.2 1.1 -1.3 0.0 -0.4 -1.0 -1.7 -1.9 -1.7 -1.9 -1.9 -0.9 -1.6 -1.3 -1.1 -0.8 -1.8
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 2.4 1.1 0.0 0.3 1.3 0.4 0.1 -1.0 1.6 0.6 0.7 0.3 0.3 0.0 0.5 0.1 0.3 0.7 0.4 1.0 1.2 -0.1 -0.1
Medication for cholesterol 0.7 1.1 5.5 -0.6 0.0 -1.8 -0.5 -0.1 -0.6 0.4 -0.2 0.9 -1.8 -0.6 -0.3 -0.8 -0.6 -0.8 -0.2 -2.3 -1.0 -1.2 -1.0 -1.7 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 6.0 0.2 0.0 1.2 1.0 1.0 2.1 -1.5 0.8 0.8 0.8 1.4 1.8 2.1 1.1 1.9 1.5 1.1 2.1 1.3 1.4 1.1 2.4
Back pain experienced in last month 0.3 0.4 1.7 -1.3 0.0 -1.1 -0.8 -0.6 -0.6 0.7 -1.2 0.2 -0.8 -0.4 -0.5 0.5 -0.8 -0.3 0.3 0.1 -0.1 -0.7 -0.6 -0.4 -0.1
Mineral and other dietary supplements 0.3 0.4 1.7 -0.5 0.0 -0.6 0.6 1.3 0.6 -0.5 0.6 1.1 -0.4 0.4 -0.0 -0.3 0.1 -0.3 0.6 -0.3 0.1 0.4 -0.5 -1.3 -0.1
Breast cancer (self-reported) 1.7 2.1 4.6 2.0 0.0 0.6 1.8 0.7 1.4 -1.4 1.6 -0.2 1.0 1.1 1.9 1.5 1.7 2.1 1.7 0.9 1.3 1.3 1.7 1.1 2.1
Asthma (self-reported) 0.2 0.4 2.1 0.7 0.0 -0.7 -0.1 0.4 -0.6 0.2 0.3 -0.9 -0.5 -0.3 -0.6 1.4 -0.1 -0.2 -0.3 0.1 1.3 0.3 -0.6 -0.6 -0.4
Osteoporosis (self-reported) 0.2 0.3 0.9 -0.5 0.0 -0.8 0.8 0.8 0.7 -0.9 0.4 -0.0 -0.3 -0.0 -0.1 0.8 -0.1 -0.6 0.1 0.1 0.7 0.6 0.2 -0.1 -0.3
Osteoarthritis (self-reported) 0.7 0.9 5.5 2.3 0.0 -0.3 0.7 0.3 0.4 -0.3 0.8 -1.1 0.3 0.1 1.0 1.5 1.6 1.2 0.8 -0.4 1.2 0.9 0.5 0.5 0.5
Medication: Aspirin 0.2 0.2 1.1 0.4 0.0 -0.4 -0.3 0.1 -0.3 0.8 0.1 0.6 -0.4 -1.0 0.2 0.4 0.2 0.6 0.1 -0.2 0.8 0.3 -0.3 0.4 0.6
Medication: Gliclazide 4.2 4.7 11.6 -1.3 0.0 -2.4 -2.3 -1.4 -2.3 2.5 -1.6 -1.4 -3.1 -3.2 -1.8 -2.6 -1.7 -1.9 -1.9 -3.4 -2.2 -2.4 -2.4 -1.1 -2.2
Illnesses of father: None of the above (group 1) 0.3 0.4 2.8 -1.0 0.0 -0.6 -0.4 0.1 -0.3 0.4 -0.2 1.0 -1.7 -0.7 0.0 0.6 -0.6 0.0 0.3 -0.6 0.8 -0.7 0.2 -1.0 0.2
Smoking status: Current 1.7 2.7 5.7 -1.8 0.0 -0.8 -1.6 -2.1 -2.1 1.4 -1.9 1.9 -1.0 -1.7 -1.8 -2.4 -2.1 -1.7 -1.8 -0.5 -1.6 -1.9 -1.2 -0.5 -1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.6 3.2 -1.8 0.0 -1.7 -1.4 -0.4 -0.6 0.8 -1.5 -0.5 -1.5 -0.4 -1.2 -1.7 -1.2 -1.6 -1.4 -0.2 -1.5 -1.3 -0.8 -1.6 -1.6
