Hub : Genes

R3HCC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.1580	0.0420	1.1e-05	0.077	NA	0.111	NA	0.098	6.3e-07	NA	2.0e-09	NA	1.8e-08
2	NTR	Blood	0.0235	0.0083	7.2e-04	0.014	0.011	0.015	0.012	0.015	1.8e-05	0.00016	6.8e-06	5.2e-05	9.0e-06
3	YFS	Blood	0.0345	0.0124	6.4e-04	0.014	0.004	0.003	0.006	0.009	1.7e-05	0.01300	2.3e-02	3.8e-03	5.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.1	1.7	3.1	-0.7	-1.8	-1.2
Bipolar Disorder or Schizophrenia	0.2	0.6	1.3	-0.3	-1.1	-0.6
Depressed Affect (Nagel 2018)	1.9	4.0	5.2	-1.5	2.3	2.1
Depression (Nagel 2018)	1.2	1.8	3.6	-0.3	1.9	1.3
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.4	0.1	-0.7
Neuroticism (Nagel 2018)	1.6	3.8	5.2	-1.2	2.2	2.3
Schizophrenia (2018)	0.0	0.0	0.0	0.2	-0.0	0.1
Schizophrenia vs Biploar Disorder	1.9	2.5	5.3	0.2	2.3	1.5
Worry (Nagel 2018)	0.3	0.7	1.0	-1.0	0.6	0.8
Alzheimer’s Disease (in mother)	1.7	2.0	5.0	-0.9	-0.5	-2.2
Alzheimer’s Disease (in father)	0.8	0.8	1.6	-1.2	0.6	0.8
Alzheimer’s Disease (including proxy)	2.2	3.2	8.1	-2.8	0.8	-0.9
Crohns Disease (2017)	0.5	1.2	2.3	0.9	-1.5	-0.6
Irritable Bowel Disease (IBD)	0.3	0.7	1.1	0.8	-1.0	-0.7
Ulcerative Colitis (UC)	0.2	0.3	0.7	0.3	-0.4	-0.9
Major Depression (MDD)	0.1	0.2	0.4	-0.6	-0.1	-0.3
Reaction Time	1.6	3.0	3.7	1.5	-1.9	-1.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.9	-0.0	-0.5	-0.9
Breast Cancer	0.2	0.4	0.6	0.6	0.4	0.7
Ovarian Cancer	1.2	1.5	3.1	0.7	-1.0	-1.8
Prostate Cancer	3.0	4.1	12.0	-3.5	-0.5	-0.5
Age at First Birth	0.2	0.2	0.5	0.5	-0.7	0.2
Bipolar Disorder (2011)	0.4	0.4	1.0	0.4	-1.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.1	-0.8	1.0	0.1
Coronary Artery Disease (CAD)	1.5	1.8	4.0	-1.1	-0.4	-2.0
Crohns Disease (2012)	0.3	0.4	0.6	0.0	-0.8	-0.8
Mean Putamen Volume	0.3	0.3	0.6	0.5	0.7	0.2
Fasting Glucose	0.2	0.2	0.3	0.5	0.6	0.3
HbA1C	1.0	1.1	2.8	-0.7	-0.1	-1.7
HDL Cholesterol	1.0	1.7	2.7	0.3	-1.5	-1.6
LDL Cholesterol	0.6	1.0	2.6	-1.6	0.3	0.4
Lupus	0.0	0.0	0.0	-0.2	-0.1	0.0
Neuroticism (2016)	1.6	2.3	5.0	-2.2	1.3	0.4
Primary Biliary Cirrhosis	0.3	0.5	0.9	0.9	-0.2	0.7
Rheumatoid Arthritis	0.9	1.2	1.9	0.7	-1.1	-1.4
Schizophrenia (2014)	0.0	0.1	0.1	-0.3	0.2	0.2
Triglycerides	1.3	2.1	4.4	-0.4	1.4	2.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	-0.1	-0.8	-1.1
Ulcerative Colitis	0.1	0.2	0.5	-0.0	0.7	-0.3
Blood Eosinophil Count	0.8	6.1	9.9	-1.0	3.1	2.7
Blood Platelet Count	0.0	0.5	1.5	-1.2	0.2	-0.1
Blood Red Count	0.6	5.9	12.3	-3.5	2.3	-0.2
Blood White Count	0.5	3.7	4.5	-1.8	2.1	1.8
Heel T-Score	0.1	0.8	1.7	0.4	0.8	1.3
BMI	0.7	4.1	8.6	-0.7	1.8	2.9
Height	3.6	69.8	75.9	-8.5	8.7	7.8
Waist Hip Ratio (WHR)	0.0	0.2	0.6	-0.8	-0.1	0.1
Systolic Blood Pressure	0.4	1.9	4.4	-2.1	-0.3	-1.0
Smoking Status	0.7	1.6	2.3	-0.5	1.5	1.5
