[Hub]/) : Traits : Trunk fat-free mass :

chr3:51,860,817-53,860,103

Best TWAS P=1.06e-15 · Best GWAS P=1.4e-12 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex NT5DC2 0.11 0.05 enet 22 0.04 5.0e-06 4.2 -5.6 2.8e-08 -0.47 0.36 0.56 FALSE
2 CommonMind Brain Pre-frontal Cortex RFT1 0.21 0.22 lasso 3 0.22 5.7e-26 5.7 6.1 1.1e-09 0.43 0.94 0.06 FALSE
3 GTEx Adipose Subcutaneous RFT1 0.21 0.19 enet 24 0.17 3.7e-14 5.7 5.6 2.4e-08 0.33 0.95 0.05 FALSE
4 GTEx Adipose Visceral Omentum RFT1 0.16 0.15 enet 12 0.10 1.0e-05 5.7 5.8 7.5e-09 0.33 0.93 0.05 FALSE
5 GTEx Artery Aorta RFT1 0.40 0.32 lasso 13 0.31 8.1e-18 5.7 -5.5 3.1e-08 -0.35 0.95 0.05 FALSE
6 GTEx Artery Coronary RFT1 0.38 0.33 lasso 5 0.34 2.6e-12 5.7 5.7 1.5e-08 0.36 0.94 0.06 FALSE
7 GTEx Artery Tibial RFT1 0.40 0.38 enet 22 0.40 8.2e-33 5.7 5.3 1.2e-07 0.30 0.95 0.05 FALSE
8 GTEx Breast Mammary Tissue (Male) RFT1 0.23 0.12 enet 8 0.13 5.5e-04 5.7 5.7 1.5e-08 0.35 0.10 0.13 FALSE
9 GTEx Breast Mammary Tissue (Female) RFT1 0.09 0.00 enet 15 0.00 2.8e-01 5.0 6.1 1.2e-09 0.39 0.05 0.11 FALSE
10 GTEx Cells Transformed fibroblasts RFT1 0.22 0.21 enet 16 0.22 2.8e-16 5.7 5.2 2.3e-07 0.33 0.95 0.05 FALSE
11 GTEx Colon Sigmoid RFT1 0.55 0.45 enet 15 0.43 1.0e-16 5.7 5.3 9.2e-08 0.31 0.95 0.05 FALSE
12 GTEx Colon Transverse RFT1 0.30 0.27 enet 16 0.24 8.0e-12 5.7 5.7 1.2e-08 0.38 0.95 0.05 FALSE
13 GTEx Esophagus Mucosa RFT1 0.24 0.24 enet 10 0.22 6.2e-15 5.7 6.6 4.8e-11 0.50 0.95 0.05 FALSE
14 GTEx Lung RFT1 0.24 0.23 enet 12 0.23 2.7e-17 5.7 5.6 2.8e-08 0.36 0.94 0.06 FALSE
15 GTEx Muscle Skeletal RFT1 0.17 0.16 enet 17 0.15 3.0e-14 5.7 6.0 2.5e-09 0.37 0.95 0.05 FALSE
16 GTEx Nerve Tibial RFT1 0.35 0.31 enet 17 0.27 1.9e-19 5.7 6.2 4.2e-10 0.44 0.95 0.05 FALSE
17 GTEx Nerve Tibial SFMBT1 0.21 0.10 enet 11 0.07 1.4e-05 5.7 -5.4 6.1e-08 -0.30 0.94 0.05 FALSE
18 GTEx Ovary RFT1 0.40 0.20 enet 29 0.17 6.6e-05 5.1 5.6 1.8e-08 0.47 0.33 0.20 FALSE
19 GTEx Pancreas RFT1 0.32 0.13 lasso 4 0.17 1.3e-07 7.1 5.9 2.9e-09 0.93 0.00 1.00 TRUE
20 GTEx Prostate RFT1 0.39 0.18 enet 17 0.24 1.1e-06 5.7 7.9 2.7e-15 0.68 0.09 0.85 TRUE
21 GTEx Skin Not Sun Exposed Suprapubic GNL3 0.07 0.06 lasso 4 0.06 4.5e-04 4.5 6.1 1.1e-09 0.73 0.06 0.79 FALSE
22 GTEx Skin Sun Exposed Lower leg RFT1 0.18 0.16 enet 7 0.13 1.1e-10 5.7 5.7 1.2e-08 0.35 0.95 0.05 FALSE
23 GTEx Small Intestine Terminal Ileum RFT1 0.20 0.20 enet 19 0.11 2.2e-03 5.7 5.2 2.4e-07 0.32 0.23 0.12 FALSE
