TWAS hub - AKAP13

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1990	0.0440	5.3e-13	0.098	0.146	0.107	0.140	0.118	5.7e-12	2.2e-17	6.2e-13	9.8e-17	3.9e-14
2	GTEx	Brain Frontal Cortex BA9	0.2994	0.1074	2.1e-03	-0.006	NA	0.013	NA	0.043	5.2e-01	NA	1.4e-01	NA	2.7e-02
3	GTEx	Cells EBV-transformed lymphocytes	0.2310	0.0790	2.4e-03	0.056	NA	0.005	NA	0.051	6.8e-03	NA	2.1e-01	NA	9.0e-03
4	YFS	Blood	0.1380	0.0214	0.0e+00	0.094	0.140	0.144	0.143	0.149	4.5e-29	2.4e-43	1.0e-44	1.6e-44	2.6e-46
5	TCGA	Brain Lower Grade Glioma	0.0591	0.0242	6.5e-05	0.003	0.039	0.030	NA	0.026	1.3e-01	2.6e-05	1.9e-04	NA	5.8e-04
6	TCGA	Prostate Adenocarcinoma	0.0778	0.0303	3.6e-06	0.027	0.058	0.076	NA	0.053	7.3e-04	1.0e-06	2.3e-08	NA	3.2e-06
7	TCGA	Thyroid Carcinoma	0.0760	0.0340	1.6e-03	0.055	0.044	0.043	NA	0.047	4.8e-06	3.8e-05	4.7e-05	NA	2.2e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hearing difficulty/problems with background noise	5.8	9.3	24.2	2.7	4.9	-3.0	2.3	4.3	1.0	0.4
Birth weight of first child	4.9	8.8	27.0	1.1	1.6	1.3	5.2	4.5	-3.0	0.4
Heart disease (mother)	4.7	5.7	16.5	0.1	-0.1	-4.1	0.0	0.3	3.7	-3.2
Hearing difficulty/problems: Yes	3.9	6.0	16.9	1.5	3.0	-2.9	1.9	4.1	1.5	-0.0
Medication: Bendroflumethiazide	3.4	5.1	11.2	-1.7	-1.4	-2.5	-1.1	-1.4	3.4	-3.2
Bipolar Disorder (2011)	3.2	3.1	11.2	-1.0	-0.4	3.4	-0.3	-2.1	-2.0	0.7
Hypothyroidism (self reported)	3.2	7.4	24.5	1.4	0.0	-5.0	-0.7	2.5	4.3	-0.5
Medication: Blood pressure	3.1	5.9	12.9	-1.0	-2.5	-1.4	-2.6	-2.7	3.6	-2.2
Medication: Ventolin 100micrograms inhaler	3.0	3.8	13.7	1.4	3.7	-2.0	0.2	2.3	1.0	0.8
Asthma (self-reported)	3.0	6.0	20.0	2.5	4.5	0.4	2.8	2.7	-0.1	0.6
Tinnitus: Yes, now most or all of the time	3.0	3.5	8.4	1.5	2.6	-1.9	1.6	2.9	-0.1	1.0
Asthma	2.9	5.7	20.0	2.5	4.5	0.2	2.6	2.6	0.2	0.4
Ever highly irritable/argumentative for 2 days	2.9	3.5	7.6	1.7	0.8	-2.7	-1.8	1.5	2.8	-0.3
Hypothyroidism/myxoedema (self-reported)	2.7	5.3	14.3	2.1	0.5	-3.6	-1.2	2.1	3.8	-0.3
Trunk fat-free mass	2.6	14.8	48.9	-1.8	0.6	5.5	0.2	-0.7	-7.0	4.5
Alzheimer’s Disease (in mother)	2.5	2.9	10.3	3.2	2.1	2.0	1.0	-0.1	-0.9	0.5
Diabetes (mother)	2.5	3.2	11.2	2.0	3.4	0.4	0.6	2.0	0.3	1.5
Medication: Levothyroxine sodium	2.5	4.3	12.6	0.1	-1.8	-2.9	-2.1	0.6	3.5	-0.9
Pulse wave Arterial Stiffness index	2.5	2.9	8.9	0.4	0.4	3.0	0.9	-1.7	-2.7	0.3
Trunk predicted mass	2.5	14.3	47.1	-1.7	0.5	5.4	0.1	-0.7	-6.9	4.4
Long-standing illness, disability or infirmity	2.5	3.8	9.2	3.0	2.6	-1.4	0.9	1.8	1.9	-0.9
Medication: Aspirin	2.5	3.3	5.9	-1.5	-1.9	-2.3	-1.7	-0.8	2.4	-1.4
Alcohol drinker status: Previous	2.5	2.8	11.2	2.0	3.3	-0.0	1.6	1.4	0.0	0.2
Respiratory disease	2.4	5.4	15.4	2.7	3.9	0.1	2.9	2.6	0.0	-0.2
Medication: Aspirin	2.4	3.1	6.2	-1.7	-1.6	-2.5	-1.4	-0.5	2.4	-1.5
Medication: Atenolol	2.3	2.9	5.7	-1.7	-2.1	-1.7	-1.7	-0.7	2.4	-0.8
Hair/balding pattern: Pattern 4	2.3	5.6	14.0	3.7	3.4	1.6	-2.0	-0.3	-1.1	2.4
Neck or shoulder pain in last month	2.3	3.3	14.1	-0.2	1.8	0.7	-0.9	1.9	-1.0	3.8
Family relationship satisfaction	2.3	2.8	7.1	-0.3	1.5	1.1	0.7	1.6	-2.5	2.7
Mean Putamen Volume	2.2	2.6	6.5	-1.1	0.1	1.1	-1.6	-0.3	-2.5	2.5
Hand grip strength (left)	2.2	5.8	13.8	0.8	2.9	0.9	0.0	2.9	-3.0	3.7
Relative age voice broke	2.2	3.4	7.7	-1.2	-1.4	-2.3	1.3	0.8	2.2	-2.8
