TWAS hub - STC1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.4380	0.1340	6.1e-03	0.027	NA	0.130	NA	0.005	7.0e-02	NA	3.3e-04	NA	2.3e-01
2	TCGA	Breast Invasive Carcinoma	0.0365	0.0145	1.0e-09	0.054	0.051	0.057	NA	0.057	3.3e-11	1.0e-10	8.9e-12	NA	1.0e-11
3	TCGA	Pancreatic Adenocarcinoma	0.1210	0.0640	2.8e-03	0.036	0.041	0.025	NA	0.026	1.2e-02	7.9e-03	3.0e-02	NA	2.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3
Knee pain experienced in last month	3.9	6.0	13.5	3.7	-2.1
Mother’s age at death	3.9	4.9	13.0	-3.6	1.3
Breast Cancer	3.5	8.5	25.2	5.0	-0.5
Irritability	3.5	5.9	16.1	1.3	-4.0
Sitting height	3.3	23.1	61.5	7.8	-2.8
Osteoporosis (self-reported)	2.9	3.6	5.9	-2.4	2.2
Arm fat-free mass (left)	2.7	13.6	36.4	6.0	-2.1
Arm predicted mass (left)	2.7	13.9	37.3	6.1	-2.1
Hand grip strength (right)	2.6	7.1	17.5	-2.0	4.2
Hip circumference	2.6	11.3	28.2	5.3	-2.4
Medication: Ibuprofen	2.6	3.1	7.4	2.7	-1.4
Mood swings	2.6	4.6	11.4	1.6	-3.4
Arm fat-free mass (right)	2.5	12.6	35.0	5.9	-1.7
Arm predicted mass (right)	2.4	12.1	33.2	5.8	-1.7
Family relationship satisfaction	2.4	3.0	7.0	2.6	-1.4
Trunk fat-free mass	2.3	13.3	38.1	6.2	-1.4
Trunk predicted mass	2.3	12.9	36.8	6.1	-1.4
Breast cancer (self-reported)	2.3	2.7	5.8	-1.6	2.4
Hand grip strength (left)	2.2	5.9	17.3	-0.6	4.2
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	4.8	2.2	-1.6
Number of operations (self-reported)	2.2	3.2	7.4	2.7	-1.5
Serious illness, injury or assault to yourself	1.9	2.3	3.9	1.8	-2.0
Peak expiratory flow (PEF)	1.9	4.4	9.2	-2.0	3.0
Basal metabolic rate	1.9	10.3	29.7	5.5	-1.1
Pain experienced in last month	1.9	3.2	5.2	-2.1	2.3
Leg fat mass (right)	1.8	7.0	15.4	3.9	-2.4
Whole body water mass	1.8	10.3	30.2	5.5	-0.8
Leg fat percentage (left)	1.8	6.4	12.3	2.6	-3.5
Average weekly beer plus cider intake	1.8	2.6	4.0	2.0	-1.9
Leg fat mass (left)	1.8	6.9	14.4	3.8	-2.5
Townsend deprivation index at recruitment	1.7	2.4	7.2	2.7	-0.1
Weight	1.7	8.4	21.7	4.7	-1.9
Exposure to tobacco smoke at home	1.7	1.9	4.8	-0.9	2.2
Whole body fat-free mass	1.7	10.0	29.3	5.4	-0.8
Pain type(s) experienced in last month: Hip pain	1.7	2.1	3.9	1.6	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	6.7	2.6	-0.9
Leg fat percentage (right)	1.6	5.6	10.0	2.6	-3.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.8	4.4	1.1	-2.1
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.1	1.8	-1.5
Waist circumference	1.4	5.1	9.4	3.1	-2.4
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	4.8	2.2	-0.6
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	6.8	0.3	2.6
Whole body fat mass	1.4	6.0	12.9	3.6	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	8.1	2.8	-0.8
Crohns Disease (2012)	1.3	2.1	3.2	1.8	-1.7
Average weekly spirits intake	1.3	1.6	4.7	-2.2	0.4
Number of full brothers	1.3	1.7	4.1	-0.9	2.0
HDL Cholesterol	1.2	1.9	5.2	-0.8	2.3
Trunk fat mass	1.2	5.2	12.0	3.5	-1.9
Cholesterol lowering medication	1.2	1.7	3.4	-1.8	1.4
