Best TWAS P=2.7e-12 · Best GWAS P=7.57e-18 conditioned to 3.6e-10
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells EBV-transformed lymphocytes | AKAP13 | 0.23 | 0.06 | lasso | 6 | 0.05 | 9.0e-03 | -5.6 | 5.5 | 3.3e-08 | -0.41 | 0.30 | 0.10 | FALSE |
2 | GTEx | Cells EBV-transformed lymphocytes | RP11-815J21.2 | 0.20 | 0.09 | lasso | 5 | 0.08 | 1.8e-03 | -5.9 | 5.9 | 2.8e-09 | -0.45 | 0.17 | 0.17 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | RP11-158M2.3 | 0.17 | 0.04 | lasso | 8 | 0.00 | 3.8e-01 | -5.6 | 5.6 | 2.8e-08 | -0.44 | 0.21 | 0.13 | FALSE |
4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AKAP13 | 0.08 | 0.03 | enet | 11 | 0.08 | 2.3e-08 | -6.4 | -7.0 | 2.7e-12 | 0.41 | 0.13 | 0.86 | TRUE |