Best TWAS P=1.03e-14 · Best GWAS P=2.37e-14 conditioned to 2.25e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PIP4K2B | 0.15 | 0.07 | lasso | 5 | 0.07 | 2.2e-06 | -7.5 | -6.6 | 4.2e-11 | 0.04 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Aorta | PSMB3 | 0.23 | 0.17 | enet | 26 | 0.22 | 2.1e-12 | -7.5 | -6.6 | 4.2e-11 | 0.03 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Tibial | PSMB3 | 0.10 | 0.02 | enet | 12 | 0.03 | 1.2e-03 | -7.5 | -6.8 | 8.2e-12 | 0.05 | 0.00 | 0.99 | FALSE |
| 4 | GTEx | Artery Tibial | PIP4K2B | 0.37 | 0.16 | enet | 49 | 0.22 | 2.1e-17 | -7.5 | -6.1 | 1.0e-09 | 0.04 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Esophagus Mucosa | CWC25 | 0.11 | 0.07 | enet | 7 | 0.05 | 1.5e-04 | -5.3 | -5.5 | 4.1e-08 | 0.01 | 0.30 | 0.58 | FALSE |
| 6 | GTEx | Testis | PSMB3 | 0.30 | 0.24 | lasso | 4 | 0.21 | 8.9e-10 | -7.5 | -7.7 | 1.0e-14 | 0.05 | 0.00 | 1.00 | TRUE |
| 7 | METSIM | Adipose | MSL1 | 0.12 | 0.06 | lasso | 10 | 0.06 | 1.8e-09 | 4.9 | -5.2 | 1.7e-07 | 0.30 | 0.99 | 0.00 | TRUE |
| 8 | METSIM | Adipose | PSMB3 | 0.04 | 0.02 | lasso | 5 | 0.01 | 2.3e-03 | -4.4 | -5.5 | 4.1e-08 | 0.01 | 0.14 | 0.35 | FALSE |
| 9 | NTR | Blood | PIP4K2B | 0.02 | 0.01 | lasso | 3 | 0.01 | 6.4e-04 | -7.5 | 7.4 | 1.0e-13 | -0.06 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PIP4K2B | 0.04 | 0.01 | blup | 56 | 0.03 | 6.3e-04 | -7.6 | -5.4 | 5.9e-08 | 0.09 | 0.00 | 0.95 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PSMB3 | 0.14 | 0.05 | blup | 42 | 0.05 | 8.9e-07 | -7.6 | -5.2 | 1.7e-07 | 0.05 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PIP4K2B | 0.05 | 0.04 | blup | 56 | 0.05 | 5.3e-06 | -5.7 | -6.1 | 1.2e-09 | 0.07 | 0.00 | 0.99 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMB3 | 0.11 | 0.07 | blup | 42 | 0.07 | 9.4e-08 | -7.5 | -5.4 | 6.6e-08 | 0.05 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PSMB3 | 0.12 | 0.09 | lasso | 3 | 0.06 | 3.0e-03 | -7.6 | -7.5 | 5.4e-14 | 0.06 | 0.00 | 0.94 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB3 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.4e-05 | -7.5 | -7.5 | 4.7e-14 | 0.05 | 0.00 | 1.00 | FALSE |