Pulse rate	2.2	3.6	8.2	1.3	1.8	2.9	2.5	-0.4	-2.4	0.0
Noisy workplace	2.2	2.7	6.4	-2.3	-1.7	-2.5	0.1	1.2	1.6	-0.8
Arm predicted mass (right)	2.2	11.3	35.8	-1.3	0.8	4.6	-0.2	-0.5	-6.0	4.4
Illnesses of father: High blood pressure	2.2	2.8	6.3	0.1	0.2	-1.7	-2.5	-2.2	2.3	0.1
Height	2.1	40.2	141.6	0.1	-0.3	9.8	1.6	-2.7	-11.9	5.8
Father’s age at death	2.1	2.8	6.2	2.3	2.5	0.6	2.0	1.6	-1.0	0.6
Arm fat-free mass (right)	2.1	10.9	33.9	-1.5	0.7	4.5	-0.1	-0.3	-5.8	4.4
Chest pain or discomfort	2.1	3.0	9.5	-0.0	0.8	-3.1	1.9	1.8	1.1	-1.7
Whole body fat-free mass	2.1	12.2	40.4	-2.1	0.5	4.9	0.4	-0.5	-6.4	4.0
Whole body water mass	2.1	12.1	39.7	-2.0	0.4	4.9	0.3	-0.4	-6.3	4.0
Breast Cancer	2.0	4.7	11.2	3.3	3.3	-0.4	1.5	2.8	0.7	0.1
Wheeze or whistling in the chest in last year	2.0	3.5	10.2	1.4	2.7	-0.1	3.2	2.0	0.3	-1.1
Supplements: Vitamin C	2.0	2.4	6.1	-0.1	0.6	0.9	2.5	1.6	-2.4	1.1
Illnesses of father: Heart disease	2.0	2.7	9.5	-0.7	-0.3	-2.6	-1.0	0.9	3.1	-0.7
Arm fat-free mass (left)	2.0	10.0	32.7	-1.2	0.6	4.5	0.0	-0.3	-5.7	4.0
Supplements: Calcium	2.0	2.2	6.0	0.7	0.5	2.3	0.6	0.7	-2.5	1.6
Arm predicted mass (left)	2.0	9.9	31.6	-1.6	0.4	4.5	0.1	-0.3	-5.6	3.9
Coronary Artery Disease (CAD)	1.9	2.3	6.1	-0.1	-0.4	-2.2	0.6	-0.9	1.9	-2.5
Allergy	1.9	4.3	11.4	-2.3	-3.4	0.0	-1.0	-3.0	0.5	-1.8
Happiness	1.9	2.3	7.9	1.5	2.8	-0.1	0.3	1.5	-1.2	1.6
Birth weight	1.9	4.1	9.8	-0.4	1.0	1.8	3.1	2.5	-2.7	0.7
Vascular/heart problems diagnosed by doctor	1.9	5.2	9.4	0.4	2.1	0.4	3.0	2.9	-3.1	2.2
Systolic Blood Pressure	1.8	9.1	14.8	-2.4	-3.0	-2.5	-3.3	-3.7	3.9	-1.9
Worrier / anxious feelings	1.8	3.3	9.6	1.1	1.9	-3.1	-0.7	2.2	0.8	1.7
Exposure to tobacco smoke at home	1.8	2.0	3.5	-1.4	1.1	-0.7	1.0	1.8	-1.6	1.9
Angina	1.7	2.2	8.6	0.3	-0.9	-1.8	-2.9	-0.7	1.4	0.5
Pulse wave peak to peak time	1.7	2.1	6.1	-0.5	-0.6	-2.5	-0.7	1.5	2.2	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	5.5	-1.9	0.2	0.1	-0.7	2.3	-0.4	2.1
Smoking status: Current	1.7	2.7	7.1	-1.9	-1.6	1.0	2.7	0.0	-1.6	-1.5
Basal metabolic rate	1.7	9.2	31.1	-1.6	0.6	4.0	0.5	-0.1	-5.6	3.7
Blood Eosinophil Count	1.6	12.2	27.7	3.4	4.0	-1.7	5.0	5.3	0.6	-1.3
Ever used hormone-replacement therapy (HRT)	1.6	2.0	5.7	-1.1	1.1	2.0	1.0	0.1	-2.4	1.0
Systolic blood pressure, automated reading	1.6	4.8	8.7	-2.1	-1.4	-1.3	-2.7	-3.0	2.8	-1.2
Severe depression (siblings)	1.6	1.8	3.5	0.9	1.9	0.9	1.3	1.3	-1.4	1.5
High blood pressure	1.6	4.5	9.9	-0.0	-1.8	0.2	-2.6	-3.1	2.5	-2.2
Lung cancer (father)	1.6	1.9	5.1	-0.9	-0.8	1.8	0.3	-1.8	-2.3	0.3
Standing height	1.6	16.3	58.8	-0.3	-0.4	5.7	0.5	-1.6	-7.7	4.5
Angina (self-reported)	1.6	2.0	7.4	-0.0	-1.0	-1.9	-2.7	-0.3	1.3	0.5
Number of full sisters	1.6	1.9	4.2	-1.2	0.7	-1.9	1.8	0.4	0.4	-2.1
Hypertension (Self-reported)	1.6	4.4	10.0	-0.0	-1.9	0.1	-2.6	-3.2	2.4	-2.2
Allergy or Eczema	1.5	3.9	8.9	2.0	3.0	0.8	-1.3	1.9	-0.9	2.8
Hayfever, allergic rhinitis or eczema	1.5	3.2	9.1	2.4	3.0	0.6	-1.4	1.0	-0.2	2.1
Impedance of arm (right)	1.5	7.0	15.1	2.6	-0.7	-3.9	1.7	0.6	3.3	-3.6
Mouth/teeth dental problems: Dentures	1.5	2.5	8.4	-0.7	0.6	2.9	1.7	-0.4	-2.1	-0.7
Emphysema/chronic bronchitis	1.5	1.7	3.9	0.2	0.9	-1.7	1.8	2.0	0.4	-0.8
Leg fat-free mass (right)	1.5	8.0	25.6	-2.5	-0.1	3.9	0.5	-0.2	-5.1	3.0
