Hub : Genes

CHMP7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1930	0.0680	5.0e-03	0.049	NA	0.027	NA	0.062	1.1e-03	NA	1.2e-02	NA	2.5e-04
2	GTEx	Cells Transformed fibroblasts	0.3180	0.0560	7.0e-10	0.076	NA	0.150	NA	0.168	2.5e-06	NA	2.2e-11	NA	1.3e-12
3	GTEx	Muscle Skeletal	0.1857	0.0434	7.7e-06	0.042	NA	0.090	NA	0.060	5.0e-05	NA	4.0e-09	NA	1.5e-06
4	GTEx	Skin Sun Exposed Lower leg	0.1110	0.0400	2.1e-03	0.050	NA	0.056	NA	0.056	5.6e-05	NA	2.1e-05	NA	2.1e-05
5	METSIM	Adipose	0.0482	0.0184	2.9e-03	-0.001	0.017	0.003	0.016	0.003	5.3e-01	1.0e-03	1.1e-01	1.3e-03	9.1e-02
6	ROSMAP	Brain Pre-frontal Cortex	0.1294	0.0318	3.2e-07	0.131	0.067	0.107	0.118	0.126	1.8e-16	5.6e-09	1.1e-13	6.9e-15	7.2e-16
7	TCGA	Brain Lower Grade Glioma	0.0920	0.0318	7.8e-06	0.011	0.045	0.028	NA	0.013	2.0e-02	6.4e-06	3.2e-04	NA	1.1e-02
8	TCGA	Ovarian Serous Cystadenocarcinoma	0.0470	0.0250	9.3e-03	0.016	0.033	0.021	NA	0.022	2.7e-02	2.5e-03	1.3e-02	NA	1.1e-02
9	TCGA	Prostate Adenocarcinoma	0.0302	0.0151	4.8e-03	0.030	0.009	0.000	NA	0.007	3.6e-04	3.8e-02	3.1e-01	NA	6.0e-02
10	TCGA	Thyroid Carcinoma	0.1020	0.0390	3.7e-05	0.019	0.038	0.042	NA	0.042	5.6e-03	1.3e-04	6.0e-05	NA	5.4e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.9	1.5	9.6	0.2	0.8	-0.6	1.2	3.1	0.4	-0.1	1.0	1.1	0.3
Bipolar Disorder or Schizophrenia	0.8	2.1	8.8	-0.6	1.1	-1.9	1.4	3.0	0.3	0.6	1.4	1.2	1.0
Depressed Affect (Nagel 2018)	2.1	4.3	8.8	0.1	-2.0	-1.4	-2.4	-1.1	-2.6	-1.8	-2.4	-3.0	-2.4
Depression (Nagel 2018)	1.4	2.1	5.8	0.6	-0.7	-1.8	-1.2	-0.4	-2.4	-0.8	-0.7	-1.7	-2.4
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.5	-1.9	0.2	-1.9	0.0	0.3	0.6	-0.2	0.4	0.2	2.1
Neuroticism (Nagel 2018)	1.1	2.6	7.3	-0.6	-1.2	-1.5	-1.8	0.4	-2.2	-0.3	-1.7	-2.7	-1.8
Schizophrenia (2018)	0.6	1.1	4.0	-0.9	0.8	-2.0	0.8	1.4	0.0	0.9	1.0	0.7	1.1
Schizophrenia vs Biploar Disorder	0.8	1.0	3.1	1.8	-1.0	-0.3	-1.8	-0.6	0.3	1.1	-0.5	-1.1	0.3
Worry (Nagel 2018)	0.4	0.9	3.0	-0.4	-0.3	-1.0	-0.2	0.9	-1.7	0.5	-0.6	-1.4	-1.2
Alzheimer’s Disease (in mother)	0.6	0.7	4.1	0.6	0.2	-0.7	0.2	2.0	-0.5	0.6	0.6	0.8	-0.2
Alzheimer’s Disease (in father)	1.0	1.1	4.1	1.3	-0.2	2.0	-0.8	-0.7	-0.4	-0.2	-0.9	-1.5	-0.9
Alzheimer’s Disease (including proxy)	0.5	0.8	2.0	1.0	-0.4	0.4	-1.0	1.4	-1.2	-0.2	-0.9	-0.2	-1.1
Crohns Disease (2017)	0.5	1.2	2.5	-0.9	1.2	0.8	1.3	0.7	1.6	0.8	1.0	1.4	0.9
Irritable Bowel Disease (IBD)	0.6	1.3	2.4	-1.2	1.4	-0.2	1.6	0.7	1.5	1.2	1.5	0.9	0.5
Ulcerative Colitis (UC)	0.5	0.8	2.5	-1.6	1.1	-1.1	1.2	0.4	0.2	0.5	1.2	-0.2	-0.4
Major Depression (MDD)	1.0	1.2	5.5	-0.9	0.3	-2.3	0.7	1.0	-0.4	1.6	1.2	-0.2	0.3
Reaction Time	1.5	2.9	7.7	0.5	1.0	-1.5	1.6	0.6	1.3	2.0	2.8	2.1	2.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.7	-0.5	0.1	-0.6	0.3	2.0	1.6	-0.2	0.7	1.0	2.2
Breast Cancer	0.7	1.7	7.8	0.3	-1.1	2.8	-1.6	-0.5	-0.6	-1.1	-1.6	-1.0	-0.7
Ovarian Cancer	0.5	0.7	3.1	0.3	0.9	0.7	1.2	-0.2	0.2	0.1	0.6	1.8	1.0
Prostate Cancer	1.0	1.5	3.6	-1.3	-1.9	0.9	-0.4	0.1	1.1	-1.7	-0.4	1.6	1.2
Age at First Birth	0.4	0.6	2.3	-0.7	0.6	0.7	0.3	1.5	0.6	1.3	0.7	0.4	0.4
Bipolar Disorder (2011)	1.0	1.0	6.2	-0.5	0.9	1.3	0.9	2.5	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.4	6.8	1.2	-0.4	0.5	-0.8	-2.6	-0.7	-0.3	-1.0	-1.7	-0.5
Coronary Artery Disease (CAD)	0.9	1.1	4.6	-0.1	1.3	-1.0	1.8	2.2	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.4	0.7	3.3	0.2	0.3	1.8	0.2	0.3	1.2	0.3	0.3	1.0	0.7
Mean Putamen Volume	0.7	0.8	1.9	-0.6	0.0	1.1	-0.5	-1.4	-0.8	-0.6	-0.5	-1.4	-1.1
Fasting Glucose	0.2	0.3	0.6	-0.7	0.5	-0.5	-0.1	0.4	-0.2	0.3	0.7	-0.8	-0.8
HbA1C	0.2	0.2	1.0	-0.3	0.2	-0.0	0.3	-1.0	-0.4	-0.1	0.4	0.3	0.4
HDL Cholesterol	0.3	0.5	1.4	1.0	-0.1	-0.7	1.0	-0.3	-0.0	0.1	0.6	1.2	0.9
LDL Cholesterol	0.6	0.9	4.6	1.3	-0.6	1.0	-0.3	-2.2	0.0	-0.1	-0.9	0.2	0.9
Lupus	0.4	0.6	2.6	-0.2	0.6	0.5	0.5	-0.9	0.7	1.6	0.6	0.2	0.5
Neuroticism (2016)	0.5	0.7	2.3	0.1	-1.1	-0.9	-1.1	0.1	-0.5	-0.6	-1.5	-0.4	-0.9
