Best TWAS P=2.31e-12 · Best GWAS P=1.04e-11 conditioned to 0.00844
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SF3B1 | 0.06 | 0.07 | enet | 10 | 0.07 | 2.5e-09 | 5.6 | 5.7 | 1.5e-08 | 0.84 | 0.73 | 0.27 | FALSE |
2 | GTEx | Breast Mammary Tissue | SF3B1 | 0.06 | 0.06 | lasso | 4 | 0.03 | 6.6e-03 | 5.7 | 5.2 | 2.1e-07 | 0.83 | 0.07 | 0.87 | FALSE |
3 | GTEx | Esophagus Mucosa | SF3B1 | 0.04 | 0.02 | lasso | 4 | 0.01 | 5.7e-02 | 5.4 | 6.0 | 2.7e-09 | 0.90 | 0.03 | 0.91 | FALSE |
4 | GTEx | Lung | SF3B1 | 0.06 | 0.04 | enet | 23 | 0.02 | 2.2e-02 | 5.4 | 7.0 | 2.3e-12 | 0.70 | 0.26 | 0.56 | TRUE |
5 | GTEx | Nerve Tibial | SF3B1 | 0.06 | 0.09 | lasso | 8 | 0.08 | 3.3e-06 | 5.7 | 5.4 | 5.7e-08 | 0.82 | 0.78 | 0.21 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | SF3B1 | 0.08 | 0.00 | enet | 19 | 0.01 | 1.6e-01 | 5.6 | 5.4 | 8.2e-08 | 0.75 | 0.14 | 0.57 | FALSE |
7 | GTEx | Testis | ANKRD44 | 0.33 | 0.35 | enet | 15 | 0.36 | 6.2e-17 | 6.8 | 6.5 | 8.7e-11 | 0.98 | 0.00 | 1.00 | FALSE |
8 | GTEx | Testis | SF3B1 | 0.10 | 0.07 | enet | 17 | 0.08 | 2.6e-04 | 5.6 | 5.6 | 1.7e-08 | 0.89 | 0.21 | 0.77 | FALSE |
9 | METSIM | Adipose | HSPD1 | 0.02 | 0.00 | blup | 323 | 0.01 | 1.8e-02 | -2.7 | 5.6 | 2.7e-08 | 0.64 | 0.12 | 0.46 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | SF3B1 | 0.02 | 0.01 | blup | 336 | 0.01 | 6.2e-03 | 5.2 | 6.2 | 4.4e-10 | 0.82 | 0.27 | 0.56 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | RFTN2 | 0.03 | 0.04 | blup | 351 | 0.03 | 1.5e-04 | 4.0 | -5.7 | 1.2e-08 | -0.76 | 0.41 | 0.56 | FALSE |