Heart attack/myocardial infarction (self-reported)	1.2	1.5	4.5	-0.2	2.1
Alzheimer’s Disease (in father)	1.1	1.2	3.5	-1.9	-0.4
Height	1.1	21.7	61.6	7.8	-1.9
Number of treatments/medications taken	1.1	2.0	5.0	2.2	-1.0
Severe depression (siblings)	1.1	1.2	2.7	1.0	-1.6
Had other major operations	1.1	1.3	3.8	1.9	-0.3
Heart attack	1.1	1.5	4.3	-0.3	2.1
Pain all over the body in last month	1.1	1.2	3.4	-1.9	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	3.2	1.5	-1.8
Impedance of arm (left)	1.1	5.1	12.5	-3.5	1.7
Standing height	1.1	11.0	31.4	5.6	-1.2
Tense / ‘highly strung’	1.1	1.8	4.8	0.7	-2.2
Medication for pain relief, constipation, heartburn	1.1	1.8	5.2	-2.3	0.5
Medication: Seretide 50 evohaler	1.1	1.3	2.6	1.6	-1.1
Risk taking	1.1	1.7	2.7	1.7	-1.5
Bipolar Disorder (2011)	1.0	1.0	2.4	1.5	-0.8
Triglycerides	1.0	1.7	2.9	1.7	-1.5
Diabetes (father)	1.0	1.2	3.5	0.0	1.9
Leg fat-free mass (left)	1.0	5.2	15.3	3.9	0.6
Chronic bronchitis/emphysema (father)	1.0	1.1	3.3	1.8	0.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.8	1.9	-0.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.5	1.1	-1.6
Arm fat mass (right)	1.0	4.1	10.7	3.3	-1.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.1	-1.8	0.6
Medication for cholesterol	1.0	1.4	2.6	1.3	-1.6
Medication: Gliclazide	1.0	1.1	3.1	0.4	1.8
Arm fat mass (left)	1.0	4.1	10.7	3.3	-1.3
Alcohol drinker status: Never	1.0	1.2	3.5	0.3	-1.9
Diastolic blood pressure, automated reading	1.0	2.9	7.3	1.2	-2.7
Ever depressed for a whole week	1.0	1.2	2.9	1.7	-0.8
Leg predicted mass (left)	0.9	5.0	14.8	3.8	0.6
Financial difficulties in last 2 years	0.9	1.2	3.5	1.9	-0.2
Falls in the last year	0.9	1.2	2.3	1.1	1.5
Body fat percentage	0.9	3.4	5.5	2.4	-2.2
Neck or shoulder pain in last month	0.9	1.3	2.8	1.7	-1.1
Leg predicted mass (right)	0.9	4.6	13.5	3.7	0.4
Commuting to job workplace: Public transport	0.9	1.0	3.1	1.8	-0.0
Waist Hip Ratio (WHR)	0.8	3.8	5.9	-2.4	-2.3
Hearing difficulty/problems: Yes	0.8	1.2	3.5	0.2	-1.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	1.8	1.2	-1.4
Hayfever, allergic rhinitis or eczema	0.8	1.6	4.5	-0.6	2.1
Medication: Levothyroxine sodium	0.8	1.4	3.7	1.9	-0.7
Had menopause	0.8	1.0	2.4	-1.6	-0.7
Time employed in main current job	0.8	0.9	2.0	0.8	-1.4
Number of children fathered	0.8	0.9	2.5	-1.6	-0.4
Health satisfaction	0.8	1.0	2.8	1.7	0.5
Shortness of breath walking on level ground	0.8	0.9	1.7	1.3	-1.1
Emphysema/chronic bronchitis	0.8	0.9	2.5	1.6	-0.2
Mean time to correctly identify matches	0.8	1.5	4.2	-2.1	0.6
Alcohol intake frequency.	0.8	1.8	3.7	1.3	-1.9
Leg fat-free mass (right)	0.8	4.5	13.3	3.6	0.5
Schizophrenia vs Biploar Disorder	0.7	0.9	2.4	0.6	-1.6
Prostate Cancer	0.7	0.9	2.1	1.4	-0.8
HbA1C	0.7	0.8	1.9	1.4	0.7
Lupus	0.7	1.0	2.5	-0.7	1.6
BMI	0.7	3.9	8.9	3.0	-1.6
Lung FEV1/FVC ratio	0.7	3.4	7.4	-1.6	2.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.4	0.9	-1.2
