Best TWAS P=6.25e-36 · Best GWAS P=1.79e-60 conditioned to 6.68e-27
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-446E9.1 | 0.07 | 0.00 | lasso | 6 | 0.00 | 6.6e-01 | -7.5 | 8.9 | 6.7e-19 | -0.76 | 0.02 | 0.75 | FALSE |
| 2 | GTEx | Brain Cerebellum | RPS20 | 0.26 | 0.07 | enet | 17 | 0.10 | 5.4e-04 | -10.8 | -9.7 | 2.4e-22 | 0.60 | 0.30 | 0.24 | FALSE |
| 3 | GTEx | Brain Cerebellum | RP11-446E9.1 | 0.15 | 0.05 | lasso | 3 | 0.03 | 3.7e-02 | -7.6 | 7.3 | 2.0e-13 | -0.53 | 0.05 | 0.54 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | RPS20 | 0.41 | 0.05 | lasso | 8 | 0.13 | 3.1e-04 | -8.0 | -7.5 | 4.9e-14 | 0.53 | 0.05 | 0.24 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | LYN | 0.35 | 0.07 | enet | 37 | 0.17 | 4.5e-06 | 11.6 | -5.6 | 2.4e-08 | -0.07 | 0.15 | 0.04 | FALSE |
| 6 | GTEx | Esophagus Muscularis | RPS20 | 0.12 | 0.04 | lasso | 6 | 0.05 | 7.2e-04 | -10.8 | -10.7 | 1.1e-26 | 0.76 | 0.22 | 0.65 | FALSE |
| 7 | GTEx | Muscle Skeletal | RPS20 | 0.07 | 0.09 | lasso | 1 | 0.07 | 1.5e-07 | -7.5 | -7.5 | 8.1e-14 | 0.49 | 0.99 | 0.01 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | RPS20 | 0.18 | 0.03 | enet | 12 | 0.07 | 1.5e-04 | -10.4 | -12.5 | 6.2e-36 | 0.81 | 0.11 | 0.60 | TRUE |
| 9 | GTEx | Stomach | RP11-446E9.1 | 0.12 | 0.08 | lasso | 4 | 0.03 | 1.7e-02 | -6.8 | 6.7 | 1.6e-11 | -0.48 | 0.30 | 0.08 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | RPS20 | 0.24 | 0.20 | lasso | 6 | 0.23 | 3.4e-29 | -9.4 | -8.4 | 4.4e-17 | 0.51 | 1.00 | 0.00 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | RP11-446E9.1 | 0.23 | 0.32 | lasso | 7 | 0.34 | 2.0e-45 | -7.5 | 8.6 | 1.1e-17 | -0.53 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PENK | 0.03 | 0.01 | blup | 40 | 0.03 | 9.1e-04 | -5.5 | -6.1 | 1.3e-09 | -0.01 | 0.02 | 0.77 | TRUE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PENK | 0.03 | 0.04 | enet | 7 | 0.05 | 6.2e-10 | 4.9 | -5.7 | 1.0e-08 | -0.06 | 0.15 | 0.85 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | PENK | 0.11 | 0.13 | lasso | 2 | 0.14 | 2.6e-08 | -5.8 | -6.0 | 2.1e-09 | 0.06 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Esophageal Carcinoma | PENK | 0.35 | 0.21 | enet | 12 | 0.33 | 3.8e-11 | 5.1 | -5.7 | 1.0e-08 | -0.02 | 0.04 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PENK | 0.07 | 0.06 | enet | 8 | 0.08 | 2.4e-09 | -5.3 | -6.0 | 1.5e-09 | 0.04 | 0.02 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS20 | 0.04 | 0.02 | blup | 29 | 0.03 | 4.8e-04 | -9.1 | -8.3 | 1.4e-16 | 0.49 | 0.03 | 0.03 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPS20 | 0.33 | 0.07 | enet | 8 | 0.07 | 1.7e-08 | -9.4 | -10.6 | 3.8e-26 | 0.49 | 0.96 | 0.03 | FALSE |
| 19 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PENK | 0.23 | 0.15 | lasso | 5 | 0.22 | 8.2e-10 | 4.9 | -5.7 | 1.4e-08 | -0.02 | 0.04 | 0.96 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS20 | 0.04 | 0.03 | lasso | 3 | 0.04 | 1.3e-04 | -9.4 | -9.3 | 1.5e-20 | 0.58 | 0.15 | 0.05 | FALSE |
| 21 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PENK | 0.18 | 0.11 | lasso | 1 | 0.09 | 3.4e-03 | -5.8 | -5.8 | 8.5e-09 | 0.08 | 0.01 | 0.67 | FALSE |
| 22 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PENK | 0.07 | 0.08 | lasso | 2 | 0.06 | 2.0e-05 | -5.3 | -5.3 | 1.2e-07 | 0.11 | 0.02 | 0.98 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | LYN | 0.09 | 0.12 | lasso | 2 | 0.12 | 8.4e-12 | -6.8 | 6.9 | 4.9e-12 | -0.49 | 1.00 | 0.00 | FALSE |