Hub : Genes

CHMP7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1930 0.0680 5.0e-03 0.049 NA 0.027 NA 0.062 1.1e-03 NA 1.2e-02 NA 2.5e-04
2 GTEx Cells Transformed fibroblasts 0.3180 0.0560 7.0e-10 0.076 NA 0.150 NA 0.168 2.5e-06 NA 2.2e-11 NA 1.3e-12
3 GTEx Muscle Skeletal 0.1857 0.0434 7.7e-06 0.042 NA 0.090 NA 0.060 5.0e-05 NA 4.0e-09 NA 1.5e-06
4 GTEx Skin Sun Exposed Lower leg 0.1110 0.0400 2.1e-03 0.050 NA 0.056 NA 0.056 5.6e-05 NA 2.1e-05 NA 2.1e-05
5 METSIM Adipose 0.0482 0.0184 2.9e-03 -0.001 0.017 0.003 0.016 0.003 5.3e-01 1.0e-03 1.1e-01 1.3e-03 9.1e-02
6 ROSMAP Brain Pre-frontal Cortex 0.1294 0.0318 3.2e-07 0.131 0.067 0.107 0.118 0.126 1.8e-16 5.6e-09 1.1e-13 6.9e-15 7.2e-16
7 TCGA Brain Lower Grade Glioma 0.0920 0.0318 7.8e-06 0.011 0.045 0.028 NA 0.013 2.0e-02 6.4e-06 3.2e-04 NA 1.1e-02
8 TCGA Ovarian Serous Cystadenocarcinoma 0.0470 0.0250 9.3e-03 0.016 0.033 0.021 NA 0.022 2.7e-02 2.5e-03 1.3e-02 NA 1.1e-02
9 TCGA Prostate Adenocarcinoma 0.0302 0.0151 4.8e-03 0.030 0.009 0.000 NA 0.007 3.6e-04 3.8e-02 3.1e-01 NA 6.0e-02
10 TCGA Thyroid Carcinoma 0.1020 0.0390 3.7e-05 0.019 0.038 0.042 NA 0.042 5.6e-03 1.3e-04 6.0e-05 NA 5.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.9 1.5 9.6 0.2 0.8 -0.6 1.2 3.1 0.4 -0.1 1.0 1.1 0.3
Bipolar Disorder or Schizophrenia 0.8 2.1 8.8 -0.6 1.1 -1.9 1.4 3.0 0.3 0.6 1.4 1.2 1.0
Depressed Affect (Nagel 2018) 2.1 4.3 8.8 0.1 -2.0 -1.4 -2.4 -1.1 -2.6 -1.8 -2.4 -3.0 -2.4
Depression (Nagel 2018) 1.4 2.1 5.8 0.6 -0.7 -1.8 -1.2 -0.4 -2.4 -0.8 -0.7 -1.7 -2.4
Intelligence (Savage-Jansen 2018) 0.4 1.3 4.5 -1.9 0.2 -1.9 0.0 0.3 0.6 -0.2 0.4 0.2 2.1
Neuroticism (Nagel 2018) 1.1 2.6 7.3 -0.6 -1.2 -1.5 -1.8 0.4 -2.2 -0.3 -1.7 -2.7 -1.8
Schizophrenia (2018) 0.6 1.1 4.0 -0.9 0.8 -2.0 0.8 1.4 0.0 0.9 1.0 0.7 1.1
Schizophrenia vs Biploar Disorder 0.8 1.0 3.1 1.8 -1.0 -0.3 -1.8 -0.6 0.3 1.1 -0.5 -1.1 0.3
Worry (Nagel 2018) 0.4 0.9 3.0 -0.4 -0.3 -1.0 -0.2 0.9 -1.7 0.5 -0.6 -1.4 -1.2
Alzheimer’s Disease (in mother) 0.6 0.7 4.1 0.6 0.2 -0.7 0.2 2.0 -0.5 0.6 0.6 0.8 -0.2
Alzheimer’s Disease (in father) 1.0 1.1 4.1 1.3 -0.2 2.0 -0.8 -0.7 -0.4 -0.2 -0.9 -1.5 -0.9
Alzheimer’s Disease (including proxy) 0.5 0.8 2.0 1.0 -0.4 0.4 -1.0 1.4 -1.2 -0.2 -0.9 -0.2 -1.1
Crohns Disease (2017) 0.5 1.2 2.5 -0.9 1.2 0.8 1.3 0.7 1.6 0.8 1.0 1.4 0.9
Irritable Bowel Disease (IBD) 0.6 1.3 2.4 -1.2 1.4 -0.2 1.6 0.7 1.5 1.2 1.5 0.9 0.5
Ulcerative Colitis (UC) 0.5 0.8 2.5 -1.6 1.1 -1.1 1.2 0.4 0.2 0.5 1.2 -0.2 -0.4
Major Depression (MDD) 1.0 1.2 5.5 -0.9 0.3 -2.3 0.7 1.0 -0.4 1.6 1.2 -0.2 0.3
Reaction Time 1.5 2.9 7.7 0.5 1.0 -1.5 1.6 0.6 1.3 2.0 2.8 2.1 2.2
Verbal and Numeric Reasoning (VNR) 0.6 1.4 4.7 -0.5 0.1 -0.6 0.3 2.0 1.6 -0.2 0.7 1.0 2.2
Breast Cancer 0.7 1.7 7.8 0.3 -1.1 2.8 -1.6 -0.5 -0.6 -1.1 -1.6 -1.0 -0.7
Ovarian Cancer 0.5 0.7 3.1 0.3 0.9 0.7 1.2 -0.2 0.2 0.1 0.6 1.8 1.0
Prostate Cancer 1.0 1.5 3.6 -1.3 -1.9 0.9 -0.4 0.1 1.1 -1.7 -0.4 1.6 1.2
Age at First Birth 0.4 0.6 2.3 -0.7 0.6 0.7 0.3 1.5 0.6 1.3 0.7 0.4 0.4
Bipolar Disorder (2011) 1.0 1.0 6.2 -0.5 0.9 1.3 0.9 2.5 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.0 1.4 6.8 1.2 -0.4 0.5 -0.8 -2.6 -0.7 -0.3 -1.0 -1.7 -0.5
Coronary Artery Disease (CAD) 0.9 1.1 4.6 -0.1 1.3 -1.0 1.8 2.2 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.4 0.7 3.3 0.2 0.3 1.8 0.2 0.3 1.2 0.3 0.3 1.0 0.7
Mean Putamen Volume 0.7 0.8 1.9 -0.6 0.0 1.1 -0.5 -1.4 -0.8 -0.6 -0.5 -1.4 -1.1
Fasting Glucose 0.2 0.3 0.6 -0.7 0.5 -0.5 -0.1 0.4 -0.2 0.3 0.7 -0.8 -0.8
HbA1C 0.2 0.2 1.0 -0.3 0.2 -0.0 0.3 -1.0 -0.4 -0.1 0.4 0.3 0.4
HDL Cholesterol 0.3 0.5 1.4 1.0 -0.1 -0.7 1.0 -0.3 -0.0 0.1 0.6 1.2 0.9
LDL Cholesterol 0.6 0.9 4.6 1.3 -0.6 1.0 -0.3 -2.2 0.0 -0.1 -0.9 0.2 0.9
Lupus 0.4 0.6 2.6 -0.2 0.6 0.5 0.5 -0.9 0.7 1.6 0.6 0.2 0.5
Neuroticism (2016) 0.5 0.7 2.3 0.1 -1.1 -0.9 -1.1 0.1 -0.5 -0.6 -1.5 -0.4 -0.9
