TWAS hub - PBRM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.042	0.0210	2.4e-03	-0.001	0.014	0.004	0.018	0.001	4.0e-01	6.2e-03	8.2e-02	0.0024	2.5e-01
2	GTEx	Artery Tibial	0.163	0.0454	1.7e-15	0.205	NA	0.206	NA	0.206	5.9e-16	NA	4.8e-16	NA	5.0e-16
3	GTEx	Cells Transformed fibroblasts	0.032	0.0170	4.4e-03	0.040	NA	0.014	NA	0.018	5.2e-04	NA	2.7e-02	NA	1.6e-02
4	GTEx	Thyroid	0.185	0.0470	0.0e+00	0.329	NA	0.295	NA	0.311	7.0e-26	NA	6.8e-23	NA	2.7e-24
5	TCGA	Cervical Squamous Cell Carcinoma	0.409	0.1420	7.5e-03	-0.004	0.005	-0.003	NA	-0.002	5.9e-01	1.7e-01	4.6e-01	NA	4.1e-01
6	TCGA	Brain Lower Grade Glioma	0.124	0.0628	1.6e-04	0.023	0.037	0.040	NA	0.033	1.2e-03	4.7e-05	2.1e-05	NA	9.9e-05
7	TCGA	Thyroid Carcinoma	0.152	0.0560	3.7e-14	0.136	0.148	0.155	NA	0.148	4.0e-13	2.7e-14	7.0e-15	NA	2.9e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Worry (Nagel 2018)	11.0	23.2	49.8	-1.1	-5.5	7.1	-5.9	-0.4	0.8	-6.7
Waist Hip Ratio (WHR)	10.7	48.0	104.0	5.2	-7.1	10.2	-6.9	-3.0	-4.2	-9.0
Bipolar Disorder or Schizophrenia	8.3	20.3	43.5	0.2	-5.2	5.8	-5.8	2.0	0.1	-6.6
Intelligence (Savage-Jansen 2018)	7.8	24.0	42.2	3.3	6.4	-5.3	6.2	0.8	-2.6	6.5
Verbal and Numeric Reasoning (VNR)	7.5	18.0	33.9	2.1	5.7	-4.8	5.2	1.2	-1.8	5.8
Bipolar Disorder (2011)	7.5	7.3	24.0	-1.3	-3.7	3.4	-4.9	0.0	0.0	0.0
Nervous feelings	7.3	13.7	24.5	-0.2	-4.7	4.9	-4.8	0.0	1.0	-5.0
Impedance of whole body	7.1	36.1	90.1	2.6	-7.1	6.0	-7.7	3.1	-0.3	-9.5
Prospective memory result	6.7	8.2	14.8	-2.1	-3.9	3.4	-3.3	0.1	2.2	-3.3
Impedance of arm (left)	6.6	30.5	72.6	1.4	-6.5	5.3	-7.4	3.6	0.9	-8.5
Schizophrenia (2014)	6.4	14.1	33.5	0.3	-4.4	4.8	-4.7	1.0	-0.1	-5.8
Neuroticism	6.2	15.0	25.9	-2.7	-4.5	4.8	-5.1	0.4	2.5	-4.7
Impedance of arm (right)	6.1	28.6	69.7	2.0	-6.0	5.3	-7.2	3.2	0.8	-8.3
Worrier / anxious feelings	6.1	11.5	27.4	0.4	-3.6	4.8	-4.0	-0.2	0.4	-5.2
Suffer from ‘nerves’	6.1	9.7	16.2	-1.8	-4.0	3.8	-3.9	0.6	2.6	-3.3
Bipolar Disorder (2018)	5.7	9.0	17.8	0.8	-3.1	4.2	-4.0	1.2	0.0	-4.2
Neuroticism (Nagel 2018)	5.7	13.3	22.7	-2.5	-4.4	4.8	-4.4	-0.1	2.4	-4.4
Schizophrenia (2018)	5.5	11.5	25.8	-0.4	-4.3	4.0	-4.2	1.5	0.1	-5.1
Happiness	5.5	6.6	8.7	-3.0	-2.8	2.5	-2.8	1.5	2.8	-2.4
Headache pain in last month	5.5	9.5	17.1	-0.7	-4.0	4.0	-4.1	0.2	1.8	-3.7
Impedance of leg (left)	5.3	25.5	66.9	3.3	-5.8	5.1	-5.8	1.9	-1.8	-8.2
Smoking Status	4.9	11.7	22.3	1.3	4.0	-2.8	4.7	-1.8	-3.1	4.6
Age when periods started (menarche)	4.8	11.5	26.3	-1.4	3.2	-5.1	3.8	2.6	2.2	4.0
Frequency of tenseness / restlessness in last 2 weeks	4.7	7.3	16.4	-2.0	-3.1	4.0	-3.1	-0.7	1.6	-2.9
Impedance of leg (right)	4.6	22.5	60.7	3.2	-5.3	4.7	-5.4	1.9	-2.0	-7.8
Blood Red Count	4.5	43.6	92.2	-3.5	-8.4	8.0	-8.0	-1.7	-0.4	-9.6
Pulse rate	4.5	7.6	15.5	1.0	-3.3	3.9	-3.3	-1.2	-0.3	-3.7
LDL Cholesterol	4.4	6.9	15.6	2.2	2.9	-1.4	3.4	-0.9	-3.9	2.5
Height	4.4	84.8	169.0	-5.9	-10.5	8.5	-11.6	3.4	13.0	-7.8
Family relationship satisfaction	4.4	5.4	10.0	-1.0	-2.7	3.1	-3.2	-0.4	1.4	-2.8
Fluid intelligence score	4.3	8.9	15.9	2.2	3.9	-3.4	3.3	1.6	-1.4	4.0
Mouth/teeth dental problems: Bleeding gums	4.3	5.6	14.8	-0.2	-3.0	2.7	-2.7	0.4	-0.6	-3.9
Guilty feelings	4.3	6.5	12.7	-1.8	-3.6	3.0	-3.0	-0.1	2.0	-2.8
Wears glasses or contact lenses	4.3	5.0	10.5	-0.6	2.7	-3.2	2.4	1.6	0.7	2.7