Whole body water mass 0.2 1.2 4.8 0.7 0.0 -0.0 -1.7 -2.2 -1.6 1.9 -1.6 1.5 0.6 -1.0 -0.7 -1.0 -0.3 0.0 -0.7 -0.1 -0.5 -1.1 -0.6 1.6 -0.2
Leg predicted mass (right) 0.1 0.7 3.0 1.2 0.0 0.4 -0.9 -1.5 -0.8 1.4 -0.9 1.2 1.4 -0.2 -0.2 -0.2 0.2 0.4 -0.1 0.6 -0.1 -0.6 -0.1 1.7 0.3
Arm fat mass (left) 2.0 8.2 15.8 3.3 0.0 2.5 3.5 2.4 3.0 -2.7 3.6 1.1 4.0 3.4 2.8 3.3 2.7 2.7 3.0 3.2 2.7 2.8 3.4 0.2 2.8
Number of self-reported non-cancer illnesses 0.3 0.6 4.0 0.5 0.0 0.5 0.0 -0.5 0.5 -0.2 -0.3 0.0 0.3 -0.1 0.2 2.0 0.3 0.7 0.5 0.8 1.2 0.7 1.0 1.8 0.8
Average weekly champagne plus white wine intake 0.8 1.1 6.9 -0.5 0.0 -2.6 -1.1 -0.4 -0.5 0.9 -0.9 -0.4 -2.0 -1.1 -0.1 0.3 -0.3 0.1 -0.2 -2.4 -0.6 -0.8 -1.2 0.4 0.3
Miserableness 1.5 2.6 7.4 1.2 0.0 1.1 1.6 1.7 1.5 -1.8 1.8 0.9 1.7 2.3 1.8 0.6 1.5 1.2 2.1 2.7 2.1 1.7 1.5 -0.6 1.4
Guilty feelings 1.2 1.8 5.1 0.6 0.0 -0.2 1.0 1.8 2.1 -1.3 1.1 -0.1 1.0 1.7 1.5 2.3 1.6 1.3 1.0 1.1 1.7 1.7 1.0 0.9 1.7
Wears glasses or contact lenses 0.7 0.8 3.2 1.2 0.0 1.6 0.5 0.9 0.9 -0.5 0.9 0.2 1.8 1.0 1.1 0.6 1.3 0.9 0.4 -0.3 0.4 0.9 -0.0 0.1 0.7
Ever taken oral contraceptive pill 2.1 2.3 4.1 -1.9 0.0 -1.7 -2.0 -1.7 -1.7 1.8 -1.9 0.9 -1.6 -1.8 -1.4 -1.5 -1.8 -1.1 -1.8 -1.5 -0.9 -1.5 -1.7 0.9 -0.7
Hearing aid user 0.2 0.2 1.1 -0.3 0.0 0.3 -0.5 -0.0 -0.1 0.6 0.0 -0.2 0.4 -0.1 -0.1 -1.1 -0.1 0.2 -0.2 -0.2 -0.4 0.0 -0.9 0.7 0.5
Mother’s age at death 0.4 0.5 2.1 0.7 0.0 1.0 1.0 1.2 0.5 -0.7 1.0 -1.5 1.0 0.5 0.4 -0.1 0.7 0.1 0.2 -0.3 0.3 0.8 -0.5 -0.7 -0.3
Financial situation satisfaction 0.7 0.9 2.4 -1.0 0.0 -0.3 -1.2 -1.2 -0.9 0.9 -1.3 -0.4 -0.3 -0.9 -1.2 -1.1 -1.0 -1.0 -1.6 -0.1 -1.0 -0.7 -0.9 1.4 -0.9
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.4 -0.3 0.0 1.3 1.0 1.3 0.9 -1.4 0.6 -0.7 0.8 1.3 0.2 -0.3 -0.2 -0.0 0.2 1.1 0.2 0.6 1.0 -1.5 0.4
