TWAS hub - XBP1P1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0660	0.0280	0.0050	0.005	NA	0.003	NA	0.004	0.11000	NA	0.1700	NA	0.13000
2	GTEx	Brain Cerebellum	0.2920	0.1080	0.0079	-0.005	NA	0.012	NA	0.005	0.47000	NA	0.1300	NA	0.22000
3	GTEx	Nerve Tibial	0.0573	0.0296	0.0096	0.049	NA	0.024	NA	0.042	0.00021	NA	0.0079	NA	0.00061

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Mean time to correctly identify matches	12.0	22.9	32.5	4.8	-3.6	5.7
Reaction Time	11.7	22.4	36.8	4.8	-2.6	6.1
Knee pain experienced in last month	5.6	8.7	14.4	2.7	-2.2	3.8
Guilty feelings	5.5	8.2	10.8	-3.3	2.6	-2.7
Worry (Nagel 2018)	5.4	11.4	12.3	-3.5	3.3	-3.3
Worrier / anxious feelings	5.1	9.6	12.0	-3.5	3.0	-2.8
Chest pain or discomfort	4.9	7.0	13.1	2.5	-1.2	3.6
Risk taking	4.6	6.7	10.2	3.2	-2.0	2.4
Hair/balding pattern: Pattern 2	4.0	5.0	9.2	2.3	-0.7	3.0
Qualifications: O levels/GCSEs or equivalent	4.0	6.3	13.4	2.3	-3.7	-0.6
Sensitivity / hurt feelings	3.8	6.4	11.3	-2.3	3.4	-1.6
Osteoporosis (self-reported)	3.8	4.7	11.7	-1.5	0.4	-3.4
Illnesses of mother	3.5	4.3	8.7	-3.0	0.3	-2.1
Heel T-Score	3.2	25.8	41.0	5.0	-3.4	6.4
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.8	6.0	1.7	-1.6	2.5
Supplements: Calcium	3.0	3.3	5.5	-1.8	1.1	-2.3
Nervous feelings	2.9	5.3	9.3	-1.9	1.7	-3.1
Fractured/broken bones in last 5 years	2.9	3.7	7.6	-1.7	0.8	-2.8
Arm predicted mass (left)	2.8	14.4	25.4	3.6	-2.3	5.0
Peak expiratory flow (PEF)	2.7	6.2	14.2	-1.9	1.0	-3.8
Financial situation satisfaction	2.7	3.3	7.1	-1.3	1.1	2.7
Arm fat-free mass (left)	2.7	13.6	25.2	3.3	-2.1	5.0
Ever had hysterectomy (womb removed)	2.6	2.9	5.5	0.3	-1.7	2.4
Illnesses of siblings	2.6	3.7	8.2	-1.5	-0.8	-2.9
Trunk fat-free mass	2.6	14.9	26.6	3.4	-2.5	5.2
Trunk predicted mass	2.6	14.8	26.3	3.4	-2.5	5.1
Arm fat-free mass (right)	2.6	13.5	24.8	3.2	-2.4	5.0
Medication: Ibuprofen	2.6	3.1	5.7	1.3	-1.3	2.4
Arm predicted mass (right)	2.6	13.1	24.2	3.2	-2.2	4.9
Suffer from ‘nerves’	2.6	4.1	5.5	-1.7	2.0	-2.4
Eye problems/disorders: None of the above	2.5	2.8	5.1	2.3	0.4	1.8
Whole body water mass	2.5	14.4	25.0	3.4	-2.5	5.0
Whole body fat-free mass	2.4	13.8	24.1	3.3	-2.5	4.9
Basal metabolic rate	2.4	13.0	23.4	3.1	-2.4	4.8
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	4.5	0.9	-1.9	2.1
Impedance of arm (left)	2.3	10.7	16.0	-4.0	2.0	-3.5
High blood pressure (siblings)	2.3	3.3	7.0	1.3	1.0	2.6
Ever had bowel cancer screening	2.3	2.7	5.7	0.9	-1.3	2.4
Number of treatments/medications taken	2.2	4.0	9.4	1.0	1.3	3.1
Severe depression (siblings)	2.2	2.5	3.6	0.8	1.8	1.9
Pulse wave Arterial Stiffness index	2.2	2.6	6.1	0.7	-1.1	2.5
Age at last live birth	2.2	3.2	6.9	-0.8	1.4	-2.6
Leg pain on walking	2.2	2.8	7.7	0.8	0.3	2.8