Primary Biliary Cirrhosis 0.5 0.7 3.1 1.8 -0.4 -0.1 -0.5 -0.8 0.5 -1.4 -0.4 0.6 -0.0
Rheumatoid Arthritis 1.2 1.7 4.2 -0.4 1.9 -0.7 2.1 -0.6 0.8 1.2 1.7 0.8 1.6
Schizophrenia (2014) 0.2 0.4 1.9 -0.7 -0.5 -1.4 -0.2 0.8 0.1 -0.0 0.3 0.6 0.4
Triglycerides 0.3 0.4 1.1 0.7 0.2 0.6 -0.7 -0.9 0.5 0.5 -0.2 -1.0 0.3
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.8 -0.6 0.1 -0.4 0.5 -0.4 -0.0 -0.6 0.4 0.2 0.9
Ulcerative Colitis 0.6 0.8 2.9 -0.2 1.7 -0.2 1.2 0.6 0.0 1.1 1.1 -0.6 -0.7
Blood Eosinophil Count 0.6 4.3 16.9 4.1 -1.1 1.5 -3.1 -1.3 -0.3 -0.5 -1.7 -2.4 -1.4
Blood Platelet Count 0.1 1.3 5.1 -0.2 -0.6 -2.2 -0.7 -1.4 0.8 -1.4 -1.1 1.2 -0.2
Blood Red Count 0.6 5.4 19.9 1.0 -4.5 1.1 -3.0 -2.4 -1.3 -2.6 -2.8 -0.6 -0.2
Blood White Count 0.7 5.4 17.1 -0.1 -0.6 2.2 -2.0 -1.2 -3.0 -1.3 -2.6 -4.1 -2.9
Heel T-Score 0.1 1.1 3.6 0.8 0.5 -0.2 -0.9 1.6 -0.7 -0.5 -0.8 -1.4 -1.9
BMI 1.3 7.7 19.2 0.9 -1.9 -0.3 -2.4 -4.4 -2.9 -2.6 -2.8 -3.3 -3.7
Height 2.0 38.1 89.5 -2.5 -4.3 -5.0 -6.7 -1.4 -7.1 -5.7 -6.2 -9.5 -8.6
Waist Hip Ratio (WHR) 0.2 1.1 6.1 1.5 -0.9 2.5 -0.7 1.0 -0.6 0.1 -0.3 -0.1 -0.1
Systolic Blood Pressure 0.6 2.8 11.6 -0.4 2.4 0.5 2.4 3.4 -0.1 1.5 1.4 0.8 0.4
Smoking Status 1.0 2.5 4.9 1.7 -1.6 1.3 -2.1 0.1 -1.1 -1.6 -2.2 -2.0 -1.0
Allergy or Eczema 0.6 1.5 5.8 2.4 -1.8 1.5 -1.3 -1.2 -0.5 -0.6 -0.6 -0.2 -0.4
Cardiovascular Disease 0.5 1.6 4.2 -1.0 1.8 2.0 2.1 1.1 -0.6 0.9 0.9 0.4 0.1
Hypothyroidism (self reported) 0.5 1.1 2.6 -0.0 1.0 -0.9 0.9 -1.6 0.9 1.1 1.6 1.1 0.6
Respiratory disease 0.5 1.2 4.5 2.1 -0.7 2.1 -0.1 1.0 0.8 0.0 -0.1 0.4 0.8
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.7 0.1 0.5 1.3 0.4 -0.4 -0.4 1.1 -0.1 -1.0 0.0
Lung FEV1/FVC ratio 0.4 1.9 3.1 -0.6 -1.3 -1.2 -1.6 -1.7 -0.6 -1.7 -1.8 -1.2 -1.4
Lung FVC 0.2 0.9 2.6 0.0 0.7 -0.8 1.1 -0.7 0.4 0.8 0.8 1.5 1.6
Neuroticism 0.5 1.2 4.9 -0.2 -0.2 -1.0 -1.1 0.5 -1.3 0.5 -0.7 -2.2 -1.4
Chronotype (morning person) 3.8 8.8 22.9 0.8 -4.2 0.5 -4.8 -2.0 -1.5 -3.5 -4.2 -2.1 -2.5
Hair Pigment 0.1 1.8 6.0 -1.5 0.6 2.4 0.8 -0.8 2.0 0.5 0.5 1.9 0.5
Tanning 0.0 0.4 1.5 -0.2 0.1 1.1 0.2 1.2 -0.3 -0.2 -0.6 -0.3 -0.3
Hand grip strength (left) 0.8 2.1 9.9 0.3 3.1 0.2 2.0 0.5 0.1 1.4 2.0 0.6 -0.5
Number of treatments/medications taken 0.5 0.9 1.8 0.1 0.8 1.1 1.3 0.7 0.4 1.1 0.9 1.0 1.1
Average weekly spirits intake 1.1 1.4 4.4 0.3 -0.7 -0.3 -0.7 -0.1 -1.3 -1.3 -1.6 -2.1 -1.6
Sensitivity / hurt feelings 0.1 0.2 0.7 0.5 0.2 0.5 -0.0 0.8 -0.1 0.6 -0.0 -0.5 0.7
Frequency of depressed mood in last 2 weeks 0.9 1.3 3.0 1.7 -0.8 -0.8 -1.4 -0.9 -1.0 -0.3 -1.1 -1.3 -1.5
Hearing difficulty/problems: Yes 0.5 0.7 2.9 -0.7 0.1 -0.1 1.3 0.7 0.2 -1.0 -0.1 1.7 0.6
Relative age of first facial hair 0.4 0.7 2.4 -0.6 0.6 -1.5 0.6 1.6 -0.9 -0.7 0.4 0.0 -0.1
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 4.0 -0.1 -2.0 0.2 -1.8 -0.3 -1.8 -0.3 -1.4 -1.0 -2.0
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.7 0.8 -1.2 -0.5 -0.9 0.0 -0.2 -0.8 -1.3 -0.4 -1.3
Ever had hysterectomy (womb removed) 0.5 0.6 3.0 -0.8 -0.3 1.7 0.0 -0.5 -0.0 0.1 -0.7 -0.8 -0.9
Systolic blood pressure, automated reading 0.4 1.0 4.1 0.5 1.1 1.1 1.1 2.0 -0.7 1.1 0.4 -0.1 -0.7
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 4.1 0.9 -2.0 0.9 -2.0 -0.3 -0.2 -1.0 -1.2 -0.9 -0.6
Angina 0.9 1.2 4.3 0.2 -0.8 0.2 -0.8 -0.7 -2.1 -0.7 -1.2 -1.3 -1.4
Medication for hormone replacement therapy 0.5 0.5 2.0 0.2 -0.0 -0.0 0.6 0.9 -1.1 -0.9 -0.3 0.0 -1.4
Vitamin and mineral supplements 1.4 1.9 4.9 0.5 -1.0 0.4 -2.2 -1.1 -1.1 -0.2 -1.1 -2.1 -2.2
Supplements: Zinc 0.3 0.3 1.0 0.9 0.2 0.2 0.8 0.2 0.2 0.3 0.2 1.0 0.7
Medication: Co-codamol 0.8 0.9 2.6 -0.2 1.6 -0.4 0.9 1.3 1.1 1.0 0.8 -0.1 0.9
Medication: Metformin 1.3 1.8 5.1 0.4 -1.7 0.2 -2.2 -0.6 -1.0 -0.4 -2.3 -1.8 -1.0
Diabetes (father) 1.2 1.5 6.0 0.9 -0.0 -0.1 -1.2 -1.1 -1.3 -0.8 -1.2 -2.5 -1.4
Diabetes (mother) 0.3 0.4 1.2 0.1 1.0 -0.3 0.5 0.5 0.6 0.4 0.7 0.2 1.1
