Hub : Genes

STC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.4380 0.1340 6.1e-03 0.027 NA 0.130 NA 0.005 7.0e-02 NA 3.3e-04 NA 2.3e-01
2 TCGA Breast Invasive Carcinoma 0.0365 0.0145 1.0e-09 0.054 0.051 0.057 NA 0.057 3.3e-11 1.0e-10 8.9e-12 NA 1.0e-11
3 TCGA Pancreatic Adenocarcinoma 0.1210 0.0640 2.8e-03 0.036 0.041 0.025 NA 0.026 1.2e-02 7.9e-03 3.0e-02 NA 2.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.0 0.1 0.1 0.0 0.2 0.4
Bipolar Disorder or Schizophrenia 0.2 0.5 1.4 0.0 -0.3 1.2
Depressed Affect (Nagel 2018) 0.4 0.8 2.5 0.0 -0.1 -1.6
Depression (Nagel 2018) 0.2 0.2 0.4 0.0 0.7 -0.5
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.6 0.0 -1.3 0.6
Neuroticism (Nagel 2018) 0.3 0.7 1.7 0.0 -0.7 -1.3
Schizophrenia (2018) 0.3 0.7 1.6 0.0 -0.6 1.3
Schizophrenia vs Biploar Disorder 0.7 0.9 2.4 0.0 0.6 -1.6
Worry (Nagel 2018) 0.2 0.4 0.9 0.0 -0.6 -0.9
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 0.0 0.0 -0.0
Alzheimer’s Disease (in father) 1.1 1.2 3.5 0.0 -1.9 -0.4
Alzheimer’s Disease (including proxy) 0.4 0.7 1.8 0.0 -1.4 0.3
Crohns Disease (2017) 0.2 0.5 1.5 0.0 1.2 -0.2
Irritable Bowel Disease (IBD) 0.1 0.2 0.6 0.0 0.8 -0.3
Ulcerative Colitis (UC) 0.1 0.2 0.5 0.0 0.7 -0.3
Major Depression (MDD) 0.6 0.7 1.5 0.0 0.8 -1.2
Reaction Time 0.4 0.8 1.3 0.0 -1.0 1.1
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.6 0.0 -0.3 0.8
Breast Cancer 3.5 8.5 25.2 0.0 5.0 -0.5
Ovarian Cancer 0.0 0.0 0.1 0.0 0.0 0.4
Prostate Cancer 0.7 0.9 2.1 0.0 1.4 -0.8
Age at First Birth 0.2 0.3 0.6 0.0 0.5 0.8
Bipolar Disorder (2011) 1.0 1.0 2.4 0.0 1.5 -0.8
Body Mass Index (BMI) (2010) 0.2 0.2 0.4 0.0 0.6 -0.6
Coronary Artery Disease (CAD) 0.3 0.3 0.6 0.0 -0.8 -0.6
Crohns Disease (2012) 1.3 2.1 3.2 0.0 1.8 -1.7
Mean Putamen Volume 0.2 0.3 0.5 0.0 -0.7 0.5
Fasting Glucose 0.2 0.3 0.4 0.0 0.6 -0.6
HbA1C 0.7 0.8 1.9 0.0 1.4 0.7
HDL Cholesterol 1.2 1.9 5.2 0.0 -0.8 2.3
LDL Cholesterol 0.6 1.0 1.6 0.0 1.1 -1.3
Lupus 0.7 1.0 2.5 0.0 -0.7 1.6
Neuroticism (2016) 0.3 0.5 1.4 0.0 -1.2 -0.2
Primary Biliary Cirrhosis 0.4 0.5 1.6 0.0 -0.2 1.3
Rheumatoid Arthritis 0.3 0.4 0.9 0.0 -0.6 1.0
Schizophrenia (2014) 0.2 0.4 1.0 0.0 -0.3 1.0
Triglycerides 1.0 1.7 2.9 0.0 1.7 -1.5
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 -0.1 -0.2
Ulcerative Colitis 0.1 0.2 0.5 0.0 -0.7 0.1
Blood Eosinophil Count 0.1 0.6 1.6 0.0 1.3 -0.5
Blood Platelet Count 0.2 2.2 4.5 0.0 1.5 -2.1
Blood Red Count 0.1 1.1 2.1 0.0 -1.5 1.1
Blood White Count 0.3 2.3 5.0 0.0 1.3 -2.2
Heel T-Score 0.1 1.0 2.7 0.0 -1.6 -0.6
BMI 0.7 3.9 8.9 0.0 3.0 -1.6
Height 1.1 21.7 61.6 0.0 7.8 -1.9
Waist Hip Ratio (WHR) 0.8 3.8 5.9 0.0 -2.4 -2.3
Systolic Blood Pressure 0.4 2.2 5.2 0.0 -2.3 1.1