Primary Biliary Cirrhosis	0.5	0.7	3.1	1.8	-0.4	-0.1	-0.5	-0.8	0.5	-1.4	-0.4	0.6	-0.0
Rheumatoid Arthritis	1.2	1.7	4.2	-0.4	1.9	-0.7	2.1	-0.6	0.8	1.2	1.7	0.8	1.6
Schizophrenia (2014)	0.2	0.4	1.9	-0.7	-0.5	-1.4	-0.2	0.8	0.1	-0.0	0.3	0.6	0.4
Triglycerides	0.3	0.4	1.1	0.7	0.2	0.6	-0.7	-0.9	0.5	0.5	-0.2	-1.0	0.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.8	-0.6	0.1	-0.4	0.5	-0.4	-0.0	-0.6	0.4	0.2	0.9
Ulcerative Colitis	0.6	0.8	2.9	-0.2	1.7	-0.2	1.2	0.6	0.0	1.1	1.1	-0.6	-0.7
Blood Eosinophil Count	0.6	4.3	16.9	4.1	-1.1	1.5	-3.1	-1.3	-0.3	-0.5	-1.7	-2.4	-1.4
Blood Platelet Count	0.1	1.3	5.1	-0.2	-0.6	-2.2	-0.7	-1.4	0.8	-1.4	-1.1	1.2	-0.2
Blood Red Count	0.6	5.4	19.9	1.0	-4.5	1.1	-3.0	-2.4	-1.3	-2.6	-2.8	-0.6	-0.2
Blood White Count	0.7	5.4	17.1	-0.1	-0.6	2.2	-2.0	-1.2	-3.0	-1.3	-2.6	-4.1	-2.9
Heel T-Score	0.1	1.1	3.6	0.8	0.5	-0.2	-0.9	1.6	-0.7	-0.5	-0.8	-1.4	-1.9
BMI	1.3	7.7	19.2	0.9	-1.9	-0.3	-2.4	-4.4	-2.9	-2.6	-2.8	-3.3	-3.7
Height	2.0	38.1	89.5	-2.5	-4.3	-5.0	-6.7	-1.4	-7.1	-5.7	-6.2	-9.5	-8.6
Waist Hip Ratio (WHR)	0.2	1.1	6.1	1.5	-0.9	2.5	-0.7	1.0	-0.6	0.1	-0.3	-0.1	-0.1
Systolic Blood Pressure	0.6	2.8	11.6	-0.4	2.4	0.5	2.4	3.4	-0.1	1.5	1.4	0.8	0.4
Smoking Status	1.0	2.5	4.9	1.7	-1.6	1.3	-2.1	0.1	-1.1	-1.6	-2.2	-2.0	-1.0
Allergy or Eczema	0.6	1.5	5.8	2.4	-1.8	1.5	-1.3	-1.2	-0.5	-0.6	-0.6	-0.2	-0.4
Cardiovascular Disease	0.5	1.6	4.2	-1.0	1.8	2.0	2.1	1.1	-0.6	0.9	0.9	0.4	0.1
Hypothyroidism (self reported)	0.5	1.1	2.6	-0.0	1.0	-0.9	0.9	-1.6	0.9	1.1	1.6	1.1	0.6
Respiratory disease	0.5	1.2	4.5	2.1	-0.7	2.1	-0.1	1.0	0.8	0.0	-0.1	0.4	0.8
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.7	0.1	0.5	1.3	0.4	-0.4	-0.4	1.1	-0.1	-1.0	0.0
Lung FEV1/FVC ratio	0.4	1.9	3.1	-0.6	-1.3	-1.2	-1.6	-1.7	-0.6	-1.7	-1.8	-1.2	-1.4
Lung FVC	0.2	0.9	2.6	0.0	0.7	-0.8	1.1	-0.7	0.4	0.8	0.8	1.5	1.6
Neuroticism	0.5	1.2	4.9	-0.2	-0.2	-1.0	-1.1	0.5	-1.3	0.5	-0.7	-2.2	-1.4
Chronotype (morning person)	3.8	8.8	22.9	0.8	-4.2	0.5	-4.8	-2.0	-1.5	-3.5	-4.2	-2.1	-2.5
Hair Pigment	0.1	1.8	6.0	-1.5	0.6	2.4	0.8	-0.8	2.0	0.5	0.5	1.9	0.5
Tanning	0.0	0.4	1.5	-0.2	0.1	1.1	0.2	1.2	-0.3	-0.2	-0.6	-0.3	-0.3
Hand grip strength (left)	0.8	2.1	9.9	0.3	3.1	0.2	2.0	0.5	0.1	1.4	2.0	0.6	-0.5
Number of treatments/medications taken	0.5	0.9	1.8	0.1	0.8	1.1	1.3	0.7	0.4	1.1	0.9	1.0	1.1
Average weekly spirits intake	1.1	1.4	4.4	0.3	-0.7	-0.3	-0.7	-0.1	-1.3	-1.3	-1.6	-2.1	-1.6
Sensitivity / hurt feelings	0.1	0.2	0.7	0.5	0.2	0.5	-0.0	0.8	-0.1	0.6	-0.0	-0.5	0.7
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.0	1.7	-0.8	-0.8	-1.4	-0.9	-1.0	-0.3	-1.1	-1.3	-1.5
Hearing difficulty/problems: Yes	0.5	0.7	2.9	-0.7	0.1	-0.1	1.3	0.7	0.2	-1.0	-0.1	1.7	0.6
Relative age of first facial hair	0.4	0.7	2.4	-0.6	0.6	-1.5	0.6	1.6	-0.9	-0.7	0.4	0.0	-0.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	4.0	-0.1	-2.0	0.2	-1.8	-0.3	-1.8	-0.3	-1.4	-1.0	-2.0
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.7	0.8	-1.2	-0.5	-0.9	0.0	-0.2	-0.8	-1.3	-0.4	-1.3
Ever had hysterectomy (womb removed)	0.5	0.6	3.0	-0.8	-0.3	1.7	0.0	-0.5	-0.0	0.1	-0.7	-0.8	-0.9
Systolic blood pressure, automated reading	0.4	1.0	4.1	0.5	1.1	1.1	1.1	2.0	-0.7	1.1	0.4	-0.1	-0.7
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	4.1	0.9	-2.0	0.9	-2.0	-0.3	-0.2	-1.0	-1.2	-0.9	-0.6
Angina	0.9	1.2	4.3	0.2	-0.8	0.2	-0.8	-0.7	-2.1	-0.7	-1.2	-1.3	-1.4
Medication for hormone replacement therapy	0.5	0.5	2.0	0.2	-0.0	-0.0	0.6	0.9	-1.1	-0.9	-0.3	0.0	-1.4
Vitamin and mineral supplements	1.4	1.9	4.9	0.5	-1.0	0.4	-2.2	-1.1	-1.1	-0.2	-1.1	-2.1	-2.2
Supplements: Zinc	0.3	0.3	1.0	0.9	0.2	0.2	0.8	0.2	0.2	0.3	0.2	1.0	0.7
Medication: Co-codamol	0.8	0.9	2.6	-0.2	1.6	-0.4	0.9	1.3	1.1	1.0	0.8	-0.1	0.9
Medication: Metformin	1.3	1.8	5.1	0.4	-1.7	0.2	-2.2	-0.6	-1.0	-0.4	-2.3	-1.8	-1.0
Diabetes (father)	1.2	1.5	6.0	0.9	-0.0	-0.1	-1.2	-1.1	-1.3	-0.8	-1.2	-2.5	-1.4
Diabetes (mother)	0.3	0.4	1.2	0.1	1.0	-0.3	0.5	0.5	0.6	0.4	0.7	0.2	1.1