Severe depression (siblings) 0.4 0.5 1.4 -1.1 -0.1 -0.3 -0.0 -0.8 -1.2 -0.1 -0.7 -0.9 -0.3
Pack years adult smoking proportion 2.2 3.3 9.3 -0.3 -2.2 -0.5 -2.7 0.6 -1.2 -2.3 -3.0 -1.9 -0.9
Impedance of leg (right) 0.5 2.6 8.4 -1.4 1.7 -0.2 2.1 0.3 0.8 1.9 1.9 0.7 2.9
Leg fat-free mass (left) 2.8 14.9 34.9 -0.0 -2.8 -1.5 -4.4 -3.1 -3.9 -3.9 -4.3 -5.2 -5.9
Trunk fat percentage 3.3 13.4 25.0 0.5 -3.4 -0.8 -4.0 -4.8 -4.2 -2.9 -3.9 -5.0 -4.0
Hand grip strength (right) 1.2 3.4 14.4 -0.3 3.8 -0.7 2.6 1.3 -0.0 1.8 2.5 0.5 -0.2
Townsend deprivation index at recruitment 1.1 1.5 5.5 -0.3 1.4 1.0 1.4 -0.6 2.3 0.4 0.8 1.3 1.3
Current tobacco smoking 0.4 0.6 2.2 0.7 0.1 -1.5 -0.5 -0.0 -0.6 -0.7 -0.6 -1.2 -0.3
Average weekly fortified wine intake 1.3 1.5 3.2 1.8 0.4 0.1 -0.5 -0.8 -0.9 -1.7 -1.3 -1.6 -1.8
Maternal smoking around birth 0.9 1.3 3.0 0.9 -0.6 1.5 -0.6 -0.4 -1.3 -1.7 -1.7 -0.8 -0.8
Fed-up feelings 0.3 0.6 2.8 1.7 -0.5 0.1 -0.7 -0.8 -0.7 0.3 -0.7 -0.9 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 4.1 1.0 -1.1 -1.0 -1.2 -0.9 -2.0 -0.4 -0.7 -1.2 -1.5
Relative age voice broke 1.0 1.5 5.3 -0.9 0.8 -1.9 1.1 2.3 -1.3 -0.9 0.5 0.4 0.3
Taking other prescription medications 0.4 0.6 1.6 1.3 -0.5 0.8 -0.0 0.2 0.5 -0.1 -0.1 1.1 1.2
Age when periods started (menarche) 1.1 2.6 6.7 -0.4 -2.0 0.5 -2.2 -0.9 -0.4 -1.7 -2.6 -1.6 -1.7
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.9 -0.5 -0.5 -0.8 -1.4 -0.8 -0.7 -0.0 -1.0 -1.4 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 3.8 2.0 -0.2 0.0 -1.6 0.1 0.4 -0.4 -0.7 -1.5 -1.5
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 -0.6 0.5 0.4 0.9 -0.2 0.1 -0.6 -0.5 0.7 -0.4
Qualifications: CSEs or equivalent 0.2 0.3 1.1 1.0 -0.3 0.7 0.3 -0.7 0.4 -0.3 -0.2 -0.0 0.4
Serious illness, injury or assault to yourself 1.4 1.7 6.0 0.5 -2.4 1.6 -1.6 -0.7 -1.4 -0.4 -1.2 -0.7 -0.7
High blood pressure 0.6 1.7 6.0 -2.4 0.2 2.0 1.1 0.5 -1.8 -1.1 -0.4 -0.1 -0.8
Hayfever, allergic rhinitis or eczema 0.4 0.9 3.3 1.8 -1.0 1.7 -0.3 -0.8 0.1 0.4 0.1 0.4 0.8
Multivitamins +/- minerals 1.1 1.5 4.4 -0.4 1.2 -0.8 2.1 0.7 0.6 -0.3 1.1 1.8 1.6
Stomach or abdominal pain in last month 1.1 1.4 6.0 0.6 -2.5 0.4 -2.1 -0.3 -0.4 -1.3 -1.0 -0.5 -0.1
Supplements: Glucosamine 0.5 0.7 2.5 0.4 -1.2 -1.6 -0.6 0.8 -0.6 -0.5 -0.5 0.5 -0.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 3.2 -0.3 -1.1 -1.8 -0.3 -0.2 -0.1 -0.8 -0.2 0.0 -0.8
Medication: Atenolol 1.3 1.7 8.4 -2.9 2.2 -1.0 1.0 -0.2 -0.5 0.0 0.2 -0.9 -0.4
Medication: Levothyroxine sodium 0.4 0.7 2.2 0.3 0.2 -0.2 0.2 -1.5 1.3 -0.4 0.2 1.4 0.8
Sitting height 1.9 13.2 27.8 -0.1 -2.8 -3.2 -4.7 -2.1 -3.5 -3.2 -3.5 -5.3 -5.0
Chronic bronchitis/emphysema (father) 0.6 0.7 2.1 -0.7 -1.4 0.9 -0.4 0.0 -1.2 -0.5 -1.0 0.2 -0.5
High blood pressure (mother) 0.9 1.2 3.6 -1.4 1.6 -0.7 1.9 1.2 -0.0 0.1 1.1 0.7 0.7
Body mass index (BMI) 2.0 8.3 17.4 0.8 -2.6 0.1 -3.2 -4.2 -2.9 -2.4 -3.4 -3.3 -3.5
Impedance of leg (left) 0.5 2.3 6.9 -1.1 1.8 -0.3 2.1 0.5 0.7 1.6 1.8 0.7 2.6
Leg predicted mass (left) 2.8 15.1 35.8 -0.1 -2.8 -1.5 -4.4 -3.1 -3.9 -3.9 -4.3 -5.2 -6.0
Trunk fat mass 4.2 18.1 34.0 0.3 -3.7 -0.9 -4.7 -5.0 -4.7 -3.5 -4.7 -5.8 -5.3
Waist circumference 2.7 10.0 18.7 0.2 -2.9 -0.1 -3.5 -3.6 -3.6 -2.9 -3.6 -3.6 -4.3
Number of incorrect matches in round 0.4 0.6 3.2 0.3 0.6 0.8 0.2 1.8 -0.1 1.1 0.1 -0.9 0.2
Past tobacco smoking 0.6 1.1 3.7 -1.5 1.6 -1.9 1.4 -0.4 -0.3 -0.3 0.8 0.3 0.4
Alcohol usually taken with meals 0.2 0.3 1.4 -0.3 0.4 -0.6 -0.1 0.4 -1.2 -0.3 -0.0 -1.0 -0.5
Nervous feelings 0.4 0.8 3.5 0.6 1.1 -0.5 0.9 0.9 -0.6 1.9 0.8 -0.6 -0.3
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.8 5.3 2.3 -0.6 -1.5 -1.3 -0.1 -1.5 -0.0 -0.9 -1.7 -1.6
Hearing difficulty/problems with background noise 0.8 1.3 4.1 -1.1 1.4 -0.7 2.0 1.1 0.9 0.8 1.0 1.1 0.7
Hair/balding pattern: Pattern 2 0.4 0.5 2.0 -0.3 -0.6 -1.4 -0.8 -0.7 -0.9 -0.3 -0.3 -0.3 0.0