Maternal smoking around birth	0.7	1.0	2.9	1.7	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.0	1.4	-0.9
High blood pressure (mother)	0.7	1.0	2.4	-1.6	0.7
Medication: Amlodipine	0.7	1.0	2.7	0.6	-1.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.8	-0.7	1.3
Wheeze or whistling in the chest in last year	0.7	1.3	2.4	1.5	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.6	0.3	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.9	-1.4	0.7
Average weekly champagne plus white wine intake	0.7	1.0	2.3	-0.8	1.5
Financial situation satisfaction	0.7	0.9	1.7	1.3	1.0
Ever smoked	0.7	1.3	2.5	1.6	-1.2
Supplements: Calcium	0.7	0.8	1.6	-0.9	1.3
Major Depression (MDD)	0.6	0.7	1.5	0.8	-1.2
LDL Cholesterol	0.6	1.0	1.6	1.1	-1.3
Allergy or Eczema	0.6	1.7	4.5	-0.8	2.1
Trunk fat percentage	0.6	2.5	4.6	2.1	-1.7
Taking other prescription medications	0.6	1.0	2.7	1.6	-0.4
Body mass index (BMI)	0.6	2.8	6.2	2.5	-1.4
Impedance of leg (left)	0.6	3.0	8.9	0.1	-3.0
Neuroticism score	0.6	1.2	2.9	0.9	-1.7
Impedance of arm (right)	0.6	2.9	7.3	-2.7	1.2
Father’s age at death	0.6	0.8	1.5	-1.0	1.2
Birth weight of first child	0.6	1.0	2.4	-0.8	1.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.6	1.3	-0.7
Exposure to tobacco smoke outside home	0.6	0.7	2.1	-0.3	1.5
Comparative height size at age 10	0.6	3.4	5.7	2.1	2.4
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.2	0.4	-1.5
Mineral and other dietary supplements	0.6	0.8	1.3	-1.0	1.2
Ever taken oral contraceptive pill	0.6	0.7	1.7	1.3	-0.6
Hypothyroidism (self reported)	0.5	1.1	2.9	1.7	-0.7
Pack years adult smoking proportion	0.5	0.8	2.5	1.6	0.2
Relative age voice broke	0.5	0.7	2.1	0.0	1.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	-0.3	-1.3
Medication: Simvastatin	0.5	0.7	1.9	-1.4	0.4
Noisy workplace	0.5	0.7	1.7	-0.6	-1.3
Gout (self-reported)	0.5	0.7	1.8	0.4	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.7	1.3	-0.5
Pulse wave peak to peak time	0.5	0.6	1.1	1.0	-0.9
Eye problems/disorders: None of the above	0.5	0.6	1.7	0.1	1.3
Number of full sisters	0.5	0.6	1.0	0.8	-1.0
Chest pain or discomfort	0.5	0.7	2.1	1.5	0.3
Number of self-reported non-cancer illnesses	0.5	0.8	1.2	1.1	-1.1
Depressed Affect (Nagel 2018)	0.4	0.8	2.5	-0.1	-1.6
Alzheimer’s Disease (including proxy)	0.4	0.7	1.8	-1.4	0.3
Reaction Time	0.4	0.8	1.3	-1.0	1.1
Primary Biliary Cirrhosis	0.4	0.5	1.6	-0.2	1.3
Systolic Blood Pressure	0.4	2.2	5.2	-2.3	1.1
Medication: Atenolol	0.4	0.5	1.3	-0.4	1.1
Qualifications: None of the above	0.4	0.9	2.7	0.0	-1.6
Arm fat percentage (right)	0.4	1.5	3.7	1.9	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	1.2	-0.8	1.1
Happiness	0.4	0.5	1.0	0.7	1.0
Illnesses of mother	0.4	0.5	0.9	0.9	-0.8
Pulse wave reflection index	0.4	0.5	1.3	-1.1	0.4
Blood clot in the leg (DVT)	0.4	0.5	1.5	1.2	-0.3
Forced vital capacity (FVC), Best measure	0.4	1.5	3.8	1.9	-0.8
Worry too long after embarrassment	0.4	0.7	1.9	-0.3	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	-1.2	0.3