Leg predicted mass (right)	1.5	8.1	26.2	-2.3	-0.1	4.0	0.4	-0.2	-5.1	3.1
Commuting to job workplace: Public transport	1.5	1.8	5.8	-1.4	-1.5	-0.1	-0.1	-0.9	1.2	-2.4
Bipolar Disorder (2018)	1.4	2.3	4.9	-1.9	-0.4	2.2	-0.4	-1.5	-2.1	0.8
Worry (Nagel 2018)	1.4	2.9	6.2	1.5	1.9	-2.5	-1.1	1.5	2.0	1.1
Prostate Cancer	1.4	1.9	4.3	-2.0	-1.4	-2.1	-1.6	0.4	0.8	0.2
Ulcerative Colitis	1.4	2.0	6.0	-0.8	0.8	0.5	1.2	2.4	-1.3	1.7
Smoking Status	1.4	3.4	7.6	-2.1	-1.5	2.4	1.8	-0.1	-2.8	0.7
Impedance of leg (right)	1.4	6.7	17.6	4.2	1.1	-3.8	0.1	0.3	3.3	-1.7
Leg fat-free mass (left)	1.4	7.4	24.3	-2.5	0.1	3.5	0.7	-0.1	-4.9	2.9
Tinnitus: Yes, but not now, but have in the past	1.4	1.4	5.3	-1.3	-0.5	-0.2	-0.7	-2.3	0.1	-1.5
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	4.8	-1.7	-0.8	-0.9	1.4	0.3	0.7	-2.2
Impedance of leg (left)	1.4	6.8	23.7	4.9	0.9	-3.3	-0.2	0.2	3.2	-1.5
Leg predicted mass (left)	1.4	7.2	23.4	-2.5	0.1	3.4	0.7	0.0	-4.8	2.9
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	3.1	1.5	0.4	-1.4	-1.7	1.8	1.1	1.2
Handedness (chirality/laterality): Left-handed	1.4	1.6	4.5	0.7	0.8	-1.3	2.1	1.6	0.2	-1.3
Medication: Atorvastatin	1.4	1.8	5.2	0.9	1.2	-1.9	0.8	2.3	1.0	0.1
Fractured/broken bones in last 5 years	1.4	1.8	6.2	-0.5	-0.0	-0.1	1.4	2.5	-1.5	1.3
Ever depressed for a whole week	1.4	1.7	3.8	0.6	2.0	-0.8	1.8	1.8	-0.6	0.4
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	3.8	-0.4	-0.5	-2.0	1.4	1.1	1.6	-1.3
Current tobacco smoking	1.3	2.2	6.2	-1.5	-1.1	1.2	2.5	0.2	-1.8	-1.0
Fluid intelligence score	1.3	2.7	8.0	1.2	-0.8	2.8	0.1	-2.8	-0.9	-0.7
Time employed in main current job	1.3	1.4	4.1	1.1	1.6	0.3	-2.0	-0.9	0.1	1.1
Impedance of arm (left)	1.3	5.8	13.8	2.4	-1.1	-3.7	1.2	0.3	3.1	-3.1
Blood clot in the leg (DVT)	1.3	1.6	5.1	-0.8	0.5	0.2	2.3	1.5	-1.8	0.3
Comparative height size at age 10	1.3	7.0	25.0	-1.0	-0.7	3.1	0.2	-0.4	-5.0	3.5
Had major operations	1.3	1.5	3.7	-0.2	-1.2	-0.7	1.9	1.0	0.9	-1.8
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.1	1.5	1.8	0.4	1.5	1.3	-0.7	0.7
Breast cancer (self-reported)	1.3	1.5	3.7	-1.9	-1.7	0.2	1.2	-0.4	-1.5	-0.2
Guilty feelings	1.3	2.0	4.7	0.2	-0.4	-2.2	-1.6	2.0	1.6	0.5
Diastolic blood pressure, automated reading	1.3	3.9	12.7	-0.9	-2.0	0.7	-2.8	-3.6	1.3	-0.2
Impedance of whole body	1.3	6.6	15.4	3.9	-0.2	-3.8	0.6	0.3	3.3	-2.3
Blood Platelet Count	1.2	14.2	33.2	-3.3	2.2	0.1	5.8	4.5	-5.1	1.8
Blood Red Count	1.2	11.2	27.7	-0.4	-1.4	-4.2	-5.2	-1.8	5.3	0.1
Cardiovascular Disease	1.2	3.8	10.3	0.6	-1.1	-1.5	-1.6	-1.9	3.2	-2.6
Taking other prescription medications	1.2	1.8	4.4	0.7	2.1	-1.2	1.1	2.1	0.6	-0.4
High blood pressure (mother)	1.2	1.6	3.6	0.4	-1.1	-1.4	-1.9	-1.2	1.6	-0.5
Number of incorrect matches in round	1.2	2.0	4.9	-1.6	-0.7	1.5	0.8	0.5	-2.2	1.8
Neuroticism score	1.2	2.4	4.5	1.7	1.2	-2.1	-1.8	1.3	1.8	0.5
Number of live births	1.2	1.7	4.3	-1.0	1.3	-0.3	1.6	1.2	-2.1	0.9
Medication: Seretide 50 evohaler	1.2	1.4	3.8	1.7	2.0	0.5	0.8	1.0	-0.6	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	7.0	2.7	0.5	0.7	-1.4	-0.1	0.5	0.4
Ulcerative Colitis (UC)	1.1	2.1	8.7	0.8	1.1	0.8	0.5	2.9	-0.3	1.7
Sensitivity / hurt feelings	1.1	1.9	5.9	2.2	2.4	-0.5	-0.5	0.3	-0.2	1.3
Ever had hysterectomy (womb removed)	1.1	1.3	5.8	-0.7	0.3	0.6	2.4	0.5	-1.4	-0.0
