[Hub]/) : Traits : Trunk fat mass :

chr15:65,989,359-69,178,312

Best TWAS P=1.37e-19 · Best GWAS P=3.79e-19 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex AAGAB 0.06 0.05 enet 11 0.05 3.2e-07 -7.2 -7.5 5.2e-14 0.45 0.99 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex IQCH 0.13 0.11 bslmm 597 0.10 5.9e-12 -7.6 6.8 7.8e-12 -0.40 1.00 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex MAP2K5 0.11 0.07 bslmm 474 0.08 1.2e-09 -7.7 6.7 2.4e-11 -0.74 0.86 0.14 FALSE
4 GTEx Adipose Subcutaneous MAP2K5 0.14 0.18 lasso 4 0.18 1.0e-14 -7.7 7.7 1.0e-14 -0.82 0.99 0.01 FALSE
5 GTEx Adipose Visceral Omentum MAP2K5 0.07 0.08 lasso 3 0.05 1.0e-03 -7.9 8.1 4.0e-16 -0.83 0.04 0.94 FALSE
6 GTEx Artery Aorta MAP2K5 0.06 0.05 enet 6 0.05 7.7e-04 -7.7 8.1 5.4e-16 -0.83 0.22 0.66 FALSE
7 GTEx Artery Coronary MAP2K5 0.11 0.00 enet 28 0.03 4.5e-02 -7.6 7.6 2.6e-14 -0.61 0.10 0.31 FALSE
8 GTEx Artery Tibial MAP2K5 0.15 0.18 lasso 3 0.18 6.3e-14 -7.7 7.9 3.3e-15 -0.81 0.96 0.04 FALSE
9 GTEx Brain Cerebellum MAP2K5 0.27 0.12 lasso 5 0.14 7.9e-05 -7.4 8.0 1.8e-15 -0.69 0.32 0.36 FALSE
10 GTEx Brain Hippocampus IQCH-AS1 0.20 0.08 enet 11 0.05 2.2e-02 3.6 -5.8 6.8e-09 0.47 0.14 0.23 FALSE
11 GTEx Breast Mammary Tissue MAP2K5 0.14 0.07 lasso 5 0.09 2.8e-05 -8.5 7.3 2.2e-13 -0.89 0.04 0.96 FALSE
12 GTEx Cells Transformed fibroblasts SMAD3 0.12 0.01 lasso 9 0.06 3.6e-05 -1.3 -6.7 2.1e-11 0.19 0.25 0.04 FALSE
13 GTEx Esophagus Muscularis MAP2K5 0.24 0.14 lasso 4 0.13 2.1e-08 -7.7 7.9 2.7e-15 -0.82 0.98 0.02 FALSE
14 GTEx Heart Atrial Appendage MAP2K5 0.16 0.08 lasso 5 0.16 1.3e-07 -7.6 7.6 2.9e-14 -0.78 0.10 0.90 FALSE
15 GTEx Heart Left Ventricle MAP2K5 0.10 0.10 lasso 3 0.10 9.4e-06 -7.7 7.7 2.0e-14 -0.84 0.50 0.45 FALSE
16 GTEx Lung MAP2K5 0.12 0.09 enet 11 0.07 3.6e-06 -7.6 7.1 9.1e-13 -0.76 0.84 0.13 FALSE
17 GTEx Muscle Skeletal MAP2K5 0.08 0.03 lasso 6 0.05 1.9e-05 6.1 8.2 2.5e-16 -0.69 0.02 0.98 FALSE
18 GTEx Muscle Skeletal SMAD3 0.13 0.10 enet 8 0.10 4.2e-10 5.6 5.5 3.4e-08 -0.02 1.00 0.00 TRUE
19 GTEx Nerve Tibial MAP2K5 0.19 0.21 lasso 2 0.20 3.3e-14 -7.7 7.7 1.9e-14 -0.82 0.96 0.04 FALSE
20 GTEx Ovary MAP2K5 0.19 0.24 lasso 3 0.21 8.3e-06 -7.7 7.9 2.7e-15 -0.81 0.08 0.81 FALSE
21 GTEx Skin Sun Exposed Lower leg MAP2K5 0.13 0.06 lasso 4 0.09 4.4e-08 3.7 6.3 3.3e-10 -0.68 0.87 0.12 TRUE
22 GTEx Spleen MAP2K5 0.25 0.19 lasso 3 0.18 2.1e-05 -7.7 6.4 2.0e-10 -0.80 0.12 0.78 FALSE
23 GTEx Thyroid MAP2K5 0.11 0.16 lasso 4 0.15 9.6e-12 -7.7 8.0 1.5e-15 -0.82 0.88 0.12 FALSE
24 GTEx Whole Blood MAP2K5 0.09 0.06 lasso 6 0.06 8.1e-06 -7.7 9.1 1.4e-19 -0.79 0.69 0.18 TRUE
25 METSIM Adipose IQCH 0.04 0.02 bslmm 593 0.02 3.3e-04 -2.1 6.2 7.4e-10 -0.09 0.40 0.33 TRUE
26 METSIM Adipose MAP2K5 0.07 0.05 enet 19 0.06 2.8e-09 -8.4 7.5 6.2e-14 -0.87 0.03 0.97 FALSE
27 NTR Blood MAP2K5 0.02 0.00 enet 13 0.01 5.7e-04 -7.8 6.5 6.1e-11 -0.74 0.33 0.61 FALSE
28 YFS Blood MAP2K1 0.07 0.05 lasso 3 0.05 2.0e-17 -5.1 5.6 2.4e-08 -0.07 0.89 0.11 TRUE
29 YFS Blood MAP2K5 0.05 0.07 lasso 4 0.07 1.2e-21 -7.7 7.5 6.5e-14 -0.82 0.99 0.01 FALSE