Long-standing illness, disability or infirmity	0.4	0.6	1.7	1.3	-0.2
Ever had bowel cancer screening	0.4	0.5	0.8	0.8	-0.9
Qualifications: nursing, teaching	0.4	0.7	1.7	1.3	0.6
Commuting to job workplace: Walk	0.4	0.4	0.7	-0.8	0.8
Eye problems/disorders: Cataract	0.4	0.5	1.1	0.6	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.0	1.0	1.0
Medication: Paracetamol	0.4	0.7	1.4	1.2	-0.8
Fractured/broken bones in last 5 years	0.4	0.6	1.3	-1.1	-0.6
Pack years of smoking	0.4	0.6	1.8	1.3	0.0
Neuroticism (Nagel 2018)	0.3	0.7	1.7	-0.7	-1.3
Schizophrenia (2018)	0.3	0.7	1.6	-0.6	1.3
Coronary Artery Disease (CAD)	0.3	0.3	0.6	-0.8	-0.6
Neuroticism (2016)	0.3	0.5	1.4	-1.2	-0.2
Rheumatoid Arthritis	0.3	0.4	0.9	-0.6	1.0
Blood White Count	0.3	2.3	5.0	1.3	-2.2
Respiratory disease	0.3	0.7	1.2	1.1	-0.9
Lung FVC	0.3	1.3	3.2	-0.8	-1.8
Hair Pigment	0.3	8.6	21.1	4.6	-2.2
Relative age of first facial hair	0.3	0.5	0.8	0.9	-0.9
Systolic blood pressure, automated reading	0.3	0.8	1.9	-1.4	-0.7
Vitamin and mineral supplements	0.3	0.4	1.0	1.0	0.5
Diabetes (mother)	0.3	0.4	0.8	0.7	0.9
Impedance of leg (right)	0.3	1.6	4.8	0.1	-2.2
Fed-up feelings	0.3	0.6	0.9	1.0	-0.8
Supplements: Glucosamine	0.3	0.4	0.7	0.7	-0.8
Past tobacco smoking	0.3	0.6	1.6	-1.2	0.6
Alcohol usually taken with meals	0.3	0.5	1.2	-0.6	1.1
Allergy	0.3	0.6	1.1	-1.1	-0.9
Number of live births	0.3	0.5	1.3	-0.4	-1.1
Medication: Cholesterol lowering	0.3	0.5	1.3	0.4	-1.1
Breastfed as a baby	0.3	0.4	1.0	0.5	-1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.3	-0.2	1.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.2	-0.6	1.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.1	1.0	-0.7
High blood pressure (siblings)	0.3	0.5	0.7	0.8	-0.8
Qualifications: College or University degree	0.3	0.9	2.4	0.5	1.6
Medication: Omeprazole	0.3	0.4	1.0	0.3	-1.0
Heart disease (mother)	0.3	0.3	0.7	0.5	0.8
Supplements: Vitamin C	0.3	0.3	0.9	-1.0	0.3
Average weekly red wine intake	0.3	0.4	1.1	1.1	0.2
Back pain experienced in last month	0.3	0.4	1.3	1.1	-0.0
Miserableness	0.3	0.5	1.4	0.2	-1.2
Guilty feelings	0.3	0.4	1.1	0.4	-1.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.0	-0.1	1.0
Medication: Blood pressure	0.3	0.5	0.8	-0.9	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	1.0	-0.5
Medication: Atorvastatin	0.3	0.4	1.1	0.1	-1.0
Myopia	0.3	0.4	1.1	0.1	1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	1.0	-0.4
Alcohol drinker status: Previous	0.3	0.3	1.0	1.0	0.2
Impedance of whole body	0.3	1.7	4.9	-2.2	-0.2
Bipolar Disorder or Schizophrenia	0.2	0.5	1.4	-0.3	1.2
Depression (Nagel 2018)	0.2	0.2	0.4	0.7	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.6	-1.3	0.6
Worry (Nagel 2018)	0.2	0.4	0.9	-0.6	-0.9
Crohns Disease (2017)	0.2	0.5	1.5	1.2	-0.2
Age at First Birth	0.2	0.3	0.6	0.5	0.8
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	0.6	-0.6
Mean Putamen Volume	0.2	0.3	0.5	-0.7	0.5
Fasting Glucose	0.2	0.3	0.4	0.6	-0.6
