Best TWAS P=9.77e-12 · Best GWAS P=7.13e-12 conditioned to 0.00178
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SRP19 | 0.08 | 0.06 | lasso | 5 | 0.07 | 1.3e-08 | 5.3 | -5.6 | 1.7e-08 | 0.63 | 0.56 | 0.44 | FALSE |
2 | GTEx | Adipose Subcutaneous | REEP5 | 0.10 | 0.09 | lasso | 2 | 0.05 | 2.8e-05 | 5.1 | 5.3 | 1.1e-07 | -0.64 | 0.24 | 0.74 | FALSE |
3 | GTEx | Adipose Visceral Omentum | REEP5 | 0.09 | 0.05 | lasso | 5 | 0.02 | 4.9e-02 | 5.9 | 5.8 | 7.4e-09 | -0.60 | 0.04 | 0.90 | FALSE |
4 | GTEx | Artery Aorta | REEP5 | 0.17 | 0.07 | lasso | 13 | 0.10 | 4.2e-06 | 6.4 | 6.0 | 1.8e-09 | -0.74 | 0.02 | 0.98 | FALSE |
5 | GTEx | Artery Tibial | REEP5 | 0.17 | 0.12 | lasso | 5 | 0.13 | 3.0e-10 | 5.1 | 5.3 | 1.0e-07 | -0.58 | 0.41 | 0.59 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | CTC-487M23.5 | 0.07 | 0.03 | lasso | 3 | 0.03 | 2.9e-03 | -4.5 | -5.6 | 2.4e-08 | 0.66 | 0.04 | 0.89 | FALSE |
7 | GTEx | Colon Transverse | REEP5 | 0.12 | 0.14 | lasso | 2 | 0.14 | 4.4e-07 | 5.7 | 5.8 | 5.4e-09 | -0.58 | 0.13 | 0.86 | FALSE |
8 | GTEx | Esophagus Gastroesophageal Junction | REEP5 | 0.18 | 0.03 | lasso | 3 | 0.03 | 3.7e-02 | 6.1 | 6.0 | 2.1e-09 | -0.61 | 0.03 | 0.88 | FALSE |
9 | GTEx | Esophagus Mucosa | REEP5 | 0.19 | 0.10 | lasso | 5 | 0.09 | 1.5e-06 | 6.1 | 6.1 | 1.0e-09 | -0.60 | 0.04 | 0.94 | FALSE |
10 | GTEx | Esophagus Muscularis | REEP5 | 0.18 | 0.09 | lasso | 4 | 0.14 | 5.9e-09 | 5.7 | 5.5 | 3.9e-08 | -0.68 | 0.28 | 0.72 | FALSE |
11 | GTEx | Nerve Tibial | REEP5 | 0.16 | 0.13 | lasso | 3 | 0.10 | 9.2e-08 | 5.1 | 5.3 | 1.2e-07 | -0.59 | 0.83 | 0.16 | FALSE |
12 | GTEx | Nerve Tibial | XBP1P1 | 0.06 | 0.05 | lasso | 2 | 0.04 | 6.1e-04 | 4.7 | 5.2 | 2.5e-07 | -0.78 | 0.40 | 0.29 | FALSE |
13 | GTEx | Skin Not Sun Exposed Suprapubic | REEP5 | 0.11 | 0.10 | lasso | 7 | 0.10 | 6.3e-06 | 5.1 | 5.6 | 1.9e-08 | -0.63 | 0.13 | 0.86 | FALSE |
14 | GTEx | Skin Not Sun Exposed Suprapubic | CTC-487M23.5 | 0.10 | 0.06 | lasso | 3 | 0.05 | 6.7e-04 | 5.5 | 5.5 | 4.7e-08 | -0.56 | 0.18 | 0.51 | FALSE |
15 | GTEx | Skin Not Sun Exposed Suprapubic | CTC-487M23.7 | 0.08 | 0.09 | enet | 7 | 0.10 | 3.9e-06 | 5.5 | 5.9 | 4.4e-09 | -0.65 | 0.12 | 0.84 | FALSE |
16 | GTEx | Skin Sun Exposed Lower leg | REEP5 | 0.08 | 0.05 | lasso | 4 | 0.03 | 1.9e-03 | 5.1 | 5.3 | 1.4e-07 | -0.70 | 0.17 | 0.81 | FALSE |
17 | GTEx | Skin Sun Exposed Lower leg | CTC-487M23.5 | 0.17 | 0.07 | lasso | 6 | 0.06 | 7.7e-06 | 5.6 | 5.8 | 8.9e-09 | -0.60 | 0.30 | 0.70 | FALSE |
18 | GTEx | Skin Sun Exposed Lower leg | CTC-487M23.7 | 0.06 | 0.07 | lasso | 1 | 0.04 | 2.4e-04 | 5.6 | 5.6 | 1.8e-08 | -0.52 | 0.06 | 0.92 | FALSE |
19 | GTEx | Testis | REEP5 | 0.22 | 0.14 | lasso | 5 | 0.14 | 6.6e-07 | 5.7 | 6.2 | 7.4e-10 | -0.59 | 0.07 | 0.92 | FALSE |
20 | NTR | Blood | REEP5 | 0.03 | 0.04 | lasso | 9 | 0.04 | 3.3e-12 | 6.4 | 6.8 | 9.8e-12 | -0.66 | 0.02 | 0.98 | TRUE |
21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | APC | 0.03 | 0.02 | blup | 77 | 0.02 | 5.2e-03 | 5.8 | 5.5 | 2.9e-08 | -0.45 | 0.02 | 0.49 | FALSE |
22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SRP19 | 0.05 | 0.04 | lasso | 3 | 0.04 | 3.7e-05 | 5.5 | -5.6 | 1.9e-08 | 0.60 | 0.60 | 0.34 | FALSE |
23 | The Cancer Genome Atlas | Stomach Adenocarcinoma | REEP5 | 0.03 | 0.02 | blup | 47 | 0.03 | 4.1e-03 | 5.5 | 5.7 | 1.1e-08 | -0.67 | 0.04 | 0.37 | FALSE |
24 | The Cancer Genome Atlas | Thyroid Carcinoma | APC | 0.02 | 0.02 | enet | 5 | 0.02 | 4.2e-03 | -5.2 | 5.2 | 1.9e-07 | -0.74 | 0.08 | 0.63 | FALSE |