TWAS
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Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Trunk fat-free mass
:
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→
chr8:22,428,708-23,954,601
Best TWAS P=6.77e-10 · Best GWAS P=1.27e-11 conditioned to 3.01e-10
22.4M
22.6M
22.8M
23M
23.2M
23.4M
23.6M
23.8M
24M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
STC1
0.04
0.05
enet
7
0.06
8.9e-12
-6.3
6.2
6.8e-10
0.03
0.01
0.99
TRUE
3
The Cancer Genome Atlas
Thyroid Carcinoma
CHMP7
0.10
0.02
lasso
6
0.04
5.4e-05
2.8
-5.9
3.9e-09
-0.05
0.00
0.99
TRUE
1
YFS
Blood
R3HCC1
0.03
0.01
lasso
6
0.01
5.3e-04
-5.9
5.7
1.6e-08
0.01
0.12
0.85
FALSE