Best TWAS P=1.07e-19 · Best GWAS P=3.23e-21 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C20orf26 | 0.20 | 0.17 | lasso | 6 | 0.18 | 4.9e-21 | -6.3 | 6.2 | 5.8e-10 | -0.06 | 0.40 | 0.60 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | INSM1 | 0.07 | 0.00 | bslmm | 522 | 0.02 | 2.2e-03 | 4.3 | 6.1 | 8.2e-10 | -0.01 | 0.09 | 0.09 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | PLK1S1 | 0.08 | 0.01 | lasso | 3 | 0.04 | 1.1e-05 | 7.8 | 7.3 | 3.4e-13 | 0.82 | 0.02 | 0.98 | FALSE |
4 | GTEx | Artery Tibial | PLK1S1 | 0.07 | 0.08 | enet | 10 | 0.08 | 4.0e-07 | 9.4 | 9.1 | 1.1e-19 | 0.97 | 0.01 | 0.99 | TRUE |
5 | GTEx | Esophagus Mucosa | PLK1S1 | 0.11 | 0.11 | lasso | 5 | 0.09 | 7.8e-07 | 7.4 | 7.4 | 1.6e-13 | 0.83 | 0.13 | 0.87 | FALSE |
6 | GTEx | Heart Atrial Appendage | PLK1S1 | 0.15 | -0.01 | lasso | 4 | 0.00 | 6.1e-01 | 1.1 | 6.3 | 3.1e-10 | 0.56 | 0.05 | 0.40 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | PLK1S1 | 0.21 | 0.09 | lasso | 6 | 0.12 | 5.3e-07 | 9.0 | 8.0 | 1.6e-15 | 0.93 | 0.06 | 0.93 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | PLK1S1 | 0.15 | 0.13 | enet | 10 | 0.15 | 3.9e-12 | 7.5 | 7.1 | 1.4e-12 | 0.83 | 0.92 | 0.08 | FALSE |
9 | GTEx | Testis | PLK1S1 | 0.64 | 0.34 | enet | 33 | 0.39 | 1.0e-18 | 7.5 | 7.8 | 8.2e-15 | 0.79 | 0.65 | 0.35 | FALSE |
10 | GTEx | Whole Blood | PLK1S1 | 0.08 | 0.04 | enet | 9 | 0.02 | 4.0e-03 | 7.5 | 8.2 | 3.3e-16 | 0.89 | 0.06 | 0.94 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | NKX2-2 | 0.11 | 0.06 | lasso | 5 | 0.06 | 2.3e-08 | 5.0 | -5.6 | 2.2e-08 | -0.61 | 1.00 | 0.00 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | INSM1 | 0.19 | 0.10 | lasso | 5 | 0.14 | 4.3e-17 | 3.2 | 5.2 | 1.8e-07 | 0.07 | 1.00 | 0.00 | TRUE |
13 | YFS | Blood | CRNKL1 | 0.21 | 0.25 | enet | 18 | 0.27 | 2.3e-89 | -6.4 | -6.2 | 7.4e-10 | 0.03 | 0.34 | 0.66 | FALSE |
14 | YFS | Blood | XRN2 | 0.34 | 0.61 | lasso | 10 | 0.61 | 3.5e-258 | 5.4 | 5.5 | 4.0e-08 | 0.49 | 1.00 | 0.00 | FALSE |
15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLK1S1 | 0.05 | 0.07 | enet | 9 | 0.07 | 5.5e-15 | 7.2 | 7.9 | 3.4e-15 | 0.88 | 0.16 | 0.84 | FALSE |
16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NAA20 | 0.04 | 0.01 | enet | 11 | 0.02 | 7.6e-04 | -6.9 | -5.6 | 2.0e-08 | 0.03 | 0.01 | 0.64 | FALSE |
17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NKX2-2 | 0.02 | 0.03 | lasso | 4 | 0.02 | 1.0e-03 | 5.0 | -5.3 | 1.4e-07 | -0.57 | 0.03 | 0.70 | FALSE |
18 | The Cancer Genome Atlas | Lung Adenocarcinoma | PLK1S1 | 0.04 | 0.03 | blup | 64 | 0.04 | 4.0e-05 | 7.5 | 8.4 | 3.6e-17 | 0.88 | 0.13 | 0.87 | FALSE |
19 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PLK1S1 | 0.09 | 0.02 | blup | 64 | 0.05 | 3.1e-03 | 7.8 | 8.4 | 4.1e-17 | 0.78 | 0.03 | 0.52 | FALSE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLK1S1 | 0.19 | 0.12 | enet | 14 | 0.13 | 4.3e-13 | 7.5 | 7.5 | 5.6e-14 | 0.80 | 0.92 | 0.08 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | PLK1S1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 1.5e-04 | 7.5 | 7.7 | 1.6e-14 | 0.85 | 0.16 | 0.58 | FALSE |