Commuting to job workplace: Public transport 0.6 0.7 5.2 1.4 0.0 0.6 -0.2 -0.3 -0.0 0.3 -0.1 0.4 0.6 -0.1 0.8 0.7 1.1 1.3 0.7 -0.1 1.1 0.6 -0.5 2.3 1.0
Eye problems/disorders: Glaucoma 0.7 0.9 2.5 0.2 0.0 0.5 1.0 0.4 1.4 -1.2 0.4 0.7 0.9 1.3 1.0 1.6 0.6 0.8 1.1 1.3 0.9 0.7 1.2 0.2 1.1
Medication: Blood pressure 4.4 8.5 13.7 3.2 0.0 2.6 3.2 2.3 3.0 -2.7 3.0 0.3 2.9 2.6 2.9 2.9 3.3 3.4 2.7 3.6 3.2 3.7 3.5 2.5 3.4
Pain type(s) experienced in last month: Hip pain 2.1 2.6 6.1 1.9 0.0 0.5 1.5 1.4 1.9 -1.4 1.6 0.6 1.3 1.6 2.0 2.5 2.4 1.6 1.7 1.5 2.1 1.8 2.0 1.0 1.3
Supplements: Fish oil (including cod liver oil) 0.7 0.9 4.1 1.2 0.0 1.6 0.3 -0.7 0.1 -0.4 0.0 -0.5 1.4 0.5 0.9 0.6 0.8 1.3 0.3 1.3 0.6 0.5 1.6 2.0 0.9
High cholesterol (Self-reported) 1.4 2.6 5.3 -2.3 0.0 -1.3 -2.0 -1.8 -1.0 1.6 -2.3 -1.3 -1.6 -2.0 -1.8 -0.6 -2.1 -1.4 -1.9 -1.2 -1.9 -1.7 -1.4 1.1 -0.7
Medication: Bendroflumethiazide 7.4 11.2 19.1 3.5 0.0 2.4 4.1 3.6 3.7 -3.9 3.9 0.8 2.9 3.6 3.4 3.4 3.9 3.1 3.4 4.4 3.3 4.2 4.0 1.1 3.0
Medication: Paracetamol 0.4 0.7 2.0 -1.1 0.0 -1.0 -0.2 0.5 -0.4 0.4 0.6 0.2 0.0 -0.2 -1.4 -1.2 -1.2 -1.4 -1.2 0.0 -0.5 -0.4 -0.8 -0.8 -1.1
Medication: Lisinopril 0.5 0.7 2.5 1.0 0.0 1.4 0.2 -0.9 0.7 -0.3 -0.0 1.5 1.0 0.2 0.5 -0.4 0.6 0.5 -0.3 1.4 0.6 0.3 1.2 1.6 0.5
Medication: Atorvastatin 2.5 3.1 10.3 -0.5 0.0 -0.9 -2.8 -2.8 -1.8 2.3 -3.2 -1.0 -1.2 -2.1 -1.5 -1.1 -0.9 -0.7 -2.0 -1.4 -1.6 -1.6 -1.5 2.5 -0.9
Illnesses of father: High blood pressure 0.2 0.3 1.2 0.5 0.0 0.5 -0.5 -0.6 -0.4 0.9 0.1 -1.1 1.0 -0.1 -0.2 -0.7 0.0 -0.0 -0.2 0.0 -0.6 -0.1 -0.7 0.8 -0.3
Alcohol drinker status: Never 1.2 1.4 5.7 0.4 0.0 1.3 1.1 1.0 1.3 -1.3 0.6 1.7 1.5 1.4 1.0 0.3 0.8 1.0 0.8 2.4 1.1 1.0 1.4 1.4 1.1
Ever smoked 4.2 7.4 11.6 -3.0 0.0 -2.5 -2.9 -2.3 -2.9 3.4 -2.7 -0.4 -2.5 -3.1 -2.9 -2.5 -3.0 -2.8 -3.4 -2.9 -3.1 -3.4 -3.4 -0.9 -2.5
Basal metabolic rate 0.1 0.7 2.9 1.1 0.0 0.5 -0.9 -1.5 -0.9 1.2 -0.8 1.7 1.3 -0.2 -0.2 -0.3 0.1 0.4 -0.1 0.6 0.0 -0.5 0.1 1.4 0.2