Stomach or abdominal pain in last month	1.1	1.3	2.4	-1.6	-0.8	-1.4	0.9	1.5	1.0	-0.1
Sitting height	1.1	7.9	25.1	0.3	-0.2	4.0	0.1	-1.4	-5.0	3.5
Nervous feelings	1.1	2.0	5.4	1.8	2.3	-1.0	-0.7	1.3	1.3	0.5
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.1	1.2	1.8	-0.2	0.3	1.6	-1.0	1.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.1	-0.4	0.0	-1.5	0.6	-1.1	1.5	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	8.7	1.3	1.0	0.8	-0.4	0.7	-1.9	3.0
Loneliness, isolation	1.1	1.5	6.8	1.3	2.6	-0.3	0.1	-0.1	0.8	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	2.7	0.3	-0.4	0.8	-1.6	-1.5	1.0	-1.0
Number of self-reported non-cancer illnesses	1.1	1.9	6.3	1.4	2.5	0.2	1.1	1.6	-0.6	0.9
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.6	0.1	-1.6	-0.2	-1.6	-0.5	1.6	-0.9
Pain experienced in last month	1.1	1.9	6.9	-0.0	-1.4	0.1	0.4	-2.1	-0.2	-2.6
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	4.4	-0.6	0.7	0.5	2.1	1.1	-1.8	0.3
LDL Cholesterol	1.0	1.5	4.8	-0.1	2.2	1.0	1.3	1.0	-1.1	1.0
Alcohol usually taken with meals	1.0	1.7	4.2	0.1	2.1	1.0	-0.6	1.0	-1.0	2.0
Had other major operations	1.0	1.2	2.0	-1.4	-1.0	0.9	0.7	-1.2	-1.2	-1.1
Illnesses of mother	1.0	1.2	3.2	-0.9	-0.1	0.5	0.7	1.2	-1.8	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.8	1.1	2.2	-1.1	0.2	1.6	0.8	0.4
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.4	2.1	0.8	1.1	1.4	-0.9	-0.2	-1.6
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.3	-0.7	-0.9	1.3	1.2	0.3	-2.1	1.7
Gout (self-reported)	1.0	1.4	2.8	0.4	0.7	1.4	-1.5	-1.7	-1.2	0.8
Worry too long after embarrassment	1.0	1.6	3.5	1.7	1.4	-1.9	0.0	1.1	0.2	1.2
Pulse rate, automated reading	1.0	3.1	8.5	0.5	2.6	1.6	2.9	0.6	-1.9	0.4
Diabetes diagnosed by doctor	1.0	1.6	4.0	0.9	1.6	0.5	2.0	0.3	-1.8	0.7
Osteoporosis (self-reported)	1.0	1.2	4.1	0.9	1.4	0.3	-0.6	2.0	1.0	0.5
Hearing aid user	1.0	1.2	2.8	0.6	1.1	-1.7	-0.1	1.5	1.3	-0.3
Unable to work because of sickness or disability	1.0	1.3	2.5	-1.6	0.0	0.8	1.4	0.7	-1.5	1.0
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.5	-1.9	-1.3	-0.1	-0.0	1.2	-0.6	1.3
Crohns Disease (2017)	0.9	2.0	4.0	-1.3	0.2	1.5	-1.3	-0.7	-2.0	2.0
Irritable Bowel Disease (IBD)	0.9	2.1	6.3	-0.4	0.7	1.5	-0.2	1.5	-1.8	2.5
Fasting Glucose	0.9	1.0	4.4	-0.3	2.1	0.5	0.5	-0.3	-1.3	0.7
HDL Cholesterol	0.9	1.5	5.1	0.4	-0.8	1.7	0.6	-0.1	-2.3	1.2
Average weekly fortified wine intake	0.9	1.0	3.1	1.8	1.3	0.2	-0.7	0.7	-0.2	1.2
Past tobacco smoking	0.9	1.7	3.7	0.9	-0.5	-1.6	-1.7	-0.6	1.9	-1.0
Hair/balding pattern: Pattern 3	0.9	1.4	4.7	-0.5	0.1	0.8	1.7	-1.1	-0.4	-2.2
Medication: Cholesterol lowering	0.9	1.4	4.5	0.8	2.1	-1.6	-0.3	0.6	1.3	-0.4
Peak expiratory flow (PEF)	0.9	2.0	4.8	2.2	1.1	1.0	-1.5	0.5	-0.0	2.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.7	1.2	1.1	0.2	0.4	1.4	-0.6	1.6
Number of full brothers	0.9	1.2	3.4	-1.4	-1.1	0.5	1.9	-0.1	-1.2	-0.3
Medication: Allopurinol	0.9	1.2	3.1	0.9	1.7	0.2	-1.8	-0.5	0.1	1.3
Medication: Omeprazole	0.9	1.0	2.4	-1.4	-0.3	0.3	0.5	1.2	-0.9	1.5
Smoking status: Previous	0.9	1.4	2.6	-0.3	0.9	1.6	0.9	0.7	-1.6	1.6
Medication for cholesterol	0.9	1.4	3.3	1.6	1.1	1.0	0.8	0.3	-1.8	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.9	1.4	1.2	-0.4	1.0	1.1	0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	5.4	1.4	0.3	-1.6	-0.8	2.3	1.4	1.1
