Best TWAS P=2.19e-22 · Best GWAS P=1.93e-27 conditioned to 0.0203
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | COBLL1 | 0.05 | 0.01 | lasso | 6 | 0.03 | 3.3e-04 | -6.8 | 5.7 | 1.2e-08 | 0.41 | 0.40 | 0.06 | TRUE |
| 2 | GTEx | Breast Mammary Tissue | SLC38A11 | 0.20 | 0.19 | lasso | 4 | 0.17 | 4.7e-09 | 3.5 | 5.1 | 3.0e-07 | 0.51 | 0.97 | 0.01 | FALSE |
| 3 | GTEx | Esophagus Muscularis | GRB14 | 0.14 | 0.09 | lasso | 7 | 0.06 | 1.6e-04 | 9.5 | -9.7 | 2.2e-22 | -0.46 | 0.29 | 0.42 | TRUE |
| 4 | GTEx | Thyroid | COBLL1 | 0.07 | 0.05 | lasso | 3 | 0.05 | 1.5e-04 | -7.3 | 7.2 | 7.3e-13 | 0.59 | 0.57 | 0.25 | TRUE |
| 5 | METSIM | Adipose | GRB14 | 0.04 | 0.00 | bslmm | 376 | 0.01 | 1.6e-02 | -2.6 | -5.8 | 5.3e-09 | -0.26 | 0.12 | 0.13 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | GRB14 | 0.09 | 0.01 | blup | 82 | 0.03 | 4.6e-03 | 9.1 | -7.4 | 1.7e-13 | -0.54 | 0.02 | 0.64 | FALSE |