Leg fat percentage (left) 3.1 11.1 22.0 3.0 0.0 3.6 4.3 3.4 3.7 -3.6 4.7 1.5 4.2 3.9 3.1 3.6 2.8 2.7 3.3 3.4 3.1 3.4 3.9 -0.5 3.0
Arm fat-free mass (left) 0.2 0.8 4.0 1.1 0.0 0.4 -1.1 -1.6 -0.9 1.3 -0.8 1.8 1.2 -0.5 -0.1 -0.3 0.2 0.6 0.0 0.3 0.1 -0.4 0.0 2.0 0.5
Number of operations (self-reported) 0.2 0.3 0.9 -0.9 0.0 -0.6 -0.6 -0.5 -0.0 0.8 -0.6 -0.9 -0.5 -0.7 -0.7 -0.0 -0.7 -0.8 -0.8 -0.1 -0.4 -0.2 -0.2 -0.0 -0.5
Average weekly beer plus cider intake 1.0 1.5 3.6 1.5 0.0 0.4 1.1 0.1 1.4 -1.2 0.9 0.7 1.8 1.9 1.1 1.7 1.3 0.9 1.4 1.9 1.0 1.3 1.3 0.9 0.8
Irritability 0.1 0.2 0.7 0.7 0.0 -0.1 0.2 0.9 0.6 -0.2 0.4 0.9 0.1 0.4 0.3 0.7 0.6 0.3 0.3 0.3 0.6 0.5 -0.2 0.6 0.6
Risk taking 1.6 2.3 8.3 -1.3 0.0 -2.9 -1.8 -1.2 -1.7 1.9 -1.3 -0.1 -1.2 -1.2 -1.8 -0.3 -1.3 -1.6 -1.7 -1.5 -1.7 -1.4 -1.8 -0.6 -1.7
Ever had prostate specific antigen (PSA) test 0.2 0.3 1.1 -0.6 0.0 -0.6 0.2 0.6 0.7 -0.3 0.2 -0.7 -1.1 0.1 0.7 0.5 0.1 0.5 0.3 -0.4 -0.0 0.0 -0.1 -0.9 0.9
Fractured/broken bones in last 5 years 0.4 0.5 1.5 0.9 0.0 -1.1 0.8 1.1 0.4 -0.4 1.2 -0.7 0.1 0.5 0.3 0.6 0.7 0.2 0.4 0.4 0.4 1.2 0.1 -1.0 -0.1
Age started oral contraceptive pill 7.5 9.4 16.8 3.7 0.0 1.5 2.9 2.6 2.8 -3.1 2.7 2.6 2.2 2.9 3.8 3.8 4.0 3.7 3.7 2.4 4.1 3.6 2.9 1.9 3.2
Diastolic blood pressure, automated reading 5.5 17.0 29.9 4.3 0.0 5.0 4.9 3.7 4.2 -4.4 4.8 2.2 5.5 5.0 3.7 4.8 3.8 3.2 3.8 4.3 4.5 4.4 5.0 1.3 3.4
Ever depressed for a whole week 3.4 4.2 10.5 -2.2 0.0 -0.7 -1.2 -1.2 -2.4 1.0 -1.4 -1.1 -1.6 -1.8 -2.5 -3.2 -2.5 -3.1 -2.2 -1.0 -2.2 -1.7 -1.5 -3.2 -3.2
Unable to work because of sickness or disability 0.2 0.2 0.9 -0.8 0.0 -0.0 0.0 -0.3 -0.1 -0.1 -0.5 -0.9 0.5 -0.0 -0.2 0.6 -0.7 -0.1 0.1 1.0 0.7 -0.1 0.8 -0.4 0.2
Commuting to job workplace: Cycle 2.1 2.5 5.2 -0.9 0.0 -1.6 -1.5 -1.4 -1.7 1.8 -1.8 -1.7 -1.4 -2.0 -1.8 -2.0 -1.2 -1.6 -1.4 -2.2 -1.2 -1.3 -2.3 -0.2 -1.9
Myopia 0.3 0.4 1.6 -0.1 0.0 -0.5 0.0 0.6 0.4 0.4 0.3 -0.8 -0.6 0.1 0.8 1.3 0.5 0.6 1.1 -1.3 0.4 -0.2 -0.8 -0.9 0.6