Medication: Aspirin	2.2	2.9	4.4	1.8	-1.1	2.1
Ever taken oral contraceptive pill	2.2	2.4	3.2	1.8	-1.5	1.3
Depressed Affect (Nagel 2018)	2.1	4.4	12.2	0.6	0.8	3.5
Lung FEV1/FVC ratio	2.1	10.7	19.7	-4.4	0.5	-3.5
Glaucoma (self-reported)	2.1	2.4	4.8	-1.6	-0.3	-2.2
Impedance of arm (right)	2.0	9.4	13.1	-3.6	2.1	-3.3
Worry too long after embarrassment	2.0	3.4	5.2	-1.3	1.8	-2.3
Mouth/teeth dental problems: Loose teeth	2.0	2.4	3.3	1.8	-1.8	0.9
Mood swings	2.0	3.6	9.3	1.3	0.0	3.0
Number of self-reported non-cancer illnesses	2.0	3.4	6.4	1.7	1.0	2.5
Medication: Co-codamol	1.9	2.2	3.3	1.0	-1.5	1.8
Breastfed as a baby	1.9	2.4	3.7	1.5	-1.0	1.9
Loneliness, isolation	1.9	2.6	4.6	-0.4	2.2	1.7
Medication: Aspirin	1.9	2.5	4.0	1.5	-1.0	2.0
Impedance of whole body	1.9	9.5	13.0	-3.6	2.8	-2.7
Leg fat-free mass (left)	1.8	9.6	16.4	2.7	-2.3	4.0
Leg predicted mass (left)	1.8	9.6	16.2	2.7	-2.3	4.0
Ever highly irritable/argumentative for 2 days	1.8	2.2	2.3	-1.5	1.5	1.4
Miserableness	1.8	3.1	8.8	0.6	0.4	3.0
Smoking Status	1.7	4.0	9.3	1.4	-0.7	3.1
Diabetes (father)	1.7	2.0	2.7	1.6	-1.0	1.6
Number of incorrect matches in round	1.7	2.9	3.1	-1.8	1.6	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	8.1	0.5	0.2	2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.7	4.7	0.5	2.2	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	8.9	-0.7	1.2	-3.0
Cardiovascular Disease	1.6	5.2	11.8	1.9	-0.4	3.4
Neuroticism	1.6	3.8	8.4	-1.7	2.9	-0.4
Sitting height	1.6	11.5	27.2	2.5	-1.0	5.2
Neuroticism score	1.6	3.3	7.3	-1.6	2.7	-0.4
Weight	1.6	7.7	16.7	2.0	-1.6	4.1
Pulse wave peak to peak time	1.6	1.9	4.5	-0.6	1.0	-2.1
Leg fat-free mass (right)	1.6	8.6	13.2	2.6	-2.4	3.6
Medication: Gliclazide	1.6	1.8	3.1	1.5	-0.2	1.8
Illnesses of father: None of the above (group 1)	1.6	2.0	4.0	-1.1	2.0	-0.8
Leg predicted mass (right)	1.6	8.7	13.2	2.6	-2.5	3.6
Lupus	1.5	2.3	2.8	1.7	-1.6	-1.3
BMI	1.5	9.0	13.0	2.7	-2.6	3.6
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	3.4	0.6	-1.9	1.2
Qualifications: None of the above	1.5	3.3	7.4	0.1	1.6	2.7
Ever smoked	1.5	2.6	4.7	1.6	-0.8	2.2
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.1	-1.1	1.8	0.8
Townsend deprivation index at recruitment	1.4	2.0	4.8	1.0	0.2	2.2
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.1	3.9	1.5	-2.0	1.8
Qualifications: A levels/AS levels or equivalent	1.4	3.1	5.3	1.4	-2.3	-1.4
Mouth/teeth dental problems: Dentures	1.4	2.3	5.1	1.3	0.0	2.3
Medication: Paracetamol	1.4	2.2	6.2	-0.5	2.5	0.3
Basal cell carcinoma (self-reported)	1.4	1.7	2.8	1.7	-1.4	-0.5
Neuroticism (Nagel 2018)	1.3	3.0	5.5	-1.8	2.3	-0.6
HDL Cholesterol	1.3	2.2	4.0	2.0	-1.6	0.4
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.6	0.4	-0.4	2.2
Systolic blood pressure, automated reading	1.3	3.8	7.4	1.6	-1.2	2.7