Allergy or Eczema	0.6	1.6	4.7	0.2	0.3	2.2
Cardiovascular Disease	0.3	1.1	2.2	-1.0	-1.5	-0.0
Hypothyroidism (self reported)	0.8	1.8	3.3	1.8	-1.5	-0.2
Respiratory disease	0.1	0.2	0.5	0.7	-0.3	-0.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.3	-0.9	0.8	1.1
Lung FEV1/FVC ratio	0.8	4.1	4.7	-1.9	1.9	2.2
Lung FVC	0.9	4.7	10.5	-1.9	0.3	-3.2
Neuroticism	0.7	1.8	2.6	-0.8	1.6	1.5
Chronotype (morning person)	3.9	8.9	11.6	-2.6	3.4	2.9
Hair Pigment	0.2	6.7	12.3	3.5	-2.4	1.4
Tanning	0.0	0.4	0.8	-0.9	0.1	-0.7
Hand grip strength (left)	1.0	2.5	6.0	2.4	-1.2	-0.6
Number of treatments/medications taken	0.2	0.4	0.5	-0.6	-0.5	0.7
Average weekly spirits intake	0.9	1.1	1.4	-0.9	1.0	1.2
Sensitivity / hurt feelings	0.0	0.0	0.1	0.0	0.3	-0.0
Frequency of depressed mood in last 2 weeks	1.9	2.7	4.1	-1.5	2.0	1.3
Hearing difficulty/problems: Yes	1.2	1.9	3.3	0.5	-1.8	-1.4
Relative age of first facial hair	0.9	1.9	4.5	-2.1	0.5	-0.9
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	4.3	-2.1	0.9	1.6
Ever used hormone-replacement therapy (HRT)	1.4	1.8	5.0	0.6	0.2	2.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	0.6	-0.4	0.5
Systolic blood pressure, automated reading	0.1	0.2	0.3	-0.5	0.1	0.5
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	5.0	-2.2	1.0	1.9
Angina	0.4	0.5	0.9	-1.0	0.6	-0.2
Medication for hormone replacement therapy	1.0	1.1	2.3	0.7	-1.5	0.8
Vitamin and mineral supplements	1.5	2.0	3.1	1.0	1.8	1.4
Supplements: Zinc	0.4	0.5	0.9	-0.3	-0.6	-1.0
Medication: Co-codamol	0.1	0.1	0.2	0.3	0.4	-0.1
Medication: Metformin	3.9	5.5	7.4	-2.3	2.7	2.0
Diabetes (father)	1.7	2.1	3.3	-1.8	1.6	0.7
Diabetes (mother)	0.5	0.6	1.8	0.1	-0.3	-1.4
Severe depression (siblings)	0.9	1.0	1.4	-0.9	1.2	-0.8
Pack years adult smoking proportion	3.4	5.2	6.8	-1.8	2.6	2.3
Impedance of leg (right)	0.5	2.7	6.5	-1.2	0.4	-2.5
Leg fat-free mass (left)	3.4	17.9	28.9	-3.2	3.8	5.4
Trunk fat percentage	3.0	12.1	16.9	-3.1	4.1	3.1
Hand grip strength (right)	0.7	1.8	3.1	1.8	-1.2	-1.0
Townsend deprivation index at recruitment	0.3	0.4	0.8	0.7	-0.9	-0.1
Current tobacco smoking	0.1	0.2	0.3	-0.3	0.6	0.4
Average weekly fortified wine intake	0.7	0.8	0.9	-0.8	0.9	1.0
Maternal smoking around birth	0.7	1.0	2.4	-1.5	0.6	-0.5
Fed-up feelings	0.0	0.1	0.1	0.2	0.3	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.8	-0.8	1.3	0.7
Relative age voice broke	0.9	1.3	2.5	-1.2	-0.5	-1.6
Taking other prescription medications	0.1	0.1	0.3	-0.3	-0.6	0.0
Age when periods started (menarche)	0.2	0.4	0.6	0.2	0.7	0.8
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.7	-0.1	1.3	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.4	0.4	0.8	1.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.3	-0.7	0.2