Mother’s age at death	0.9	1.2	3.0	1.7	0.9	-0.5	-1.2	-0.0	1.7	0.1
Heart disease (siblings)	0.9	1.1	2.8	0.0	0.7	-0.6	1.7	1.3	1.0	-1.1
Bipolar Disorder or Schizophrenia	0.8	1.8	6.3	-2.5	-0.9	1.1	0.7	-0.7	-1.8	-0.4
Alzheimer’s Disease (including proxy)	0.8	1.1	2.4	1.3	0.4	1.0	1.2	-1.1	-0.1	-1.5
Reaction Time	0.8	1.6	4.0	-0.5	-0.3	0.9	2.0	-1.3	0.2	-2.0
Rheumatoid Arthritis	0.8	1.1	3.6	-1.1	-0.6	-0.4	1.9	-0.7	-0.2	-1.3
Average weekly spirits intake	0.8	0.9	2.3	1.4	1.2	0.4	1.5	0.5	0.1	-0.7
Supplements: Zinc	0.8	0.9	2.7	-1.6	-0.9	-0.2	1.0	-0.6	-1.0	-0.4
Diabetes (father)	0.8	1.0	1.6	0.5	1.3	1.1	1.0	0.4	-1.2	1.2
Age when periods started (menarche)	0.8	1.9	7.1	-0.5	1.7	0.3	2.7	1.1	-1.0	-1.0
Had menopause	0.8	1.0	3.8	0.1	2.0	0.9	-0.4	0.4	-0.8	1.2
Forced vital capacity (FVC)	0.8	2.9	5.2	-1.4	-1.5	2.3	-0.7	-1.6	-2.3	1.7
Qualifications: A levels/AS levels or equivalent	0.8	1.7	4.6	1.6	-0.1	0.1	-0.4	-1.2	1.8	-2.1
Body fat percentage	0.8	3.0	6.3	1.8	1.9	-2.5	1.2	1.8	1.6	-0.6
Leg fat percentage (right)	0.8	2.7	5.3	1.6	2.1	-2.3	0.8	1.2	1.9	-0.8
Health satisfaction	0.8	1.0	2.4	1.1	1.2	0.8	-0.6	0.6	-0.7	1.6
Medication: Blood pressure	0.8	1.5	3.8	0.1	-0.3	-0.2	-1.2	-1.9	1.2	-1.9
Mean time to correctly identify matches	0.8	1.6	6.0	-0.4	-0.1	0.5	1.9	-0.6	0.9	-2.4
Overall health rating	0.8	1.7	4.0	0.6	0.7	-1.8	0.6	1.4	2.0	-1.2
Leg pain on walking	0.8	1.0	1.7	1.1	0.4	-1.2	-1.1	1.0	1.3	0.3
Qualifications: nursing, teaching	0.8	1.3	4.0	0.7	-0.2	-0.5	-1.4	-0.4	2.0	-1.5
Commuting to job workplace: Walk	0.8	0.9	2.8	0.3	1.0	0.7	-1.7	-1.2	0.3	0.2
Illnesses of father: None of the above (group 1)	0.8	1.0	5.2	0.1	-0.4	0.8	0.1	-0.0	-2.3	0.8
Ever smoked	0.8	1.3	3.1	-1.2	-0.0	1.6	1.4	0.2	-1.8	0.6
Risk taking	0.8	1.1	1.8	-1.3	-1.3	0.2	-1.0	-0.9	-0.7	1.4
Age started oral contraceptive pill	0.8	1.0	2.7	-0.2	1.6	0.7	-0.9	-0.2	-0.5	1.5
Lupus	0.7	1.0	2.3	0.7	1.1	-1.4	-0.3	0.0	1.5	-1.0
Neuroticism (2016)	0.7	1.0	3.2	0.3	1.2	1.0	0.3	0.7	-0.9	1.8
Primary Biliary Cirrhosis	0.7	0.9	2.2	0.7	0.6	-0.5	1.2	1.5	0.9	-1.0
Blood White Count	0.7	5.5	24.0	-4.9	-2.5	-2.4	-0.7	-0.8	1.2	-0.5
Waist Hip Ratio (WHR)	0.7	3.1	9.3	-0.4	-0.7	-3.0	-0.3	2.0	2.5	-1.0
Type 2 Diabetes (T2D) (2018)	0.7	1.4	4.2	1.3	1.0	-0.6	2.0	1.2	-0.8	0.1
Lung FEV1/FVC ratio	0.7	3.4	10.7	1.1	-0.4	-2.6	0.4	3.3	1.8	1.1
Chronotype (morning person)	0.7	1.6	5.6	-0.6	-2.4	-1.4	-0.6	-0.1	1.5	-0.8
Number of treatments/medications taken	0.7	1.2	5.5	-0.0	1.3	-0.6	0.3	2.3	0.5	0.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	4.8	-0.3	0.2	-0.6	-2.2	0.6	0.9	0.8
Medication for hormone replacement therapy	0.7	0.8	2.1	-1.4	-0.8	0.2	1.0	1.4	-0.4	0.0
Trunk fat percentage	0.7	2.9	6.2	1.9	1.7	-2.5	1.2	1.9	1.5	-0.6
Hand grip strength (right)	0.7	1.8	3.9	0.0	1.9	0.1	-0.2	1.4	-1.9	2.0
Chronic bronchitis/emphysema (father)	0.7	0.8	4.0	-0.6	0.0	0.8	2.0	0.4	-0.4	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.8	-0.6	1.3	-0.7	-1.7	0.7	0.4	1.1
Hair/balding pattern: Pattern 2	0.7	1.0	2.8	0.5	-0.4	-0.5	-0.8	1.7	0.2	1.6
Heart attack	0.7	0.9	2.6	0.3	0.4	-1.6	0.5	1.6	0.8	-0.3
Pain all over the body in last month	0.7	0.8	2.8	-1.7	-0.8	-0.2	0.1	-0.9	-0.8	0.8