Smoking Status 0.2 0.6 1.0 0.0 1.0 -0.9
Allergy or Eczema 0.6 1.7 4.5 0.0 -0.8 2.1
Cardiovascular Disease 0.2 0.7 1.9 0.0 1.4 -0.3
Hypothyroidism (self reported) 0.5 1.1 2.9 0.0 1.7 -0.7
Respiratory disease 0.3 0.7 1.2 0.0 1.1 -0.9
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.7 0.0 0.6 0.8
Lung FEV1/FVC ratio 0.7 3.4 7.4 0.0 -1.6 2.7
Lung FVC 0.3 1.3 3.2 0.0 -0.8 -1.8
Neuroticism 0.1 0.2 0.7 0.0 -0.1 -0.8
Chronotype (morning person) 0.1 0.2 0.3 0.0 -0.5 0.6
Hair Pigment 0.3 8.6 21.1 0.0 4.6 -2.2
Tanning 0.0 0.2 0.3 0.0 -0.4 -0.6
Hand grip strength (left) 2.2 5.9 17.3 0.0 -0.6 4.2
Number of treatments/medications taken 1.1 2.0 5.0 0.0 2.2 -1.0
Average weekly spirits intake 1.3 1.6 4.7 0.0 -2.2 0.4
Sensitivity / hurt feelings 0.1 0.2 0.7 0.0 -0.0 -0.9
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 0.0 0.4 0.3
Hearing difficulty/problems: Yes 0.8 1.2 3.5 0.0 0.2 -1.9
Relative age of first facial hair 0.3 0.5 0.8 0.0 0.9 -0.9
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 1.8 0.0 1.2 -1.4
Ever used hormone-replacement therapy (HRT) 1.4 1.8 3.1 0.0 1.8 -1.5
Ever had hysterectomy (womb removed) 0.0 0.1 0.1 0.0 -0.2 0.3
Systolic blood pressure, automated reading 0.3 0.8 1.9 0.0 -1.4 -0.7
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.4 0.0 0.9 -1.2
Angina 0.2 0.2 0.7 0.0 0.9 -0.1
Medication for hormone replacement therapy 0.0 0.0 0.1 0.0 -0.0 0.3
Vitamin and mineral supplements 0.3 0.4 1.0 0.0 1.0 0.5
Supplements: Zinc 0.1 0.1 0.3 0.0 -0.3 0.6
Medication: Co-codamol 0.2 0.3 0.8 0.0 0.2 -0.9
Medication: Metformin 0.2 0.3 0.8 0.0 0.1 -0.9
Diabetes (father) 1.0 1.2 3.5 0.0 0.0 1.9
Diabetes (mother) 0.3 0.4 0.8 0.0 0.7 0.9
Severe depression (siblings) 1.1 1.2 2.7 0.0 1.0 -1.6
Pack years adult smoking proportion 0.5 0.8 2.5 0.0 1.6 0.2
Impedance of leg (right) 0.3 1.6 4.8 0.0 0.1 -2.2
Leg fat-free mass (left) 1.0 5.2 15.3 0.0 3.9 0.6
Trunk fat percentage 0.6 2.5 4.6 0.0 2.1 -1.7
Hand grip strength (right) 2.6 7.1 17.5 0.0 -2.0 4.2
Townsend deprivation index at recruitment 1.7 2.4 7.2 0.0 2.7 -0.1
Current tobacco smoking 0.0 0.1 0.2 0.0 0.3 -0.4
Average weekly fortified wine intake 0.2 0.3 0.8 0.0 -0.9 0.3
Maternal smoking around birth 0.7 1.0 2.9 0.0 1.7 0.4
Fed-up feelings 0.3 0.6 0.9 0.0 1.0 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.0 0.0 1.4 -0.9
Relative age voice broke 0.5 0.7 2.1 0.0 0.0 1.4
Taking other prescription medications 0.6 1.0 2.7 0.0 1.6 -0.4
Age when periods started (menarche) 0.2 0.5 0.8 0.0 -0.9 -0.9
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.5 0.0 0.7 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.8 0.0 -0.9 -0.2
Tinnitus: Yes, but not now, but have in the past 2.2 2.4 4.8 0.0 2.2 -1.6