Qualifications: CSEs or equivalent	0.1	0.2	0.3	0.4	-0.3	-0.5
Serious illness, injury or assault to yourself	0.9	1.1	3.0	-1.7	0.5	-0.1
High blood pressure	0.4	1.1	2.0	-1.2	-1.4	-0.3
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	0.1	-0.3	0.9
Multivitamins +/- minerals	1.2	1.6	3.6	0.2	-1.9	-1.0
Stomach or abdominal pain in last month	0.3	0.4	1.0	-1.0	-0.1	-0.4
Supplements: Glucosamine	0.5	0.7	1.4	-1.2	0.5	0.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.3	-0.5	0.0
Medication: Atenolol	0.2	0.2	0.3	-0.4	0.3	0.6
Medication: Levothyroxine sodium	0.8	1.3	2.4	1.5	-1.2	-0.1
Sitting height	3.6	25.3	29.8	-4.6	5.5	5.0
Chronic bronchitis/emphysema (father)	0.7	0.9	1.8	1.4	-0.9	0.2
High blood pressure (mother)	0.6	0.8	1.5	-0.9	-1.2	-0.0
Body mass index (BMI)	1.3	5.5	9.5	-1.3	2.3	3.1
Impedance of leg (left)	0.6	3.2	8.2	-1.1	0.4	-2.9
Leg predicted mass (left)	3.4	18.2	29.5	-3.2	3.9	5.4
Trunk fat mass	4.2	18.2	21.9	-3.7	4.7	4.4
Waist circumference	2.2	8.1	11.3	-2.4	2.7	3.4
Number of incorrect matches in round	0.2	0.3	0.5	0.2	0.7	0.7
Past tobacco smoking	0.5	0.9	1.5	-1.1	-0.1	-1.2
Alcohol usually taken with meals	0.3	0.5	1.1	-1.0	0.7	0.1
Nervous feelings	0.1	0.2	0.6	0.1	-0.4	-0.8
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.8	6.7	-1.6	2.6	1.5
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.2	-0.9	-0.2
Hair/balding pattern: Pattern 2	0.9	1.1	1.8	-1.3	1.1	0.7
Had menopause	0.1	0.2	0.3	0.3	0.3	0.5
Had other major operations	0.6	0.7	1.9	-0.1	0.6	1.4
Forced vital capacity (FVC)	1.2	4.7	10.3	-3.2	1.9	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	3.5	-0.9	1.4	1.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	-0.5	0.5	0.8
Qualifications: None of the above	0.6	1.4	2.2	-1.5	1.1	0.9
Financial difficulties in last 2 years	1.5	2.0	3.3	1.8	-1.4	-0.9
Mouth/teeth dental problems	0.9	1.4	2.4	1.5	-1.3	-0.1
Heart attack	0.1	0.1	0.2	-0.3	0.1	-0.5
Allergy	0.2	0.4	0.7	-0.8	0.7	-0.4
Pain all over the body in last month	0.2	0.2	0.4	-0.1	-0.4	0.7
Diabetes (self-reported)	1.5	2.3	3.5	-1.9	1.5	1.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.4	1.2	-0.8	0.9
Medication: Ramipril	0.9	1.2	3.0	-1.7	-0.1	-0.7
Medication: Simvastatin	0.3	0.4	0.7	-0.8	-0.0	-0.7
Fluid intelligence score	0.6	1.3	3.1	-1.8	0.9	0.3
Illnesses of siblings	2.5	3.5	6.1	2.5	-1.7	-1.3
Neuroticism score	0.3	0.7	1.5	-0.1	0.7	1.2
Weight	4.6	22.5	29.3	-3.9	4.8	5.4
Impedance of arm (right)	0.6	3.0	8.2	-0.2	-0.9	-2.9
Arm fat percentage (right)	0.9	3.5	4.6	-1.3	2.2	2.0
Trunk fat-free mass	3.7	21.3	31.9	-3.9	4.1	5.7
Hip circumference	2.9	12.6	19.0	-2.5	3.6	4.4
Time employed in main current job	0.5	0.6	1.0	0.1	-1.0	1.0
Alcohol intake versus 10 years previously	1.1	1.7	3.6	-0.9	0.8	1.9