Fed-up feelings	1.3	2.4	6.2	1.0	-0.2	2.5
Pain all over the body in last month	1.3	1.4	2.1	1.4	-0.3	1.4
Fluid intelligence score	1.3	2.7	5.1	0.9	-2.2	-1.5
Exposure to tobacco smoke at home	1.3	1.5	3.4	0.6	-0.9	1.8
Medication for pain relief, constipation, heartburn	1.3	2.2	5.4	-1.2	-0.1	-2.3
Commuting to job workplace: Car/motor vehicle	1.3	1.4	2.0	-0.6	1.4	1.4
Handedness (chirality/laterality): Left-handed	1.3	1.5	2.7	1.6	0.6	1.3
Osteoarthritis (self-reported)	1.3	1.7	3.1	0.5	-1.3	1.8
Diastolic blood pressure, automated reading	1.3	4.1	7.7	2.0	-0.7	2.8
Vascular/heart problems diagnosed by doctor	1.3	3.4	8.2	-1.4	0.4	-2.9
Alzheimer’s Disease (in father)	1.2	1.3	2.4	-1.5	-0.2	-1.2
Height	1.2	22.6	58.5	2.3	-2.1	7.6
Respiratory disease	1.2	2.7	5.2	1.7	0.5	2.3
Average weekly spirits intake	1.2	1.4	2.2	1.5	0.2	1.5
Current tobacco smoking	1.2	2.0	2.7	0.8	-1.7	1.6
Stomach or abdominal pain in last month	1.2	1.5	4.1	0.6	-0.2	2.0
Waist circumference	1.2	4.2	8.3	1.4	-1.5	2.9
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	5.7	-0.1	-0.3	2.4
Medication: Paracetamol	1.2	2.0	5.1	-0.9	2.3	-0.1
Birth weight	1.2	2.6	3.9	1.9	-0.5	2.0
Health satisfaction	1.2	1.5	4.5	0.2	0.3	2.1
Neck or shoulder pain in last month	1.2	1.6	3.0	0.9	-1.1	1.7
Hypertension (Self-reported)	1.2	3.3	8.1	1.1	-0.8	2.8
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.2	-1.0	1.8	0.4
Intelligence (Savage-Jansen 2018)	1.1	3.4	7.0	1.7	-2.7	0.2
Ovarian Cancer	1.1	1.4	2.4	0.9	1.0	1.5
Age when periods started (menarche)	1.1	2.6	4.1	2.0	1.1	1.5
High blood pressure	1.1	3.0	6.9	1.2	-0.8	2.6
Supplements: Glucosamine	1.1	1.5	2.7	0.6	-1.1	1.6
Pulse rate	1.1	1.8	3.2	0.9	-1.8	1.1
Arm fat mass (right)	1.1	4.6	10.2	1.4	-1.3	3.2
Medication: Amlodipine	1.1	1.6	2.2	1.5	-1.2	1.1
Medication: Ventolin 100micrograms inhaler	1.1	1.5	3.3	-0.7	1.8	-0.8
Medication: Omeprazole	1.1	1.4	2.1	-1.5	1.4	-0.3
Leg fat mass (right)	1.1	4.3	9.7	1.4	-1.2	3.1
Family relationship satisfaction	1.1	1.3	2.6	0.3	1.6	1.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.8	-0.3	-1.1	-1.7
Long-standing illness, disability or infirmity	1.1	1.7	3.7	0.8	-1.0	1.9
Irritability	1.1	1.9	4.8	1.0	-0.1	2.2
Cholesterol lowering medication	1.1	1.6	2.8	1.3	-0.5	1.7
Pain experienced in last month	1.1	1.8	5.4	-0.4	-0.0	-2.3
Leg fat mass (left)	1.1	4.3	9.5	1.4	-1.2	3.1
Coronary Artery Disease (CAD)	1.0	1.2	3.3	-0.4	1.8	-0.0
Mean Putamen Volume	1.0	1.2	1.6	-1.3	1.2	-0.6
HbA1C	1.0	1.2	2.7	0.7	0.5	1.6
Ulcerative Colitis	1.0	1.4	1.6	-1.1	1.2	-1.3
Hypothyroidism (self reported)	1.0	2.4	5.1	1.4	0.3	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.0	1.0	-0.1	1.7
Financial difficulties in last 2 years	1.0	1.3	3.3	0.5	0.7	1.8