Medication for cholesterol	4.2	6.3	17.9	-2.6	-2.4	0.5	-2.5	2.5	4.2	-1.2
BMI	4.1	23.7	57.9	-3.1	5.7	-5.1	6.0	-2.0	0.5	7.6
Standing height	4.1	40.3	76.9	-3.8	-7.6	5.9	-8.0	3.2	8.8	-5.0
Friendships satisfaction	4.0	5.0	8.5	-2.7	-2.5	2.3	-2.9	-0.1	2.1	-1.9
Ever smoked	3.9	6.8	13.8	0.6	3.2	-3.1	3.6	-0.2	-0.9	3.7
Major Depression (MDD)	3.8	4.6	9.6	-1.2	-2.7	2.2	-3.1	-0.6	1.1	-2.9
Neuroticism score	3.8	7.9	14.2	-1.9	-3.4	3.8	-3.5	-0.3	2.3	-2.9
Myopia	3.7	5.4	12.0	1.6	3.5	-2.4	2.4	1.5	-1.6	2.6
Neuroticism (2016)	3.6	5.2	11.4	-1.8	-2.6	3.4	-2.6	0.6	1.3	-2.5
Tense / ‘highly strung’	3.6	6.0	13.8	-1.4	-2.3	3.7	-3.1	0.4	0.9	-3.1
Comparative height size at age 10	3.6	19.7	36.1	-2.5	-5.3	5.0	-6.0	1.1	5.2	-3.6
Forced expiratory volume in 1-second (FEV1), predicted	3.6	7.4	14.6	-1.8	-3.7	2.0	-3.8	0.7	3.4	-2.1
Basal cell carcinoma (self-reported)	3.6	4.3	10.9	-0.2	-2.3	3.3	-2.3	0.3	0.0	-2.9
Migraine (self-reported)	3.5	4.3	6.7	-2.5	-2.6	1.3	-2.5	0.8	1.8	-2.3
HDL Cholesterol	3.4	5.7	15.0	-2.4	0.2	-2.0	-0.4	3.7	3.9	1.1
Mood swings	3.4	6.2	11.0	-2.9	-2.8	2.5	-2.8	-0.3	3.3	-1.6
Sitting height	3.3	23.6	59.1	-4.4	-5.5	3.7	-6.0	0.7	7.7	-2.4
Ever highly irritable/argumentative for 2 days	3.3	4.0	7.7	0.9	2.7	-1.8	2.5	-0.4	-1.3	2.8
Stomach or abdominal pain in last month	3.2	4.0	9.2	0.1	-2.4	3.0	-2.0	-1.0	0.1	-2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	3.2	4.2	10.1	-0.6	-2.3	3.2	-2.5	-0.7	0.5	-2.5
Ever used hormone-replacement therapy (HRT)	3.1	3.9	10.5	2.4	0.9	1.8	1.2	-2.4	-3.2	0.2
Relative age voice broke	3.1	4.7	7.9	2.0	2.7	-2.8	2.7	0.1	-1.1	2.2
Body mass index (BMI)	3.1	13.2	29.2	-2.0	4.3	-3.4	4.6	-2.6	-1.0	5.4
Past tobacco smoking	3.1	5.8	11.7	-0.8	-2.8	2.6	-3.3	0.6	1.4	-3.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.1	4.7	9.8	-1.0	-2.8	2.8	-3.1	-0.1	0.5	-2.6
Average weekly champagne plus white wine intake	3.1	4.2	7.4	0.9	2.7	-2.6	2.6	1.4	-0.4	2.4
Depression (Nagel 2018)	3.0	4.5	8.3	-1.1	-2.6	2.7	-2.9	1.2	0.5	-2.5
Pulse rate, automated reading	3.0	9.6	15.8	3.1	-2.2	4.0	-2.1	-2.1	-3.6	-3.8
Diabetes diagnosed by doctor	3.0	4.9	9.5	1.3	2.6	-2.0	3.1	-1.5	-2.0	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	9.1	-1.8	-1.6	1.9	-1.9	0.9	3.0	-1.4
Systolic blood pressure, automated reading	2.9	8.3	16.2	0.5	3.2	-4.0	3.5	-2.7	-0.7	3.4
Gout (self-reported)	2.9	3.9	8.7	-1.5	-2.9	2.6	-1.6	-1.6	0.6	-2.1
Hearing aid user	2.9	3.2	6.1	-0.8	1.6	-1.7	2.2	-2.2	-0.9	2.5
Age at First Birth	2.8	4.1	8.3	-0.2	2.3	-2.5	2.5	1.5	0.3	2.9
Frequency of depressed mood in last 2 weeks	2.8	3.9	9.4	-1.3	-2.5	3.1	-2.5	0.5	1.2	-1.6
Glaucoma (self-reported)	2.8	3.3	7.1	1.4	-1.2	2.4	-1.3	-2.2	-0.6	-2.7
Wheeze or whistling in the chest in last year	2.8	5.0	9.6	-1.7	-3.1	2.9	-2.6	-0.5	1.5	-2.2
Depressed Affect (Nagel 2018)	2.7	5.7	11.9	-3.3	-2.7	1.7	-2.3	-0.4	3.4	-1.4
Type 2 Diabetes (T2D) (2012)	2.7	3.1	6.5	1.3	-2.1	2.6	-1.2	-1.8	-1.1	-1.8
Loneliness, isolation	2.7	3.7	9.2	-3.0	-2.2	0.9	-1.8	1.1	2.4	-0.8
Ulcerative Colitis	2.6	3.7	5.7	-1.9	-2.3	2.3	-2.4	0.1	0.8	-2.4
Number of incorrect matches in round	2.6	4.2	7.6	-1.2	-2.2	1.7	-2.7	2.0	1.4	-2.8
Pulse wave reflection index	2.6	3.2	8.3	0.1	2.9	-1.9	1.9	0.0	-0.1	2.5
Chest pain or discomfort	2.6	3.8	6.8	-1.0	-2.6	2.5	-2.3	0.2	0.7	-2.6