Severe depression (siblings)	0.4	0.5	1.4	-1.1	-0.1	-0.3	-0.0	-0.8	-1.2	-0.1	-0.7	-0.9	-0.3
Pack years adult smoking proportion	2.2	3.3	9.3	-0.3	-2.2	-0.5	-2.7	0.6	-1.2	-2.3	-3.0	-1.9	-0.9
Impedance of leg (right)	0.5	2.6	8.4	-1.4	1.7	-0.2	2.1	0.3	0.8	1.9	1.9	0.7	2.9
Leg fat-free mass (left)	2.8	14.9	34.9	-0.0	-2.8	-1.5	-4.4	-3.1	-3.9	-3.9	-4.3	-5.2	-5.9
Trunk fat percentage	3.3	13.4	25.0	0.5	-3.4	-0.8	-4.0	-4.8	-4.2	-2.9	-3.9	-5.0	-4.0
Hand grip strength (right)	1.2	3.4	14.4	-0.3	3.8	-0.7	2.6	1.3	-0.0	1.8	2.5	0.5	-0.2
Townsend deprivation index at recruitment	1.1	1.5	5.5	-0.3	1.4	1.0	1.4	-0.6	2.3	0.4	0.8	1.3	1.3
Current tobacco smoking	0.4	0.6	2.2	0.7	0.1	-1.5	-0.5	-0.0	-0.6	-0.7	-0.6	-1.2	-0.3
Average weekly fortified wine intake	1.3	1.5	3.2	1.8	0.4	0.1	-0.5	-0.8	-0.9	-1.7	-1.3	-1.6	-1.8
Maternal smoking around birth	0.9	1.3	3.0	0.9	-0.6	1.5	-0.6	-0.4	-1.3	-1.7	-1.7	-0.8	-0.8
Fed-up feelings	0.3	0.6	2.8	1.7	-0.5	0.1	-0.7	-0.8	-0.7	0.3	-0.7	-0.9	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	4.1	1.0	-1.1	-1.0	-1.2	-0.9	-2.0	-0.4	-0.7	-1.2	-1.5
Relative age voice broke	1.0	1.5	5.3	-0.9	0.8	-1.9	1.1	2.3	-1.3	-0.9	0.5	0.4	0.3
Taking other prescription medications	0.4	0.6	1.6	1.3	-0.5	0.8	-0.0	0.2	0.5	-0.1	-0.1	1.1	1.2
Age when periods started (menarche)	1.1	2.6	6.7	-0.4	-2.0	0.5	-2.2	-0.9	-0.4	-1.7	-2.6	-1.6	-1.7
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.9	-0.5	-0.5	-0.8	-1.4	-0.8	-0.7	-0.0	-1.0	-1.4	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.8	2.0	-0.2	0.0	-1.6	0.1	0.4	-0.4	-0.7	-1.5	-1.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	-0.6	0.5	0.4	0.9	-0.2	0.1	-0.6	-0.5	0.7	-0.4
Qualifications: CSEs or equivalent	0.2	0.3	1.1	1.0	-0.3	0.7	0.3	-0.7	0.4	-0.3	-0.2	-0.0	0.4
Serious illness, injury or assault to yourself	1.4	1.7	6.0	0.5	-2.4	1.6	-1.6	-0.7	-1.4	-0.4	-1.2	-0.7	-0.7
High blood pressure	0.6	1.7	6.0	-2.4	0.2	2.0	1.1	0.5	-1.8	-1.1	-0.4	-0.1	-0.8
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.3	1.8	-1.0	1.7	-0.3	-0.8	0.1	0.4	0.1	0.4	0.8
Multivitamins +/- minerals	1.1	1.5	4.4	-0.4	1.2	-0.8	2.1	0.7	0.6	-0.3	1.1	1.8	1.6
Stomach or abdominal pain in last month	1.1	1.4	6.0	0.6	-2.5	0.4	-2.1	-0.3	-0.4	-1.3	-1.0	-0.5	-0.1
Supplements: Glucosamine	0.5	0.7	2.5	0.4	-1.2	-1.6	-0.6	0.8	-0.6	-0.5	-0.5	0.5	-0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	3.2	-0.3	-1.1	-1.8	-0.3	-0.2	-0.1	-0.8	-0.2	0.0	-0.8
Medication: Atenolol	1.3	1.7	8.4	-2.9	2.2	-1.0	1.0	-0.2	-0.5	0.0	0.2	-0.9	-0.4
Medication: Levothyroxine sodium	0.4	0.7	2.2	0.3	0.2	-0.2	0.2	-1.5	1.3	-0.4	0.2	1.4	0.8
Sitting height	1.9	13.2	27.8	-0.1	-2.8	-3.2	-4.7	-2.1	-3.5	-3.2	-3.5	-5.3	-5.0
Chronic bronchitis/emphysema (father)	0.6	0.7	2.1	-0.7	-1.4	0.9	-0.4	0.0	-1.2	-0.5	-1.0	0.2	-0.5
High blood pressure (mother)	0.9	1.2	3.6	-1.4	1.6	-0.7	1.9	1.2	-0.0	0.1	1.1	0.7	0.7
Body mass index (BMI)	2.0	8.3	17.4	0.8	-2.6	0.1	-3.2	-4.2	-2.9	-2.4	-3.4	-3.3	-3.5
Impedance of leg (left)	0.5	2.3	6.9	-1.1	1.8	-0.3	2.1	0.5	0.7	1.6	1.8	0.7	2.6
Leg predicted mass (left)	2.8	15.1	35.8	-0.1	-2.8	-1.5	-4.4	-3.1	-3.9	-3.9	-4.3	-5.2	-6.0
Trunk fat mass	4.2	18.1	34.0	0.3	-3.7	-0.9	-4.7	-5.0	-4.7	-3.5	-4.7	-5.8	-5.3
Waist circumference	2.7	10.0	18.7	0.2	-2.9	-0.1	-3.5	-3.6	-3.6	-2.9	-3.6	-3.6	-4.3
Number of incorrect matches in round	0.4	0.6	3.2	0.3	0.6	0.8	0.2	1.8	-0.1	1.1	0.1	-0.9	0.2
Past tobacco smoking	0.6	1.1	3.7	-1.5	1.6	-1.9	1.4	-0.4	-0.3	-0.3	0.8	0.3	0.4
Alcohol usually taken with meals	0.2	0.3	1.4	-0.3	0.4	-0.6	-0.1	0.4	-1.2	-0.3	-0.0	-1.0	-0.5
Nervous feelings	0.4	0.8	3.5	0.6	1.1	-0.5	0.9	0.9	-0.6	1.9	0.8	-0.6	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	5.3	2.3	-0.6	-1.5	-1.3	-0.1	-1.5	-0.0	-0.9	-1.7	-1.6
Hearing difficulty/problems with background noise	0.8	1.3	4.1	-1.1	1.4	-0.7	2.0	1.1	0.9	0.8	1.0	1.1	0.7
Hair/balding pattern: Pattern 2	0.4	0.5	2.0	-0.3	-0.6	-1.4	-0.8	-0.7	-0.9	-0.3	-0.3	-0.3	0.0