Mouth/teeth dental problems	1.0	1.5	2.5	-1.6	-1.0	-1.1
Alcohol intake versus 10 years previously	1.0	1.5	4.3	-0.1	-0.3	2.1
Gout (self-reported)	1.0	1.3	2.5	0.9	1.6	0.8
Comparative height size at age 10	1.0	5.6	16.2	0.5	-0.7	4.0
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	2.5	1.4	1.3	1.6
Eye problems/disorders: Cataract	1.0	1.2	2.6	-1.6	-0.0	-1.0
Smoking status: Current	1.0	1.6	2.1	0.8	-1.5	1.5
Eye problems/disorders: Glaucoma	1.0	1.2	1.8	-1.4	0.3	-1.3
Number of operations (self-reported)	1.0	1.5	4.1	0.1	0.6	2.0
Alcohol drinker status: Previous	1.0	1.2	3.5	0.1	-1.9	0.2
Alzheimer’s Disease (including proxy)	0.9	1.3	2.5	-1.0	-0.5	-1.6
Verbal and Numeric Reasoning (VNR)	0.9	2.3	5.5	0.9	-2.3	-0.7
Hearing difficulty/problems: Yes	0.9	1.4	3.5	-0.6	1.9	0.5
Impedance of leg (right)	0.9	4.2	7.3	-2.0	2.7	-1.1
Qualifications: CSEs or equivalent	0.9	1.2	2.9	-0.7	1.7	-0.4
High blood pressure (mother)	0.9	1.3	2.0	1.4	0.3	1.4
Impedance of leg (left)	0.9	4.4	5.8	-2.1	2.4	-1.7
Hearing difficulty/problems with background noise	0.9	1.5	4.5	-0.0	2.1	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	4.3	0.9	-2.1	1.1
Falls in the last year	0.9	1.2	1.9	1.1	0.7	1.4
Prospective memory result	0.9	1.1	2.1	-0.6	0.9	1.5
Qualifications: College or University degree	0.9	2.8	5.6	0.8	-2.4	-1.5
Whole body fat mass	0.9	3.5	9.7	0.8	-0.6	3.1
Number of full sisters	0.9	1.1	2.3	0.1	1.5	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.2	-1.5	0.7	0.3
Arm fat mass (left)	0.9	3.8	8.2	1.2	-1.2	2.9
Medication: Blood pressure	0.9	1.6	4.5	0.7	0.1	2.1
Medication: Bendroflumethiazide	0.9	1.4	4.3	0.0	0.1	2.1
Crohns Disease (2017)	0.8	1.6	3.9	0.9	0.5	2.0
Rheumatoid Arthritis	0.8	1.2	2.4	1.5	-0.1	1.0
Trunk fat mass	0.8	3.4	9.7	0.5	-0.4	3.1
Heart attack	0.8	1.1	2.3	-1.5	0.8	-0.5
Hip circumference	0.8	3.6	6.2	1.9	-0.9	2.5
Number of live births	0.8	1.1	2.3	-1.5	0.9	0.5
Standing height	0.8	8.1	21.3	1.6	-0.8	4.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.3	1.5	1.3	-0.2
Hearing aid user	0.8	0.9	2.6	-0.2	-0.3	1.6
Illnesses of father: High blood pressure	0.8	1.0	1.7	0.2	-1.3	1.2
Commuting to job workplace: Cycle	0.8	0.9	1.8	0.8	-0.6	-1.3
Myopia	0.8	1.1	2.5	0.4	-1.6	-0.8
Pack years of smoking	0.8	1.2	2.4	0.9	-0.6	1.5
Schizophrenia (2018)	0.7	1.5	3.4	-0.7	-0.8	-1.8
Ulcerative Colitis (UC)	0.7	1.4	2.4	-1.0	1.6	-0.9
Bipolar Disorder (2011)	0.7	0.7	1.2	0.9	1.1	0.3
Body Mass Index (BMI) (2010)	0.7	0.9	1.5	0.7	-1.2	0.9
Crohns Disease (2012)	0.7	1.1	1.3	0.8	1.1	1.1
Chronotype (morning person)	0.7	1.6	2.7	1.6	0.0	1.4
Pack years adult smoking proportion	0.7	1.1	1.8	1.0	-0.8	1.3
Maternal smoking around birth	0.7	1.0	1.6	-1.1	0.3	1.3
Medication: Cholesterol lowering	0.7	1.1	1.6	1.1	-0.8	1.3
Length of working week for main job	0.7	0.7	2.0	-1.4	0.4	0.1