Qualifications: CSEs or equivalent 0.1 0.1 0.2 0.0 -0.4 -0.4
Serious illness, injury or assault to yourself 1.9 2.3 3.9 0.0 1.8 -2.0
High blood pressure 0.0 0.0 0.1 0.0 0.1 -0.2
Hayfever, allergic rhinitis or eczema 0.8 1.6 4.5 0.0 -0.6 2.1
Multivitamins +/- minerals 0.2 0.3 0.8 0.0 -0.3 -0.9
Stomach or abdominal pain in last month 0.0 0.1 0.1 0.0 0.3 -0.2
Supplements: Glucosamine 0.3 0.4 0.7 0.0 0.7 -0.8
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.6 0.0 -0.3 -1.3
Medication: Atenolol 0.4 0.5 1.3 0.0 -0.4 1.1
Medication: Levothyroxine sodium 0.8 1.4 3.7 0.0 1.9 -0.7
Sitting height 3.3 23.1 61.5 0.0 7.8 -2.8
Chronic bronchitis/emphysema (father) 1.0 1.1 3.3 0.0 1.8 0.3
High blood pressure (mother) 0.7 1.0 2.4 0.0 -1.6 0.7
Body mass index (BMI) 0.6 2.8 6.2 0.0 2.5 -1.4
Impedance of leg (left) 0.6 3.0 8.9 0.0 0.1 -3.0
Leg predicted mass (left) 0.9 5.0 14.8 0.0 3.8 0.6
Trunk fat mass 1.2 5.2 12.0 0.0 3.5 -1.9
Waist circumference 1.4 5.1 9.4 0.0 3.1 -2.4
Number of incorrect matches in round 0.2 0.3 0.5 0.0 -0.7 0.6
Past tobacco smoking 0.3 0.6 1.6 0.0 -1.2 0.6
Alcohol usually taken with meals 0.3 0.5 1.2 0.0 -0.6 1.1
Nervous feelings 0.2 0.4 1.2 0.0 -0.1 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.2 0.0 0.3 -0.5
Hearing difficulty/problems with background noise 0.1 0.1 0.3 0.0 -0.0 -0.6
Hair/balding pattern: Pattern 2 0.0 0.0 0.1 0.0 0.3 -0.1
Had menopause 0.8 1.0 2.4 0.0 -1.6 -0.7
Had other major operations 1.1 1.3 3.8 0.0 1.9 -0.3
Forced vital capacity (FVC) 0.1 0.5 0.8 0.0 0.9 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.8 0.0 -0.3 -0.9
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 3.8 0.0 1.9 -0.1
Qualifications: None of the above 0.4 0.9 2.7 0.0 0.0 -1.6
Financial difficulties in last 2 years 0.9 1.2 3.5 0.0 1.9 -0.2
Mouth/teeth dental problems 0.0 0.0 0.1 0.0 -0.0 -0.2
Heart attack 1.1 1.5 4.3 0.0 -0.3 2.1
Allergy 0.3 0.6 1.1 0.0 -1.1 -0.9
Pain all over the body in last month 1.1 1.2 3.4 0.0 -1.9 0.2
Diabetes (self-reported) 0.2 0.3 0.8 0.0 0.9 -0.2
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 2.5 0.0 1.1 -1.6
Medication: Ramipril 0.1 0.1 0.3 0.0 0.5 -0.4
Medication: Simvastatin 0.5 0.7 1.9 0.0 -1.4 0.4
Fluid intelligence score 0.1 0.2 0.6 0.0 -0.2 0.8
Illnesses of siblings 0.2 0.3 0.6 0.0 -0.8 0.4
Neuroticism score 0.6 1.2 2.9 0.0 0.9 -1.7
Weight 1.7 8.4 21.7 0.0 4.7 -1.9
Impedance of arm (right) 0.6 2.9 7.3 0.0 -2.7 1.2
Arm fat percentage (right) 0.4 1.5 3.7 0.0 1.9 -0.9
Trunk fat-free mass 2.3 13.3 38.1 0.0 6.2 -1.4
Hip circumference 2.6 11.3 28.2 0.0 5.3 -2.4
Time employed in main current job 0.8 0.9 2.0 0.0 0.8 -1.4
Alcohol intake versus 10 years previously 0.2 0.2 0.6 0.0 0.8 0.4
Father’s age at death 0.6 0.8 1.5 0.0 -1.0 1.2