Had menopause	0.6	0.8	2.5	0.1	-1.2	-0.9	-1.0	0.3	-0.6	-1.6	-0.6	-0.3	-1.1
Had other major operations	0.4	0.4	1.0	-0.1	-0.9	0.8	-0.6	-0.4	-0.3	0.7	-0.4	-0.9	-1.0
Forced vital capacity (FVC)	0.2	0.8	2.5	-0.4	1.1	-1.6	0.0	-1.1	-0.9	0.2	0.4	-1.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	4.7	0.7	-1.0	-0.4	-2.0	-1.0	-1.2	-1.2	-1.6	-2.2	-1.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.7	0.5	-1.2	1.0	-0.8	-0.5	-0.4	-0.9	-1.3	-0.4	-0.3
Qualifications: None of the above	0.7	1.6	4.9	-0.5	-1.5	-0.6	-1.1	-0.4	-2.2	-0.4	-1.5	-1.1	-1.8
Financial difficulties in last 2 years	0.5	0.7	1.7	-0.2	0.8	-1.3	1.0	-0.5	1.0	-0.3	1.0	1.0	0.8
Mouth/teeth dental problems	0.5	0.8	1.7	-1.0	1.0	0.5	1.3	1.2	0.2	0.8	1.1	0.8	0.2
Heart attack	0.6	0.7	2.8	-0.5	-0.1	-1.7	0.1	1.2	0.4	0.5	0.3	0.4	1.4
Allergy	0.9	2.0	10.0	-3.2	1.5	-2.3	0.7	0.2	-0.5	-0.2	0.1	-0.7	-0.8
Pain all over the body in last month	1.1	1.2	6.0	0.1	0.2	-1.1	0.1	0.1	-2.4	-1.5	-0.8	-0.9	-0.7
Diabetes (self-reported)	0.6	0.9	2.6	0.9	-1.3	1.6	-1.1	-0.5	-0.5	-0.1	-1.4	-0.8	-0.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.4	0.6	-0.0	-0.4	-0.2	-0.3	0.3	0.6	0.5	0.1	0.4
Medication: Ramipril	0.4	0.5	2.5	-1.6	-0.1	0.1	0.8	0.4	-0.6	-0.6	0.0	0.6	0.9
Medication: Simvastatin	0.1	0.2	0.5	-0.7	-0.1	0.2	0.1	-0.2	0.1	0.7	-0.2	0.6	0.5
Fluid intelligence score	0.3	0.7	1.7	-0.7	-1.1	-0.5	-1.3	0.2	0.5	-1.2	-0.9	-0.3	0.6
Illnesses of siblings	2.6	3.6	10.0	-0.8	1.9	-1.3	1.4	-0.2	2.5	1.5	2.5	1.9	3.2
Neuroticism score	0.3	0.6	1.8	1.4	-0.6	-0.4	-1.0	0.5	-0.0	0.9	-0.2	-1.1	-0.6
Weight	3.9	19.2	36.4	-0.1	-3.6	-1.3	-5.0	-4.5	-4.6	-4.0	-4.9	-5.9	-6.0
Impedance of arm (right)	0.6	2.6	6.3	-0.3	1.5	-1.4	1.9	1.4	1.0	1.3	2.3	1.1	2.5
Arm fat percentage (right)	1.8	7.2	18.8	1.0	-2.7	0.1	-3.0	-4.3	-2.8	-1.9	-2.8	-3.2	-2.6
Trunk fat-free mass	2.6	15.1	34.7	-0.7	-2.9	-1.0	-4.6	-2.6	-3.9	-4.0	-4.7	-5.1	-5.9
Hip circumference	2.4	10.5	22.4	0.2	-2.3	-1.2	-3.4	-3.8	-3.4	-2.7	-3.5	-4.3	-4.7
Time employed in main current job	1.0	1.2	3.9	2.0	-1.2	-0.1	-0.5	2.0	-0.5	-0.7	-1.0	-0.0	-0.8
Alcohol intake versus 10 years previously	0.8	1.2	3.5	0.3	-1.6	0.8	-1.9	-1.2	0.6	-0.8	-1.7	-0.1	-0.2
Father’s age at death	0.7	1.0	3.6	-0.4	-0.5	-1.5	-1.0	-1.9	-0.8	-0.5	-1.0	-0.8	-0.2
Worrier / anxious feelings	0.3	0.6	2.6	0.6	-0.4	-1.4	-0.5	1.6	-0.6	0.1	-0.1	-0.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.5	-0.4	0.1	-0.4	-0.0	-1.9	-1.7	-0.5	-0.6	-1.5	-0.6
Falls in the last year	0.1	0.1	0.5	0.1	0.1	0.5	-0.4	0.3	0.1	-0.3	-0.5	0.1	0.7
Hair/balding pattern: Pattern 3	0.4	0.5	1.9	0.6	-0.2	1.4	0.5	1.0	0.5	-0.6	-0.3	0.9	0.7
Number of live births	1.1	1.6	4.0	0.3	-1.6	1.7	-2.0	-0.7	-0.6	-0.3	-1.5	-1.2	-1.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.6	-0.3	0.7	-1.6	-0.0	-0.9	-0.6	0.1	0.4	-0.9	-0.6
Pulse rate	0.8	1.3	3.3	-0.1	-0.8	-1.2	-0.9	-1.0	-1.8	-1.8	-1.3	-1.0	-0.6
Happiness	0.3	0.4	1.9	-1.4	-0.7	-0.9	-0.3	0.4	-0.3	0.0	0.2	-0.1	0.9
Noisy workplace	0.5	0.7	4.4	-0.8	-0.4	-2.1	0.3	-0.2	-0.8	0.4	0.1	0.0	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.4	-1.2	0.7	-0.8	0.2	-0.0	-0.6	0.2	0.3	-0.8	-0.0
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.2	6.4	-1.8	1.4	-2.5	1.6	0.5	1.5	0.5	1.9	2.5	2.1
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	0.9	0.2	-0.3	-0.4	-0.9	-0.7	-0.4	-0.9	-1.1	-0.9
Asthma	1.6	3.2	11.0	2.8	-0.1	3.3	0.7	0.9	1.7	1.4	1.2	1.6	1.7
Medication: Ibuprofen (e.g. Nurofen)	4.0	5.1	10.0	0.2	2.0	-0.7	2.7	0.7	2.6	2.0	3.2	3.1	3.0
Medication: Cholesterol lowering	0.3	0.5	2.2	-0.5	-1.1	0.4	-0.5	-0.3	0.1	0.3	-0.7	0.7	1.5
Depression (self-reported)	1.3	1.6	5.2	0.2	-0.5	-0.6	-0.6	-0.5	-2.3	-1.3	-1.4	-1.1	-2.1
Medication: Lansoprazole	2.0	2.3	5.4	-1.9	-2.3	-0.1	-2.0	-0.0	-1.7	-1.6	-2.0	-0.6	-0.7
Prospective memory result	0.5	0.6	1.8	1.2	-0.2	1.1	0.2	0.1	1.0	1.3	0.6	-0.1	0.7
Lung cancer (father)	1.8	2.1	3.8	0.4	-1.5	0.3	-0.9	-2.0	-1.8	-1.9	-1.7	-1.0	-1.8