Tense / ‘highly strung’	0.7	1.1	1.8	-1.2	1.3	-0.2
Shortness of breath walking on level ground	0.7	0.8	1.8	0.8	-0.1	1.4
Emphysema/chronic bronchitis	0.7	0.8	1.0	0.8	-1.0	0.9
Commuting to job workplace: Public transport	0.7	0.8	1.6	-0.6	-0.6	-1.3
Medication: Lisinopril	0.7	0.9	2.4	0.1	-0.6	1.6
Age started oral contraceptive pill	0.7	0.8	2.3	-0.4	0.1	-1.5
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.9	-1.4	0.8	-0.3
Schizophrenia (2014)	0.6	1.2	2.2	0.3	-1.5	-1.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.0	-0.4	0.5	1.4
Diabetes (mother)	0.6	0.7	1.6	0.3	0.7	1.2
Body mass index (BMI)	0.6	2.6	4.8	1.2	-1.2	2.2
Past tobacco smoking	0.6	1.2	1.9	-1.2	-0.4	-1.4
Depression (self-reported)	0.6	0.7	2.0	1.4	0.2	0.5
Medication: Lansoprazole	0.6	0.7	1.7	0.6	-0.4	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.6	-0.9	1.9	-1.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.4	1.0	0.2	1.6
Leg fat percentage (right)	0.6	2.1	5.5	0.8	-0.5	2.3
Medication: Allopurinol	0.6	0.7	1.6	0.2	1.3	-0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.4	-1.2	0.9	-0.4
High cholesterol (Self-reported)	0.6	1.0	1.6	1.3	-0.2	1.2
Major Depression (MDD)	0.5	0.6	1.5	-0.1	-1.2	-0.5
Blood White Count	0.5	3.6	7.3	1.7	-0.9	2.7
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.2	1.1	-0.9	1.0
Relative age of first facial hair	0.5	1.1	1.7	1.3	0.0	1.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.6	-0.0	-0.0	-1.3
Relative age voice broke	0.5	0.7	0.9	0.8	-0.9	0.8
Taking other prescription medications	0.5	0.8	1.2	-0.6	0.9	1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.0	-0.7	1.0	-0.0
Medication: Atenolol	0.5	0.7	1.4	0.1	1.2	0.8
Medication: Levothyroxine sodium	0.5	0.9	2.0	0.1	0.8	1.4
Medication: Simvastatin	0.5	0.7	0.7	0.8	-0.8	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.1	-0.6	-0.3	-1.4
Angina (self-reported)	0.5	0.6	1.3	-1.1	0.5	-0.6
Overall health rating	0.5	1.0	2.1	-0.9	-0.1	1.5
Supplements: Vitamin C	0.5	0.6	0.9	-0.9	-0.9	0.2
Smoking status: Previous	0.5	0.7	1.7	0.3	1.3	0.5
Wears glasses or contact lenses	0.5	0.5	0.9	0.9	-0.0	0.9
Mother’s age at death	0.5	0.6	1.1	1.1	-0.8	-0.1
Medication: Atorvastatin	0.5	0.6	1.1	0.6	-0.5	1.0
Alcohol drinker status: Never	0.5	0.7	1.0	-0.9	1.0	-0.4
Leg fat percentage (left)	0.5	1.7	4.2	0.7	-0.7	2.0
Heart disease (siblings)	0.5	0.6	1.0	1.0	-0.2	1.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	-0.5	-0.2	-1.1
Age at First Birth	0.4	0.6	0.9	0.6	-0.9	-0.8
LDL Cholesterol	0.4	0.6	0.8	0.2	0.9	0.9
Primary Biliary Cirrhosis	0.4	0.6	1.7	-0.3	1.3	-0.1
Triglycerides	0.4	0.6	1.2	-0.5	0.6	1.1
Angina	0.4	0.6	1.1	-1.1	0.6	-0.5
Medication for hormone replacement therapy	0.4	0.5	1.4	-1.2	-0.1	-0.2
