Best TWAS P=1e-12 · Best GWAS P=8.98e-16 conditioned to 1.32e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CRELD1 | 0.46 | 0.16 | enet | 51 | 0.27 | 2.2e-22 | -6.1 | -6.8 | 8.6e-12 | 0.07 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CRELD1 | 0.19 | 0.12 | lasso | 4 | 0.10 | 4.1e-06 | -6.1 | -5.8 | 5.6e-09 | -0.02 | 0.00 | 0.99 | FALSE |
| 3 | GTEx | Artery Aorta | CRELD1 | 0.30 | 0.07 | lasso | 7 | 0.12 | 2.4e-07 | -6.1 | -6.1 | 8.4e-10 | 0.03 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Aorta | RP11-1020A11.1 | 0.15 | 0.01 | lasso | 3 | 0.00 | 4.0e-01 | -6.1 | -6.8 | 1.1e-11 | -0.03 | 0.01 | 0.78 | FALSE |
| 5 | GTEx | Artery Tibial | CRELD1 | 0.43 | 0.15 | enet | 41 | 0.21 | 1.1e-16 | -6.1 | -6.1 | 8.7e-10 | 0.08 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | CRELD1 | 0.25 | 0.19 | lasso | 6 | 0.18 | 2.2e-09 | -6.1 | -5.9 | 2.7e-09 | -0.02 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | CRELD1 | 0.39 | 0.19 | enet | 39 | 0.28 | 4.5e-21 | -6.1 | -7.1 | 1.0e-12 | 0.04 | 0.00 | 1.00 | TRUE |
| 8 | GTEx | Cells Transformed fibroblasts | HRH1 | 0.20 | 0.00 | lasso | 3 | 0.01 | 1.1e-01 | 8.0 | -6.5 | 8.5e-11 | -0.77 | 0.00 | 0.95 | TRUE |
| 9 | GTEx | Cells Transformed fibroblasts | RP11-1020A11.1 | 0.20 | 0.10 | enet | 67 | 0.09 | 1.9e-07 | -6.1 | -6.2 | 7.1e-10 | 0.01 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Esophagus Muscularis | CRELD1 | 0.21 | 0.10 | lasso | 1 | 0.08 | 1.7e-05 | -6.1 | -6.1 | 8.7e-10 | -0.02 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Nerve Tibial | CRELD1 | 0.17 | 0.05 | enet | 9 | 0.13 | 2.0e-09 | -6.1 | -5.2 | 2.1e-07 | 0.04 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | CRELD1 | 0.29 | 0.07 | enet | 25 | 0.13 | 9.7e-08 | -1.4 | -5.1 | 2.8e-07 | 0.04 | 0.04 | 0.94 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | CRELD1 | 0.29 | 0.15 | enet | 36 | 0.23 | 8.2e-19 | -6.1 | -6.3 | 3.8e-10 | 0.04 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Testis | CRELD1 | 0.22 | 0.22 | lasso | 8 | 0.26 | 1.1e-11 | 4.5 | -6.5 | 1.1e-10 | 0.00 | 0.13 | 0.87 | FALSE |
| 15 | METSIM | Adipose | BRK1 | 0.04 | 0.02 | bslmm | 559 | 0.01 | 8.9e-03 | 4.1 | -5.2 | 1.9e-07 | -0.04 | 0.22 | 0.54 | FALSE |
| 16 | METSIM | Adipose | CRELD1 | 0.23 | 0.16 | bslmm | 480 | 0.21 | 3.1e-30 | -6.1 | -5.5 | 2.9e-08 | 0.07 | 0.00 | 1.00 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | AC022007.5 | 0.05 | 0.02 | blup | 515 | 0.03 | 2.8e-04 | 5.5 | 5.1 | 2.9e-07 | 0.02 | 0.10 | 0.90 | FALSE |
| 18 | YFS | Blood | FANCD2 | 0.04 | 0.04 | lasso | 1 | 0.04 | 7.7e-13 | 5.6 | -5.6 | 2.8e-08 | -0.06 | 0.05 | 0.95 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CRELD1 | 0.03 | 0.00 | blup | 49 | 0.01 | 1.4e-02 | -2.5 | -5.2 | 2.4e-07 | 0.05 | 0.01 | 0.11 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC401052 | 0.06 | 0.07 | enet | 6 | 0.06 | 3.5e-07 | 5.6 | -5.5 | 3.3e-08 | -0.05 | 0.01 | 0.99 | FALSE |
| 21 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CRELD1 | 0.12 | 0.01 | enet | 22 | 0.04 | 1.4e-03 | -2.2 | -5.3 | 9.0e-08 | 0.04 | 0.02 | 0.19 | FALSE |