Had menopause 0.6 0.8 2.5 0.1 -1.2 -0.9 -1.0 0.3 -0.6 -1.6 -0.6 -0.3 -1.1
Had other major operations 0.4 0.4 1.0 -0.1 -0.9 0.8 -0.6 -0.4 -0.3 0.7 -0.4 -0.9 -1.0
Forced vital capacity (FVC) 0.2 0.8 2.5 -0.4 1.1 -1.6 0.0 -1.1 -0.9 0.2 0.4 -1.1 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 4.7 0.7 -1.0 -0.4 -2.0 -1.0 -1.2 -1.2 -1.6 -2.2 -1.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.7 1.7 0.5 -1.2 1.0 -0.8 -0.5 -0.4 -0.9 -1.3 -0.4 -0.3
Qualifications: None of the above 0.7 1.6 4.9 -0.5 -1.5 -0.6 -1.1 -0.4 -2.2 -0.4 -1.5 -1.1 -1.8
Financial difficulties in last 2 years 0.5 0.7 1.7 -0.2 0.8 -1.3 1.0 -0.5 1.0 -0.3 1.0 1.0 0.8
Mouth/teeth dental problems 0.5 0.8 1.7 -1.0 1.0 0.5 1.3 1.2 0.2 0.8 1.1 0.8 0.2
Heart attack 0.6 0.7 2.8 -0.5 -0.1 -1.7 0.1 1.2 0.4 0.5 0.3 0.4 1.4
Allergy 0.9 2.0 10.0 -3.2 1.5 -2.3 0.7 0.2 -0.5 -0.2 0.1 -0.7 -0.8
Pain all over the body in last month 1.1 1.2 6.0 0.1 0.2 -1.1 0.1 0.1 -2.4 -1.5 -0.8 -0.9 -0.7
Diabetes (self-reported) 0.6 0.9 2.6 0.9 -1.3 1.6 -1.1 -0.5 -0.5 -0.1 -1.4 -0.8 -0.0
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.4 0.6 -0.0 -0.4 -0.2 -0.3 0.3 0.6 0.5 0.1 0.4
Medication: Ramipril 0.4 0.5 2.5 -1.6 -0.1 0.1 0.8 0.4 -0.6 -0.6 0.0 0.6 0.9
Medication: Simvastatin 0.1 0.2 0.5 -0.7 -0.1 0.2 0.1 -0.2 0.1 0.7 -0.2 0.6 0.5
Fluid intelligence score 0.3 0.7 1.7 -0.7 -1.1 -0.5 -1.3 0.2 0.5 -1.2 -0.9 -0.3 0.6
Illnesses of siblings 2.6 3.6 10.0 -0.8 1.9 -1.3 1.4 -0.2 2.5 1.5 2.5 1.9 3.2
Neuroticism score 0.3 0.6 1.8 1.4 -0.6 -0.4 -1.0 0.5 -0.0 0.9 -0.2 -1.1 -0.6
Weight 3.9 19.2 36.4 -0.1 -3.6 -1.3 -5.0 -4.5 -4.6 -4.0 -4.9 -5.9 -6.0
Impedance of arm (right) 0.6 2.6 6.3 -0.3 1.5 -1.4 1.9 1.4 1.0 1.3 2.3 1.1 2.5
Arm fat percentage (right) 1.8 7.2 18.8 1.0 -2.7 0.1 -3.0 -4.3 -2.8 -1.9 -2.8 -3.2 -2.6
Trunk fat-free mass 2.6 15.1 34.7 -0.7 -2.9 -1.0 -4.6 -2.6 -3.9 -4.0 -4.7 -5.1 -5.9
Hip circumference 2.4 10.5 22.4 0.2 -2.3 -1.2 -3.4 -3.8 -3.4 -2.7 -3.5 -4.3 -4.7
Time employed in main current job 1.0 1.2 3.9 2.0 -1.2 -0.1 -0.5 2.0 -0.5 -0.7 -1.0 -0.0 -0.8
Alcohol intake versus 10 years previously 0.8 1.2 3.5 0.3 -1.6 0.8 -1.9 -1.2 0.6 -0.8 -1.7 -0.1 -0.2
Father’s age at death 0.7 1.0 3.6 -0.4 -0.5 -1.5 -1.0 -1.9 -0.8 -0.5 -1.0 -0.8 -0.2
Worrier / anxious feelings 0.3 0.6 2.6 0.6 -0.4 -1.4 -0.5 1.6 -0.6 0.1 -0.1 -0.2 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 3.5 -0.4 0.1 -0.4 -0.0 -1.9 -1.7 -0.5 -0.6 -1.5 -0.6
Falls in the last year 0.1 0.1 0.5 0.1 0.1 0.5 -0.4 0.3 0.1 -0.3 -0.5 0.1 0.7
Hair/balding pattern: Pattern 3 0.4 0.5 1.9 0.6 -0.2 1.4 0.5 1.0 0.5 -0.6 -0.3 0.9 0.7
Number of live births 1.1 1.6 4.0 0.3 -1.6 1.7 -2.0 -0.7 -0.6 -0.3 -1.5 -1.2 -1.3
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 2.6 -0.3 0.7 -1.6 -0.0 -0.9 -0.6 0.1 0.4 -0.9 -0.6
Pulse rate 0.8 1.3 3.3 -0.1 -0.8 -1.2 -0.9 -1.0 -1.8 -1.8 -1.3 -1.0 -0.6
Happiness 0.3 0.4 1.9 -1.4 -0.7 -0.9 -0.3 0.4 -0.3 0.0 0.2 -0.1 0.9
Noisy workplace 0.5 0.7 4.4 -0.8 -0.4 -2.1 0.3 -0.2 -0.8 0.4 0.1 0.0 0.8
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.4 -1.2 0.7 -0.8 0.2 -0.0 -0.6 0.2 0.3 -0.8 -0.0
Serious illness, injury or assault of a close relative in last 2 years 2.7 3.2 6.4 -1.8 1.4 -2.5 1.6 0.5 1.5 0.5 1.9 2.5 2.1
Mouth/teeth dental problems: Dentures 0.3 0.5 1.1 0.9 0.2 -0.3 -0.4 -0.9 -0.7 -0.4 -0.9 -1.1 -0.9
Asthma 1.6 3.2 11.0 2.8 -0.1 3.3 0.7 0.9 1.7 1.4 1.2 1.6 1.7
Medication: Ibuprofen (e.g. Nurofen) 4.0 5.1 10.0 0.2 2.0 -0.7 2.7 0.7 2.6 2.0 3.2 3.1 3.0
Medication: Cholesterol lowering 0.3 0.5 2.2 -0.5 -1.1 0.4 -0.5 -0.3 0.1 0.3 -0.7 0.7 1.5
Depression (self-reported) 1.3 1.6 5.2 0.2 -0.5 -0.6 -0.6 -0.5 -2.3 -1.3 -1.4 -1.1 -2.1
Medication: Lansoprazole 2.0 2.3 5.4 -1.9 -2.3 -0.1 -2.0 -0.0 -1.7 -1.6 -2.0 -0.6 -0.7
Prospective memory result 0.5 0.6 1.8 1.2 -0.2 1.1 0.2 0.1 1.0 1.3 0.6 -0.1 0.7
Lung cancer (father) 1.8 2.1 3.8 0.4 -1.5 0.3 -0.9 -2.0 -1.8 -1.9 -1.7 -1.0 -1.8
