[Hub]/) : Traits : Trunk fat-free mass : ← →

chr3:51,860,817-53,860,103

Best TWAS P=1.06e-15 · Best GWAS P=1.4e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
76	The Cancer Genome Atlas	Stomach Adenocarcinoma	RFT1	0.13	0.05	blup	45	0.10	6.9e-08	6.6	8.0	1.1e-15	0.85	0.01	0.99	TRUE
20	GTEx	Prostate	RFT1	0.39	0.18	enet	17	0.24	1.1e-06	5.7	7.9	2.7e-15	0.68	0.09	0.85	TRUE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	RFT1	0.18	0.09	blup	45	0.09	4.8e-10	6.6	6.6	3.2e-11	0.93	0.01	0.99	TRUE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	SPCS1	0.11	0.00	blup	41	0.01	9.9e-03	-3.6	6.3	3.7e-10	0.36	0.01	0.39	TRUE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	SFMBT1	0.27	0.07	lasso	7	0.06	2.9e-07	6.5	6.0	2.0e-09	0.97	0.01	0.99	TRUE
19	GTEx	Pancreas	RFT1	0.32	0.13	lasso	4	0.17	1.3e-07	7.1	5.9	2.9e-09	0.93	0.00	1.00	TRUE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	GLT8D1	0.10	0.01	enet	7	0.03	4.4e-06	5.6	5.6	1.9e-08	0.45	0.00	0.96	TRUE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	GLT8D1	0.22	0.08	lasso	1	0.07	8.5e-09	5.6	5.6	2.3e-08	0.54	0.00	1.00	TRUE
54	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RFT1	0.31	0.07	blup	45	0.19	1.8e-09	5.3	8.0	1.1e-15	0.86	0.02	0.98	FALSE
81	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RFT1	0.29	0.15	blup	45	0.15	6.5e-05	6.0	7.9	2.6e-15	0.85	0.01	0.87	FALSE
74	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RFT1	0.29	0.04	blup	45	0.11	8.2e-04	6.4	7.8	6.1e-15	0.79	0.01	0.86	FALSE
60	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RFT1	0.07	0.03	enet	7	0.06	1.2e-07	6.0	7.7	1.5e-14	0.75	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	RFT1	0.10	0.08	enet	11	0.15	2.3e-29	6.4	7.6	4.3e-14	0.80	0.03	0.97	FALSE
35	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RFT1	0.14	0.08	enet	12	0.15	5.5e-08	6.6	7.5	6.2e-14	0.78	0.01	0.98	FALSE
25	GTEx	Stomach	RFT1	0.23	0.03	enet	19	0.06	6.3e-04	5.7	7.5	6.3e-14	0.75	0.07	0.86	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	RFT1	0.10	0.05	enet	12	0.05	1.0e-03	6.6	7.5	8.0e-14	0.87	0.01	0.94	FALSE
63	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RFT1	0.21	0.10	lasso	6	0.23	1.9e-15	6.5	7.4	1.2e-13	0.82	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Soft Tissue Sarcoma	RFT1	0.16	0.12	enet	16	0.14	1.7e-08	6.6	7.4	1.5e-13	0.90	0.00	0.99	FALSE
45	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RFT1	0.24	0.12	lasso	5	0.20	1.3e-11	6.4	7.3	2.8e-13	0.81	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	RFT1	0.14	0.11	blup	45	0.11	1.9e-12	6.4	7.1	9.0e-13	0.92	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RFT1	0.14	0.10	lasso	4	0.12	8.4e-14	5.7	7.1	1.0e-12	0.62	0.57	0.43	FALSE
65	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RFT1	0.41	0.17	enet	12	0.16	2.4e-07	5.7	7.1	1.3e-12	0.66	0.27	0.71	FALSE
40	The Cancer Genome Atlas	Glioblastoma Multiforme	RFT1	0.20	0.14	enet	11	0.09	8.8e-04	5.7	7.0	1.9e-12	0.63	0.12	0.48	FALSE