Worrier / anxious feelings 0.2 0.3 1.0 0.0 0.2 -1.0
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 3.2 0.0 1.5 -1.8
Falls in the last year 0.9 1.2 2.3 0.0 1.1 1.5
Hair/balding pattern: Pattern 3 0.4 0.6 1.2 0.0 -0.8 1.1
Number of live births 0.3 0.5 1.3 0.0 -0.4 -1.1
Forced expiratory volume in 1-second (FEV1) 0.0 0.0 0.1 0.0 0.1 0.2
Pulse rate 0.1 0.2 0.5 0.0 0.7 0.3
Happiness 0.4 0.5 1.0 0.0 0.7 1.0
Noisy workplace 0.5 0.7 1.7 0.0 -0.6 -1.3
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.7 0.0 0.8 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.4 0.0 -0.7 -0.0
Mouth/teeth dental problems: Dentures 0.0 0.0 0.0 0.0 -0.2 0.1
Asthma 0.1 0.1 0.4 0.0 0.3 -0.6
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.7 4.8 0.0 2.2 -0.6
Medication: Cholesterol lowering 0.3 0.5 1.3 0.0 0.4 -1.1
Depression (self-reported) 0.0 0.0 0.0 0.0 -0.2 -0.2
Medication: Lansoprazole 0.1 0.1 0.2 0.0 -0.4 0.2
Prospective memory result 0.0 0.0 0.0 0.0 0.0 -0.0
Lung cancer (father) 0.2 0.2 0.6 0.0 0.8 -0.2
Illnesses of mother 0.4 0.5 0.9 0.0 0.9 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.9 0.0 1.4 -0.1
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 0.0 -0.5 0.6
Impedance of arm (left) 1.1 5.1 12.5 0.0 -3.5 1.7
Arm fat mass (right) 1.0 4.1 10.7 0.0 3.3 -1.3
Trunk predicted mass 2.3 12.9 36.8 0.0 6.1 -1.4
Standing height 1.1 11.0 31.4 0.0 5.6 -1.2
Length of working week for main job 0.2 0.2 0.4 0.0 0.6 0.4
Exposure to tobacco smoke at home 1.7 1.9 4.8 0.0 -0.9 2.2
Breastfed as a baby 0.3 0.4 1.0 0.0 0.5 -1.0
Tense / ‘highly strung’ 1.1 1.8 4.8 0.0 0.7 -2.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.5 6.7 0.0 2.6 -0.9
Hair/balding pattern: Pattern 4 0.1 0.4 0.9 0.0 -1.0 -0.4
Birth weight of first child 0.6 1.0 2.4 0.0 -0.8 1.5
Peak expiratory flow (PEF) 1.9 4.4 9.2 0.0 -2.0 3.0
Pulse wave reflection index 0.4 0.5 1.3 0.0 -1.1 0.4
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.6 0.0 1.3 -0.7
Loud music exposure frequency 0.2 0.2 0.5 0.0 0.2 -0.7
Qualifications: O levels/GCSEs or equivalent 1.4 2.3 6.8 0.0 0.3 2.6
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.3 0.0 -0.2 1.1
Blood clot in the leg (DVT) 0.4 0.5 1.5 0.0 1.2 -0.3
Medication: Paracetamol 0.2 0.4 1.0 0.0 1.0 0.4
Headache pain in last month 0.2 0.3 0.9 0.0 1.0 -0.1
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.2 0.0 -0.6 1.1
Glaucoma (self-reported) 0.2 0.2 0.7 0.0 -0.1 0.8
Gout (self-reported) 0.5 0.7 1.8 0.0 0.4 -1.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.1 0.0 1.0 -0.7
Medication: Amlodipine 0.7 1.0 2.7 0.0 0.6 -1.6
Medication: Ventolin 100micrograms inhaler 0.0 0.0 0.1 0.0 0.3 0.1
Birth weight 0.1 0.3 0.5 0.0 0.7 -0.6
