Best TWAS P=1.66e-09 · Best GWAS P=1.63e-09 conditioned to 0.233
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | HR | 0.06 | 0.01 | bslmm | 452 | 0.03 | 3.8e-05 | -3.2 | 5.2 | 1.9e-07 | 0.51 | 0.05 | 0.84 | FALSE |
2 | GTEx | Adipose Subcutaneous | NUDT18 | 0.10 | 0.07 | enet | 10 | 0.07 | 2.3e-06 | 5.9 | 5.5 | 4.6e-08 | 0.87 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adrenal Gland | NUDT18 | 0.35 | 0.20 | lasso | 6 | 0.19 | 1.6e-07 | -5.0 | -5.1 | 2.9e-07 | -0.69 | 0.16 | 0.81 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | SLC25A37 | 0.13 | 0.05 | lasso | 5 | 0.04 | 3.0e-04 | -6.0 | 5.6 | 1.8e-08 | 0.02 | 0.00 | 0.99 | TRUE |
5 | GTEx | Cells Transformed fibroblasts | FAM160B2 | 0.18 | 0.09 | lasso | 5 | 0.10 | 4.0e-08 | -5.7 | 5.4 | 7.6e-08 | 0.68 | 0.04 | 0.96 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | NUDT18 | 0.10 | 0.04 | enet | 6 | 0.03 | 4.7e-03 | 5.4 | 6.0 | 1.7e-09 | 0.89 | 0.01 | 0.94 | TRUE |
7 | GTEx | Cells Transformed fibroblasts | AC091171.1 | 0.15 | 0.06 | lasso | 2 | 0.05 | 2.2e-04 | -5.7 | 5.6 | 1.8e-08 | 0.69 | 0.05 | 0.92 | FALSE |
8 | GTEx | Esophagus Mucosa | FAM160B2 | 0.15 | 0.05 | enet | 19 | 0.09 | 1.7e-06 | 5.8 | 5.5 | 3.5e-08 | 0.77 | 0.01 | 0.99 | FALSE |
9 | GTEx | Esophagus Mucosa | NUDT18 | 0.21 | 0.23 | enet | 8 | 0.23 | 3.9e-15 | -5.0 | -5.3 | 1.5e-07 | -0.73 | 0.32 | 0.67 | FALSE |
10 | GTEx | Esophagus Mucosa | AC091171.1 | 0.14 | 0.07 | lasso | 4 | 0.05 | 2.2e-04 | 5.9 | 6.0 | 1.7e-09 | 0.94 | 0.01 | 0.99 | FALSE |
11 | GTEx | Skin Not Sun Exposed Suprapubic | NUDT18 | 0.31 | 0.15 | enet | 13 | 0.22 | 4.6e-12 | -5.0 | -5.3 | 1.5e-07 | -0.71 | 0.31 | 0.68 | FALSE |
12 | GTEx | Thyroid | NUDT18 | 0.17 | 0.19 | lasso | 3 | 0.19 | 3.2e-14 | -5.2 | -5.2 | 2.0e-07 | -0.72 | 0.28 | 0.72 | FALSE |
13 | METSIM | Adipose | FAM160B2 | 0.06 | 0.03 | enet | 10 | 0.04 | 1.2e-06 | 5.8 | 5.1 | 3.0e-07 | 0.82 | 0.01 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | NUDT18 | 0.09 | 0.03 | blup | 45 | 0.08 | 1.3e-04 | -5.4 | -5.7 | 1.5e-08 | -0.78 | 0.05 | 0.92 | FALSE |
15 | The Cancer Genome Atlas | Colon Adenocarcinoma | FAM160B2 | 0.06 | 0.07 | lasso | 1 | 0.06 | 2.3e-04 | 5.8 | 5.8 | 7.7e-09 | 0.93 | 0.01 | 0.93 | FALSE |
16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOXL2 | 0.16 | 0.03 | lasso | 4 | 0.05 | 1.2e-03 | -4.4 | 5.4 | 6.0e-08 | 0.10 | 0.01 | 0.44 | FALSE |
17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | NUDT18 | 0.10 | 0.16 | lasso | 2 | 0.16 | 2.3e-09 | -5.4 | -5.3 | 1.0e-07 | -0.71 | 0.09 | 0.91 | FALSE |
18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NUDT18 | 0.11 | 0.22 | lasso | 6 | 0.22 | 3.6e-24 | -5.7 | -5.7 | 1.4e-08 | -0.78 | 0.06 | 0.94 | FALSE |
19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NUDT18 | 0.06 | 0.08 | lasso | 3 | 0.07 | 1.6e-08 | -5.4 | -5.3 | 1.4e-07 | -0.71 | 0.12 | 0.88 | FALSE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM160B2 | 0.05 | 0.01 | enet | 11 | 0.03 | 1.7e-04 | -5.5 | 5.3 | 1.1e-07 | 0.70 | 0.03 | 0.94 | FALSE |
21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUDT18 | 0.17 | 0.25 | blup | 45 | 0.27 | 6.2e-28 | -5.0 | -5.2 | 1.9e-07 | -0.69 | 0.16 | 0.84 | FALSE |
22 | The Cancer Genome Atlas | Thyroid Carcinoma | FAM160B2 | 0.08 | 0.06 | lasso | 4 | 0.05 | 1.4e-05 | -5.7 | 5.5 | 4.8e-08 | 0.64 | 0.04 | 0.95 | FALSE |
23 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | NUDT18 | 0.15 | 0.17 | lasso | 4 | 0.12 | 2.3e-04 | -5.5 | -5.8 | 5.8e-09 | -0.78 | 0.02 | 0.95 | FALSE |