Father’s age at death	1.0	1.3	2.3	-1.2	1.5	0.3
Worrier / anxious feelings	0.2	0.4	0.7	-0.3	-0.8	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.2	-0.4	1.1	1.1
Falls in the last year	0.0	0.0	0.1	-0.3	0.1	-0.0
Hair/balding pattern: Pattern 3	1.1	1.6	3.1	0.6	-1.2	-1.8
Number of live births	3.5	4.9	6.6	-1.4	2.6	2.5
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	10.3	-3.2	1.6	0.3
Pulse rate	0.3	0.5	1.1	0.2	0.6	1.0
Happiness	0.1	0.1	0.3	0.2	-0.0	-0.5
Noisy workplace	0.1	0.1	0.1	0.1	-0.4	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	-0.4	0.8	-0.0
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	2.8	0.9	-1.6	-1.7
Mouth/teeth dental problems: Dentures	0.5	0.8	1.2	-1.0	1.1	-0.2
Asthma	1.7	3.3	6.6	2.6	-1.7	-0.7
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	3.9	1.4	-2.0	-1.6
Medication: Cholesterol lowering	0.6	0.9	2.4	-1.6	0.2	-0.3
Depression (self-reported)	0.8	1.0	1.2	-1.1	0.7	1.1
Medication: Lansoprazole	1.2	1.4	2.8	-1.7	0.9	0.7
Prospective memory result	0.2	0.3	0.8	0.4	0.9	-0.0
Lung cancer (father)	1.0	1.2	3.0	-1.7	0.5	-0.5
Illnesses of mother	0.4	0.5	1.3	0.5	1.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	10.8	-3.3	1.7	0.4
Pulse wave Arterial Stiffness index	4.7	5.5	7.3	-1.9	2.7	2.3
Impedance of arm (left)	0.4	2.1	5.5	-0.8	-0.3	-2.4
Arm fat mass (right)	2.5	10.4	13.5	-2.5	3.4	3.7
Trunk predicted mass	3.7	21.0	31.0	-3.9	4.1	5.6
Standing height	3.4	34.2	38.3	-6.2	5.9	5.4
Length of working week for main job	1.2	1.3	2.6	0.1	1.2	1.6
Exposure to tobacco smoke at home	0.6	0.7	1.7	-0.1	0.6	1.3
Breastfed as a baby	1.6	1.9	3.3	1.5	-1.8	-0.4
Tense / ‘highly strung’	0.9	1.6	2.7	-0.7	1.6	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.0	0.1	-1.0	-0.9
Hair/balding pattern: Pattern 4	0.9	2.2	4.3	2.1	-1.5	-0.2
Birth weight of first child	0.6	1.0	1.6	-1.3	1.2	0.0
Peak expiratory flow (PEF)	1.3	3.0	8.7	-3.0	0.5	0.2
Pulse wave reflection index	4.0	4.9	6.8	-2.3	2.6	1.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	-0.2	0.8	1.1
Loud music exposure frequency	2.1	2.3	4.4	-1.3	2.1	0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.9	0.6	-1.0	-1.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.1	-0.6	-0.3
Blood clot in the leg (DVT)	0.0	0.0	0.1	-0.3	0.2	0.1
Medication: Paracetamol	0.5	0.8	1.6	-0.6	0.7	1.3
Headache pain in last month	0.7	1.2	3.3	0.6	0.0	1.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.7	1.3	0.3	0.6
Glaucoma (self-reported)	0.8	1.0	2.0	0.9	-1.4	-0.0
Gout (self-reported)	1.3	1.7	3.8	-1.9	1.2	0.3
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	3.1	1.8	-1.4	-0.9
Medication: Amlodipine	1.0	1.4	2.1	0.6	-1.5	-1.3
Medication: Ventolin 100micrograms inhaler	1.6	2.1	3.7	1.9	-1.2	-1.0
