Best TWAS P=1.75e-11 · Best GWAS P=4.49e-10 conditioned to 0.159
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RER1 | 0.06 | 0.00 | blup | 359 | 0.01 | 8.1e-03 | 1.2 | -5.6 | 1.8e-08 | 0.19 | 0.04 | 0.18 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | SLC35E2 | 0.35 | 0.15 | enet | 24 | 0.17 | 1.0e-20 | -6.2 | 6.0 | 1.9e-09 | -0.82 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Subcutaneous | C1orf86 | 0.15 | 0.05 | enet | 10 | 0.04 | 2.0e-04 | -5.1 | -6.5 | 6.3e-11 | 0.28 | 0.39 | 0.12 | FALSE |
4 | GTEx | Adipose Subcutaneous | RP11-181G12.2 | 0.09 | 0.07 | lasso | 1 | 0.05 | 1.3e-04 | -5.1 | 5.1 | 2.8e-07 | 0.01 | 0.64 | 0.16 | FALSE |
5 | GTEx | Adipose Visceral Omentum | RP11-345P4.6 | 0.40 | 0.24 | enet | 28 | 0.20 | 1.8e-10 | 2.5 | 5.5 | 3.4e-08 | -0.13 | 1.00 | 0.00 | TRUE |
6 | GTEx | Brain Cerebellar Hemisphere | NADK | 0.18 | 0.11 | lasso | 7 | 0.09 | 3.1e-03 | -5.6 | -5.8 | 8.2e-09 | 0.85 | 0.04 | 0.48 | FALSE |
7 | GTEx | Brain Cerebellar Hemisphere | RP5-890O3.9 | 0.24 | 0.02 | lasso | 9 | 0.02 | 1.3e-01 | -6.2 | 6.7 | 1.8e-11 | -0.70 | 0.02 | 0.67 | TRUE |
8 | GTEx | Esophagus Gastroesophageal Junction | RP11-181G12.2 | 0.16 | 0.02 | enet | 18 | 0.01 | 1.1e-01 | 5.9 | 6.0 | 2.1e-09 | 0.06 | 0.05 | 0.58 | TRUE |
9 | GTEx | Esophagus Mucosa | TMEM52 | 0.17 | 0.18 | lasso | 2 | 0.20 | 2.9e-13 | -5.4 | 5.4 | 6.9e-08 | -0.69 | 0.64 | 0.36 | FALSE |
10 | GTEx | Esophagus Muscularis | RP11-181G12.2 | 0.23 | 0.14 | lasso | 4 | 0.19 | 1.0e-11 | 5.1 | 6.0 | 2.6e-09 | 0.04 | 0.38 | 0.62 | FALSE |
11 | GTEx | Lung | NADK | 0.07 | 0.03 | lasso | 3 | 0.02 | 8.5e-03 | 5.2 | -5.8 | 6.2e-09 | 0.73 | 0.07 | 0.80 | FALSE |
12 | GTEx | Lung | AL590822.2 | 0.09 | 0.00 | lasso | 3 | 0.00 | 2.0e-01 | 5.6 | 6.0 | 2.4e-09 | 0.07 | 0.04 | 0.54 | FALSE |
13 | GTEx | Muscle Skeletal | NADK | 0.06 | 0.00 | enet | 9 | 0.00 | 1.3e-01 | -5.6 | -6.0 | 1.7e-09 | 0.73 | 0.10 | 0.68 | FALSE |
14 | GTEx | Muscle Skeletal | C1orf86 | 0.20 | 0.16 | lasso | 4 | 0.15 | 8.0e-15 | -5.1 | -5.3 | 1.3e-07 | -0.01 | 0.87 | 0.13 | FALSE |
15 | GTEx | Muscle Skeletal | TMEM52 | 0.11 | 0.08 | lasso | 6 | 0.10 | 7.2e-10 | -5.7 | 5.7 | 1.5e-08 | -0.77 | 0.27 | 0.73 | FALSE |
16 | GTEx | Muscle Skeletal | RP11-181G12.2 | 0.12 | 0.13 | enet | 8 | 0.14 | 7.6e-14 | -5.1 | 5.4 | 7.2e-08 | 0.04 | 0.86 | 0.14 | FALSE |
17 | GTEx | Nerve Tibial | RP11-181G12.2 | 0.24 | 0.22 | lasso | 5 | 0.21 | 3.7e-15 | -5.1 | 5.4 | 8.2e-08 | 0.01 | 0.87 | 0.13 | FALSE |
18 | GTEx | Skin Not Sun Exposed Suprapubic | TMEM52 | 0.19 | 0.18 | lasso | 4 | 0.14 | 2.6e-08 | 5.2 | 5.6 | 2.3e-08 | -0.67 | 0.08 | 0.92 | FALSE |
19 | GTEx | Skin Sun Exposed Lower leg | TMEM52 | 0.17 | 0.14 | lasso | 7 | 0.15 | 2.0e-12 | 5.8 | 5.9 | 4.6e-09 | -0.68 | 0.09 | 0.91 | FALSE |
20 | METSIM | Adipose | TNFRSF14 | 0.07 | 0.05 | blup | 373 | 0.05 | 1.9e-07 | 3.2 | 6.0 | 1.8e-09 | -0.05 | 0.98 | 0.00 | TRUE |
21 | ROSMAP | Brain Pre-frontal Cortex | C1orf222 | 0.11 | 0.14 | enet | 18 | 0.14 | 1.8e-17 | -3.8 | 5.6 | 1.9e-08 | -0.65 | 1.00 | 0.00 | FALSE |
22 | ROSMAP | Brain Pre-frontal Cortex | MMP23B | 0.05 | 0.04 | lasso | 2 | 0.03 | 1.9e-04 | -5.1 | -5.1 | 2.8e-07 | 0.85 | 0.08 | 0.90 | FALSE |
23 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM52 | 0.02 | 0.01 | blup | 37 | 0.02 | 6.6e-03 | -5.5 | 5.8 | 6.8e-09 | -0.65 | 0.01 | 0.77 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C1orf86 | 0.03 | 0.02 | blup | 49 | 0.01 | 1.3e-02 | 5.9 | 5.4 | 5.6e-08 | 0.05 | 0.03 | 0.70 | FALSE |
25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC35E2 | 0.03 | 0.00 | blup | 34 | 0.01 | 5.3e-02 | -5.6 | 5.1 | 2.9e-07 | -0.81 | 0.02 | 0.53 | FALSE |