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	14.1	-0.3	-2.4	3.8	-1.8	-1.1	0.7	-1.7
Illness, injury, bereavement, stress in last 2 years	2.5	3.1	8.8	-1.3	1.0	-3.0	1.5	1.7	0.9	2.0
Medication: Bendroflumethiazide	2.5	3.8	6.7	1.3	2.2	-1.7	2.6	-1.4	-1.5	2.6
Systolic Blood Pressure	2.4	12.2	18.8	2.5	4.3	-4.3	4.2	-2.0	-2.2	3.8
Medication: Paracetamol	2.4	4.0	11.0	2.0	-2.2	3.3	-1.6	-1.5	-0.0	-1.8
Tinnitus: Yes, now most or all of the time	2.4	2.8	5.8	-0.6	-2.3	2.0	-2.0	0.6	0.2	-2.4
Medication: Blood pressure	2.4	4.6	8.0	1.6	2.8	-1.6	2.5	-1.7	-2.4	2.1
Pulse wave peak to peak time	2.3	2.7	5.5	-1.3	-2.4	1.4	-1.7	1.4	1.6	-1.5
Eye problems/disorders: None of the above	2.3	2.7	3.5	1.5	1.8	-1.6	1.8	1.1	-1.8	1.9
Triglycerides	2.2	3.7	8.7	1.9	-0.8	1.9	-0.2	-3.0	-2.9	-0.7
Blood Platelet Count	2.2	25.1	39.8	5.2	5.8	-6.3	6.2	-1.5	-3.6	4.7
Chronotype (morning person)	2.2	5.2	25.2	0.4	1.1	0.3	1.9	-5.0	-1.5	1.9
Mother’s age at death	2.2	2.7	6.6	-1.6	-1.5	-0.7	-1.2	2.6	2.0	-1.2
Lung FEV1/FVC ratio	2.1	10.9	27.0	1.0	5.2	-3.8	4.1	1.2	-1.3	3.7
Medication for hormone replacement therapy	2.1	2.3	6.5	1.9	0.2	0.8	0.5	-2.2	-2.5	-0.3
Pack years adult smoking proportion	2.1	3.2	5.4	-1.8	-2.2	2.3	-1.1	-1.9	-1.1	-1.8
Medication: Amlodipine	2.1	2.9	5.5	1.2	1.8	-1.3	2.3	-2.0	-1.1	1.9
Eye problems/disorders: Cataract	2.1	2.4	4.0	-1.6	-1.4	1.1	-1.9	0.8	1.8	-2.0
Number of treatments/medications taken	2.0	3.6	6.3	1.3	2.3	-0.3	2.5	-2.4	-1.4	2.0
Diabetes (self-reported)	2.0	3.0	6.3	0.8	2.0	-1.9	2.5	-0.6	-1.4	2.0
Depression (self-reported)	2.0	2.4	7.3	0.0	-1.1	2.7	-1.8	-0.1	1.2	-1.9
Hypertension (Self-reported)	2.0	5.5	12.7	0.7	3.6	-2.6	3.1	-0.9	-1.1	2.5
Time employed in main current job	1.9	2.2	7.2	2.7	1.3	-0.6	0.7	-1.3	-1.9	0.6
Medication: Blood pressure	1.9	3.4	6.5	-0.9	2.4	-2.6	2.0	1.0	0.7	2.1
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	4.0	-1.3	-1.7	2.0	-1.8	0.1	1.3	-1.8
Fasting Glucose	1.8	2.1	6.6	2.1	0.5	0.6	0.5	-2.6	-1.8	0.3
Multivitamins +/- minerals	1.8	2.3	5.3	0.4	1.7	-2.0	1.7	0.9	0.5	2.3
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	6.9	0.5	-2.6	2.1	-2.2	0.2	-0.4	-2.2
Comparative body size at age 10	1.8	5.0	13.0	1.3	2.7	-2.1	2.6	-0.0	-1.3	3.6
Medication: Allopurinol	1.8	2.4	4.2	-1.0	-2.1	1.9	-1.1	-1.9	0.4	-1.7
Mineral and other dietary supplements	1.8	2.4	6.9	-0.9	-1.8	0.7	-2.0	1.2	-0.1	-2.6
Pain type(s) experienced in last month: Hip pain	1.8	2.3	6.7	1.7	1.2	1.4	0.6	-1.7	-2.6	-0.0
Cardiovascular Disease	1.7	5.5	11.9	1.8	3.4	-1.6	3.1	-1.0	-1.5	2.8
Type 2 Diabetes (T2D) (2018)	1.7	3.2	5.5	1.5	1.8	-1.7	2.4	-1.5	-1.6	1.8
Average weekly spirits intake	1.7	2.1	5.2	1.1	1.9	-1.5	1.5	0.3	0.7	2.3
High blood pressure	1.7	4.8	11.4	0.8	3.4	-2.5	2.8	-1.1	-0.7	2.3
Hearing difficulty/problems with background noise	1.7	2.8	6.4	-1.1	-2.5	2.5	-1.7	-0.1	0.1	-1.7
Heart attack	1.7	2.1	5.1	0.2	1.8	-2.3	1.5	0.5	-1.8	0.7
Allergy	1.7	3.8	8.0	0.6	2.8	-2.3	2.7	-0.4	-0.3	2.3
Alcohol intake versus 10 years previously	1.7	2.6	6.0	0.8	2.0	-2.5	2.0	0.0	-0.0	1.9
Medication: Cholesterol lowering	1.7	2.7	6.6	0.0	2.6	-1.7	2.4	-0.3	-0.4	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	4.0	0.3	-0.9	1.0	-2.0	2.0	1.1	-1.7
Supplements: Fish oil (including cod liver oil)	1.7	2.2	5.8	0.4	1.9	-0.8	2.0	-1.0	0.5	2.4