Birth weight	0.1	0.3	0.6	-0.5	0.1	0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.9	-0.9	-0.7	-0.7
High blood pressure (siblings)	0.2	0.3	0.5	-0.7	-0.4	0.4
Forced vital capacity (FVC), Best measure	1.8	6.5	14.5	-3.8	2.2	0.2
Body fat percentage	2.4	9.3	13.4	-2.6	3.7	2.7
Leg fat percentage (right)	1.5	5.6	7.9	-2.0	2.8	2.2
Arm fat-free mass (right)	4.6	23.6	31.7	-4.1	4.7	5.6
Exposure to tobacco smoke outside home	1.4	1.9	3.0	-0.6	1.5	1.7
Comparative body size at age 10	0.1	0.4	0.6	0.7	-0.6	0.4
Number of full brothers	1.9	2.4	4.5	-0.9	2.1	1.4
Worry too long after embarrassment	0.0	0.1	0.2	-0.1	-0.2	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	-0.4	-0.5	-0.6
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	0.8	-0.6	-0.1
Number of children fathered	0.5	0.5	0.7	-0.8	0.6	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.6	-0.0	-0.7	-0.8
Age at first live birth	0.5	0.8	2.0	-0.6	0.3	1.4
Pulse wave peak to peak time	3.1	3.6	5.0	1.5	-2.2	-1.9
Health satisfaction	0.1	0.1	0.1	-0.4	0.4	0.0
Shortness of breath walking on level ground	0.0	0.0	0.0	0.1	-0.1	-0.1
Qualifications: College or University degree	0.1	0.3	0.5	-0.6	0.7	-0.1
Eye problems/disorders: None of the above	0.5	0.6	0.8	-0.5	0.9	-0.9
Mouth/teeth dental problems: Loose teeth	4.3	5.1	8.9	-3.0	2.4	0.7
Emphysema/chronic bronchitis	0.5	0.6	1.1	0.0	-0.8	-1.1
Medication for pain relief, constipation, heartburn	0.2	0.4	0.5	0.6	-0.6	-0.7
Neck or shoulder pain in last month	1.7	2.5	5.5	2.4	-1.3	-0.4
Medication: Blood pressure	0.6	1.1	1.8	-1.0	-0.6	-1.3
Angina (self-reported)	0.3	0.5	1.1	-1.0	0.5	-0.2
Migraine (self-reported)	0.8	1.0	1.6	1.0	-1.3	-0.6
Medication: Ibuprofen	2.6	3.1	4.3	1.5	-2.1	-1.7
Medication: Allopurinol	0.3	0.4	0.7	-0.8	0.7	0.4
Medication: Omeprazole	1.0	1.2	2.6	-0.3	-0.9	-1.6
Medication: Seretide 50 evohaler	1.7	1.9	3.4	1.5	-0.5	1.9
Mean time to correctly identify matches	1.3	2.5	3.8	1.2	-1.5	-1.9
Heart disease (mother)	0.3	0.4	1.1	0.1	-1.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	2.2	1.4	-1.4	-1.5
Whole body fat mass	3.5	14.6	17.6	-3.2	4.2	4.0
Leg fat mass (right)	2.9	11.3	14.2	-2.6	3.6	3.8
Arm predicted mass (right)	5.0	25.8	35.5	-4.2	4.9	6.0
Pulse rate, automated reading	0.5	1.5	2.7	1.6	-1.3	-0.2
Alcohol intake frequency.	0.6	1.4	2.6	-0.6	1.1	1.6
Comparative height size at age 10	3.6	19.9	21.6	-4.3	4.4	4.7
Number of full sisters	1.0	1.2	1.6	-0.5	1.3	1.3
Suffer from ‘nerves’	0.3	0.5	0.6	-0.6	-0.8	-0.8
Overall health rating	1.9	4.0	4.7	-1.6	2.1	2.2
Chest pain or discomfort	0.7	0.9	2.4	0.0	0.7	1.5
Had major operations	1.0	1.1	2.6	0.4	1.6	0.8
Age at last live birth	0.6	0.8	1.6	-0.9	0.4	1.3
Family relationship satisfaction	0.3	0.3	0.9	0.2	-0.2	-0.9