Arm fat percentage (right)	0.7	2.7	5.2	1.2	1.6	-2.3	1.2	1.9	1.8	-1.2
Tense / ‘highly strung’	0.7	1.2	2.3	0.7	1.5	-0.5	-1.5	-0.3	1.5	0.9
Forced vital capacity (FVC), Best measure	0.7	2.5	5.1	-1.2	-1.5	2.1	-0.5	-0.9	-2.3	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	3.3	1.1	1.8	-0.5	0.5	0.9	0.4	0.3
Medication for pain relief, constipation, heartburn	0.7	1.1	2.0	1.4	1.4	1.4	0.5	-0.9	-0.6	-0.5
Friendships satisfaction	0.7	0.9	2.3	0.3	1.5	0.3	0.5	0.8	-1.1	1.3
Back pain experienced in last month	0.7	1.0	3.2	0.1	1.3	0.1	0.0	1.8	-0.1	1.4
Average weekly champagne plus white wine intake	0.7	0.9	1.9	-1.0	-1.4	1.3	0.7	-0.8	-0.7	-0.5
Eye problems/disorders: Glaucoma	0.7	0.8	2.5	1.3	-0.1	-0.0	0.3	0.9	1.6	-0.8
Leg fat percentage (left)	0.7	2.4	4.0	1.9	2.0	-1.9	0.4	1.2	1.9	-0.6
Myopia	0.7	1.0	2.9	0.9	1.7	0.5	1.5	-0.4	-0.3	-0.6
Basal cell carcinoma (self-reported)	0.7	0.8	3.3	-0.4	-0.0	-0.9	-1.8	0.2	0.9	0.6
Neuroticism (Nagel 2018)	0.6	1.4	2.7	1.3	1.0	-1.4	-1.6	0.3	1.1	0.9
Crohns Disease (2012)	0.6	1.0	1.8	-1.4	-1.0	1.1	-0.6	-0.2	-1.2	1.1
Neuroticism	0.6	1.4	2.0	1.4	1.1	-1.4	-1.4	1.1	1.1	0.8
Medication: Co-codamol	0.6	0.7	2.4	-0.3	-1.5	-1.0	-1.1	0.2	0.8	0.1
Medication: Metformin	0.6	0.9	2.4	1.3	-0.1	0.5	1.5	-0.3	-1.3	-0.2
Maternal smoking around birth	0.6	0.8	1.8	-1.3	-0.6	-0.9	1.3	0.5	0.2	-0.9
Diabetes (self-reported)	0.6	0.9	3.1	-0.6	0.5	0.2	1.8	0.0	-1.5	0.2
Medication: Ramipril	0.6	0.7	1.8	0.3	-1.0	-0.5	-1.2	0.4	1.3	-0.6
Weight	0.6	2.8	9.0	-0.4	1.1	1.8	0.8	0.6	-3.0	2.2
Medication: Amlodipine	0.6	0.8	2.5	-1.6	0.3	-0.7	-0.0	-0.9	0.6	-1.2
Chronic bronchitis/emphysema (mother)	0.6	0.8	1.9	-0.7	-0.8	-0.4	1.4	0.1	0.4	-1.4
Comparative body size at age 10	0.6	1.6	4.2	1.3	-0.8	1.1	-2.0	-1.0	-0.0	1.5
Number of children fathered	0.6	0.7	1.7	-1.2	0.4	1.3	-0.7	-0.9	0.5	0.5
Age at first live birth	0.6	1.0	6.1	2.5	-0.1	0.6	-0.2	-0.4	-0.0	-0.8
Suffer from ‘nerves’	0.6	1.0	3.7	0.9	0.1	-0.5	-0.9	-0.6	1.9	-0.8
Age at last live birth	0.6	0.9	3.9	0.1	-2.0	0.6	-0.9	-0.8	-0.7	-0.4
Arm fat percentage (left)	0.6	2.5	5.8	1.0	1.5	-2.4	1.0	1.8	1.9	-1.0
Mood swings	0.6	1.1	2.8	1.2	1.7	0.6	-0.6	1.1	-0.3	1.2
Mineral and other dietary supplements	0.6	0.9	3.1	-0.1	-0.0	0.7	-1.5	-1.8	-0.1	-0.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.4	-0.5	-0.3	-0.9	1.2	1.6	0.5	-0.1
Schizophrenia (2018)	0.5	1.0	3.1	-1.8	-0.8	-0.4	1.3	0.3	-0.7	-1.1
Alzheimer’s Disease (in father)	0.5	0.6	1.2	-0.9	0.2	0.6	1.1	-0.9	-0.8	-0.6
HbA1C	0.5	0.5	1.2	1.0	0.5	0.7	0.2	1.1	-0.4	0.7
Schizophrenia (2014)	0.5	1.1	4.7	-2.2	-0.6	0.1	0.8	-0.4	-0.8	-0.9
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.9	0.2	0.3	-0.4	-0.3	-1.0	0.8	-1.4
Relative age of first facial hair	0.5	1.0	1.9	-1.1	-0.3	-1.4	0.8	1.2	0.8	-0.9
Vitamin and mineral supplements	0.5	0.6	2.2	0.1	-1.5	-0.4	-0.5	-1.1	0.4	-0.8
Multivitamins +/- minerals	0.5	0.6	1.9	-0.1	1.4	-0.1	-0.9	0.7	0.9	0.7
Supplements: Glucosamine	0.5	0.7	1.6	0.9	0.7	0.5	1.3	0.4	-1.1	0.4
Depression (self-reported)	0.5	0.6	2.3	0.4	-0.4	0.3	-1.5	0.3	-0.2	1.2
Prospective memory result	0.5	0.6	2.2	-0.4	-0.3	-1.1	-1.5	-0.2	0.8	0.2
Loud music exposure frequency	0.5	0.5	2.2	-0.0	0.3	0.2	0.2	1.0	0.2	1.5
Glaucoma (self-reported)	0.5	0.6	1.4	1.2	0.6	-0.2	0.6	0.9	0.7	-0.5