Vascular/heart problems diagnosed by doctor 2.4 6.6 11.2 -2.9 0.0 -2.5 -2.5 -1.3 -2.3 2.3 -2.4 -0.5 -2.6 -1.9 -2.4 -3.0 -2.7 -3.2 -2.2 -2.8 -3.3 -3.2 -3.1 -2.9 -3.2
Cholesterol lowering medication 0.4 0.6 1.7 -1.2 0.0 1.1 -0.7 -1.0 -0.4 0.5 -1.1 -1.3 0.2 -0.9 -1.0 -0.1 -1.1 -0.4 -0.9 0.8 -0.4 -0.7 0.2 0.9 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.8 -0.2 0.0 -0.5 -1.3 -1.1 -0.7 1.7 -0.8 -1.7 -0.9 -0.6 -0.2 -0.4 -0.1 0.2 -0.7 -1.5 -1.7 -1.1 -1.3 0.5 0.5
Pain experienced in last month 0.2 0.3 1.6 -0.3 0.0 1.3 0.6 0.6 0.4 -0.5 0.8 0.1 0.1 0.4 -0.0 -0.3 -0.4 -0.2 -0.2 0.2 0.0 0.0 0.5 -1.1 0.0
Supplements: Calcium 0.8 0.9 2.0 -1.2 0.0 -0.3 -1.2 -1.0 -0.8 0.9 -1.4 -0.9 -1.4 -1.2 -0.7 -0.0 -1.1 -0.6 -0.7 -1.1 -0.8 -1.2 -1.1 0.4 -0.3
Basal cell carcinoma (self-reported) 1.7 2.1 9.0 -1.8 0.0 -0.9 -1.9 -1.1 -0.9 1.7 -1.8 -0.6 -3.0 -1.8 -0.6 -1.0 -1.2 -0.5 -0.6 -2.1 -1.6 -1.7 -1.8 -0.6 -0.2
Heart attack/myocardial infarction (self-reported) 0.1 0.2 1.2 -0.0 0.0 0.7 0.4 -0.5 0.3 -0.3 -0.0 -0.3 0.3 0.2 -0.1 0.7 -0.3 0.0 -0.1 0.4 0.3 0.0 1.1 -0.4 0.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.5 0.2 0.0 1.2 -0.0 -0.3 -0.1 -0.3 0.1 0.3 0.8 0.5 0.3 -0.0 0.0 0.5 0.7 1.1 0.7 0.7 0.6 0.6 0.5
Heart disease (siblings) 1.7 2.0 5.7 1.0 0.0 1.2 1.9 1.8 2.0 -1.8 1.6 -0.3 1.6 2.0 1.0 1.3 1.4 1.0 0.6 2.4 0.8 1.7 1.7 -0.2 1.0
Alcohol drinker status: Previous 0.3 0.3 1.4 0.3 0.0 0.7 0.5 0.2 0.3 -0.6 -0.1 0.8 0.4 0.1 -0.2 0.8 0.2 0.0 -0.0 1.2 0.8 0.5 1.0 0.6 -0.1
Pack years of smoking 4.3 6.4 15.1 3.9 0.0 2.3 2.5 1.7 1.8 -2.5 2.8 1.7 2.6 2.3 2.7 2.3 3.0 2.9 2.7 2.7 2.4 3.0 2.9 2.1 2.3
Impedance of whole body 0.4 1.8 5.3 -0.9 0.0 0.1 2.1 1.6 1.6 -2.3 1.3 0.8 0.3 1.9 1.2 1.1 0.2 0.4 1.7 1.9 1.1 1.0 1.4 -2.2 0.6
Leg fat mass (left) 2.4 9.2 18.7 3.3 0.0 3.5 3.6 2.5 3.0 -2.8 3.9 1.8 4.3 3.5 2.8 3.3 2.7 2.6 3.1 3.4 3.1 3.0 3.6 0.2 2.8
Arm predicted mass (left) 0.2 0.9 4.0 0.9 0.0 0.5 -1.3 -1.8 -1.1 1.5 -1.0 1.7 1.1 -0.6 -0.3 -0.4 0.0 0.4 -0.3 0.2 -0.0 -0.7 -0.1 2.0 0.3