Leg pain on walking	1.8	2.3	3.7	-1.7	1.9	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.1	-0.6	-0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	-0.2	0.8	-0.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.1	0.1	-1.0	-1.1
Medication: Aspirin	0.0	0.0	0.0	0.0	-0.0	0.0
Supplements: Vitamin C	1.5	1.7	2.8	-1.3	-0.9	-1.7
Knee pain experienced in last month	2.0	3.1	4.0	-1.3	2.0	1.9
Hypertension (Self-reported)	0.4	1.1	2.0	-1.1	-1.4	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.2	-1.5	0.9	-1.1
Illnesses of father: Heart disease	0.2	0.3	0.6	-0.8	0.1	0.6
Illnesses of siblings: Diabetes	1.0	1.2	1.7	-1.3	1.3	0.6
Smoking status: Previous	0.4	0.5	1.3	1.1	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	5.0	-1.9	2.2	2.0
Whole body fat-free mass	3.7	21.4	31.9	-3.8	4.2	5.7
Leg fat-free mass (right)	3.3	17.4	28.3	-3.0	3.8	5.3
Arm fat percentage (left)	1.3	5.2	6.7	-1.8	2.6	2.4
Average weekly red wine intake	0.5	0.7	1.1	-1.1	1.0	0.2
Handedness (chirality/laterality): Left-handed	4.2	5.1	6.6	2.6	-1.9	-2.2
Mood swings	0.4	0.6	1.2	-0.5	1.1	0.6
Loneliness, isolation	1.0	1.4	3.1	-1.1	0.1	1.8
Long-standing illness, disability or infirmity	1.3	2.0	4.6	-0.4	1.1	2.2
Ever had bowel cancer screening	1.7	2.0	4.2	-2.1	1.3	0.0
Diabetes diagnosed by doctor	1.7	2.8	3.8	-2.0	1.8	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.5	0.0	0.6
Friendships satisfaction	1.7	2.1	3.7	1.0	-1.9	-1.3
Qualifications: nursing, teaching	0.2	0.3	0.4	0.6	0.1	0.7
Commuting to job workplace: Walk	0.8	0.9	2.0	0.7	-1.4	0.4
Eye problems/disorders: Cataract	0.4	0.4	0.7	-0.8	0.2	0.8
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.0	-0.2	-0.1	0.1
Medication for cholesterol	0.6	0.9	2.2	0.6	1.5	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.8	5.6	10.2	-3.2	2.0	1.6
Back pain experienced in last month	0.8	1.1	1.7	1.3	-1.2	-0.4
Mineral and other dietary supplements	0.2	0.3	0.5	0.4	0.7	-0.3
Breast cancer (self-reported)	0.6	0.7	1.3	-0.6	0.7	1.1
Asthma (self-reported)	1.5	2.9	6.7	2.6	-1.4	-0.4
Osteoporosis (self-reported)	0.4	0.5	0.7	-0.9	0.8	-0.2
Osteoarthritis (self-reported)	0.5	0.6	1.8	0.0	0.3	1.3
Medication: Aspirin	0.1	0.1	0.1	0.3	-0.3	-0.0
Medication: Gliclazide	0.1	0.1	0.2	-0.4	0.3	0.0
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	-0.1	0.4	0.8
Smoking status: Current	0.1	0.2	0.3	-0.2	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.9	8.6	-2.9	1.6	-0.7
Whole body water mass	3.7	21.1	31.6	-3.8	4.2	5.6
Leg predicted mass (right)	3.3	17.4	28.1	-3.1	3.8	5.3
Arm fat mass (left)	2.8	11.6	14.4	-2.7	3.7	3.8
Number of self-reported non-cancer illnesses	0.3	0.5	0.9	-0.9	-0.7	-0.4
Average weekly champagne plus white wine intake	1.0	1.3	2.5	1.6	-1.1	-0.4
Miserableness	0.7	1.2	2.3	-0.4	1.5	1.1
Guilty feelings	2.4	3.6	7.0	-0.2	1.9	2.6