Illnesses of mother	1.0	1.3	8.2	-0.8	-1.2	-0.6	-1.1	-2.9	0.4	-0.5	-0.3	-0.3	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.6	-0.0	-0.0	-1.6	-0.8	-0.8	-0.9	-0.9	-0.3	-0.8	-1.0
Pulse wave Arterial Stiffness index	3.3	3.8	8.7	1.0	-1.8	0.8	-2.4	-1.0	-1.9	-1.0	-2.4	-2.8	-2.9
Impedance of arm (left)	0.4	1.6	4.5	0.3	1.3	-1.2	1.4	1.0	0.7	1.2	2.1	0.4	1.9
Arm fat mass (right)	2.9	12.1	21.1	0.7	-3.0	-0.4	-3.9	-4.4	-3.7	-2.8	-3.9	-4.6	-4.3
Trunk predicted mass	2.6	14.9	34.3	-0.7	-2.8	-1.1	-4.6	-2.5	-3.8	-4.0	-4.7	-5.0	-5.9
Standing height	1.6	15.8	40.2	-1.5	-2.2	-2.9	-4.5	-1.3	-4.1	-3.5	-3.8	-6.3	-6.1
Length of working week for main job	0.5	0.5	2.7	-0.8	0.4	0.0	-0.5	-0.9	0.1	0.2	-0.3	-1.6	-0.6
Exposure to tobacco smoke at home	0.5	0.6	2.0	0.2	-0.5	0.4	-0.9	0.4	-0.2	-0.8	-1.4	-0.7	-1.1
Breastfed as a baby	0.8	1.0	3.8	0.3	-2.0	1.1	-0.9	1.3	0.2	-0.8	-0.8	0.8	0.4
Tense / ‘highly strung’	0.6	1.0	2.9	0.6	-1.2	-0.9	-1.1	0.5	-1.1	0.9	-0.5	-1.7	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.9	0.5	1.1	-0.5	1.7	-0.5	0.3	0.9	1.2	0.5	0.3
Hair/balding pattern: Pattern 4	0.2	0.5	1.2	0.4	0.4	0.8	0.6	-1.1	0.1	0.9	1.0	0.2	-0.4
Birth weight of first child	0.2	0.3	1.3	0.1	0.2	-1.2	-0.5	0.2	-0.9	-0.1	-0.2	-0.7	-0.5
Peak expiratory flow (PEF)	0.2	0.4	1.7	-1.1	0.4	-1.3	0.2	-0.6	-0.5	-0.2	0.4	-0.1	-0.1
Pulse wave reflection index	1.5	1.8	4.8	0.0	-1.2	1.4	-1.9	-0.5	-0.4	0.1	-1.8	-2.2	-1.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	2.4	0.3	0.2	-0.2	-0.3	0.9	0.4	1.5	0.3	0.2	0.5
Loud music exposure frequency	0.9	1.0	5.4	1.0	1.3	0.2	-0.3	0.2	0.1	2.3	0.7	-1.3	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.9	-0.6	0.8	-0.2	-0.1	-0.3	-0.8	-0.2	0.6	-0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.5	1.0	-0.7	1.1	0.0	0.3	1.0	-0.0	0.2	0.6	1.2
Blood clot in the leg (DVT)	0.2	0.2	0.8	0.7	-0.8	0.9	-0.4	0.1	0.2	-0.0	-0.3	0.3	-0.4
Medication: Paracetamol	0.7	1.1	3.2	1.5	1.2	0.7	0.9	1.4	0.3	1.8	0.7	-0.6	-0.3
Headache pain in last month	0.3	0.5	2.9	-0.9	0.3	-1.7	0.6	0.7	0.3	0.2	0.7	0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	2.1	1.0	0.8	-0.7	0.2	-0.1	0.1	0.4	1.0	-0.5	-1.4
Glaucoma (self-reported)	0.3	0.4	1.2	0.1	1.0	-0.2	1.1	0.4	0.4	-0.4	0.5	0.4	0.9
Gout (self-reported)	1.4	1.9	4.6	1.0	-1.8	-0.1	-1.8	-0.8	-1.1	-2.1	-1.7	-0.6	-1.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.9	0.2	1.6	-0.8	1.5	-0.5	1.4	1.7	2.0	1.5	1.2
Medication: Amlodipine	0.3	0.4	1.1	0.2	0.4	0.7	1.0	0.4	0.3	-0.4	-0.4	0.7	1.0
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.3	1.1	0.9	1.5	1.0	0.8	0.2	-0.6	-0.1	0.0	0.4
Birth weight	0.5	1.1	7.4	-0.8	1.0	-2.7	0.1	-0.6	0.3	0.4	0.6	-0.1	-1.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.4	0.5	0.6	0.1	0.8	1.6	-1.8	-0.4	-0.3	-0.7	-0.3
High blood pressure (siblings)	0.7	1.0	2.9	1.2	-0.1	0.9	0.5	1.1	-1.1	-1.3	-0.9	-0.2	-1.7
Forced vital capacity (FVC), Best measure	0.4	1.4	5.2	-0.4	0.2	-2.3	-0.7	-1.1	-1.6	-1.1	-0.5	-1.2	-1.3
Body fat percentage	3.0	11.9	25.1	0.3	-3.2	-0.4	-3.6	-5.0	-4.0	-2.5	-3.7	-4.5	-3.7
Leg fat percentage (right)	2.6	9.5	24.4	0.1	-2.8	0.6	-2.9	-4.9	-3.5	-2.1	-3.4	-3.8	-3.3
Arm fat-free mass (right)	3.5	17.9	38.7	-0.5	-3.3	-0.9	-4.9	-3.4	-4.4	-4.2	-5.1	-5.6	-6.2
Exposure to tobacco smoke outside home	0.9	1.2	2.3	1.5	-0.8	1.3	-1.5	-1.4	0.1	0.2	-1.2	-1.2	-0.6
Comparative body size at age 10	0.1	0.4	3.0	-0.3	0.1	0.2	0.1	-1.7	0.6	-0.3	0.0	0.5	-0.4
Number of full brothers	1.2	1.5	4.0	1.8	-1.2	-0.6	-2.0	-0.6	-0.7	0.2	-1.2	-1.2	-1.3
Worry too long after embarrassment	0.4	0.7	3.9	-0.3	-0.3	2.0	-0.5	1.3	0.2	0.3	-0.4	-0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.7	1.6	-1.2	0.8	-0.7	0.4	0.4	-0.7	-0.6	0.7	0.2
Wheeze or whistling in the chest in last year	1.1	1.9	3.7	1.8	-1.9	1.4	-1.1	1.1	-1.7	-1.3	-1.6	-0.7	-0.3
Number of children fathered	0.8	0.8	2.4	-0.2	-1.5	0.2	-1.4	0.9	-1.1	0.0	-0.9	-0.8	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.9	-0.9	0.0	0.3	0.2	0.7	0.1	-0.3	0.1	0.5	0.3