Illnesses of mother 1.0 1.3 8.2 -0.8 -1.2 -0.6 -1.1 -2.9 0.4 -0.5 -0.3 -0.3 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 2.6 -0.0 -0.0 -1.6 -0.8 -0.8 -0.9 -0.9 -0.3 -0.8 -1.0
Pulse wave Arterial Stiffness index 3.3 3.8 8.7 1.0 -1.8 0.8 -2.4 -1.0 -1.9 -1.0 -2.4 -2.8 -2.9
Impedance of arm (left) 0.4 1.6 4.5 0.3 1.3 -1.2 1.4 1.0 0.7 1.2 2.1 0.4 1.9
Arm fat mass (right) 2.9 12.1 21.1 0.7 -3.0 -0.4 -3.9 -4.4 -3.7 -2.8 -3.9 -4.6 -4.3
Trunk predicted mass 2.6 14.9 34.3 -0.7 -2.8 -1.1 -4.6 -2.5 -3.8 -4.0 -4.7 -5.0 -5.9
Standing height 1.6 15.8 40.2 -1.5 -2.2 -2.9 -4.5 -1.3 -4.1 -3.5 -3.8 -6.3 -6.1
Length of working week for main job 0.5 0.5 2.7 -0.8 0.4 0.0 -0.5 -0.9 0.1 0.2 -0.3 -1.6 -0.6
Exposure to tobacco smoke at home 0.5 0.6 2.0 0.2 -0.5 0.4 -0.9 0.4 -0.2 -0.8 -1.4 -0.7 -1.1
Breastfed as a baby 0.8 1.0 3.8 0.3 -2.0 1.1 -0.9 1.3 0.2 -0.8 -0.8 0.8 0.4
Tense / ‘highly strung’ 0.6 1.0 2.9 0.6 -1.2 -0.9 -1.1 0.5 -1.1 0.9 -0.5 -1.7 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 2.9 0.5 1.1 -0.5 1.7 -0.5 0.3 0.9 1.2 0.5 0.3
Hair/balding pattern: Pattern 4 0.2 0.5 1.2 0.4 0.4 0.8 0.6 -1.1 0.1 0.9 1.0 0.2 -0.4
Birth weight of first child 0.2 0.3 1.3 0.1 0.2 -1.2 -0.5 0.2 -0.9 -0.1 -0.2 -0.7 -0.5
Peak expiratory flow (PEF) 0.2 0.4 1.7 -1.1 0.4 -1.3 0.2 -0.6 -0.5 -0.2 0.4 -0.1 -0.1
Pulse wave reflection index 1.5 1.8 4.8 0.0 -1.2 1.4 -1.9 -0.5 -0.4 0.1 -1.8 -2.2 -1.7
Ever highly irritable/argumentative for 2 days 0.3 0.4 2.4 0.3 0.2 -0.2 -0.3 0.9 0.4 1.5 0.3 0.2 0.5
Loud music exposure frequency 0.9 1.0 5.4 1.0 1.3 0.2 -0.3 0.2 0.1 2.3 0.7 -1.3 -0.4
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.9 0.9 -0.6 0.8 -0.2 -0.1 -0.3 -0.8 -0.2 0.6 -0.7
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.5 1.0 -0.7 1.1 0.0 0.3 1.0 -0.0 0.2 0.6 1.2
Blood clot in the leg (DVT) 0.2 0.2 0.8 0.7 -0.8 0.9 -0.4 0.1 0.2 -0.0 -0.3 0.3 -0.4
Medication: Paracetamol 0.7 1.1 3.2 1.5 1.2 0.7 0.9 1.4 0.3 1.8 0.7 -0.6 -0.3
Headache pain in last month 0.3 0.5 2.9 -0.9 0.3 -1.7 0.6 0.7 0.3 0.2 0.7 0.2 0.1
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 2.1 1.0 0.8 -0.7 0.2 -0.1 0.1 0.4 1.0 -0.5 -1.4
Glaucoma (self-reported) 0.3 0.4 1.2 0.1 1.0 -0.2 1.1 0.4 0.4 -0.4 0.5 0.4 0.9
Gout (self-reported) 1.4 1.9 4.6 1.0 -1.8 -0.1 -1.8 -0.8 -1.1 -2.1 -1.7 -0.6 -1.4
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 3.9 0.2 1.6 -0.8 1.5 -0.5 1.4 1.7 2.0 1.5 1.2
Medication: Amlodipine 0.3 0.4 1.1 0.2 0.4 0.7 1.0 0.4 0.3 -0.4 -0.4 0.7 1.0
Medication: Ventolin 100micrograms inhaler 0.5 0.7 2.3 1.1 0.9 1.5 1.0 0.8 0.2 -0.6 -0.1 0.0 0.4
Birth weight 0.5 1.1 7.4 -0.8 1.0 -2.7 0.1 -0.6 0.3 0.4 0.6 -0.1 -1.0
Chronic bronchitis/emphysema (mother) 0.7 0.8 3.4 0.5 0.6 0.1 0.8 1.6 -1.8 -0.4 -0.3 -0.7 -0.3
High blood pressure (siblings) 0.7 1.0 2.9 1.2 -0.1 0.9 0.5 1.1 -1.1 -1.3 -0.9 -0.2 -1.7
Forced vital capacity (FVC), Best measure 0.4 1.4 5.2 -0.4 0.2 -2.3 -0.7 -1.1 -1.6 -1.1 -0.5 -1.2 -1.3
Body fat percentage 3.0 11.9 25.1 0.3 -3.2 -0.4 -3.6 -5.0 -4.0 -2.5 -3.7 -4.5 -3.7
Leg fat percentage (right) 2.6 9.5 24.4 0.1 -2.8 0.6 -2.9 -4.9 -3.5 -2.1 -3.4 -3.8 -3.3
Arm fat-free mass (right) 3.5 17.9 38.7 -0.5 -3.3 -0.9 -4.9 -3.4 -4.4 -4.2 -5.1 -5.6 -6.2
Exposure to tobacco smoke outside home 0.9 1.2 2.3 1.5 -0.8 1.3 -1.5 -1.4 0.1 0.2 -1.2 -1.2 -0.6
Comparative body size at age 10 0.1 0.4 3.0 -0.3 0.1 0.2 0.1 -1.7 0.6 -0.3 0.0 0.5 -0.4
Number of full brothers 1.2 1.5 4.0 1.8 -1.2 -0.6 -2.0 -0.6 -0.7 0.2 -1.2 -1.2 -1.3
Worry too long after embarrassment 0.4 0.7 3.9 -0.3 -0.3 2.0 -0.5 1.3 0.2 0.3 -0.4 -0.5 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 2.7 1.6 -1.2 0.8 -0.7 0.4 0.4 -0.7 -0.6 0.7 0.2
Wheeze or whistling in the chest in last year 1.1 1.9 3.7 1.8 -1.9 1.4 -1.1 1.1 -1.7 -1.3 -1.6 -0.7 -0.3
Number of children fathered 0.8 0.8 2.4 -0.2 -1.5 0.2 -1.4 0.9 -1.1 0.0 -0.9 -0.8 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.9 -0.9 0.0 0.3 0.2 0.7 0.1 -0.3 0.1 0.5 0.3