Wears glasses or contact lenses	4.7	5.4	8.5	-1.2	2.5	2.9
Ever taken oral contraceptive pill	0.1	0.2	0.2	0.5	0.2	0.5
Hearing aid user	1.4	1.5	4.2	0.0	-2.1	-0.6
Mother’s age at death	1.2	1.5	4.0	0.6	0.1	2.0
Financial situation satisfaction	2.0	2.5	3.9	1.7	-2.0	-0.8
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.1	-0.5	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.1	-0.2	-0.5
Eye problems/disorders: Glaucoma	2.0	2.4	4.2	1.7	-2.0	-0.2
Medication: Blood pressure	0.4	0.8	2.0	-0.4	-1.4	-0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.5	-0.3	1.2	-0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	-0.1	-1.2	-0.1
High cholesterol (Self-reported)	0.7	1.3	3.1	-1.8	-0.1	-0.8
Medication: Bendroflumethiazide	0.4	0.7	1.0	-0.6	-1.0	-0.8
Medication: Paracetamol	0.3	0.4	0.6	-0.8	0.4	0.8
Medication: Lisinopril	0.9	1.2	2.5	0.1	-1.0	-1.6
Medication: Atorvastatin	3.7	4.5	11.9	-1.2	-0.4	-3.5
Illnesses of father: High blood pressure	1.8	2.3	4.3	0.6	-2.1	-1.5
Alcohol drinker status: Never	0.6	0.7	2.0	-0.1	0.3	1.4
Ever smoked	0.3	0.6	1.3	0.7	0.2	1.1
Basal metabolic rate	4.1	22.9	32.9	-3.9	4.5	5.7
Leg fat percentage (left)	1.6	5.8	8.7	-1.9	3.0	2.2
Arm fat-free mass (left)	4.4	22.6	31.9	-3.8	4.6	5.6
Number of operations (self-reported)	0.6	0.9	1.4	-0.0	1.1	1.2
Average weekly beer plus cider intake	0.4	0.5	0.9	-0.2	-0.9	0.9
Irritability	0.2	0.4	1.0	0.1	1.0	-0.4
Risk taking	3.0	4.4	10.9	-3.3	1.5	-0.5
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.5	-1.9	1.2	1.3
Fractured/broken bones in last 5 years	0.4	0.5	1.2	0.3	-1.1	0.2
Age started oral contraceptive pill	0.0	0.0	0.1	-0.3	0.1	-0.2
Diastolic blood pressure, automated reading	0.1	0.3	0.8	0.2	-0.5	0.9
Ever depressed for a whole week	0.2	0.3	0.7	0.2	-0.3	0.8
Unable to work because of sickness or disability	0.2	0.3	0.8	0.1	-0.9	-0.2
Commuting to job workplace: Cycle	0.5	0.7	1.6	-1.3	0.5	0.3
Myopia	2.1	3.0	4.0	2.0	-1.9	-1.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.3	1.0	1.1	0.7
Cholesterol lowering medication	0.9	1.3	3.4	-1.8	0.6	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.8	-0.6	-0.5	-1.4
Pain experienced in last month	0.7	1.2	2.7	-0.6	-0.8	-1.7
Supplements: Calcium	0.3	0.4	1.1	0.1	-0.2	1.0
Basal cell carcinoma (self-reported)	2.7	3.2	8.1	-1.1	0.5	2.8
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	-0.2	0.0	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	-0.2	-0.1	0.1
Heart disease (siblings)	2.1	2.5	5.3	-2.3	1.5	-0.2
Alcohol drinker status: Previous	0.4	0.5	0.8	-0.9	0.8	0.3
Pack years of smoking	3.7	5.5	6.7	-1.9	2.6	2.4
Impedance of whole body	0.5	2.5	6.9	-0.8	0.1	-2.6
Leg fat mass (left)	3.0	11.7	14.4	-2.6	3.7	3.8
Arm predicted mass (left)	4.8	24.3	34.1	-4.0	4.8	5.8