Primary Biliary Cirrhosis	1.6	2.2	4.6	0.9	1.7	-1.6	2.1	0.0	-1.0	2.0
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	6.5	2.5	0.2	1.0	0.3	-1.2	-2.0	-0.5
Serious illness, injury or assault to yourself	1.6	1.9	4.3	1.9	-0.5	2.1	-0.7	-1.5	-1.1	-1.2
Medication: Atenolol	1.6	2.0	5.0	0.9	2.2	-1.4	1.7	0.2	-1.7	0.6
Blood clot in the leg (DVT)	1.6	2.1	3.6	-1.2	-1.5	1.9	-1.6	0.4	1.2	-1.8
Medication: Lisinopril	1.6	2.0	3.2	0.2	1.7	-1.2	1.6	-1.7	-1.8	1.1
Pack years of smoking	1.6	2.4	4.4	-2.1	-1.9	1.7	-0.9	-1.3	-0.9	-1.6
High blood pressure (mother)	1.5	2.1	6.2	1.0	-0.5	2.5	-0.8	-2.2	-0.8	-1.1
Hip circumference	1.5	6.5	15.5	-3.1	2.4	-2.6	2.4	-0.1	1.4	3.9
Trunk predicted mass	1.5	8.4	26.8	-4.3	0.3	-0.3	0.6	-0.4	5.2	3.5
Shortness of breath walking on level ground	1.5	1.7	4.1	-1.7	-1.4	1.1	0.1	-2.0	1.3	0.6
Had major operations	1.5	1.7	4.2	2.0	1.9	-0.9	1.4	0.8	-0.8	0.2
Illnesses of father: Heart disease	1.5	2.1	5.5	0.6	2.3	-0.8	1.6	-0.4	-2.4	0.4
Smoking status: Current	1.5	2.3	4.2	0.5	1.7	-1.2	1.9	-0.5	-1.8	2.0
Vascular/heart problems diagnosed by doctor	1.5	4.1	10.9	-0.8	-3.3	2.3	-2.5	0.9	0.7	-2.0
Heart attack/myocardial infarction (self-reported)	1.5	1.9	4.0	0.3	1.7	-1.9	1.4	0.6	-2.0	0.4
Hand grip strength (left)	1.4	3.7	9.4	-0.6	-1.9	1.1	-2.9	0.3	3.1	-1.7
Leg fat-free mass (left)	1.4	7.2	19.6	-4.0	0.9	-0.8	0.8	-0.5	4.4	3.6
Medication: Levothyroxine sodium	1.4	2.4	6.4	-2.5	1.0	-2.2	1.0	1.7	0.7	0.4
Leg predicted mass (left)	1.4	7.3	20.0	-4.0	0.9	-0.8	0.8	-0.4	4.5	3.6
Trunk fat-free mass	1.4	8.2	26.3	-4.3	0.3	-0.3	0.6	-0.4	5.1	3.5
Falls in the last year	1.4	1.9	5.7	0.7	-0.1	1.1	0.5	-2.3	-2.4	0.3
Illnesses of mother	1.4	1.7	4.6	0.0	1.1	-2.1	1.2	1.6	-0.1	1.5
Breastfed as a baby	1.4	1.7	3.9	-0.8	1.5	-2.0	1.2	1.2	0.4	1.5
Birth weight	1.4	3.1	10.1	-1.4	-1.8	1.3	-1.6	1.3	3.2	0.0
Number of full brothers	1.4	1.8	2.9	0.7	1.5	-1.4	1.5	1.4	-0.7	1.7
Worry too long after embarrassment	1.4	2.4	8.0	1.3	-1.2	2.8	-1.4	-0.3	-1.6	-1.1
Smoking status: Previous	1.4	2.1	4.7	0.6	1.7	-1.2	2.1	-0.5	-0.8	2.2
Whole body fat-free mass	1.4	8.1	24.5	-4.3	0.4	-0.4	0.6	-0.6	5.0	3.5
Long-standing illness, disability or infirmity	1.4	2.2	4.8	1.3	1.2	0.4	1.3	-2.1	-2.2	1.1
Whole body water mass	1.4	8.1	24.1	-4.1	0.6	-0.4	0.7	-0.8	4.9	3.7
Medication: Atorvastatin	1.4	1.7	2.7	1.6	1.5	-1.1	1.6	0.6	-1.6	0.5
Blood Eosinophil Count	1.3	10.4	22.9	1.0	2.6	-3.0	4.4	-3.2	-1.8	4.8
Average weekly fortified wine intake	1.3	1.5	4.9	-1.2	-0.4	0.1	-1.6	0.8	2.2	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.7	-1.1	-1.9	1.9	-1.5	0.5	0.8	-0.8
Qualifications: CSEs or equivalent	1.3	1.8	3.5	-1.7	-1.9	0.9	-1.9	-0.1	0.9	-1.0
Pulse wave Arterial Stiffness index	1.3	1.5	3.5	0.9	1.9	-1.0	1.1	-1.2	-0.9	1.2
Arm fat-free mass (right)	1.3	6.8	17.5	-3.9	0.4	-0.6	0.9	-1.1	4.2	3.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	3.0	0.2	1.4	-1.6	1.4	-0.5	-1.7	1.2
Arm predicted mass (right)	1.3	6.8	17.0	-4.0	0.6	-0.7	1.0	-0.8	4.1	3.5
Leg fat-free mass (right)	1.3	7.1	21.5	-3.9	0.6	-0.4	0.5	-0.6	4.6	3.4
Leg predicted mass (right)	1.3	7.0	20.5	-4.0	0.6	-0.4	0.6	-0.6	4.5	3.4
Eye problems/disorders: Glaucoma	1.3	1.6	4.0	0.8	-1.2	1.3	-0.9	-1.6	-0.1	-2.0
Basal metabolic rate	1.3	7.1	20.2	-4.1	0.5	-0.3	0.7	-0.9	4.5	3.4