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.8 0.0 -0.7 1.3
High blood pressure (siblings) 0.3 0.5 0.7 0.0 0.8 -0.8
Forced vital capacity (FVC), Best measure 0.4 1.5 3.8 0.0 1.9 -0.8
Body fat percentage 0.9 3.4 5.5 0.0 2.4 -2.2
Leg fat percentage (right) 1.6 5.6 10.0 0.0 2.6 -3.2
Arm fat-free mass (right) 2.5 12.6 35.0 0.0 5.9 -1.7
Exposure to tobacco smoke outside home 0.6 0.7 2.1 0.0 -0.3 1.5
Comparative body size at age 10 0.0 0.0 0.0 0.0 0.2 -0.0
Number of full brothers 1.3 1.7 4.1 0.0 -0.9 2.0
Worry too long after embarrassment 0.4 0.7 1.9 0.0 -0.3 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.7 0.0 1.3 -0.5
Wheeze or whistling in the chest in last year 0.7 1.3 2.4 0.0 1.5 -1.2
Number of children fathered 0.8 0.9 2.5 0.0 -1.6 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.2 0.0 -0.4 0.2
Age at first live birth 0.0 0.0 0.0 0.0 -0.1 0.2
Pulse wave peak to peak time 0.5 0.6 1.1 0.0 1.0 -0.9
Health satisfaction 0.8 1.0 2.8 0.0 1.7 0.5
Shortness of breath walking on level ground 0.8 0.9 1.7 0.0 1.3 -1.1
Qualifications: College or University degree 0.3 0.9 2.4 0.0 0.5 1.6
Eye problems/disorders: None of the above 0.5 0.6 1.7 0.0 0.1 1.3
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.3 0.0 0.4 -0.6
Emphysema/chronic bronchitis 0.8 0.9 2.5 0.0 1.6 -0.2
Medication for pain relief, constipation, heartburn 1.1 1.8 5.2 0.0 -2.3 0.5
Neck or shoulder pain in last month 0.9 1.3 2.8 0.0 1.7 -1.1
Medication: Blood pressure 0.2 0.3 0.8 0.0 0.9 -0.4
Angina (self-reported) 0.1 0.2 0.4 0.0 0.7 -0.3
Migraine (self-reported) 0.0 0.0 0.1 0.0 -0.0 -0.2
Medication: Ibuprofen 2.6 3.1 7.4 0.0 2.7 -1.4
Medication: Allopurinol 0.1 0.1 0.3 0.0 0.5 -0.3
Medication: Omeprazole 0.3 0.4 1.0 0.0 0.3 -1.0
Medication: Seretide 50 evohaler 1.1 1.3 2.6 0.0 1.6 -1.1
Mean time to correctly identify matches 0.8 1.5 4.2 0.0 -2.1 0.6
Heart disease (mother) 0.3 0.3 0.7 0.0 0.5 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.4 0.0 -1.2 0.3
Whole body fat mass 1.4 6.0 12.9 0.0 3.6 -2.2
Leg fat mass (right) 1.8 7.0 15.4 0.0 3.9 -2.4
Arm predicted mass (right) 2.4 12.1 33.2 0.0 5.8 -1.7
Pulse rate, automated reading 0.1 0.3 0.5 0.0 0.7 -0.6
Alcohol intake frequency. 0.8 1.8 3.7 0.0 1.3 -1.9
Comparative height size at age 10 0.6 3.4 5.7 0.0 2.1 2.4
Number of full sisters 0.5 0.6 1.0 0.0 0.8 -1.0
Suffer from ‘nerves’ 0.2 0.4 0.9 0.0 -0.5 0.9
Overall health rating 0.0 0.0 0.1 0.0 0.3 -0.1
Chest pain or discomfort 0.5 0.7 2.1 0.0 1.5 0.3
Had major operations 0.2 0.2 0.5 0.0 0.7 0.2
Age at last live birth 0.2 0.3 0.8 0.0 -0.9 -0.3
Family relationship satisfaction 2.4 3.0 7.0 0.0 2.6 -1.4
Leg pain on walking 0.2 0.2 0.7 0.0 0.8 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.6 0.0 0.3 1.6