Age at first live birth	0.9	1.6	3.2	-0.1	-1.8	0.3	-1.8	0.8	-1.5	-1.3	-1.3	-1.3	-1.2
Pulse wave peak to peak time	2.4	2.9	5.2	-1.0	1.8	-1.1	2.2	0.9	1.6	0.7	2.1	2.2	2.3
Health satisfaction	0.5	0.7	3.2	-1.8	-0.6	0.9	-0.3	-1.0	-0.1	-0.5	-1.2	-0.2	0.1
Shortness of breath walking on level ground	0.5	0.6	3.3	-0.1	-0.9	0.2	-0.6	-1.8	-0.3	-1.0	-0.7	0.1	-0.3
Qualifications: College or University degree	0.3	1.1	2.6	-1.0	0.7	-0.8	0.1	-0.1	1.6	1.4	1.5	-0.1	1.3
Eye problems/disorders: None of the above	0.5	0.5	2.3	-0.9	0.3	-1.5	0.1	0.7	0.5	0.6	0.3	0.6	0.8
Mouth/teeth dental problems: Loose teeth	8.4	9.9	20.0	1.4	-4.1	2.1	-4.5	-3.4	-2.7	-2.7	-3.6	-3.0	-2.7
Emphysema/chronic bronchitis	0.3	0.4	2.0	1.4	0.4	-0.2	0.5	0.5	0.1	-0.7	-0.3	0.1	0.8
Medication for pain relief, constipation, heartburn	0.5	0.9	1.9	0.1	-1.0	1.3	-1.1	-0.8	-0.2	-1.4	-1.1	-0.3	-1.0
Neck or shoulder pain in last month	0.9	1.3	3.6	0.9	1.2	-0.1	1.1	1.1	1.5	1.9	1.4	0.5	0.7
Medication: Blood pressure	0.5	1.0	3.1	-1.8	-0.8	0.1	0.0	0.5	-0.5	-1.4	-1.2	0.4	1.3
Angina (self-reported)	0.8	1.0	4.0	-0.1	-0.7	0.2	-0.5	-0.6	-2.0	-0.6	-1.2	-1.3	-1.3
Migraine (self-reported)	2.1	2.6	5.9	0.4	1.1	-0.2	0.9	1.9	2.4	1.6	2.1	1.9	1.8
Medication: Ibuprofen	4.5	5.4	10.8	0.4	2.0	-0.3	2.8	0.4	2.4	2.5	3.3	3.0	3.2
Medication: Allopurinol	0.8	1.1	2.3	1.5	-0.7	1.0	-1.0	-0.9	-0.3	-1.5	-1.1	-0.4	-1.1
Medication: Omeprazole	1.2	1.5	4.9	0.1	0.5	-1.8	1.2	0.3	0.4	0.9	1.4	1.2	2.2
Medication: Seretide 50 evohaler	2.0	2.3	6.7	2.2	-2.3	2.6	-1.2	0.8	1.2	0.6	-0.5	1.1	0.7
Mean time to correctly identify matches	1.0	1.9	4.8	-0.3	0.8	-1.8	1.6	0.8	0.5	1.7	2.2	1.6	1.3
Heart disease (mother)	1.2	1.4	4.3	-0.1	-1.1	-0.2	-0.3	-0.2	-2.0	-2.1	-1.7	-0.1	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.5	-0.3	0.4	0.0	1.0	0.1	1.2	0.6	1.4	2.1	2.1
Whole body fat mass	3.7	15.5	27.7	0.2	-3.4	-0.7	-4.4	-4.8	-4.4	-3.2	-4.4	-5.3	-4.9
Leg fat mass (right)	3.4	13.4	24.4	-0.0	-3.0	-0.3	-3.8	-4.9	-4.0	-2.9	-4.1	-4.8	-4.7
Arm predicted mass (right)	3.7	18.7	39.6	-0.7	-3.3	-1.1	-5.0	-3.6	-4.3	-4.3	-5.2	-5.7	-6.3
Pulse rate, automated reading	0.2	0.7	3.7	0.5	-0.5	-1.9	0.3	1.1	-0.3	-0.2	0.5	1.0	0.3
Alcohol intake frequency.	0.5	1.1	5.7	-0.9	-0.5	-1.8	-1.0	-2.4	0.1	-0.3	-0.6	-0.1	0.0
Comparative height size at age 10	1.6	8.8	23.8	-1.5	-1.5	-2.5	-3.3	-1.6	-2.5	-2.6	-2.7	-4.5	-4.9
Number of full sisters	0.7	0.8	2.0	-0.7	-0.9	-1.4	-0.8	1.3	-1.0	0.2	-0.1	-0.9	-0.9
Suffer from ‘nerves’	0.2	0.3	1.5	-0.2	0.7	0.2	1.2	-0.2	-0.3	0.6	0.1	0.1	0.3
Overall health rating	1.3	2.9	9.4	-0.8	-0.9	0.6	-1.1	-3.1	-1.9	-0.1	-1.7	-2.6	-1.8
Chest pain or discomfort	0.8	1.1	4.5	0.3	-1.0	0.9	-1.1	-2.1	-0.6	-0.1	-1.0	-1.1	-0.9
Had major operations	0.5	0.5	2.0	0.4	0.3	-0.2	-0.3	-1.0	-0.6	1.4	-0.3	-1.2	-0.1
Age at last live birth	0.5	0.7	1.6	1.3	-1.2	0.6	-1.0	1.2	-0.5	-0.2	-0.5	-0.5	0.1
Family relationship satisfaction	0.2	0.2	0.9	0.1	0.3	0.6	-0.2	-0.3	0.5	-0.4	0.1	0.3	1.0
Leg pain on walking	1.3	1.7	3.4	-0.3	-1.2	-0.6	-1.4	-0.0	-1.3	-1.4	-1.8	-1.6	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.9	0.9	-0.4	0.3	0.1	0.3	0.7	-0.3	-0.3	0.7	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.5	-0.6	-0.3	-0.6	0.5	0.3	-0.4	-0.2	-0.1	0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.9	-0.4	0.5	0.0	1.0	-0.3	-0.1	-0.3	0.2	0.4	0.7
Medication: Aspirin	0.5	0.6	2.6	-1.2	-0.3	-1.6	0.2	0.8	-0.3	-0.9	-0.0	0.5	0.7
Supplements: Vitamin C	0.9	1.1	4.2	0.6	-0.1	0.3	0.8	0.5	1.0	0.0	0.4	1.9	2.1
Knee pain experienced in last month	0.7	1.0	2.6	1.4	-1.0	-0.8	-1.6	0.2	0.1	0.2	-1.2	-1.5	-0.6
Hypertension (Self-reported)	0.5	1.4	4.1	-2.0	0.5	1.8	1.4	0.7	-1.7	-0.6	-0.1	0.1	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.4	-0.5	0.4	-1.2	-0.4	0.2	-0.2	0.5	0.5	-0.6	0.0
Illnesses of father: Heart disease	0.2	0.3	0.8	0.4	-0.9	0.8	-0.4	-0.0	-0.5	-0.2	-0.5	-0.6	0.2