Arm fat-free mass (left)	1.3	6.7	17.8	-3.8	0.7	-0.3	0.9	-1.4	4.2	3.4
Rheumatoid Arthritis	1.2	1.7	4.2	-0.1	1.2	-2.1	1.8	0.2	-0.2	1.7
Lung FVC	1.2	6.1	14.9	1.0	2.7	-2.1	3.9	0.3	-3.1	2.5
Hand grip strength (right)	1.2	3.3	11.5	-1.0	-1.3	-0.0	-2.4	1.2	3.4	-1.4
Fed-up feelings	1.2	2.1	3.8	-1.5	-1.9	1.6	-0.9	-1.2	2.0	-0.6
Forced vital capacity (FVC)	1.2	4.8	8.4	-1.9	-2.9	2.6	-2.3	0.6	2.6	-1.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.7	1.7	-0.5	1.9	-1.0	-0.5	-0.1	-1.3
Forced vital capacity (FVC), Best measure	1.2	4.2	6.9	-1.3	-2.6	2.6	-2.3	0.8	2.6	-1.4
Knee pain experienced in last month	1.2	1.9	5.5	1.6	1.3	0.1	1.2	-1.4	-2.3	0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	5.8	0.8	0.6	0.6	0.5	-2.4	-1.1	0.6
Age started oral contraceptive pill	1.2	1.5	4.3	-1.3	-0.1	-0.5	-0.2	2.1	2.0	-0.2
Commuting to job workplace: Cycle	1.2	1.5	3.8	-0.7	1.7	-1.9	1.5	-0.1	0.2	0.9
Arm predicted mass (left)	1.2	6.4	14.4	-3.5	0.9	-0.5	1.1	-1.4	3.8	3.6
Prostate Cancer	1.1	1.5	2.7	-0.9	-0.8	1.6	-1.2	0.9	1.3	-1.6
Vitamin and mineral supplements	1.1	1.5	2.5	-0.5	-1.5	1.2	-1.2	-1.3	-1.0	-1.6
Severe depression (siblings)	1.1	1.2	2.4	1.4	-0.7	1.5	-1.0	0.7	-0.6	-1.3
Mouth/teeth dental problems	1.1	1.6	5.6	1.5	2.4	-0.8	1.2	-0.0	-0.2	1.1
Pain all over the body in last month	1.1	1.2	2.8	-0.7	-1.2	1.7	-1.3	0.4	-0.0	-1.4
Medication: Lansoprazole	1.1	1.3	3.2	1.8	-0.4	1.7	-0.2	-1.0	-1.0	-0.8
Leg fat percentage (right)	1.1	4.0	6.2	-0.0	2.5	-1.8	2.5	-1.9	-2.3	2.0
Qualifications: College or University degree	1.1	3.4	8.0	-0.2	-1.1	2.3	-2.2	2.8	0.7	-1.9
Emphysema/chronic bronchitis	1.1	1.2	3.5	-1.9	-1.5	0.0	-0.7	0.9	0.4	-1.0
Medication for pain relief, constipation, heartburn	1.1	2.0	8.2	-1.0	1.0	-2.9	0.8	1.5	-0.5	0.8
Qualifications: nursing, teaching	1.1	1.8	5.1	1.8	2.3	-0.0	0.6	1.6	-0.9	0.6
Back pain experienced in last month	1.1	1.7	4.1	0.5	1.1	-1.2	1.9	-0.7	-0.8	2.0
High cholesterol (Self-reported)	1.1	2.0	4.1	0.0	1.6	-1.1	2.0	-1.9	-0.4	1.7
Medication: Paracetamol	1.1	1.7	5.0	0.9	-1.7	2.2	-0.7	-1.4	0.5	-0.6
Fractured/broken bones in last 5 years	1.1	1.5	3.2	0.6	1.5	-1.8	1.0	0.4	-1.0	1.6
Blood White Count	1.0	7.5	22.0	3.0	1.0	0.5	1.3	-4.3	-4.7	0.4
Sensitivity / hurt feelings	1.0	1.7	4.2	0.9	-1.3	1.5	-1.7	-0.6	-0.4	-2.0
Ever had hysterectomy (womb removed)	1.0	1.2	4.4	1.0	0.4	0.5	0.9	-1.1	-2.1	0.5
Current tobacco smoking	1.0	1.6	3.0	0.6	1.3	-0.5	1.6	-0.5	-1.7	1.7
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.0	0.6	-1.9	1.9	-2.0	-0.8	-0.5	-1.8
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.5	-0.3	-1.3	1.6	-1.2	-0.7	-0.6	-1.5
Weight	1.0	4.7	12.4	-3.5	0.8	-0.6	0.8	-1.1	3.0	3.0
Length of working week for main job	1.0	1.1	3.0	-1.7	-0.1	-0.9	0.1	0.5	1.7	0.8
Exposure to tobacco smoke at home	1.0	1.1	3.7	-1.2	-0.5	-0.5	-0.9	1.9	1.2	-0.4
Hair/balding pattern: Pattern 4	1.0	2.3	5.9	1.1	2.4	-1.4	1.7	-0.9	-0.8	1.6
Overall health rating	1.0	2.1	5.8	0.3	-1.2	2.1	-0.7	-2.4	-0.6	-1.3
Commuting to job workplace: Walk	1.0	1.1	3.4	1.7	0.4	-0.1	0.5	-1.0	-1.9	-0.2
Osteoarthritis (self-reported)	1.0	1.3	4.8	1.1	1.0	1.0	0.8	-2.2	-0.6	-0.1
Leg fat percentage (left)	1.0	3.7	5.5	-0.1	2.4	-1.6	2.3	-2.1	-2.0	1.9
Risk taking	1.0	1.5	6.6	0.7	-0.7	2.6	-0.7	-0.8	-0.2	-1.2
Alzheimer’s Disease (in father)	0.9	0.9	2.2	-1.3	-0.7	-0.5	-0.8	1.0	1.5	-0.5