24 GTEx Spleen RFT1 0.23 0.22 enet 7 0.13 3.6e-04 5.7 5.7 1.2e-08 0.35 0.24 0.11 FALSE
25 GTEx Stomach RFT1 0.23 0.03 enet 19 0.06 6.3e-04 5.7 7.5 6.3e-14 0.75 0.07 0.86 FALSE
26 GTEx Testis RFT1 0.20 0.12 enet 8 0.10 2.9e-05 5.7 5.7 1.2e-08 0.35 0.86 0.05 FALSE
27 METSIM Adipose RFT1 0.13 0.19 lasso 7 0.18 7.8e-27 5.7 5.7 1.4e-08 0.36 0.95 0.05 FALSE
28 YFS Blood ITIH4 0.63 0.34 enet 95 0.50 2.9e-192 6.9 -6.0 2.3e-09 -0.57 0.01 0.99 FALSE
29 YFS Blood TMEM110 0.11 0.08 lasso 9 0.09 3.8e-29 5.7 6.0 2.5e-09 0.73 0.77 0.23 FALSE
30 The Cancer Genome Atlas Bladder Urothelial Carcinoma RFT1 0.18 0.10 lasso 7 0.10 1.8e-08 6.6 6.7 2.1e-11 0.97 0.00 1.00 FALSE
31 The Cancer Genome Atlas Bladder Urothelial Carcinoma TMEM110 0.19 0.13 blup 59 0.13 4.2e-11 5.9 6.8 1.0e-11 0.84 0.08 0.92 FALSE
32 The Cancer Genome Atlas Breast Invasive Carcinoma GLT8D1 0.10 0.01 enet 7 0.03 4.4e-06 5.6 5.6 1.9e-08 0.45 0.00 0.96 TRUE
33 The Cancer Genome Atlas Breast Invasive Carcinoma RFT1 0.10 0.08 enet 11 0.15 2.3e-29 6.4 7.6 4.3e-14 0.80 0.03 0.97 FALSE
34 The Cancer Genome Atlas Breast Invasive Carcinoma TMEM110 0.13 0.09 lasso 3 0.10 5.9e-20 6.1 6.4 1.6e-10 0.82 0.37 0.63 FALSE
35 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma RFT1 0.14 0.08 enet 12 0.15 5.5e-08 6.6 7.5 6.2e-14 0.78 0.01 0.98 FALSE
36 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma TMEM110 0.24 0.09 blup 59 0.14 1.4e-07 5.9 6.0 2.5e-09 0.76 0.02 0.98 FALSE
37 The Cancer Genome Atlas Colon Adenocarcinoma RFT1 0.10 0.05 enet 12 0.05 1.0e-03 6.6 7.5 8.0e-14 0.87 0.01 0.94 FALSE
38 The Cancer Genome Atlas Colon Adenocarcinoma TMEM110 0.21 0.14 lasso 3 0.13 5.1e-08 5.2 5.2 2.1e-07 0.64 0.21 0.79 FALSE
39 The Cancer Genome Atlas Esophageal Carcinoma TMEM110 0.35 0.07 enet 18 0.21 3.2e-07 6.1 5.6 2.0e-08 0.72 0.05 0.87 FALSE
40 The Cancer Genome Atlas Glioblastoma Multiforme RFT1 0.20 0.14 enet 11 0.09 8.8e-04 5.7 7.0 1.9e-12 0.63 0.12 0.48 FALSE
41 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RFT1 0.14 0.10 lasso 4 0.12 8.4e-14 5.7 7.1 1.0e-12 0.62 0.57 0.43 FALSE
42 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TMEM110 0.27 0.10 blup 59 0.14 3.0e-15 5.7 6.6 5.3e-11 0.84 0.01 0.99 FALSE
43 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RFT1 0.15 0.21 lasso 8 0.22 1.4e-24 5.7 6.5 1.0e-10 0.49 0.56 0.44 FALSE