Illnesses of siblings: Diabetes	2.2	2.7	5.5	0.7	-2.3	0.4	-1.7	-1.3	-2.1	-1.4	-2.0	-1.4	-1.9
Smoking status: Previous	1.2	1.8	7.4	1.8	-1.7	2.7	-1.4	0.9	0.6	0.8	-0.5	0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	5.4	0.6	0.4	-0.7	-0.9	-1.4	-0.7	0.3	-0.2	-2.3	-1.8
Whole body fat-free mass	2.9	16.6	38.6	-0.5	-3.0	-1.3	-4.7	-3.0	-4.1	-4.2	-4.8	-5.3	-6.2
Leg fat-free mass (right)	2.8	15.2	36.9	0.1	-2.9	-1.6	-4.5	-2.8	-3.9	-4.1	-4.3	-5.1	-6.1
Arm fat percentage (left)	2.1	8.6	19.9	1.3	-2.8	-0.0	-3.3	-4.5	-3.0	-2.1	-3.1	-3.6	-3.0
Average weekly red wine intake	0.4	0.6	1.6	-1.3	-0.7	-0.0	-0.8	0.2	-1.0	-0.3	-0.5	-0.4	-1.2
Handedness (chirality/laterality): Left-handed	4.2	5.1	9.3	-2.0	2.3	-1.5	2.4	1.3	2.0	2.1	2.7	2.5	3.0
Mood swings	0.7	1.2	4.6	2.1	-1.5	-0.4	-1.7	0.1	-0.4	0.1	-0.4	-1.2	-0.7
Loneliness, isolation	1.9	2.6	7.3	0.9	-2.7	1.2	-1.9	0.2	-0.1	-2.4	-2.6	-0.5	-0.1
Long-standing illness, disability or infirmity	0.6	0.9	4.7	0.6	-0.7	2.2	-1.0	-0.4	0.5	0.2	-1.3	-0.3	-0.5
Ever had bowel cancer screening	4.0	4.7	14.1	-1.8	-1.7	0.0	-1.4	-1.2	-3.8	-1.8	-2.2	-2.3	-3.1
Diabetes diagnosed by doctor	0.7	1.2	3.9	0.5	-1.1	2.0	-1.3	-0.2	-0.4	0.2	-1.6	-1.3	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.7	-0.9	0.0	-0.2	0.3	-0.8	-0.5	0.7	0.4	0.1	0.4
Friendships satisfaction	2.1	2.6	7.4	-1.1	1.6	0.3	1.7	-0.1	1.8	0.8	1.8	2.1	2.7
Qualifications: nursing, teaching	0.4	0.6	2.0	-0.9	0.8	-1.0	0.1	-0.8	1.4	0.1	0.3	0.2	0.5
Commuting to job workplace: Walk	0.4	0.4	1.4	0.1	-1.1	0.3	0.1	-0.3	-0.3	-1.2	-0.6	0.9	-0.5
Eye problems/disorders: Cataract	1.0	1.2	2.0	0.6	-0.5	1.3	-0.5	0.7	-1.4	-1.1	-1.3	-1.4	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.7	-0.1	-0.5	-1.3	-0.2	-0.7	0.5	0.2	0.4	1.1	0.6
Medication for cholesterol	1.1	1.6	4.3	0.8	-0.2	-2.0	-0.9	-0.1	2.0	1.3	0.6	0.2	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.2	3.7	9.6	-0.8	-3.1	-0.2	-2.8	-0.9	-1.9	-1.8	-2.7	-1.7	-1.3
Back pain experienced in last month	1.4	2.1	5.1	0.8	1.8	0.4	2.3	0.7	0.6	2.2	1.8	1.4	0.9
Mineral and other dietary supplements	0.2	0.2	0.7	0.2	0.1	0.6	-0.8	-0.3	-0.1	0.1	-0.3	-0.9	-0.3
Breast cancer (self-reported)	0.4	0.5	4.0	-2.0	0.1	0.1	0.1	0.2	0.1	-0.1	-0.3	-0.6	0.5
Asthma (self-reported)	1.1	2.3	8.0	2.4	-0.2	2.8	0.4	0.7	1.5	1.2	1.0	1.2	1.4
Osteoporosis (self-reported)	0.8	1.0	2.5	-1.1	-1.6	0.6	-1.3	1.4	0.5	0.7	-0.5	0.1	1.1
Osteoarthritis (self-reported)	0.1	0.2	0.7	0.8	0.3	0.1	-0.1	0.6	0.9	0.1	-0.1	0.2	0.0
Medication: Aspirin	0.5	0.6	2.2	-1.0	0.0	-1.5	0.6	1.0	-0.2	-0.6	0.4	0.7	0.7
Medication: Gliclazide	0.4	0.4	1.4	-0.1	-0.9	0.7	-0.9	-1.2	-0.4	-0.1	-0.6	0.1	0.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-0.5	-1.1	-0.9	-0.8	-0.7	0.4	-0.6	-0.3	0.7	-0.7
Smoking status: Current	0.4	0.6	2.2	0.6	-0.1	-1.5	-0.6	-0.4	-0.3	-1.0	-0.8	-1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.6	-0.5	1.1	-1.3	0.6	-0.8	-0.3	1.0	0.9	-0.1	-0.4
Whole body water mass	2.9	16.3	36.8	-0.6	-3.0	-1.3	-4.6	-3.0	-4.1	-4.2	-4.7	-5.3	-6.1
Leg predicted mass (right)	2.8	14.9	35.9	0.1	-2.9	-1.5	-4.5	-2.8	-3.8	-4.0	-4.3	-5.1	-6.0
Arm fat mass (left)	3.3	13.5	23.6	1.1	-3.3	-0.4	-4.2	-4.5	-3.9	-3.0	-4.1	-4.9	-4.4
Number of self-reported non-cancer illnesses	0.5	0.9	6.2	-0.3	-0.3	2.5	0.5	-1.0	-1.0	-0.2	-0.3	-0.1	-0.1
Average weekly champagne plus white wine intake	1.9	2.6	5.5	1.9	0.2	1.1	0.6	1.5	2.3	1.4	1.2	2.3	2.1
Miserableness	1.0	1.7	3.7	1.3	-1.3	-1.2	-1.9	-0.4	-1.0	-0.5	-1.1	-1.8	-1.5
Guilty feelings	1.6	2.3	8.6	2.3	-1.7	-0.2	-2.9	0.2	0.4	-0.3	-1.5	-1.7	-1.0
Wears glasses or contact lenses	4.6	5.3	12.5	-0.8	-3.5	-0.4	-3.5	-1.4	-1.6	-1.7	-3.1	-2.1	-2.5
Ever taken oral contraceptive pill	0.4	0.4	1.4	-0.5	1.2	0.9	0.3	-0.7	0.6	0.8	0.3	-0.2	0.5
Hearing aid user	0.8	0.9	2.2	-0.6	-1.5	1.2	-0.3	0.3	0.2	-1.4	-0.6	1.4	0.4
Mother’s age at death	0.4	0.5	1.8	0.4	-1.4	-0.5	-1.0	-0.9	0.6	0.2	-0.4	0.2	-0.8
