Best TWAS P=8.35e-17 · Best GWAS P=7.63e-18 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DNAJC30 | 0.13 | 0.07 | enet | 32 | 0.07 | 2.7e-09 | 6.54 | 7.3 | 3.1e-13 | 0.36 | 1.00 | 0.00 | TRUE |
2 | GTEx | Adipose Subcutaneous | MLXIPL | 0.11 | 0.07 | enet | 16 | 0.07 | 1.6e-06 | 7.38 | 8.0 | 1.5e-15 | 0.70 | 0.55 | 0.44 | TRUE |
3 | GTEx | Adipose Visceral Omentum | MLXIPL | 0.16 | 0.02 | lasso | 3 | 0.03 | 7.8e-03 | 7.19 | 7.7 | 1.6e-14 | 0.67 | 0.70 | 0.21 | FALSE |
4 | GTEx | Adipose Visceral Omentum | NSUN5 | 0.07 | 0.03 | enet | 11 | 0.04 | 4.0e-03 | 7.79 | 6.3 | 3.5e-10 | 0.48 | 0.07 | 0.13 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | MLXIPL | 0.13 | 0.06 | enet | 6 | 0.09 | 2.2e-07 | 7.87 | 8.2 | 2.2e-16 | 0.77 | 0.45 | 0.55 | FALSE |
6 | GTEx | Heart Left Ventricle | MLXIPL | 0.14 | 0.00 | enet | 24 | 0.01 | 1.3e-01 | 0.34 | 5.7 | 1.6e-08 | 0.38 | 0.18 | 0.10 | FALSE |
7 | GTEx | Lung | MLXIPL | 0.10 | 0.07 | enet | 14 | 0.07 | 6.3e-06 | 7.38 | 5.8 | 6.2e-09 | 0.50 | 0.37 | 0.10 | TRUE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | MLXIPL | 0.11 | 0.11 | lasso | 3 | 0.06 | 2.7e-04 | 7.87 | 7.7 | 1.4e-14 | 0.62 | 0.29 | 0.48 | TRUE |
9 | GTEx | Skin Sun Exposed Lower leg | MLXIPL | 0.12 | 0.09 | lasso | 4 | 0.06 | 6.1e-06 | 7.82 | 8.0 | 1.4e-15 | 0.69 | 0.70 | 0.28 | FALSE |
10 | GTEx | Spleen | NCF1B | 0.22 | 0.10 | enet | 9 | 0.08 | 5.1e-03 | 8.18 | -8.3 | 8.4e-17 | -0.88 | 0.02 | 0.66 | TRUE |
11 | GTEx | Testis | MLXIPL | 0.10 | 0.00 | lasso | 3 | 0.00 | 3.3e-01 | 5.33 | 7.2 | 5.1e-13 | 0.58 | 0.05 | 0.09 | FALSE |
12 | GTEx | Testis | VPS37D | 0.15 | 0.01 | lasso | 5 | 0.03 | 2.7e-02 | -5.74 | -6.2 | 4.9e-10 | -0.33 | 0.13 | 0.05 | TRUE |
13 | GTEx | Thyroid | MLXIPL | 0.23 | 0.14 | lasso | 7 | 0.15 | 2.1e-11 | 7.38 | 8.3 | 1.0e-16 | 0.73 | 0.67 | 0.33 | FALSE |
14 | METSIM | Adipose | BCL7B | 0.10 | 0.02 | enet | 20 | 0.05 | 1.2e-07 | 7.19 | 5.3 | 1.0e-07 | 0.20 | 0.62 | 0.34 | TRUE |
15 | METSIM | Adipose | MLXIPL | 0.12 | 0.14 | lasso | 4 | 0.13 | 1.8e-19 | 7.82 | 8.2 | 3.0e-16 | 0.80 | 0.74 | 0.26 | FALSE |
16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | STX1A | 0.03 | 0.02 | lasso | 1 | 0.01 | 2.9e-02 | -5.87 | -5.9 | 4.4e-09 | -0.30 | 0.00 | 0.82 | FALSE |
17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MLXIPL | 0.06 | 0.05 | lasso | 2 | 0.05 | 5.1e-10 | 7.78 | 7.3 | 2.1e-13 | 0.77 | 0.12 | 0.88 | FALSE |
18 | The Cancer Genome Atlas | Lung Adenocarcinoma | MLXIPL | 0.04 | 0.03 | lasso | 1 | 0.02 | 2.3e-03 | 7.78 | 7.8 | 7.4e-15 | 0.83 | 0.02 | 0.54 | FALSE |
19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MLXIPL | 0.08 | 0.05 | enet | 4 | 0.05 | 5.3e-06 | 7.78 | 6.7 | 2.0e-11 | 0.70 | 0.04 | 0.86 | FALSE |
20 | The Cancer Genome Atlas | Soft Tissue Sarcoma | TBL2 | 0.16 | 0.00 | enet | 5 | 0.09 | 5.1e-06 | -1.12 | -5.3 | 1.4e-07 | -0.52 | 0.00 | 0.50 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | BCL7B | 0.05 | 0.01 | blup | 5 | 0.03 | 1.3e-03 | 7.78 | -7.5 | 4.5e-14 | -0.93 | 0.00 | 0.63 | FALSE |