79	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM110	0.20	0.01	lasso	2	0.09	3.2e-04	6.9	7.0	2.6e-12	0.97	0.00	0.90	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RFT1	0.39	0.22	lasso	4	0.25	3.1e-09	6.5	6.9	4.2e-12	0.94	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM110	0.19	0.13	blup	59	0.13	4.2e-11	5.9	6.8	1.0e-11	0.84	0.08	0.92	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	RFT1	0.22	0.28	enet	13	0.31	2.5e-36	5.7	6.8	1.4e-11	0.62	0.59	0.41	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RFT1	0.18	0.10	lasso	7	0.10	1.8e-08	6.6	6.7	2.1e-11	0.97	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SFMBT1	0.17	0.08	lasso	2	0.06	5.5e-04	6.6	6.6	3.2e-11	0.97	0.02	0.94	FALSE
64	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMEM110	0.20	0.13	blup	59	0.15	3.0e-10	6.9	6.6	3.5e-11	0.82	0.00	1.00	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM110	0.20	0.06	blup	59	0.10	1.2e-10	6.9	6.6	3.7e-11	0.83	0.00	1.00	FALSE
13	GTEx	Esophagus Mucosa	RFT1	0.24	0.24	enet	10	0.22	6.2e-15	5.7	6.6	4.8e-11	0.50	0.95	0.05	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM110	0.27	0.10	blup	59	0.14	3.0e-15	5.7	6.6	5.3e-11	0.84	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RFT1	0.15	0.21	lasso	8	0.22	1.4e-24	5.7	6.5	1.0e-10	0.49	0.56	0.44	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM110	0.13	0.09	lasso	3	0.10	5.9e-20	6.1	6.4	1.6e-10	0.82	0.37	0.63	FALSE
67	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RFT1	0.23	0.09	blup	45	0.08	3.8e-04	5.0	6.4	1.8e-10	0.58	0.22	0.33	FALSE
47	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM110	0.21	0.10	lasso	4	0.08	2.3e-05	5.9	6.4	1.9e-10	0.78	0.08	0.92	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM110	0.19	0.12	blup	59	0.13	1.6e-09	6.0	6.4	1.9e-10	0.79	0.27	0.73	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM110	0.29	0.16	lasso	6	0.17	1.8e-18	6.1	6.3	2.2e-10	0.78	0.40	0.60	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPCS1	0.15	0.03	lasso	3	0.04	4.3e-05	5.6	6.3	3.0e-10	0.58	0.00	0.96	FALSE
16	GTEx	Nerve Tibial	RFT1	0.35	0.31	enet	17	0.27	1.9e-19	5.7	6.2	4.2e-10	0.44	0.95	0.05	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM110	0.16	0.13	lasso	3	0.12	2.1e-14	6.1	6.1	7.9e-10	0.76	0.34	0.66	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RFT1	0.21	0.22	lasso	3	0.22	5.7e-26	5.7	6.1	1.1e-09	0.43	0.94	0.06	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	GNL3	0.07	0.06	lasso	4	0.06	4.5e-04	4.5	6.1	1.1e-09	0.73	0.06	0.79	FALSE
9	GTEx	Breast Mammary Tissue (Female)	RFT1	0.09	0.00	enet	15	0.00	2.8e-01	5.0	6.1	1.2e-09	0.39	0.05	0.11	FALSE
73	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMEM110	0.12	0.07	blup	59	0.12	7.5e-08	6.8	6.1	1.2e-09	0.73	0.02	0.98	FALSE
68	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMEM110	0.26	0.09	lasso	4	0.09	1.6e-04	6.0	6.0	2.2e-09	0.74	0.14	0.70	FALSE
28	YFS	Blood	ITIH4	0.63	0.34	enet	95	0.50	2.9e-192	6.9	-6.0	2.3e-09	-0.57	0.01	0.99	FALSE
15	GTEx	Muscle Skeletal	RFT1	0.17	0.16	enet	17	0.15	3.0e-14	5.7	6.0	2.5e-09	0.37	0.95	0.05	FALSE
29	YFS	Blood	TMEM110	0.11	0.08	lasso	9	0.09	3.8e-29	5.7	6.0	2.5e-09	0.73	0.77	0.23	FALSE
36	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TMEM110	0.24	0.09	blup	59	0.14	1.4e-07	5.9	6.0	2.5e-09	0.76	0.02	0.98	FALSE