HbA1C	0.9	0.9	4.7	-0.9	-0.3	-0.3	0.1	-2.2	0.9	-0.2
Tanning	0.9	10.5	21.4	-0.3	4.1	-3.8	4.4	-0.2	-0.4	4.6
Alcohol usually taken with meals	0.9	1.5	3.2	0.6	-1.4	1.5	-1.5	0.9	-0.0	-1.8
Had other major operations	0.9	1.0	3.3	1.8	1.1	0.7	0.4	0.0	-1.4	0.2
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.2	-0.8	-1.5	0.8	-1.0	0.6	1.1	-1.3
Medication: Ibuprofen	0.9	1.1	3.1	0.8	1.5	-0.5	1.2	-0.0	0.3	1.8
Illnesses of siblings: Diabetes	0.9	1.1	2.4	-0.6	1.0	-1.2	1.0	1.6	-0.3	1.1
Arm fat mass (left)	0.9	3.5	7.7	-2.6	1.8	-1.1	1.6	-1.6	0.9	2.8
Alcohol drinker status: Previous	0.9	1.0	3.7	-1.3	0.0	1.1	0.4	-0.3	-1.9	-0.1
Breast Cancer	0.8	1.8	4.2	0.9	1.5	-1.6	1.3	0.9	-0.6	2.0
Coronary Artery Disease (CAD)	0.8	1.0	5.0	-0.4	0.8	-0.2	0.8	-2.2	-0.6	0.5
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.4	1.8	-0.0	0.6	0.1	-0.4	-1.6	-0.6
Qualifications: A levels/AS levels or equivalent	0.8	1.9	3.8	0.3	1.9	-1.7	0.9	2.0	-0.0	1.4
Arm fat mass (right)	0.8	3.4	7.6	-2.4	1.9	-1.2	1.6	-1.5	0.9	2.8
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.0	-0.8	-1.4	1.1	-1.0	-0.4	0.6	-1.0
Medication: Omeprazole	0.8	1.0	2.7	0.7	0.0	1.6	0.6	-1.7	-0.9	0.1
Leg fat mass (right)	0.8	3.3	7.6	-1.8	2.0	-1.3	2.0	-1.6	0.0	2.8
Illnesses of father: High blood pressure	0.8	1.0	3.1	-0.7	0.9	-1.8	0.9	-0.4	1.0	0.5
Number of operations (self-reported)	0.8	1.2	4.6	2.1	1.3	0.8	0.1	0.6	-1.1	-0.3
Irritability	0.8	1.3	4.7	-2.2	0.6	-0.5	0.5	0.3	1.2	1.5
Diastolic blood pressure, automated reading	0.8	2.5	11.0	0.1	-1.2	1.1	-1.2	-3.3	-0.9	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.4	0.7	0.1	1.9	0.5	-1.4	-0.9	-0.1
Leg fat mass (left)	0.8	3.2	7.2	-1.8	1.9	-1.2	1.9	-1.8	0.2	2.7
Irritable Bowel Disease (IBD)	0.7	1.8	4.2	-0.9	-1.4	2.0	-1.3	1.2	0.1	-1.5
Ulcerative Colitis (UC)	0.7	1.3	2.9	-0.6	-1.7	1.7	-1.3	0.2	-0.1	-1.2
Respiratory disease	0.7	1.5	3.0	-1.4	-1.7	0.2	-1.4	0.8	1.5	-0.6
Angina	0.7	0.9	1.8	-0.9	0.8	-0.9	0.9	1.3	0.5	1.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.6	0.1	-0.9	1.6	-0.7	-0.8	0.3	-0.7
Hair/balding pattern: Pattern 2	0.7	0.9	4.1	-0.7	0.6	-0.7	0.4	0.8	2.0	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.6	0.5	1.2	-0.8	2.2	-1.1	-1.8	0.4
Hair/balding pattern: Pattern 3	0.7	1.0	1.6	1.0	1.2	-0.3	1.2	-0.2	-1.3	1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.5	4.9	-2.2	0.7	-1.7	0.7	1.0	0.7	0.1
Health satisfaction	0.7	0.9	4.6	0.1	-0.1	1.2	0.5	-2.2	-0.4	0.3
Neck or shoulder pain in last month	0.7	1.0	1.8	1.1	-0.5	1.3	-0.2	-1.2	-1.1	-1.0
Heart disease (mother)	0.7	0.8	2.2	1.5	0.6	0.2	0.8	-1.2	-1.0	0.0
Alcohol intake frequency.	0.7	1.6	3.8	-0.6	-1.9	1.5	-1.2	-1.4	-0.4	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.1	0.5	-0.2	0.6	-0.1	0.7	-1.8	-1.2
Average weekly beer plus cider intake	0.7	1.0	2.5	-1.4	-0.6	-0.8	-0.9	1.6	0.1	-0.9
Alzheimer’s Disease (including proxy)	0.6	0.9	2.0	-1.3	-0.7	0.2	-1.4	0.8	0.9	-0.6
Ovarian Cancer	0.6	0.8	1.4	0.9	-0.3	0.9	-0.9	-0.4	-1.2	-1.1
Body Mass Index (BMI) (2010)	0.6	0.8	2.2	-1.2	0.7	-0.4	1.0	0.6	-0.1	1.5
Crohns Disease (2012)	0.6	0.9	3.4	-0.1	-0.5	1.2	-0.7	1.8	0.2	-1.0
Mean Putamen Volume	0.6	0.6	1.3	0.6	-0.7	0.8	-1.1	0.8	0.5	-0.9
Hypothyroidism (self reported)	0.6	1.3	4.6	-2.1	0.9	-1.7	0.8	0.4	0.6	0.1
Medication: Metformin	0.6	0.8	1.9	0.4	0.8	-1.2	1.4	0.3	-0.3	1.2