Age at first live birth 0.9 1.6 3.2 -0.1 -1.8 0.3 -1.8 0.8 -1.5 -1.3 -1.3 -1.3 -1.2
Pulse wave peak to peak time 2.4 2.9 5.2 -1.0 1.8 -1.1 2.2 0.9 1.6 0.7 2.1 2.2 2.3
Health satisfaction 0.5 0.7 3.2 -1.8 -0.6 0.9 -0.3 -1.0 -0.1 -0.5 -1.2 -0.2 0.1
Shortness of breath walking on level ground 0.5 0.6 3.3 -0.1 -0.9 0.2 -0.6 -1.8 -0.3 -1.0 -0.7 0.1 -0.3
Qualifications: College or University degree 0.3 1.1 2.6 -1.0 0.7 -0.8 0.1 -0.1 1.6 1.4 1.5 -0.1 1.3
Eye problems/disorders: None of the above 0.5 0.5 2.3 -0.9 0.3 -1.5 0.1 0.7 0.5 0.6 0.3 0.6 0.8
Mouth/teeth dental problems: Loose teeth 8.4 9.9 20.0 1.4 -4.1 2.1 -4.5 -3.4 -2.7 -2.7 -3.6 -3.0 -2.7
Emphysema/chronic bronchitis 0.3 0.4 2.0 1.4 0.4 -0.2 0.5 0.5 0.1 -0.7 -0.3 0.1 0.8
Medication for pain relief, constipation, heartburn 0.5 0.9 1.9 0.1 -1.0 1.3 -1.1 -0.8 -0.2 -1.4 -1.1 -0.3 -1.0
Neck or shoulder pain in last month 0.9 1.3 3.6 0.9 1.2 -0.1 1.1 1.1 1.5 1.9 1.4 0.5 0.7
Medication: Blood pressure 0.5 1.0 3.1 -1.8 -0.8 0.1 0.0 0.5 -0.5 -1.4 -1.2 0.4 1.3
Angina (self-reported) 0.8 1.0 4.0 -0.1 -0.7 0.2 -0.5 -0.6 -2.0 -0.6 -1.2 -1.3 -1.3
Migraine (self-reported) 2.1 2.6 5.9 0.4 1.1 -0.2 0.9 1.9 2.4 1.6 2.1 1.9 1.8
Medication: Ibuprofen 4.5 5.4 10.8 0.4 2.0 -0.3 2.8 0.4 2.4 2.5 3.3 3.0 3.2
Medication: Allopurinol 0.8 1.1 2.3 1.5 -0.7 1.0 -1.0 -0.9 -0.3 -1.5 -1.1 -0.4 -1.1
Medication: Omeprazole 1.2 1.5 4.9 0.1 0.5 -1.8 1.2 0.3 0.4 0.9 1.4 1.2 2.2
Medication: Seretide 50 evohaler 2.0 2.3 6.7 2.2 -2.3 2.6 -1.2 0.8 1.2 0.6 -0.5 1.1 0.7
Mean time to correctly identify matches 1.0 1.9 4.8 -0.3 0.8 -1.8 1.6 0.8 0.5 1.7 2.2 1.6 1.3
Heart disease (mother) 1.2 1.4 4.3 -0.1 -1.1 -0.2 -0.3 -0.2 -2.0 -2.1 -1.7 -0.1 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 4.5 -0.3 0.4 0.0 1.0 0.1 1.2 0.6 1.4 2.1 2.1
Whole body fat mass 3.7 15.5 27.7 0.2 -3.4 -0.7 -4.4 -4.8 -4.4 -3.2 -4.4 -5.3 -4.9
Leg fat mass (right) 3.4 13.4 24.4 -0.0 -3.0 -0.3 -3.8 -4.9 -4.0 -2.9 -4.1 -4.8 -4.7
Arm predicted mass (right) 3.7 18.7 39.6 -0.7 -3.3 -1.1 -5.0 -3.6 -4.3 -4.3 -5.2 -5.7 -6.3
Pulse rate, automated reading 0.2 0.7 3.7 0.5 -0.5 -1.9 0.3 1.1 -0.3 -0.2 0.5 1.0 0.3
Alcohol intake frequency. 0.5 1.1 5.7 -0.9 -0.5 -1.8 -1.0 -2.4 0.1 -0.3 -0.6 -0.1 0.0
Comparative height size at age 10 1.6 8.8 23.8 -1.5 -1.5 -2.5 -3.3 -1.6 -2.5 -2.6 -2.7 -4.5 -4.9
Number of full sisters 0.7 0.8 2.0 -0.7 -0.9 -1.4 -0.8 1.3 -1.0 0.2 -0.1 -0.9 -0.9
Suffer from ‘nerves’ 0.2 0.3 1.5 -0.2 0.7 0.2 1.2 -0.2 -0.3 0.6 0.1 0.1 0.3
Overall health rating 1.3 2.9 9.4 -0.8 -0.9 0.6 -1.1 -3.1 -1.9 -0.1 -1.7 -2.6 -1.8
Chest pain or discomfort 0.8 1.1 4.5 0.3 -1.0 0.9 -1.1 -2.1 -0.6 -0.1 -1.0 -1.1 -0.9
Had major operations 0.5 0.5 2.0 0.4 0.3 -0.2 -0.3 -1.0 -0.6 1.4 -0.3 -1.2 -0.1
Age at last live birth 0.5 0.7 1.6 1.3 -1.2 0.6 -1.0 1.2 -0.5 -0.2 -0.5 -0.5 0.1
Family relationship satisfaction 0.2 0.2 0.9 0.1 0.3 0.6 -0.2 -0.3 0.5 -0.4 0.1 0.3 1.0
Leg pain on walking 1.3 1.7 3.4 -0.3 -1.2 -0.6 -1.4 -0.0 -1.3 -1.4 -1.8 -1.6 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.9 0.9 -0.4 0.3 0.1 0.3 0.7 -0.3 -0.3 0.7 0.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 0.5 -0.6 -0.3 -0.6 0.5 0.3 -0.4 -0.2 -0.1 0.4
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.9 -0.4 0.5 0.0 1.0 -0.3 -0.1 -0.3 0.2 0.4 0.7
Medication: Aspirin 0.5 0.6 2.6 -1.2 -0.3 -1.6 0.2 0.8 -0.3 -0.9 -0.0 0.5 0.7
Supplements: Vitamin C 0.9 1.1 4.2 0.6 -0.1 0.3 0.8 0.5 1.0 0.0 0.4 1.9 2.1
Knee pain experienced in last month 0.7 1.0 2.6 1.4 -1.0 -0.8 -1.6 0.2 0.1 0.2 -1.2 -1.5 -0.6
Hypertension (Self-reported) 0.5 1.4 4.1 -2.0 0.5 1.8 1.4 0.7 -1.7 -0.6 -0.1 0.1 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.4 -0.5 0.4 -1.2 -0.4 0.2 -0.2 0.5 0.5 -0.6 0.0
Illnesses of father: Heart disease 0.2 0.3 0.8 0.4 -0.9 0.8 -0.4 -0.0 -0.5 -0.2 -0.5 -0.6 0.2
