Best TWAS P=2.28e-21 · Best GWAS P=2.19e-33 conditioned to 0.00188
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RPRD2 | 0.08 | -0.01 | enet | 19 | 0.00 | 4.2e-01 | -3.1 | 7.4 | 1.1e-13 | 0.30 | 0.08 | 0.26 | TRUE |
| 2 | GTEx | Artery Tibial | HIST2H2AA3 | 0.22 | 0.02 | enet | 20 | 0.12 | 1.8e-09 | 11.5 | 8.5 | 1.7e-17 | 0.70 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-196G18.22 | 0.25 | 0.05 | lasso | 5 | 0.07 | 1.8e-06 | 6.7 | 9.5 | 2.3e-21 | 0.78 | 0.01 | 0.98 | TRUE |
| 4 | GTEx | Artery Tibial | RP11-196G18.24 | 0.31 | 0.08 | enet | 26 | 0.10 | 6.1e-08 | 11.5 | 8.0 | 8.8e-16 | 0.72 | 0.00 | 0.99 | FALSE |
| 5 | GTEx | Brain Cerebellum | ECM1 | 0.34 | 0.21 | lasso | 6 | 0.19 | 3.2e-06 | 4.5 | 5.3 | 1.5e-07 | 0.17 | 0.02 | 0.94 | FALSE |
| 6 | GTEx | Esophagus Muscularis | BOLA1 | 0.07 | 0.00 | lasso | 4 | 0.00 | 2.5e-01 | -4.8 | 5.2 | 2.4e-07 | 0.43 | 0.03 | 0.13 | FALSE |
| 7 | GTEx | Thyroid | MTMR11 | 0.09 | 0.05 | enet | 9 | 0.06 | 1.5e-05 | -4.9 | -5.3 | 1.1e-07 | -0.40 | 0.26 | 0.42 | FALSE |
| 8 | GTEx | Thyroid | ANP32E | 0.08 | 0.00 | enet | 15 | 0.01 | 8.6e-02 | -2.3 | 7.3 | 2.6e-13 | 0.37 | 0.04 | 0.11 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SV2A | 0.03 | 0.02 | enet | 3 | 0.02 | 8.0e-06 | -3.1 | 5.2 | 1.8e-07 | 0.38 | 0.13 | 0.23 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SV2A | 0.05 | 0.02 | blup | 9 | 0.03 | 2.5e-04 | -4.8 | 6.4 | 1.7e-10 | 0.48 | 0.03 | 0.07 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BNIPL | 0.03 | 0.02 | blup | 35 | 0.02 | 6.4e-03 | 3.6 | 5.3 | 1.1e-07 | 0.14 | 0.00 | 0.43 | TRUE |