Diabetes (mother)	0.6	0.8	1.7	1.0	-0.4	0.9	-0.9	0.3	-1.1	-1.3
Maternal smoking around birth	0.6	0.8	1.9	0.1	-1.1	0.8	-0.5	-0.2	-1.4	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	4.2	-0.2	1.0	-0.7	2.1	-1.0	-1.6	0.6
Had menopause	0.6	0.8	2.1	0.1	1.0	-0.5	1.4	0.1	-1.2	0.9
Qualifications: None of the above	0.6	1.4	2.5	-1.6	-0.6	-1.0	0.8	-1.3	1.6	0.9
Arm fat percentage (right)	0.6	2.3	4.6	-1.2	2.2	-1.3	1.6	-1.1	-0.3	2.1
Peak expiratory flow (PEF)	0.6	1.3	4.0	-1.7	-0.8	-0.1	-0.8	1.0	2.0	0.2
Angina (self-reported)	0.6	0.8	1.4	-1.0	0.8	-0.9	1.0	1.2	0.2	0.9
Breast cancer (self-reported)	0.6	0.8	2.3	1.2	0.6	0.6	0.2	-0.9	-1.5	-0.1
Illnesses of father: None of the above (group 1)	0.6	0.8	2.3	0.5	-1.1	1.5	-0.9	-0.6	0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.3	1.2	1.3	-0.5	1.2	1.0	-1.5	-0.2
Crohns Disease (2017)	0.5	1.0	2.4	-1.2	-0.7	1.2	-0.6	1.5	0.7	-0.8
Hearing difficulty/problems: Yes	0.5	0.8	2.6	-0.7	-1.2	0.9	0.2	-1.6	-0.2	0.0
Medication: Co-codamol	0.5	0.6	1.8	1.2	0.0	0.3	0.4	-0.3	-1.3	-0.6
Townsend deprivation index at recruitment	0.5	0.7	2.7	-0.2	0.4	-0.4	1.3	-0.5	-0.1	1.6
Supplements: Glucosamine	0.5	0.7	2.5	-0.1	0.6	0.0	1.0	-1.6	0.2	1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.7	-0.1	-0.2	1.3	0.1	-0.2	-1.6	-0.0
Medication: Ramipril	0.5	0.6	1.4	-1.1	0.7	-1.2	0.8	0.0	-0.0	0.7
Medication: Simvastatin	0.5	0.7	1.9	0.3	1.4	-0.6	1.0	-1.1	-0.5	0.7
Number of live births	0.5	0.7	3.4	0.7	0.5	-0.2	0.8	-0.0	-1.8	-0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.5	-0.4	-0.4	0.6	-1.6	1.1	0.6	-0.8
Number of children fathered	0.5	0.6	1.3	-0.0	0.9	-0.5	0.7	-1.1	-0.3	1.1
Age at first live birth	0.5	0.8	2.3	0.6	1.1	-1.5	0.0	0.7	1.1	0.5
Arm fat percentage (left)	0.5	1.9	3.4	-1.6	1.7	-1.2	1.3	-1.0	-0.3	1.8
Medication: Gliclazide	0.5	0.6	3.0	0.8	0.1	0.4	0.3	-0.1	-1.7	-0.4
Miserableness	0.5	0.9	3.3	-1.2	-0.4	-0.4	0.3	0.0	1.8	1.1
Financial situation satisfaction	0.5	0.6	2.7	-0.0	-0.5	1.0	-0.1	-1.6	0.2	-0.0
Ever depressed for a whole week	0.5	0.6	2.6	-0.4	0.6	1.0	-0.2	-0.5	-1.6	0.1
Pain experienced in last month	0.5	0.8	2.9	-0.2	0.5	-1.5	-0.1	1.7	0.1	-0.3
Supplements: Zinc	0.4	0.4	1.7	-0.6	0.1	0.4	0.6	-1.3	-0.0	0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	1.6	-0.1	-0.4	-0.9	-0.4	1.3	-0.3	-0.8
Trunk fat mass	0.4	1.5	6.5	-2.5	-0.4	0.5	-0.8	-0.1	1.8	0.3
Father’s age at death	0.4	0.5	1.3	-1.1	-0.9	0.1	-0.9	0.2	0.6	-0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.8	-1.2	-1.0	1.1	-0.9	1.1	1.7	-0.3
Noisy workplace	0.4	0.4	1.7	-0.3	0.6	-1.3	0.6	0.3	-0.3	0.7
Mouth/teeth dental problems: Dentures	0.4	0.7	1.8	-1.4	-0.1	-0.6	0.3	-1.2	0.7	0.8
Birth weight of first child	0.4	0.8	2.1	0.0	-0.3	0.4	-1.5	1.2	0.7	-1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	0.8	0.2	0.3	0.1	-1.2	-1.2	0.1
Exposure to tobacco smoke outside home	0.4	0.5	0.9	-0.8	-0.9	0.3	-0.7	-0.0	0.9	-0.8
Mean time to correctly identify matches	0.4	0.8	3.1	-0.1	1.1	-0.9	0.3	1.8	0.4	-0.1
Number of full sisters	0.4	0.5	1.4	-0.6	-0.2	-1.0	0.4	0.9	-0.2	1.2
Leg pain on walking	0.4	0.5	1.4	-0.5	0.1	-0.3	1.2	-0.6	-1.0	0.5
Medication: Aspirin	0.4	0.5	1.5	0.5	1.0	0.4	0.8	0.1	-1.2	0.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	-0.9	-0.5	0.8	-0.1	-1.0	0.7	0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.0	-1.4	-1.2	-0.2	0.1	0.5	-0.3	0.7
