Best TWAS P=2.41e-10 · Best GWAS P=1.19e-13 conditioned to 0.000105
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | NEO1 | 0.20 | 0.13 | lasso | 7 | 0.17 | 1.1e-10 | -6.3 | 5.9 | 2.8e-09 | -0.81 | 0.49 | 0.51 | FALSE |
| 2 | GTEx | Heart Atrial Appendage | RP11-1006G14.4 | 0.12 | 0.06 | lasso | 11 | 0.05 | 2.3e-03 | -6.2 | -5.5 | 4.6e-08 | 0.79 | 0.08 | 0.40 | FALSE |
| 3 | GTEx | Nerve Tibial | NEO1 | 0.07 | 0.09 | lasso | 2 | 0.09 | 3.9e-07 | -6.3 | -6.3 | 2.4e-10 | 0.87 | 0.27 | 0.72 | TRUE |
| 4 | GTEx | Pituitary | BBS4 | 0.27 | 0.02 | enet | 21 | 0.05 | 2.1e-02 | -5.2 | -5.3 | 1.1e-07 | 0.38 | 0.09 | 0.12 | FALSE |
| 5 | GTEx | Testis | ADPGK-AS1 | 0.17 | 0.05 | lasso | 4 | 0.03 | 1.3e-02 | -3.8 | 5.5 | 2.8e-08 | -0.51 | 0.08 | 0.50 | FALSE |
| 6 | NTR | Blood | NEO1 | 0.04 | 0.01 | lasso | 4 | 0.02 | 4.1e-06 | 4.2 | -5.2 | 1.7e-07 | 0.48 | 0.93 | 0.01 | FALSE |