66	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM110	0.36	0.05	blup	59	0.08	3.4e-04	6.1	6.0	2.5e-09	0.77	0.02	0.67	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM110	0.19	0.10	lasso	5	0.11	2.1e-12	6.1	5.9	3.7e-09	0.71	0.34	0.66	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	NISCH	0.06	0.05	lasso	4	0.04	7.5e-06	5.9	5.9	4.4e-09	0.54	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM110	0.13	0.06	blup	59	0.08	3.3e-09	3.1	5.8	7.1e-09	0.67	0.76	0.24	FALSE
4	GTEx	Adipose Visceral Omentum	RFT1	0.16	0.15	enet	12	0.10	1.0e-05	5.7	5.8	7.5e-09	0.33	0.93	0.05	FALSE
12	GTEx	Colon Transverse	RFT1	0.30	0.27	enet	16	0.24	8.0e-12	5.7	5.7	1.2e-08	0.38	0.95	0.05	FALSE
22	GTEx	Skin Sun Exposed Lower leg	RFT1	0.18	0.16	enet	7	0.13	1.1e-10	5.7	5.7	1.2e-08	0.35	0.95	0.05	FALSE
24	GTEx	Spleen	RFT1	0.23	0.22	enet	7	0.13	3.6e-04	5.7	5.7	1.2e-08	0.35	0.24	0.11	FALSE
26	GTEx	Testis	RFT1	0.20	0.12	enet	8	0.10	2.9e-05	5.7	5.7	1.2e-08	0.35	0.86	0.05	FALSE
27	METSIM	Adipose	RFT1	0.13	0.19	lasso	7	0.18	7.8e-27	5.7	5.7	1.4e-08	0.36	0.95	0.05	FALSE
6	GTEx	Artery Coronary	RFT1	0.38	0.33	lasso	5	0.34	2.6e-12	5.7	5.7	1.5e-08	0.36	0.94	0.06	FALSE
8	GTEx	Breast Mammary Tissue (Male)	RFT1	0.23	0.12	enet	8	0.13	5.5e-04	5.7	5.7	1.5e-08	0.35	0.10	0.13	FALSE
18	GTEx	Ovary	RFT1	0.40	0.20	enet	29	0.17	6.6e-05	5.1	5.6	1.8e-08	0.47	0.33	0.20	FALSE
39	The Cancer Genome Atlas	Esophageal Carcinoma	TMEM110	0.35	0.07	enet	18	0.21	3.2e-07	6.1	5.6	2.0e-08	0.72	0.05	0.87	FALSE
62	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GLT8D1	0.20	0.05	lasso	1	0.04	1.0e-03	5.6	5.6	2.3e-08	0.54	0.00	0.97	FALSE
3	GTEx	Adipose Subcutaneous	RFT1	0.21	0.19	enet	24	0.17	3.7e-14	5.7	5.6	2.4e-08	0.33	0.95	0.05	FALSE
75	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TMEM110	0.33	0.15	enet	10	0.16	4.6e-05	6.1	5.6	2.7e-08	0.57	0.03	0.65	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NT5DC2	0.11	0.05	enet	22	0.04	5.0e-06	4.2	-5.6	2.8e-08	-0.47	0.36	0.56	FALSE
14	GTEx	Lung	RFT1	0.24	0.23	enet	12	0.23	2.7e-17	5.7	5.6	2.8e-08	0.36	0.94	0.06	FALSE
5	GTEx	Artery Aorta	RFT1	0.40	0.32	lasso	13	0.31	8.1e-18	5.7	-5.5	3.1e-08	-0.35	0.95	0.05	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SPCS1	0.28	0.04	lasso	2	0.01	4.6e-02	5.6	5.4	5.8e-08	0.53	0.00	0.95	FALSE
17	GTEx	Nerve Tibial	SFMBT1	0.21	0.10	enet	11	0.07	1.4e-05	5.7	-5.4	6.1e-08	-0.30	0.94	0.05	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM110	0.09	0.00	blup	59	0.02	1.0e-02	5.2	5.4	8.7e-08	0.60	0.02	0.19	FALSE
11	GTEx	Colon Sigmoid	RFT1	0.55	0.45	enet	15	0.43	1.0e-16	5.7	5.3	9.2e-08	0.31	0.95	0.05	FALSE
7	GTEx	Artery Tibial	RFT1	0.40	0.38	enet	22	0.40	8.2e-33	5.7	5.3	1.2e-07	0.30	0.95	0.05	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	GNL3	0.20	0.07	lasso	3	0.07	1.0e-08	5.9	5.3	1.2e-07	0.54	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM110	0.21	0.14	lasso	3	0.13	5.1e-08	5.2	5.2	2.1e-07	0.64	0.21	0.79	FALSE
10	GTEx	Cells Transformed fibroblasts	RFT1	0.22	0.21	enet	16	0.22	2.8e-16	5.7	5.2	2.3e-07	0.33	0.95	0.05	FALSE
23	GTEx	Small Intestine Terminal Ileum	RFT1	0.20	0.20	enet	19	0.11	2.2e-03	5.7	5.2	2.4e-07	0.32	0.23	0.12	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	PBRM1	0.12	0.02	enet	7	0.04	2.1e-05	5.9	5.1	2.9e-07	0.51	0.00	0.99	FALSE