Commuting to job workplace: Car/motor vehicle 1.0 1.1 3.1 0.0 -1.8 0.6
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.0 0.0 -0.1 0.2
Medication: Aspirin 0.1 0.1 0.2 0.0 0.5 0.4
Supplements: Vitamin C 0.3 0.3 0.9 0.0 -1.0 0.3
Knee pain experienced in last month 3.9 6.0 13.5 0.0 3.7 -2.1
Hypertension (Self-reported) 0.1 0.1 0.3 0.0 0.3 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.9 0.0 -1.4 0.7
Illnesses of father: Heart disease 0.1 0.1 0.2 0.0 -0.1 0.5
Illnesses of siblings: Diabetes 0.2 0.3 0.5 0.0 0.7 -0.5
Smoking status: Previous 0.2 0.3 0.8 0.0 0.9 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.9 8.1 0.0 2.8 -0.8
Whole body fat-free mass 1.7 10.0 29.3 0.0 5.4 -0.8
Leg fat-free mass (right) 0.8 4.5 13.3 0.0 3.6 0.5
Arm fat percentage (left) 0.2 0.8 2.1 0.0 1.4 -0.7
Average weekly red wine intake 0.3 0.4 1.1 0.0 1.1 0.2
Handedness (chirality/laterality): Left-handed 0.6 0.8 2.2 0.0 0.4 -1.5
Mood swings 2.6 4.6 11.4 0.0 1.6 -3.4
Loneliness, isolation 0.2 0.3 0.9 0.0 0.9 -0.0
Long-standing illness, disability or infirmity 0.4 0.6 1.7 0.0 1.3 -0.2
Ever had bowel cancer screening 0.4 0.5 0.8 0.0 0.8 -0.9
Diabetes diagnosed by doctor 0.2 0.4 1.0 0.0 1.0 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.0 0.3 -0.4
Friendships satisfaction 0.0 0.0 0.0 0.0 0.1 -0.2
Qualifications: nursing, teaching 0.4 0.7 1.7 0.0 1.3 0.6
Commuting to job workplace: Walk 0.4 0.4 0.7 0.0 -0.8 0.8
Eye problems/disorders: Cataract 0.4 0.5 1.1 0.0 0.6 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.0 0.0 1.0 1.0
Medication for cholesterol 1.0 1.4 2.6 0.0 1.3 -1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.8 4.4 0.0 1.1 -2.1
Back pain experienced in last month 0.3 0.4 1.3 0.0 1.1 -0.0
Mineral and other dietary supplements 0.6 0.8 1.3 0.0 -1.0 1.2
Breast cancer (self-reported) 2.3 2.7 5.8 0.0 -1.6 2.4
Asthma (self-reported) 0.2 0.3 0.7 0.0 0.6 -0.9
Osteoporosis (self-reported) 2.9 3.6 5.9 0.0 -2.4 2.2
Osteoarthritis (self-reported) 0.1 0.2 0.5 0.0 -0.7 -0.2
Medication: Aspirin 0.1 0.1 0.1 0.0 0.3 0.3
Medication: Gliclazide 1.0 1.1 3.1 0.0 0.4 1.8
Illnesses of father: None of the above (group 1) 0.0 0.0 0.0 0.0 -0.0 -0.2
Smoking status: Current 0.0 0.1 0.2 0.0 0.1 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.4 0.0 -0.3 -0.6
Whole body water mass 1.8 10.3 30.2 0.0 5.5 -0.8
Leg predicted mass (right) 0.9 4.6 13.5 0.0 3.7 0.4
Arm fat mass (left) 1.0 4.1 10.7 0.0 3.3 -1.3
Number of self-reported non-cancer illnesses 0.5 0.8 1.2 0.0 1.1 -1.1
Average weekly champagne plus white wine intake 0.7 1.0 2.3 0.0 -0.8 1.5
Miserableness 0.3 0.5 1.4 0.0 0.2 -1.2
Guilty feelings 0.3 0.4 1.1 0.0 0.4 -1.1