Schizophrenia (2014)	0.2	0.4	1.0	-0.3	1.0
Blood Platelet Count	0.2	2.2	4.5	1.5	-2.1
Smoking Status	0.2	0.6	1.0	1.0	-0.9
Cardiovascular Disease	0.2	0.7	1.9	1.4	-0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	0.6	0.8
Angina	0.2	0.2	0.7	0.9	-0.1
Medication: Co-codamol	0.2	0.3	0.8	0.2	-0.9
Medication: Metformin	0.2	0.3	0.8	0.1	-0.9
Average weekly fortified wine intake	0.2	0.3	0.8	-0.9	0.3
Age when periods started (menarche)	0.2	0.5	0.8	-0.9	-0.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.5	0.7	-0.6
Multivitamins +/- minerals	0.2	0.3	0.8	-0.3	-0.9
Number of incorrect matches in round	0.2	0.3	0.5	-0.7	0.6
Nervous feelings	0.2	0.4	1.2	-0.1	-1.1
Diabetes (self-reported)	0.2	0.3	0.8	0.9	-0.2
Illnesses of siblings	0.2	0.3	0.6	-0.8	0.4
Alcohol intake versus 10 years previously	0.2	0.2	0.6	0.8	0.4
Worrier / anxious feelings	0.2	0.3	1.0	0.2	-1.0
Lung cancer (father)	0.2	0.2	0.6	0.8	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.9	1.4	-0.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.5	0.6
Length of working week for main job	0.2	0.2	0.4	0.6	0.4
Loud music exposure frequency	0.2	0.2	0.5	0.2	-0.7
Medication: Paracetamol	0.2	0.4	1.0	1.0	0.4
Headache pain in last month	0.2	0.3	0.9	1.0	-0.1
Glaucoma (self-reported)	0.2	0.2	0.7	-0.1	0.8
Medication: Blood pressure	0.2	0.3	0.8	0.9	-0.4
Suffer from ‘nerves’	0.2	0.4	0.9	-0.5	0.9
Had major operations	0.2	0.2	0.5	0.7	0.2
Age at last live birth	0.2	0.3	0.8	-0.9	-0.3
Leg pain on walking	0.2	0.2	0.7	0.8	0.2
Illnesses of siblings: Diabetes	0.2	0.3	0.5	0.7	-0.5
Smoking status: Previous	0.2	0.3	0.8	0.9	-0.1
Arm fat percentage (left)	0.2	0.8	2.1	1.4	-0.7
Loneliness, isolation	0.2	0.3	0.9	0.9	-0.0
Diabetes diagnosed by doctor	0.2	0.4	1.0	1.0	-0.4
Asthma (self-reported)	0.2	0.3	0.7	0.6	-0.9
Hearing aid user	0.2	0.3	0.6	-0.4	0.8
Unable to work because of sickness or disability	0.2	0.2	0.6	0.8	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.0	-0.8
Heart disease (siblings)	0.2	0.3	0.9	-0.9	-0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	0.8	-0.3
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.7	-0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.6	-0.3	0.8
Ulcerative Colitis	0.1	0.2	0.5	-0.7	0.1
Blood Eosinophil Count	0.1	0.6	1.6	1.3	-0.5
Blood Red Count	0.1	1.1	2.1	-1.5	1.1
Heel T-Score	0.1	1.0	2.7	-1.6	-0.6
Neuroticism	0.1	0.2	0.7	-0.1	-0.8
Chronotype (morning person)	0.1	0.2	0.3	-0.5	0.6
Sensitivity / hurt feelings	0.1	0.2	0.7	-0.0	-0.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.4	0.3
Supplements: Zinc	0.1	0.1	0.3	-0.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.8	-0.9	-0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.4	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.3	-0.5
Hearing difficulty/problems with background noise	0.1	0.1	0.3	-0.0	-0.6
Forced vital capacity (FVC)	0.1	0.5	0.8	0.9	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	-0.3	-0.9
