TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Trunk fat-free mass
:
←
→
chr10:119,742,699-121,632,800
Best TWAS P=2.99e-12 · Best GWAS P=3.52e-11 conditioned to 0.227
120M
120.5M
121M
121.5M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Pheochromocytoma and Paraganglioma
C10orf46
0.23
0.04
lasso
4
0.04
8.6e-03
-6.4
7.0
3.0e-12
0.66
0.01
0.58
TRUE
3
GTEx
Esophagus Gastroesophageal Junction
FAM45A
0.24
0.13
enet
51
0.09
2.7e-04
4.7
6.0
2.0e-09
0.19
0.14
0.08
TRUE
4
ROSMAP
Brain Pre-frontal Cortex
CACUL1
0.12
0.08
lasso
4
0.06
1.2e-08
-6.4
6.3
2.5e-10
0.57
0.01
0.99
FALSE
2
GTEx
Breast Mammary Tissue (Female)
PRDX3
0.34
0.11
enet
31
0.12
1.9e-04
4.0
5.2
1.9e-07
0.21
0.11
0.05
FALSE
1
GTEx
Breast Mammary Tissue
PRDX3
0.27
0.00
enet
30
0.02
3.9e-02
4.8
5.1
2.9e-07
0.06
0.12
0.04
FALSE