Shortness of breath walking on level ground	0.5	0.6	1.6	0.5	1.3	-1.0	0.5	0.9	0.3	0.4
Eye problems/disorders: None of the above	0.5	0.6	1.5	0.8	-0.1	0.6	-0.5	-0.5	-1.2	1.2
Migraine (self-reported)	0.5	0.6	1.6	1.0	0.3	-0.2	0.0	0.9	-1.3	1.0
Ever had bowel cancer screening	0.5	0.6	2.2	-0.1	0.3	-1.5	0.0	0.9	1.2	-0.2
Medication: Gliclazide	0.5	0.6	2.3	0.9	1.5	0.3	0.3	0.1	-0.5	0.8
Wears glasses or contact lenses	0.5	0.5	2.6	-0.1	0.1	0.3	1.6	0.3	-1.0	0.2
Ever taken oral contraceptive pill	0.5	0.5	1.2	0.4	1.1	0.9	0.1	1.1	0.6	0.1
Financial situation satisfaction	0.5	0.6	1.5	-1.2	-0.0	-0.2	0.7	0.4	-1.1	1.0
Medication: Lisinopril	0.5	0.7	2.8	0.5	0.9	-0.1	-0.6	-1.7	0.7	-0.4
Irritability	0.5	0.9	2.3	-0.2	-1.2	-0.4	-1.4	0.6	0.0	1.5
Depression (Nagel 2018)	0.4	0.6	2.3	-0.7	0.4	-0.6	-1.5	0.3	0.8	0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.9	0.4	-0.9	1.4	-0.1	-1.7	-0.3	-0.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.2	0.4	-0.1	-1.1	0.3	1.1	-0.2	0.8
Fed-up feelings	0.4	0.7	3.3	0.4	0.1	0.4	-1.8	-0.6	-0.7	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.2	0.7	-0.4	0.3	-1.4	-1.5	1.0	-0.9
Financial difficulties in last 2 years	0.4	0.6	1.5	-1.2	0.4	0.4	1.0	-0.8	-0.1	-0.8
Medication: Simvastatin	0.4	0.6	2.8	-0.0	1.7	-0.4	-0.5	-0.8	0.4	-0.3
Alcohol intake versus 10 years previously	0.4	0.7	3.0	0.1	0.2	-0.2	-1.7	0.1	0.0	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.3	0.5	0.7	0.8	0.3	-0.3	-1.5	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	5.6	-0.1	-0.9	0.8	-1.2	0.2	-0.9	2.4
Medication: Paracetamol	0.4	0.7	1.9	-1.4	-0.6	-0.5	-0.8	0.5	-0.2	1.1
Whole body fat mass	0.4	1.5	3.6	1.2	1.9	-0.7	1.2	1.7	-0.5	0.7
Knee pain experienced in last month	0.4	0.6	1.0	-0.6	0.3	-0.9	0.9	1.0	0.7	-0.8
Eye problems/disorders: Cataract	0.4	0.4	1.1	0.2	1.0	1.0	0.4	-0.4	-0.7	0.5
Osteoarthritis (self-reported)	0.4	0.5	1.1	-1.0	-0.8	-0.4	1.0	-0.0	-0.2	-0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.9	0.4	0.0	-0.6	-0.3	0.9	1.4	0.1
High cholesterol (Self-reported)	0.4	0.7	2.4	-0.3	0.7	-1.6	-0.0	0.4	1.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.8	0.3	0.4	-1.2	0.5	1.3	0.5	-0.2
Depressed Affect (Nagel 2018)	0.3	0.6	1.7	0.9	0.8	0.1	-1.3	-0.4	0.7	-0.4
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.5	-0.2	-1.6	0.6	-0.4	-1.6	0.2	-1.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	1.0	0.8	-0.6	0.3	0.7	0.1	-0.1
Major Depression (MDD)	0.3	0.4	1.3	-1.2	-1.0	-0.3	0.1	0.4	0.1	0.3
Age at First Birth	0.3	0.4	1.3	-0.4	-0.2	-0.3	-0.6	-0.2	1.2	-1.0
Hair Pigment	0.3	7.3	16.2	-2.4	-2.5	4.0	-1.1	-4.0	-2.0	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.4	-1.2	0.1	-0.1	-0.2	-0.8	-0.3	-0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.1	-1.0	-0.5	0.2	0.2	-0.8	-0.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	3.1	-0.0	-0.5	0.6	-0.8	-1.8	0.2	-0.7
Serious illness, injury or assault to yourself	0.3	0.4	1.1	0.6	0.2	0.6	-1.0	-0.7	-0.4	0.7
Trunk fat mass	0.3	1.4	3.1	1.2	1.8	-0.7	1.2	1.5	-0.6	0.7
Mouth/teeth dental problems	0.3	0.5	1.0	0.2	-1.0	-0.6	-0.8	-0.9	0.6	-0.4
Illnesses of siblings	0.3	0.4	0.9	-1.0	-0.1	-0.9	-0.5	-0.4	0.4	-0.6