Alcohol drinker status: Never	0.4	0.5	1.5	0.0	-0.3	0.8	-0.6	-1.0	0.3	-1.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-0.8	0.8	0.1	0.0	0.9	1.1	0.3
Cholesterol lowering medication	0.4	0.5	1.8	0.8	0.6	0.1	0.7	-0.7	-1.3	0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.8	-0.4	-0.7	0.6	0.5	0.8	-0.1
Reaction Time	0.3	0.5	2.3	-0.3	0.1	-0.1	-0.3	1.5	0.7	-0.5
Allergy or Eczema	0.3	0.9	2.3	0.1	-1.2	0.8	-1.5	-0.3	-0.4	-1.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.6	0.2	0.0	0.8	-0.1	-0.9	0.4
Diabetes (father)	0.3	0.3	1.3	0.8	0.2	-0.1	0.3	0.3	-1.1	0.2
Taking other prescription medications	0.3	0.4	1.3	-0.0	0.3	1.2	0.3	-0.7	-0.4	-0.8
Waist circumference	0.3	1.1	3.0	-0.9	-0.3	1.7	-0.1	-1.5	-1.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.2	0.7	0.6	0.4	0.2	0.2	0.7	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.9	-0.5	-0.8	1.4	-0.7	1.0	1.4	-0.4
Loud music exposure frequency	0.3	0.3	0.9	-0.1	-0.4	0.1	-0.3	0.9	-0.6	-0.8
Whole body fat mass	0.3	1.3	5.1	-2.3	0.7	-0.3	0.5	-0.7	1.1	1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.1	-0.6	-0.7	-0.1	-0.1	0.6	1.1	0.1
Ever had bowel cancer screening	0.3	0.3	1.0	1.0	0.2	0.7	0.1	0.5	-0.6	-0.1
Medication: Aspirin	0.3	0.4	1.1	0.5	1.0	0.4	0.7	0.1	-1.0	-0.2
Ever taken oral contraceptive pill	0.3	0.3	0.8	0.5	0.6	0.2	0.6	-0.4	-0.5	0.9
Unable to work because of sickness or disability	0.3	0.4	1.9	0.5	0.0	-0.2	0.1	0.7	-1.4	-0.1
Alzheimer’s Disease (in mother)	0.2	0.3	0.8	-0.8	-0.1	0.4	-0.9	-0.4	-0.1	-0.2
Heel T-Score	0.2	1.8	5.3	-0.4	0.7	-1.0	2.3	-1.7	-1.6	-0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	0.2	-0.5	0.4	-0.8	0.1	-0.4	-0.9
Trunk fat percentage	0.2	0.7	2.2	-1.5	-0.6	0.7	-1.1	0.2	0.3	-0.9
Financial difficulties in last 2 years	0.2	0.3	1.6	0.1	-0.3	1.3	-0.0	-0.2	-0.5	-0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.7	-0.4	0.3	-0.2	0.3	-0.5	-0.4	0.8
Age at last live birth	0.2	0.3	1.1	0.1	0.4	-0.8	0.0	0.1	1.1	0.2
Supplements: Vitamin C	0.2	0.2	0.6	-0.1	0.4	0.4	0.8	-0.8	0.0	0.4
Average weekly red wine intake	0.2	0.3	0.6	0.6	0.5	-0.4	-0.1	-0.5	0.6	0.8
Osteoporosis (self-reported)	0.2	0.2	0.6	0.1	0.8	-0.5	0.4	0.0	-0.6	0.1
Number of self-reported non-cancer illnesses	0.2	0.3	1.5	0.4	0.3	0.1	0.5	-1.2	0.0	0.2
Commuting to job workplace: Public transport	0.2	0.3	0.4	-0.3	-0.4	0.6	-0.6	-0.7	0.1	-0.6
Supplements: Calcium	0.2	0.2	0.5	-0.1	-0.1	0.7	0.3	-0.0	0.7	0.3
Lupus	0.1	0.2	0.4	-0.6	-0.5	0.6	0.2	0.2	0.6	0.0
Relative age of first facial hair	0.1	0.1	0.4	0.6	0.2	-0.6	0.2	0.3	-0.0	-0.2
Illnesses of siblings	0.1	0.1	0.7	0.8	-0.1	-0.2	-0.3	-0.4	-0.1	-0.2
Asthma	0.1	0.1	0.2	-0.3	-0.5	0.3	-0.3	0.5	0.3	0.0
Lung cancer (father)	0.1	0.1	0.2	0.2	0.1	0.2	-0.5	0.2	-0.1	-0.5
High blood pressure (siblings)	0.1	0.2	0.4	0.1	0.4	0.4	0.6	-0.0	-0.1	0.6
Body fat percentage	0.1	0.3	1.2	-1.1	0.6	-0.2	0.2	-0.5	-0.6	0.3
Asthma (self-reported)	0.1	0.3	0.6	-0.4	-0.8	0.5	-0.6	0.5	0.4	-0.2
Heart disease (siblings)	0.1	0.1	0.3	-0.3	-0.5	0.3	-0.1	-0.3	0.1	-0.5
Hair Pigment	0.0	0.3	1.3	1.1	-0.1	-0.6	0.1	0.4	-0.3	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.2	0.0	-0.2	0.1	-0.4	-0.1	0.1	0.4

Hub : Genes

PBRM1

Models

Trait associations