Vitamin and mineral supplements	0.4	0.5	1.0	0.7	1.0	-0.4
Supplements: Zinc	0.4	0.4	1.1	0.1	-0.3	1.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.8	-1.3	0.7	-0.7
Multivitamins +/- minerals	0.4	0.5	1.2	-0.5	-1.1	0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	1.7	-1.1	1.3	-1.3
Asthma	0.4	0.8	2.2	-0.0	1.5	0.4
Hair/balding pattern: Pattern 4	0.4	1.0	3.0	-1.7	0.1	0.2
Body fat percentage	0.4	1.4	4.1	-0.1	0.2	2.0
Exposure to tobacco smoke outside home	0.4	0.6	1.2	-0.7	1.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.5	0.3	0.1	1.2
Medication: Blood pressure	0.4	0.7	1.8	0.5	0.2	1.3
Pulse rate, automated reading	0.4	1.1	2.1	0.3	-1.5	1.1
Illnesses of siblings: Diabetes	0.4	0.5	0.8	-0.9	0.9	-0.1
Medication for cholesterol	0.4	0.6	1.8	-0.1	0.3	-1.3
Asthma (self-reported)	0.4	0.8	1.9	0.1	1.4	0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	1.8	-0.1	-0.8	-1.3
Breast Cancer	0.3	0.8	1.6	-0.8	0.5	-1.2
Neuroticism (2016)	0.3	0.4	0.6	-0.5	0.8	0.6
Waist Hip Ratio (WHR)	0.3	1.5	4.3	-0.1	-0.5	2.1
Systolic Blood Pressure	0.3	1.3	3.3	0.7	-0.3	1.8
Lung FVC	0.3	1.4	3.1	1.0	-0.1	-1.8
Trunk fat percentage	0.3	1.3	3.6	-0.3	0.3	1.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	1.0	-0.4	0.1
Alcohol usually taken with meals	0.3	0.4	0.8	0.9	0.4	0.5
Had menopause	0.3	0.4	0.7	-0.7	0.9	-0.1
Had other major operations	0.3	0.3	0.6	-0.1	-0.6	0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.7	-0.3	0.6	0.8
Diabetes (self-reported)	0.3	0.5	1.1	-0.5	-1.1	-0.1
Arm fat percentage (right)	0.3	1.2	3.4	0.2	-0.5	1.8
Father’s age at death	0.3	0.4	1.2	0.2	-0.2	-1.1
Hair/balding pattern: Pattern 3	0.3	0.5	1.1	-0.5	-0.1	-1.1
Noisy workplace	0.3	0.4	1.0	-0.0	0.5	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.5	0.7	0.2	-0.7
Forced vital capacity (FVC), Best measure	0.3	0.9	2.4	0.6	1.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	-0.6	0.0	-0.8
Heart disease (mother)	0.3	0.4	0.7	0.3	0.9	0.6
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.5	-0.4	-0.8
Diabetes diagnosed by doctor	0.3	0.5	1.1	0.1	-1.1	0.6
Average weekly beer plus cider intake	0.3	0.5	1.0	-0.3	1.0	-0.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	0.9	0.2	0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.4	0.5	0.9
Depression (Nagel 2018)	0.2	0.3	0.5	-0.5	0.1	0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.1	-0.3	1.1	0.7
Average weekly fortified wine intake	0.2	0.2	0.6	0.0	-0.1	0.8
Forced vital capacity (FVC)	0.2	0.8	1.3	0.9	1.2	0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	0.1	0.3	-0.8
Medication: Ramipril	0.2	0.3	0.5	-0.7	0.3	-0.6
Time employed in main current job	0.2	0.3	0.7	-0.2	-0.3	-0.8
Lung cancer (father)	0.2	0.2	0.3	-0.5	0.0	0.5
Birth weight of first child	0.2	0.3	0.8	0.9	-0.4	-0.2
