Best TWAS P=2.99e-12 · Best GWAS P=3.52e-11 conditioned to 0.227
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | PRDX3 | 0.27 | 0.00 | enet | 30 | 0.02 | 3.9e-02 | 4.8 | 5.1 | 2.9e-07 | 0.06 | 0.12 | 0.04 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | PRDX3 | 0.34 | 0.11 | enet | 31 | 0.12 | 1.9e-04 | 4.0 | 5.2 | 1.9e-07 | 0.21 | 0.11 | 0.05 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | FAM45A | 0.24 | 0.13 | enet | 51 | 0.09 | 2.7e-04 | 4.7 | 6.0 | 2.0e-09 | 0.19 | 0.14 | 0.08 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | CACUL1 | 0.12 | 0.08 | lasso | 4 | 0.06 | 1.2e-08 | -6.4 | 6.3 | 2.5e-10 | 0.57 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C10orf46 | 0.23 | 0.04 | lasso | 4 | 0.04 | 8.6e-03 | -6.4 | 7.0 | 3.0e-12 | 0.66 | 0.01 | 0.58 | TRUE |