44 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TMEM110 0.29 0.16 lasso 6 0.17 1.8e-18 6.1 6.3 2.2e-10 0.78 0.40 0.60 FALSE
45 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RFT1 0.24 0.12 lasso 5 0.20 1.3e-11 6.4 7.3 2.8e-13 0.81 0.02 0.98 FALSE
46 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SPCS1 0.28 0.04 lasso 2 0.01 4.6e-02 5.6 5.4 5.8e-08 0.53 0.00 0.95 FALSE
47 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TMEM110 0.21 0.10 lasso 4 0.08 2.3e-05 5.9 6.4 1.9e-10 0.78 0.08 0.92 FALSE
48 The Cancer Genome Atlas Brain Lower Grade Glioma GLT8D1 0.22 0.08 lasso 1 0.07 8.5e-09 5.6 5.6 2.3e-08 0.54 0.00 1.00 TRUE
49 The Cancer Genome Atlas Brain Lower Grade Glioma NISCH 0.06 0.05 lasso 4 0.04 7.5e-06 5.9 5.9 4.4e-09 0.54 0.00 1.00 FALSE
50 The Cancer Genome Atlas Brain Lower Grade Glioma PBRM1 0.12 0.02 enet 7 0.04 2.1e-05 5.9 5.1 2.9e-07 0.51 0.00 0.99 FALSE
51 The Cancer Genome Atlas Brain Lower Grade Glioma RFT1 0.22 0.28 enet 13 0.31 2.5e-36 5.7 6.8 1.4e-11 0.62 0.59 0.41 FALSE
52 The Cancer Genome Atlas Brain Lower Grade Glioma SPCS1 0.15 0.03 lasso 3 0.04 4.3e-05 5.6 6.3 3.0e-10 0.58 0.00 0.96 FALSE
53 The Cancer Genome Atlas Brain Lower Grade Glioma TMEM110 0.13 0.06 blup 59 0.08 3.3e-09 3.1 5.8 7.1e-09 0.67 0.76 0.24 FALSE
54 The Cancer Genome Atlas Liver Hepatocellular Carcinoma RFT1 0.31 0.07 blup 45 0.19 1.8e-09 5.3 8.0 1.1e-15 0.86 0.02 0.98 FALSE
55 The Cancer Genome Atlas Liver Hepatocellular Carcinoma SFMBT1 0.17 0.08 lasso 2 0.06 5.5e-04 6.6 6.6 3.2e-11 0.97 0.02 0.94 FALSE
56 The Cancer Genome Atlas Lung Adenocarcinoma GNL3 0.20 0.07 lasso 3 0.07 1.0e-08 5.9 5.3 1.2e-07 0.54 0.00 1.00 FALSE
57 The Cancer Genome Atlas Lung Adenocarcinoma RFT1 0.14 0.11 blup 45 0.11 1.9e-12 6.4 7.1 9.0e-13 0.92 0.01 0.99 FALSE
58 The Cancer Genome Atlas Lung Adenocarcinoma SPCS1 0.11 0.00 blup 41 0.01 9.9e-03 -3.6 6.3 3.7e-10 0.36 0.01 0.39 TRUE
59 The Cancer Genome Atlas Lung Adenocarcinoma TMEM110 0.16 0.13 lasso 3 0.12 2.1e-14 6.1 6.1 7.9e-10 0.76 0.34 0.66 FALSE
60 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RFT1 0.07 0.03 enet 7 0.06 1.2e-07 6.0 7.7 1.5e-14 0.75 0.02 0.98 FALSE
61 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TMEM110 0.19 0.10 lasso 5 0.11 2.1e-12 6.1 5.9 3.7e-09 0.71 0.34 0.66 FALSE
62 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma GLT8D1 0.20 0.05 lasso 1 0.04 1.0e-03 5.6 5.6 2.3e-08 0.54 0.00 0.97 FALSE