Wears glasses or contact lenses 0.1 0.1 0.3 0.0 -0.5 0.2
Ever taken oral contraceptive pill 0.6 0.7 1.7 0.0 1.3 -0.6
Hearing aid user 0.2 0.3 0.6 0.0 -0.4 0.8
Mother’s age at death 3.9 4.9 13.0 0.0 -3.6 1.3
Financial situation satisfaction 0.7 0.9 1.7 0.0 1.3 1.0
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.0 0.0 -0.1 1.0
Commuting to job workplace: Public transport 0.9 1.0 3.1 0.0 1.8 -0.0
Eye problems/disorders: Glaucoma 0.0 0.0 0.0 0.0 -0.0 -0.0
Medication: Blood pressure 0.3 0.5 0.8 0.0 -0.9 0.8
Pain type(s) experienced in last month: Hip pain 1.7 2.1 3.9 0.0 1.6 -2.0
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.0 0.0 1.0 -0.5
High cholesterol (Self-reported) 0.1 0.2 0.5 0.0 -0.7 0.4
Medication: Bendroflumethiazide 0.0 0.1 0.1 0.0 -0.3 -0.3
Medication: Paracetamol 0.4 0.7 1.4 0.0 1.2 -0.8
Medication: Lisinopril 0.0 0.1 0.1 0.0 -0.1 0.4
Medication: Atorvastatin 0.3 0.4 1.1 0.0 0.1 -1.0
Illnesses of father: High blood pressure 0.0 0.0 0.1 0.0 -0.2 -0.3
Alcohol drinker status: Never 1.0 1.2 3.5 0.0 0.3 -1.9
Ever smoked 0.7 1.3 2.5 0.0 1.6 -1.2
Basal metabolic rate 1.9 10.3 29.7 0.0 5.5 -1.1
Leg fat percentage (left) 1.8 6.4 12.3 0.0 2.6 -3.5
Arm fat-free mass (left) 2.7 13.6 36.4 0.0 6.0 -2.1
Number of operations (self-reported) 2.2 3.2 7.4 0.0 2.7 -1.5
Average weekly beer plus cider intake 1.8 2.6 4.0 0.0 2.0 -1.9
Irritability 3.5 5.9 16.1 0.0 1.3 -4.0
Risk taking 1.1 1.7 2.7 0.0 1.7 -1.5
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.0 0.0 0.2 0.2
Fractured/broken bones in last 5 years 0.4 0.6 1.3 0.0 -1.1 -0.6
Age started oral contraceptive pill 0.1 0.1 0.3 0.0 -0.6 0.1
Diastolic blood pressure, automated reading 1.0 2.9 7.3 0.0 1.2 -2.7
Ever depressed for a whole week 1.0 1.2 2.9 0.0 1.7 -0.8
Unable to work because of sickness or disability 0.2 0.2 0.6 0.0 0.8 0.1
Commuting to job workplace: Cycle 0.1 0.2 0.4 0.0 0.2 -0.7
Myopia 0.3 0.4 1.1 0.0 0.1 1.1
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.4 0.0 -0.0 -0.6
Cholesterol lowering medication 1.2 1.7 3.4 0.0 -1.8 1.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.6 0.0 -0.0 -0.8
Pain experienced in last month 1.9 3.2 5.2 0.0 -2.1 2.3
Supplements: Calcium 0.7 0.8 1.6 0.0 -0.9 1.3
Basal cell carcinoma (self-reported) 0.0 0.0 0.0 0.0 0.1 0.0
Heart attack/myocardial infarction (self-reported) 1.2 1.5 4.5 0.0 -0.2 2.1
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.9 0.0 1.0 -0.4
Heart disease (siblings) 0.2 0.3 0.9 0.0 -0.9 -0.1
Alcohol drinker status: Previous 0.3 0.3 1.0 0.0 1.0 0.2
Pack years of smoking 0.4 0.6 1.8 0.0 1.3 0.0
Impedance of whole body 0.3 1.7 4.9 0.0 -2.2 -0.2
Leg fat mass (left) 1.8 6.9 14.4 0.0 3.8 -2.5
Arm predicted mass (left) 2.7 13.9 37.3 0.0 6.1 -2.1