Best TWAS P=2.1e-10 · Best GWAS P=3.76e-08 conditioned to 0.873
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LRRFIP2 | 0.04 | 0.00 | bslmm | 481 | 0.02 | 3.5e-03 | -4.3 | -5.4 | 5.4e-08 | 0.73 | 0.12 | 0.77 | FALSE |
| 2 | GTEx | Nerve Tibial | LRRFIP2 | 0.09 | 0.10 | lasso | 2 | 0.07 | 5.8e-06 | -5.0 | -5.2 | 1.7e-07 | 0.91 | 0.09 | 0.91 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | GOLGA4 | 0.09 | 0.02 | enet | 4 | 0.01 | 5.3e-02 | 4.1 | -5.3 | 8.6e-08 | 0.68 | 0.08 | 0.62 | FALSE |
| 4 | GTEx | Whole Blood | LRRFIP2 | 0.04 | 0.05 | lasso | 3 | 0.04 | 1.4e-04 | -5.4 | 5.4 | 7.1e-08 | -0.94 | 0.05 | 0.94 | FALSE |
| 5 | YFS | Blood | GOLGA4 | 0.01 | 0.00 | blup | 460 | 0.01 | 2.2e-03 | -5.5 | -6.3 | 2.1e-10 | 0.85 | 0.07 | 0.90 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | EPM2AIP1 | 0.04 | 0.04 | blup | 31 | 0.04 | 8.3e-05 | 3.3 | -5.5 | 5.0e-08 | 0.95 | 0.02 | 0.98 | FALSE |