Medication: Ramipril	0.1	0.1	0.3	0.5	-0.4
Fluid intelligence score	0.1	0.2	0.6	-0.2	0.8
Pulse rate	0.1	0.2	0.5	0.7	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	0.8	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.7	-0.0
Asthma	0.1	0.1	0.4	0.3	-0.6
Medication: Lansoprazole	0.1	0.1	0.2	-0.4	0.2
Hair/balding pattern: Pattern 4	0.1	0.4	0.9	-1.0	-0.4
Birth weight	0.1	0.3	0.5	0.7	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.4	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	0.4	-0.6
Angina (self-reported)	0.1	0.2	0.4	0.7	-0.3
Medication: Allopurinol	0.1	0.1	0.3	0.5	-0.3
Pulse rate, automated reading	0.1	0.3	0.5	0.7	-0.6
Medication: Aspirin	0.1	0.1	0.2	0.5	0.4
Hypertension (Self-reported)	0.1	0.1	0.3	0.3	-0.6
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.3	-0.4
Osteoarthritis (self-reported)	0.1	0.2	0.5	-0.7	-0.2
Medication: Aspirin	0.1	0.1	0.1	0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.3	-0.6
Wears glasses or contact lenses	0.1	0.1	0.3	-0.5	0.2
High cholesterol (Self-reported)	0.1	0.2	0.5	-0.7	0.4
Age started oral contraceptive pill	0.1	0.1	0.3	-0.6	0.1
Commuting to job workplace: Cycle	0.1	0.2	0.4	0.2	-0.7
Bipolar Disorder (2018)	0.0	0.1	0.1	0.2	0.4
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.0	-0.0
Ovarian Cancer	0.0	0.0	0.1	0.0	0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	-0.1	-0.2
Tanning	0.0	0.2	0.3	-0.4	-0.6
Ever had hysterectomy (womb removed)	0.0	0.1	0.1	-0.2	0.3
Medication for hormone replacement therapy	0.0	0.0	0.1	-0.0	0.3
Current tobacco smoking	0.0	0.1	0.2	0.3	-0.4
High blood pressure	0.0	0.0	0.1	0.1	-0.2
Stomach or abdominal pain in last month	0.0	0.1	0.1	0.3	-0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	0.3	-0.1
Mouth/teeth dental problems	0.0	0.0	0.1	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.1	0.1	0.2
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	-0.2	0.1
Depression (self-reported)	0.0	0.0	0.0	-0.2	-0.2
Prospective memory result	0.0	0.0	0.0	0.0	-0.0
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.3	0.1
Comparative body size at age 10	0.0	0.0	0.0	0.2	-0.0
Age at first live birth	0.0	0.0	0.0	-0.1	0.2
Migraine (self-reported)	0.0	0.0	0.1	-0.0	-0.2
Overall health rating	0.0	0.0	0.1	0.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.1	0.2
Friendships satisfaction	0.0	0.0	0.0	0.1	-0.2
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	-0.0	-0.2
Smoking status: Current	0.0	0.1	0.2	0.1	-0.4
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	-0.0	-0.0
Medication: Bendroflumethiazide	0.0	0.1	0.1	-0.3	-0.3
Medication: Lisinopril	0.0	0.1	0.1	-0.1	0.4
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.2	-0.3
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	0.2	0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.4	-0.0	-0.6
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	0.1	0.0

Hub : Genes

STC1

Models

Trait associations