Best TWAS P=1.13e-20 · Best GWAS P=1.22e-33 conditioned to 1.21e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FNDC3B | 0.07 | 0.06 | enet | 8 | 0.05 | 3.2e-07 | -10.0 | 9.3 | 1.1e-20 | 0.04 | 0.97 | 0.00 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Female) | PLD1 | 0.07 | -0.01 | lasso | 1 | 0.01 | 2.2e-01 | 5.7 | 5.7 | 1.2e-08 | 0.01 | 0.05 | 0.06 | FALSE |
| 3 | GTEx | Ovary | TNFSF10 | 0.40 | 0.01 | lasso | 10 | 0.05 | 1.8e-02 | 1.3 | 7.3 | 2.7e-13 | 0.41 | 0.03 | 0.50 | TRUE |
| 4 | METSIM | Adipose | FNDC3B | 0.09 | 0.08 | lasso | 9 | 0.07 | 5.0e-11 | -3.2 | -5.2 | 2.6e-07 | -0.02 | 1.00 | 0.00 | TRUE |
| 5 | YFS | Blood | TNFSF10 | 0.09 | 0.04 | bslmm | 462 | 0.08 | 1.6e-24 | 7.8 | 7.2 | 5.9e-13 | 0.38 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | FNDC3B | 0.27 | 0.05 | lasso | 6 | 0.08 | 1.8e-03 | 4.1 | -5.7 | 9.1e-09 | -0.67 | 0.03 | 0.58 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FNDC3B | 0.07 | 0.02 | enet | 6 | 0.02 | 3.9e-03 | 8.6 | -8.6 | 1.2e-17 | -0.83 | 0.01 | 0.98 | TRUE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TNFSF10 | 0.17 | 0.11 | lasso | 2 | 0.09 | 6.0e-04 | -5.0 | 5.1 | 2.8e-07 | 0.26 | 0.03 | 0.17 | FALSE |