63 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RFT1 0.21 0.10 lasso 6 0.23 1.9e-15 6.5 7.4 1.2e-13 0.82 0.01 0.99 FALSE
64 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma TMEM110 0.20 0.13 blup 59 0.15 3.0e-10 6.9 6.6 3.5e-11 0.82 0.00 1.00 FALSE
65 The Cancer Genome Atlas Pancreatic Adenocarcinoma RFT1 0.41 0.17 enet 12 0.16 2.4e-07 5.7 7.1 1.3e-12 0.66 0.27 0.71 FALSE
66 The Cancer Genome Atlas Pancreatic Adenocarcinoma TMEM110 0.36 0.05 blup 59 0.08 3.4e-04 6.1 6.0 2.5e-09 0.77 0.02 0.67 FALSE
67 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RFT1 0.23 0.09 blup 45 0.08 3.8e-04 5.0 6.4 1.8e-10 0.58 0.22 0.33 FALSE
68 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma TMEM110 0.26 0.09 lasso 4 0.09 1.6e-04 6.0 6.0 2.2e-09 0.74 0.14 0.70 FALSE
69 The Cancer Genome Atlas Prostate Adenocarcinoma RFT1 0.18 0.09 blup 45 0.09 4.8e-10 6.6 6.6 3.2e-11 0.93 0.01 0.99 TRUE
70 The Cancer Genome Atlas Prostate Adenocarcinoma SFMBT1 0.27 0.07 lasso 7 0.06 2.9e-07 6.5 6.0 2.0e-09 0.97 0.01 0.99 TRUE
71 The Cancer Genome Atlas Prostate Adenocarcinoma TMEM110 0.20 0.06 blup 59 0.10 1.2e-10 6.9 6.6 3.7e-11 0.83 0.00 1.00 FALSE
72 The Cancer Genome Atlas Soft Tissue Sarcoma RFT1 0.16 0.12 enet 16 0.14 1.7e-08 6.6 7.4 1.5e-13 0.90 0.00 0.99 FALSE
73 The Cancer Genome Atlas Soft Tissue Sarcoma TMEM110 0.12 0.07 blup 59 0.12 7.5e-08 6.8 6.1 1.2e-09 0.73 0.02 0.98 FALSE
74 The Cancer Genome Atlas Skin Cutaneous Melanoma RFT1 0.29 0.04 blup 45 0.11 8.2e-04 6.4 7.8 6.1e-15 0.79 0.01 0.86 FALSE
75 The Cancer Genome Atlas Skin Cutaneous Melanoma TMEM110 0.33 0.15 enet 10 0.16 4.6e-05 6.1 5.6 2.7e-08 0.57 0.03 0.65 FALSE
76 The Cancer Genome Atlas Stomach Adenocarcinoma RFT1 0.13 0.05 blup 45 0.10 6.9e-08 6.6 8.0 1.1e-15 0.85 0.01 0.99 TRUE
77 The Cancer Genome Atlas Stomach Adenocarcinoma TMEM110 0.19 0.12 blup 59 0.13 1.6e-09 6.0 6.4 1.9e-10 0.79 0.27 0.73 FALSE
78 The Cancer Genome Atlas Testicular Germ Cell Tumors RFT1 0.39 0.22 lasso 4 0.25 3.1e-09 6.5 6.9 4.2e-12 0.94 0.01 0.99 FALSE
79 The Cancer Genome Atlas Testicular Germ Cell Tumors TMEM110 0.20 0.01 lasso 2 0.09 3.2e-04 6.9 7.0 2.6e-12 0.97 0.00 0.90 FALSE
80 The Cancer Genome Atlas Thyroid Carcinoma TMEM110 0.09 0.00 blup 59 0.02 1.0e-02 5.2 5.4 8.7e-08 0.60 0.02 0.19 FALSE
81 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma RFT1 0.29 0.15 blup 45 0.15 6.5e-05 6.0 7.9 2.6e-15 0.85 0.01 0.87 FALSE