Illnesses of siblings: Diabetes 2.2 2.7 5.5 0.7 -2.3 0.4 -1.7 -1.3 -2.1 -1.4 -2.0 -1.4 -1.9
Smoking status: Previous 1.2 1.8 7.4 1.8 -1.7 2.7 -1.4 0.9 0.6 0.8 -0.5 0.3 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 5.4 0.6 0.4 -0.7 -0.9 -1.4 -0.7 0.3 -0.2 -2.3 -1.8
Whole body fat-free mass 2.9 16.6 38.6 -0.5 -3.0 -1.3 -4.7 -3.0 -4.1 -4.2 -4.8 -5.3 -6.2
Leg fat-free mass (right) 2.8 15.2 36.9 0.1 -2.9 -1.6 -4.5 -2.8 -3.9 -4.1 -4.3 -5.1 -6.1
Arm fat percentage (left) 2.1 8.6 19.9 1.3 -2.8 -0.0 -3.3 -4.5 -3.0 -2.1 -3.1 -3.6 -3.0
Average weekly red wine intake 0.4 0.6 1.6 -1.3 -0.7 -0.0 -0.8 0.2 -1.0 -0.3 -0.5 -0.4 -1.2
Handedness (chirality/laterality): Left-handed 4.2 5.1 9.3 -2.0 2.3 -1.5 2.4 1.3 2.0 2.1 2.7 2.5 3.0
Mood swings 0.7 1.2 4.6 2.1 -1.5 -0.4 -1.7 0.1 -0.4 0.1 -0.4 -1.2 -0.7
Loneliness, isolation 1.9 2.6 7.3 0.9 -2.7 1.2 -1.9 0.2 -0.1 -2.4 -2.6 -0.5 -0.1
Long-standing illness, disability or infirmity 0.6 0.9 4.7 0.6 -0.7 2.2 -1.0 -0.4 0.5 0.2 -1.3 -0.3 -0.5
Ever had bowel cancer screening 4.0 4.7 14.1 -1.8 -1.7 0.0 -1.4 -1.2 -3.8 -1.8 -2.2 -2.3 -3.1
Diabetes diagnosed by doctor 0.7 1.2 3.9 0.5 -1.1 2.0 -1.3 -0.2 -0.4 0.2 -1.6 -1.3 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 0.7 -0.9 0.0 -0.2 0.3 -0.8 -0.5 0.7 0.4 0.1 0.4
Friendships satisfaction 2.1 2.6 7.4 -1.1 1.6 0.3 1.7 -0.1 1.8 0.8 1.8 2.1 2.7
Qualifications: nursing, teaching 0.4 0.6 2.0 -0.9 0.8 -1.0 0.1 -0.8 1.4 0.1 0.3 0.2 0.5
Commuting to job workplace: Walk 0.4 0.4 1.4 0.1 -1.1 0.3 0.1 -0.3 -0.3 -1.2 -0.6 0.9 -0.5
Eye problems/disorders: Cataract 1.0 1.2 2.0 0.6 -0.5 1.3 -0.5 0.7 -1.4 -1.1 -1.3 -1.4 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.7 -0.1 -0.5 -1.3 -0.2 -0.7 0.5 0.2 0.4 1.1 0.6
Medication for cholesterol 1.1 1.6 4.3 0.8 -0.2 -2.0 -0.9 -0.1 2.0 1.3 0.6 0.2 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.2 3.7 9.6 -0.8 -3.1 -0.2 -2.8 -0.9 -1.9 -1.8 -2.7 -1.7 -1.3
Back pain experienced in last month 1.4 2.1 5.1 0.8 1.8 0.4 2.3 0.7 0.6 2.2 1.8 1.4 0.9
Mineral and other dietary supplements 0.2 0.2 0.7 0.2 0.1 0.6 -0.8 -0.3 -0.1 0.1 -0.3 -0.9 -0.3
Breast cancer (self-reported) 0.4 0.5 4.0 -2.0 0.1 0.1 0.1 0.2 0.1 -0.1 -0.3 -0.6 0.5
Asthma (self-reported) 1.1 2.3 8.0 2.4 -0.2 2.8 0.4 0.7 1.5 1.2 1.0 1.2 1.4
Osteoporosis (self-reported) 0.8 1.0 2.5 -1.1 -1.6 0.6 -1.3 1.4 0.5 0.7 -0.5 0.1 1.1
Osteoarthritis (self-reported) 0.1 0.2 0.7 0.8 0.3 0.1 -0.1 0.6 0.9 0.1 -0.1 0.2 0.0
Medication: Aspirin 0.5 0.6 2.2 -1.0 0.0 -1.5 0.6 1.0 -0.2 -0.6 0.4 0.7 0.7
Medication: Gliclazide 0.4 0.4 1.4 -0.1 -0.9 0.7 -0.9 -1.2 -0.4 -0.1 -0.6 0.1 0.5
Illnesses of father: None of the above (group 1) 0.4 0.5 1.2 -0.5 -1.1 -0.9 -0.8 -0.7 0.4 -0.6 -0.3 0.7 -0.7
Smoking status: Current 0.4 0.6 2.2 0.6 -0.1 -1.5 -0.6 -0.4 -0.3 -1.0 -0.8 -1.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.6 -0.5 1.1 -1.3 0.6 -0.8 -0.3 1.0 0.9 -0.1 -0.4
Whole body water mass 2.9 16.3 36.8 -0.6 -3.0 -1.3 -4.6 -3.0 -4.1 -4.2 -4.7 -5.3 -6.1
Leg predicted mass (right) 2.8 14.9 35.9 0.1 -2.9 -1.5 -4.5 -2.8 -3.8 -4.0 -4.3 -5.1 -6.0
Arm fat mass (left) 3.3 13.5 23.6 1.1 -3.3 -0.4 -4.2 -4.5 -3.9 -3.0 -4.1 -4.9 -4.4
Number of self-reported non-cancer illnesses 0.5 0.9 6.2 -0.3 -0.3 2.5 0.5 -1.0 -1.0 -0.2 -0.3 -0.1 -0.1
Average weekly champagne plus white wine intake 1.9 2.6 5.5 1.9 0.2 1.1 0.6 1.5 2.3 1.4 1.2 2.3 2.1
Miserableness 1.0 1.7 3.7 1.3 -1.3 -1.2 -1.9 -0.4 -1.0 -0.5 -1.1 -1.8 -1.5
Guilty feelings 1.6 2.3 8.6 2.3 -1.7 -0.2 -2.9 0.2 0.4 -0.3 -1.5 -1.7 -1.0
Wears glasses or contact lenses 4.6 5.3 12.5 -0.8 -3.5 -0.4 -3.5 -1.4 -1.6 -1.7 -3.1 -2.1 -2.5
Ever taken oral contraceptive pill 0.4 0.4 1.4 -0.5 1.2 0.9 0.3 -0.7 0.6 0.8 0.3 -0.2 0.5
Hearing aid user 0.8 0.9 2.2 -0.6 -1.5 1.2 -0.3 0.3 0.2 -1.4 -0.6 1.4 0.4
Mother’s age at death 0.4 0.5 1.8 0.4 -1.4 -0.5 -1.0 -0.9 0.6 0.2 -0.4 0.2 -0.8
Financial situation satisfaction 1.5 1.9 6.7 -0.6 0.9 -0.2 1.8 0.5 1.4 0.5 1.3 1.8 2.6