Financial situation satisfaction	1.5	1.9	6.7	-0.6	0.9	-0.2	1.8	0.5	1.4	0.5	1.3	1.8	2.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.5	-1.5	-0.4	-0.3	-0.2	-0.7	-1.4	-1.1	-0.3	0.1	-1.6
Commuting to job workplace: Public transport	0.4	0.4	1.1	-0.2	0.4	-1.0	0.8	-0.6	0.6	0.4	0.5	1.0	0.6
Eye problems/disorders: Glaucoma	1.4	1.7	3.1	1.2	1.7	-0.4	1.8	1.2	1.1	0.4	1.5	1.2	1.5
Medication: Blood pressure	0.6	1.1	3.7	-1.9	1.1	0.8	1.6	0.4	-0.9	-1.0	0.2	0.3	-0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.9	-0.3	-0.4	-0.6	-0.9	0.1	0.7	0.3	-0.6	0.2	0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.4	0.4	0.3	-0.4	1.2	1.2	-0.2	0.0	0.7	1.0	0.7
High cholesterol (Self-reported)	0.6	1.1	4.1	-0.8	-1.6	2.0	-0.9	-0.9	0.2	-0.1	-0.8	1.1	0.3
Medication: Bendroflumethiazide	0.3	0.4	1.5	-0.5	0.8	0.3	1.2	0.5	-0.7	-0.2	0.3	0.6	0.5
Medication: Paracetamol	1.2	1.8	7.2	0.8	1.8	-0.1	1.4	1.8	0.1	2.7	1.3	-0.0	0.5
Medication: Lisinopril	0.6	0.7	2.5	1.0	-1.4	1.6	-0.8	0.3	0.1	-0.4	-0.6	0.2	0.6
Medication: Atorvastatin	0.9	1.1	2.6	-0.8	0.5	1.6	1.6	-1.3	0.1	0.2	0.7	0.7	1.6
Illnesses of father: High blood pressure	3.9	4.8	12.1	0.3	3.5	0.9	3.3	1.5	1.8	2.0	2.4	1.3	2.7
Alcohol drinker status: Never	1.4	1.6	6.9	-1.6	0.1	-2.6	-0.0	-2.1	0.8	-0.7	-0.5	0.7	0.6
Ever smoked	0.8	1.4	4.1	1.8	-1.8	2.0	-1.5	0.1	0.2	0.0	-0.9	-0.4	-0.8
Basal metabolic rate	3.2	17.7	38.6	-0.4	-3.1	-1.4	-4.8	-3.4	-4.3	-4.2	-4.9	-5.6	-6.2
Leg fat percentage (left)	2.7	9.7	22.5	0.3	-2.6	0.5	-2.9	-4.7	-3.7	-2.3	-3.5	-3.9	-3.6
Arm fat-free mass (left)	3.5	17.9	36.3	-0.6	-3.4	-1.2	-4.9	-3.5	-4.4	-4.3	-5.1	-5.5	-6.0
Number of operations (self-reported)	0.7	1.0	2.4	1.1	-0.7	1.3	-1.0	-1.1	-0.3	0.4	-0.9	-1.5	-1.1
Average weekly beer plus cider intake	0.3	0.4	1.2	0.4	-0.3	0.7	0.4	0.1	0.1	-1.1	-0.8	0.4	-1.0
Irritability	0.5	0.8	4.0	0.4	-0.0	-1.4	-0.1	0.4	0.1	2.0	1.1	-0.1	0.7
Risk taking	0.7	1.0	3.5	-0.6	-1.9	-0.2	-1.1	-0.6	0.0	-1.0	-1.5	-0.2	1.0
Ever had prostate specific antigen (PSA) test	1.5	1.7	4.1	0.2	-1.8	2.0	-1.5	-0.5	-0.9	-0.8	-1.9	-0.9	-1.1
Fractured/broken bones in last 5 years	0.4	0.5	1.4	-0.5	0.8	-0.5	0.9	1.2	0.8	-0.4	0.6	0.7	0.5
Age started oral contraceptive pill	0.2	0.3	1.1	0.5	-0.1	-0.0	0.1	-0.3	-0.5	-0.7	-0.4	-0.7	-1.0
Diastolic blood pressure, automated reading	0.5	1.7	7.2	0.8	2.0	0.4	1.5	2.7	0.5	1.3	1.0	0.0	0.1
Ever depressed for a whole week	0.9	1.1	4.0	-0.1	-0.8	0.7	-0.5	-0.4	-1.1	-2.0	-1.4	-0.8	-1.2
Unable to work because of sickness or disability	0.4	0.6	1.8	0.1	-0.4	0.2	0.2	1.4	0.4	-0.2	0.1	1.3	1.2
Commuting to job workplace: Cycle	1.0	1.2	2.4	1.1	-0.8	0.8	-1.2	-1.0	-0.7	-1.2	-1.0	-1.5	-1.2
Myopia	0.4	0.6	2.1	-0.3	0.7	0.9	1.5	0.8	0.2	0.1	1.0	1.1	-0.3
Vascular/heart problems diagnosed by doctor	0.4	1.2	5.0	2.2	-0.4	-1.2	-1.1	-0.1	1.8	0.8	0.0	0.0	0.4
Cholesterol lowering medication	0.8	1.2	2.3	-1.5	-0.9	1.5	-0.4	-1.3	-0.8	-1.0	-1.4	-0.1	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.1	0.1	0.5	-1.1	0.8	0.5	0.6	0.5	0.7	0.9	1.8
Pain experienced in last month	0.2	0.3	2.1	-0.5	-0.2	0.6	0.1	0.4	-0.2	-1.4	-0.1	0.4	0.5
Supplements: Calcium	1.2	1.3	3.4	-0.5	-1.8	0.3	-1.7	-0.0	-0.8	-1.4	-1.8	-0.4	-0.6
Basal cell carcinoma (self-reported)	1.9	2.3	7.9	-0.6	-1.5	0.7	-1.6	-0.9	-0.8	-2.2	-2.8	-0.9	-1.6
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.9	-0.4	-0.2	-1.4	0.0	1.4	0.7	0.4	0.3	0.5	1.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	0.7	-0.8	0.9	-0.3	0.2	0.2	-0.1	-0.2	0.5	-0.3
Heart disease (siblings)	0.7	0.9	4.8	0.5	-0.3	0.6	0.0	1.2	-0.8	2.2	0.3	-0.5	-0.9
Alcohol drinker status: Previous	0.2	0.3	0.9	0.6	0.1	-0.2	-0.3	0.8	0.5	-0.2	-0.4	-0.2	0.9
Pack years of smoking	2.7	4.0	10.9	-0.0	-2.6	-0.2	-3.0	0.5	-1.4	-2.4	-3.3	-1.9	-1.2
Impedance of whole body	0.4	2.3	6.0	-0.5	1.5	-0.9	1.8	1.3	0.9	1.6	2.2	0.6	2.5
Leg fat mass (left)	3.5	13.5	23.5	-0.1	-2.9	-0.4	-3.7	-4.8	-4.1	-3.0	-4.2	-4.8	-4.8
Arm predicted mass (left)	3.6	18.5	37.9	-0.9	-3.3	-1.3	-4.9	-3.5	-4.4	-4.3	-5.2	-5.7	-6.2