Loud music exposure frequency	0.2	0.3	0.4	0.6	0.2	-0.6
Headache pain in last month	0.2	0.4	1.0	0.2	-0.1	1.0
Comparative body size at age 10	0.2	0.7	1.8	-0.5	-1.3	-0.0
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	0.6	0.2	0.9
Age at first live birth	0.2	0.3	0.7	0.5	0.3	-0.8
Migraine (self-reported)	0.2	0.2	0.4	-0.4	0.2	-0.6
Medication: Seretide 50 evohaler	0.2	0.3	0.4	0.3	-0.6	0.6
Arm fat percentage (left)	0.2	0.9	2.4	0.0	-0.6	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.4	-0.1	-0.7
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.3	-0.4	0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	0.0	-0.7	0.6
Ever depressed for a whole week	0.2	0.3	0.7	-0.3	0.8	0.1
Unable to work because of sickness or disability	0.2	0.2	0.3	-0.6	-0.6	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.8	0.3	-0.0
Bipolar Disorder (2018)	0.1	0.2	0.5	0.7	-0.3	0.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	0.3	-0.3	-0.3
Prostate Cancer	0.1	0.1	0.4	0.1	0.0	-0.6
Fasting Glucose	0.1	0.1	0.1	0.3	-0.3	0.0
Blood Eosinophil Count	0.1	0.8	1.9	0.5	0.3	1.4
Blood Platelet Count	0.1	1.3	3.6	1.9	0.5	0.4
Allergy or Eczema	0.1	0.2	0.4	-0.6	0.5	0.0
Hair Pigment	0.1	2.1	3.6	1.9	-0.7	1.5
Tanning	0.1	1.0	2.0	1.0	-0.4	1.4
Hand grip strength (left)	0.1	0.2	0.2	-0.3	0.5	-0.4
Medication: Metformin	0.1	0.2	0.3	-0.5	-0.3	0.5
Serious illness, injury or assault to yourself	0.1	0.2	0.5	-0.3	-0.0	0.7
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.4	0.5	-0.1
Allergy	0.1	0.3	0.5	0.7	-0.6	-0.1
Happiness	0.1	0.1	0.1	-0.2	0.4	0.2
Pulse wave reflection index	0.1	0.1	0.2	-0.1	0.5	-0.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	0.2	0.1	-0.6
Blood clot in the leg (DVT)	0.1	0.2	0.3	-0.3	0.2	0.6
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.1	-0.1	0.5
Number of full brothers	0.1	0.2	0.3	0.2	-0.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	0.4	0.0	-0.3
Alcohol intake frequency.	0.1	0.2	0.4	-0.4	0.1	0.7
Had major operations	0.1	0.1	0.3	-0.3	0.6	0.1
Friendships satisfaction	0.1	0.2	0.5	-0.1	-0.2	0.7
Commuting to job workplace: Walk	0.1	0.2	0.3	0.6	-0.3	-0.3
Back pain experienced in last month	0.1	0.1	0.3	-0.3	0.5	0.1
Breast cancer (self-reported)	0.1	0.1	0.2	0.2	0.2	-0.5
Blood Red Count	0.0	0.3	0.6	-0.8	-0.4	0.0
Hand grip strength (right)	0.0	0.1	0.2	0.1	0.4	0.3
Number of children fathered	0.0	0.0	0.1	0.0	-0.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.1	-0.3	0.2	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.0	-0.0	-0.2	-0.2
Average weekly red wine intake	0.0	0.0	0.1	-0.0	0.1	0.2
Qualifications: nursing, teaching	0.0	0.1	0.1	0.3	-0.3	-0.0
Mineral and other dietary supplements	0.0	0.0	0.1	0.3	-0.1	0.1

Hub : Genes

XBP1P1

Models

Trait associations