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.5 -1.5 -0.4 -0.3 -0.2 -0.7 -1.4 -1.1 -0.3 0.1 -1.6
Commuting to job workplace: Public transport 0.4 0.4 1.1 -0.2 0.4 -1.0 0.8 -0.6 0.6 0.4 0.5 1.0 0.6
Eye problems/disorders: Glaucoma 1.4 1.7 3.1 1.2 1.7 -0.4 1.8 1.2 1.1 0.4 1.5 1.2 1.5
Medication: Blood pressure 0.6 1.1 3.7 -1.9 1.1 0.8 1.6 0.4 -0.9 -1.0 0.2 0.3 -0.9
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.9 -0.3 -0.4 -0.6 -0.9 0.1 0.7 0.3 -0.6 0.2 0.4
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.4 0.4 0.3 -0.4 1.2 1.2 -0.2 0.0 0.7 1.0 0.7
High cholesterol (Self-reported) 0.6 1.1 4.1 -0.8 -1.6 2.0 -0.9 -0.9 0.2 -0.1 -0.8 1.1 0.3
Medication: Bendroflumethiazide 0.3 0.4 1.5 -0.5 0.8 0.3 1.2 0.5 -0.7 -0.2 0.3 0.6 0.5
Medication: Paracetamol 1.2 1.8 7.2 0.8 1.8 -0.1 1.4 1.8 0.1 2.7 1.3 -0.0 0.5
Medication: Lisinopril 0.6 0.7 2.5 1.0 -1.4 1.6 -0.8 0.3 0.1 -0.4 -0.6 0.2 0.6
Medication: Atorvastatin 0.9 1.1 2.6 -0.8 0.5 1.6 1.6 -1.3 0.1 0.2 0.7 0.7 1.6
Illnesses of father: High blood pressure 3.9 4.8 12.1 0.3 3.5 0.9 3.3 1.5 1.8 2.0 2.4 1.3 2.7
Alcohol drinker status: Never 1.4 1.6 6.9 -1.6 0.1 -2.6 -0.0 -2.1 0.8 -0.7 -0.5 0.7 0.6
Ever smoked 0.8 1.4 4.1 1.8 -1.8 2.0 -1.5 0.1 0.2 0.0 -0.9 -0.4 -0.8
Basal metabolic rate 3.2 17.7 38.6 -0.4 -3.1 -1.4 -4.8 -3.4 -4.3 -4.2 -4.9 -5.6 -6.2
Leg fat percentage (left) 2.7 9.7 22.5 0.3 -2.6 0.5 -2.9 -4.7 -3.7 -2.3 -3.5 -3.9 -3.6
Arm fat-free mass (left) 3.5 17.9 36.3 -0.6 -3.4 -1.2 -4.9 -3.5 -4.4 -4.3 -5.1 -5.5 -6.0
Number of operations (self-reported) 0.7 1.0 2.4 1.1 -0.7 1.3 -1.0 -1.1 -0.3 0.4 -0.9 -1.5 -1.1
Average weekly beer plus cider intake 0.3 0.4 1.2 0.4 -0.3 0.7 0.4 0.1 0.1 -1.1 -0.8 0.4 -1.0
Irritability 0.5 0.8 4.0 0.4 -0.0 -1.4 -0.1 0.4 0.1 2.0 1.1 -0.1 0.7
Risk taking 0.7 1.0 3.5 -0.6 -1.9 -0.2 -1.1 -0.6 0.0 -1.0 -1.5 -0.2 1.0
Ever had prostate specific antigen (PSA) test 1.5 1.7 4.1 0.2 -1.8 2.0 -1.5 -0.5 -0.9 -0.8 -1.9 -0.9 -1.1
Fractured/broken bones in last 5 years 0.4 0.5 1.4 -0.5 0.8 -0.5 0.9 1.2 0.8 -0.4 0.6 0.7 0.5
Age started oral contraceptive pill 0.2 0.3 1.1 0.5 -0.1 -0.0 0.1 -0.3 -0.5 -0.7 -0.4 -0.7 -1.0
Diastolic blood pressure, automated reading 0.5 1.7 7.2 0.8 2.0 0.4 1.5 2.7 0.5 1.3 1.0 0.0 0.1
Ever depressed for a whole week 0.9 1.1 4.0 -0.1 -0.8 0.7 -0.5 -0.4 -1.1 -2.0 -1.4 -0.8 -1.2
Unable to work because of sickness or disability 0.4 0.6 1.8 0.1 -0.4 0.2 0.2 1.4 0.4 -0.2 0.1 1.3 1.2
Commuting to job workplace: Cycle 1.0 1.2 2.4 1.1 -0.8 0.8 -1.2 -1.0 -0.7 -1.2 -1.0 -1.5 -1.2
Myopia 0.4 0.6 2.1 -0.3 0.7 0.9 1.5 0.8 0.2 0.1 1.0 1.1 -0.3
Vascular/heart problems diagnosed by doctor 0.4 1.2 5.0 2.2 -0.4 -1.2 -1.1 -0.1 1.8 0.8 0.0 0.0 0.4
Cholesterol lowering medication 0.8 1.2 2.3 -1.5 -0.9 1.5 -0.4 -1.3 -0.8 -1.0 -1.4 -0.1 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 3.1 0.1 0.5 -1.1 0.8 0.5 0.6 0.5 0.7 0.9 1.8
Pain experienced in last month 0.2 0.3 2.1 -0.5 -0.2 0.6 0.1 0.4 -0.2 -1.4 -0.1 0.4 0.5
Supplements: Calcium 1.2 1.3 3.4 -0.5 -1.8 0.3 -1.7 -0.0 -0.8 -1.4 -1.8 -0.4 -0.6
Basal cell carcinoma (self-reported) 1.9 2.3 7.9 -0.6 -1.5 0.7 -1.6 -0.9 -0.8 -2.2 -2.8 -0.9 -1.6
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.9 -0.4 -0.2 -1.4 0.0 1.4 0.7 0.4 0.3 0.5 1.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.7 0.7 -0.8 0.9 -0.3 0.2 0.2 -0.1 -0.2 0.5 -0.3
Heart disease (siblings) 0.7 0.9 4.8 0.5 -0.3 0.6 0.0 1.2 -0.8 2.2 0.3 -0.5 -0.9
Alcohol drinker status: Previous 0.2 0.3 0.9 0.6 0.1 -0.2 -0.3 0.8 0.5 -0.2 -0.4 -0.2 0.9
Pack years of smoking 2.7 4.0 10.9 -0.0 -2.6 -0.2 -3.0 0.5 -1.4 -2.4 -3.3 -1.9 -1.2
Impedance of whole body 0.4 2.3 6.0 -0.5 1.5 -0.9 1.8 1.3 0.9 1.6 2.2 0.6 2.5
Leg fat mass (left) 3.5 13.5 23.5 -0.1 -2.9 -0.4 -3.7 -4.8 -4.1 -3.0 -4.2 -4.8 -4.8
Arm predicted mass (left) 3.6 18.5 37.9 -0.9 -3.3 -1.3 -4.9 -3.5 -4.4 -4.3 -5.2 -5.7 -6.2