Best TWAS P=2.51e-08 · Best GWAS P=1.27e-11 conditioned to 0.109
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADARB1 | 0.12 | 0.03 | blup | 656 | 0.03 | 3.6e-04 | -4.5 | -5.4 | 5.8e-08 | 0.51 | 0.31 | 0.64 | TRUE |
| 2 | GTEx | Muscle Skeletal | PTTG1IP | 0.07 | 0.01 | enet | 6 | 0.00 | 9.7e-02 | -6.4 | 5.6 | 2.5e-08 | -0.71 | 0.01 | 0.89 | TRUE |
| 3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ADARB1 | 0.07 | 0.01 | blup | 139 | 0.04 | 4.5e-03 | 5.0 | -5.4 | 7.1e-08 | 0.83 | 0.01 | 0.90 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C21orf122 | 0.05 | 0.04 | lasso | 3 | 0.04 | 6.5e-05 | 5.6 | -5.4 | 5.2e-08 | 0.60 | 0.00 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C21orf122 | 0.20 | 0.04 | lasso | 6 | 0.08 | 2.6e-04 | 5.6 | -5.5 | 4.4e-08 | 0.57 | 0.00 | 0.96 | FALSE |