Falls in the last year	0.3	0.5	1.9	0.7	-1.4	0.4	0.2	0.1	0.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.7	-0.1	-1.1	0.9	-1.1	-0.3	-0.9	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.9	-0.5	-0.9	1.0	-0.4	-0.0	0.1	-0.6
Length of working week for main job	0.3	0.3	1.2	-1.1	0.1	0.2	0.0	-0.8	-0.4	0.7
High blood pressure (siblings)	0.3	0.5	1.3	0.3	-0.6	0.6	-0.9	-1.1	0.5	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.9	-0.7	0.0	0.9	0.4	0.1	-0.8	0.4
Leg fat mass (right)	0.3	1.1	3.9	1.0	2.0	-0.5	0.8	1.2	-0.3	0.7
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.2	-0.5	0.6	-0.5	-0.5	1.1	0.1	0.7
Miserableness	0.3	0.5	2.2	0.4	-0.0	-0.5	-1.5	0.2	0.7	0.3
Medication: Paracetamol	0.3	0.5	1.2	-0.8	-0.3	-0.6	-1.0	0.5	-0.1	1.1
Number of operations (self-reported)	0.3	0.5	1.5	-0.2	-0.5	0.8	1.2	0.7	-0.6	-0.7
Average weekly beer plus cider intake	0.3	0.4	1.5	-0.5	-0.6	0.7	1.2	0.1	-0.7	-0.2
Commuting to job workplace: Cycle	0.3	0.4	1.1	-0.4	-1.1	-0.7	-0.8	0.5	0.3	0.1
Cholesterol lowering medication	0.3	0.5	2.0	-1.4	-0.5	-0.8	-0.3	0.4	0.6	0.2
Pack years of smoking	0.3	0.4	0.9	0.0	-0.0	0.7	0.8	0.9	-0.8	-0.5
Leg fat mass (left)	0.3	1.2	4.2	1.2	2.0	-0.2	0.6	1.1	-0.4	0.8
Ovarian Cancer	0.2	0.3	1.0	0.1	1.0	-0.1	0.2	0.5	-0.5	0.5
Body Mass Index (BMI) (2010)	0.2	0.2	1.1	0.1	1.0	0.3	0.1	-0.4	0.2	-0.2
Triglycerides	0.2	0.4	1.0	-0.8	1.0	-0.2	0.1	-0.9	-0.3	-0.1
Heel T-Score	0.2	1.9	8.1	0.7	2.9	-0.3	-0.8	0.5	0.5	1.8
BMI	0.2	1.1	3.2	-0.1	1.4	-0.6	1.3	1.8	-0.2	0.5
Lung FVC	0.2	1.1	3.6	-1.9	-1.8	0.2	0.6	0.1	-0.7	-0.0
Pack years adult smoking proportion	0.2	0.3	0.5	-0.1	-0.4	0.6	0.5	0.6	-0.5	-0.7
Qualifications: CSEs or equivalent	0.2	0.3	1.3	0.0	0.2	-0.3	-1.2	0.3	0.1	0.6
Body mass index (BMI)	0.2	0.8	2.4	-0.3	1.6	-0.6	0.6	1.5	0.3	0.3
Waist circumference	0.2	0.8	2.3	0.5	1.0	-1.1	0.4	1.5	0.5	0.2
Qualifications: None of the above	0.2	0.4	1.0	-0.4	-0.8	-0.0	-1.0	-0.1	0.7	0.4
Hip circumference	0.2	0.9	1.9	0.7	1.2	0.5	0.8	0.6	-1.4	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.3	-0.1	-0.3	-0.5	-1.2	0.3	0.5	0.5
Arm fat mass (right)	0.2	0.8	2.2	0.7	1.5	-0.3	0.9	1.4	-0.3	0.4
Breastfed as a baby	0.2	0.2	1.1	-0.2	0.3	1.0	-0.4	-0.3	0.1	-0.4
Pulse wave reflection index	0.2	0.3	0.9	0.8	0.0	0.9	-0.5	-0.4	-0.2	0.0
Headache pain in last month	0.2	0.3	0.9	0.1	0.5	-0.3	0.8	0.7	0.1	0.9
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.5	0.8	-0.3	-0.6	-0.6	0.0	0.4
Alcohol intake frequency.	0.2	0.5	2.6	-0.2	1.6	-0.5	0.3	0.8	0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.0	-0.6	-0.1	0.1	0.3	0.1	-0.8	1.0
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.4	0.5	-0.2	-0.0	-0.2	-0.7	0.7
Average weekly red wine intake	0.2	0.3	0.7	-0.9	-0.2	-0.3	0.8	0.7	-0.3	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	-0.1	-0.1	-0.8	0.2	0.7	0.5	0.8
Arm fat mass (left)	0.2	0.9	2.4	0.4	1.5	-0.3	0.8	1.3	-0.6	0.7
Alcohol drinker status: Never	0.2	0.2	0.7	0.1	0.8	0.7	-0.3	-0.4	-0.4	-0.1
Tanning	0.1	1.1	4.1	-2.0	-0.9	0.3	-0.8	-0.7	-1.1	0.5
Townsend deprivation index at recruitment	0.1	0.2	0.4	0.3	0.4	0.0	0.6	0.5	0.2	-0.5
Medication: Lansoprazole	0.1	0.1	0.4	-0.2	0.4	0.3	-0.6	0.2	0.2	0.5
Qualifications: College or University degree	0.1	0.3	0.7	0.8	-0.6	0.8	-0.1	-0.6	-0.1	-0.5
Medication: Ibuprofen	0.1	0.1	0.2	0.4	0.3	-0.3	-0.5	0.3	0.4	0.2

Hub : Genes

AKAP13

Models

Trait associations