30 YFS Blood PIAS1 0.08 0.04 lasso 7 0.06 1.3e-18 3.3 -5.2 2.2e-07 0.08 1.00 0.00 TRUE
31 The Cancer Genome Atlas Bladder Urothelial Carcinoma IQCH 0.13 0.07 blup 112 0.10 5.2e-09 -5.6 7.2 6.3e-13 -0.25 0.18 0.82 FALSE
32 The Cancer Genome Atlas Breast Invasive Carcinoma IQCH 0.06 0.05 blup 112 0.06 5.2e-12 -7.5 8.8 2.2e-18 -0.49 0.06 0.94 FALSE
33 The Cancer Genome Atlas Colon Adenocarcinoma IQCH 0.08 0.02 blup 111 0.05 4.2e-04 -5.6 7.1 1.4e-12 -0.47 0.13 0.71 FALSE
34 The Cancer Genome Atlas Glioblastoma Multiforme IQCH 0.19 0.14 enet 21 0.12 2.4e-04 -5.6 7.5 5.1e-14 -0.59 0.12 0.78 FALSE
35 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IQCH 0.06 0.04 blup 111 0.03 1.0e-04 -5.6 7.5 5.3e-14 -0.33 0.25 0.52 FALSE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IQCH 0.12 0.10 enet 22 0.12 4.0e-13 -5.5 7.4 1.7e-13 -0.30 1.00 0.00 FALSE
37 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MAP2K5 0.03 0.03 blup 142 0.02 1.6e-03 -7.7 7.0 2.7e-12 -0.90 0.06 0.91 TRUE
38 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma IQCH 0.13 0.01 blup 111 0.08 2.4e-05 -2.9 5.8 8.8e-09 -0.07 0.43 0.05 FALSE
39 The Cancer Genome Atlas Brain Lower Grade Glioma IQCH 0.05 0.04 blup 111 0.04 7.7e-06 -5.6 7.7 1.7e-14 -0.40 0.24 0.72 FALSE
40 The Cancer Genome Atlas Liver Hepatocellular Carcinoma IQCH 0.10 0.01 blup 111 0.03 1.4e-02 5.8 7.3 2.1e-13 -0.31 0.05 0.22 FALSE
41 The Cancer Genome Atlas Lung Adenocarcinoma IQCH 0.04 0.02 enet 8 0.01 1.6e-02 -6.2 7.8 4.7e-15 -0.42 0.12 0.10 FALSE
42 The Cancer Genome Atlas Lung Adenocarcinoma MAP2K5 0.04 0.04 lasso 3 0.03 8.7e-05 -7.7 7.8 5.5e-15 -0.84 0.08 0.90 FALSE
43 The Cancer Genome Atlas Lung Adenocarcinoma SMAD3 0.06 0.06 lasso 2 0.06 2.5e-07 6.6 6.2 6.0e-10 0.01 0.82 0.12 TRUE
44 The Cancer Genome Atlas Lung Squamous Cell Carcinoma IQCH 0.04 0.02 enet 6 0.03 1.6e-04 -7.9 8.7 4.6e-18 -0.73 0.01 0.97 TRUE
45 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma IQCH 0.11 0.10 blup 112 0.10 2.3e-07 -6.2 7.8 4.3e-15 -0.57 0.08 0.92 FALSE
46 The Cancer Genome Atlas Pancreatic Adenocarcinoma IQCH 0.35 0.04 blup 112 0.12 1.5e-05 -5.6 9.0 1.9e-19 -0.40 0.12 0.75 FALSE
47 The Cancer Genome Atlas Prostate Adenocarcinoma IQCH 0.19 0.07 blup 111 0.16 7.4e-17 -2.8 6.6 3.9e-11 -0.21 1.00 0.00 FALSE
48 The Cancer Genome Atlas Soft Tissue Sarcoma IQCH 0.08 0.09 enet 8 0.08 2.3e-05 -5.6 5.5 2.8e-08 -0.32 0.70 0.06 TRUE
49 The Cancer Genome Atlas Stomach Adenocarcinoma IQCH 0.08 0.03 blup 111 0.04 9.2e-04 -5.6 8.0 1.3e-15 -0.39 0.06 0.41 FALSE
50 The Cancer Genome Atlas Thyroid Carcinoma IQCH 0.15 0.17 enet 19 0.17 1.3e-16 -5.5 6.9 6.3e-12 -0.47 1.00 0.00 FALSE
51 The Cancer Genome Atlas Thyroid Carcinoma LBXCOR1 0.06 0.01 lasso 3 0.03 7.0e-04 -4.4 5.2 2.7e-07 -0.62 0.09 0.54 FALSE
52 The Cancer Genome Atlas Thyroid Carcinoma MAP2K5 0.10 0.06 lasso 5 0.04 6.1e-05 -7.7 7.5 4.2e-14 -0.86 0.50 0.47 FALSE
53 The Cancer Genome Atlas Thyroid Carcinoma SNAPC5 0.05 0.02 lasso 2 0.03 5.1e-04 3.5 -5.2 2.6e-07 0.07 0.01 0.64 FALSE