Best TWAS P=7.01e-16 · Best GWAS P=1.03e-12 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NT5DC2 | 0.11 | 0.05 | enet | 22 | 0.04 | 5.0e-06 | 4.4 | -5.7 | 1.4e-08 | -0.47 | 0.32 | 0.62 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | RFT1 | 0.21 | 0.22 | lasso | 3 | 0.22 | 5.7e-26 | 5.7 | 6.1 | 1.0e-09 | 0.43 | 0.96 | 0.04 | FALSE |
3 | GTEx | Adipose Subcutaneous | RFT1 | 0.21 | 0.19 | enet | 24 | 0.17 | 3.7e-14 | 5.7 | 5.6 | 2.4e-08 | 0.33 | 0.96 | 0.04 | FALSE |
4 | GTEx | Adipose Visceral Omentum | RFT1 | 0.16 | 0.15 | enet | 12 | 0.10 | 1.0e-05 | 5.7 | 5.8 | 6.9e-09 | 0.33 | 0.94 | 0.04 | FALSE |
5 | GTEx | Artery Aorta | RFT1 | 0.40 | 0.32 | lasso | 13 | 0.31 | 8.1e-18 | 5.7 | -5.5 | 2.9e-08 | -0.35 | 0.96 | 0.04 | FALSE |
6 | GTEx | Artery Coronary | RFT1 | 0.38 | 0.33 | lasso | 5 | 0.34 | 2.6e-12 | 5.7 | 5.7 | 1.4e-08 | 0.36 | 0.96 | 0.04 | FALSE |
7 | GTEx | Artery Tibial | RFT1 | 0.40 | 0.38 | enet | 22 | 0.40 | 8.2e-33 | 5.7 | 5.3 | 1.2e-07 | 0.30 | 0.96 | 0.04 | FALSE |
8 | GTEx | Breast Mammary Tissue (Male) | RFT1 | 0.23 | 0.12 | enet | 8 | 0.13 | 5.5e-04 | 5.7 | 5.7 | 1.4e-08 | 0.35 | 0.10 | 0.12 | FALSE |
9 | GTEx | Breast Mammary Tissue (Female) | RFT1 | 0.09 | 0.00 | enet | 15 | 0.00 | 2.8e-01 | 5.0 | 6.1 | 9.4e-10 | 0.39 | 0.05 | 0.11 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | RFT1 | 0.22 | 0.21 | enet | 16 | 0.22 | 2.8e-16 | 5.7 | 5.2 | 2.2e-07 | 0.33 | 0.96 | 0.04 | FALSE |
11 | GTEx | Colon Sigmoid | RFT1 | 0.55 | 0.45 | enet | 15 | 0.43 | 1.0e-16 | 5.7 | 5.3 | 9.1e-08 | 0.31 | 0.96 | 0.04 | FALSE |
12 | GTEx | Colon Transverse | RFT1 | 0.30 | 0.27 | enet | 16 | 0.24 | 8.0e-12 | 5.7 | 5.7 | 9.6e-09 | 0.38 | 0.96 | 0.04 | FALSE |
13 | GTEx | Esophagus Mucosa | RFT1 | 0.24 | 0.24 | enet | 10 | 0.22 | 6.2e-15 | 5.7 | 6.6 | 4.4e-11 | 0.50 | 0.96 | 0.04 | FALSE |
14 | GTEx | Lung | RFT1 | 0.24 | 0.23 | enet | 12 | 0.23 | 2.7e-17 | 5.7 | 5.6 | 2.5e-08 | 0.36 | 0.96 | 0.04 | FALSE |
15 | GTEx | Muscle Skeletal | RFT1 | 0.17 | 0.16 | enet | 17 | 0.15 | 3.0e-14 | 5.7 | 6.0 | 2.1e-09 | 0.37 | 0.96 | 0.04 | FALSE |
16 | GTEx | Nerve Tibial | RFT1 | 0.35 | 0.31 | enet | 17 | 0.27 | 1.9e-19 | 5.7 | 6.3 | 3.7e-10 | 0.44 | 0.96 | 0.04 | FALSE |
17 | GTEx | Nerve Tibial | SFMBT1 | 0.21 | 0.10 | enet | 11 | 0.07 | 1.4e-05 | 5.7 | -5.4 | 5.8e-08 | -0.30 | 0.96 | 0.04 | FALSE |
18 | GTEx | Ovary | RFT1 | 0.40 | 0.20 | enet | 29 | 0.17 | 6.6e-05 | 5.1 | 5.6 | 1.9e-08 | 0.47 | 0.33 | 0.20 | FALSE |
19 | GTEx | Pancreas | RFT1 | 0.32 | 0.13 | lasso | 4 | 0.17 | 1.3e-07 | 7.1 | 6.0 | 2.1e-09 | 0.93 | 0.00 | 1.00 | TRUE |
20 | GTEx | Prostate | RFT1 | 0.39 | 0.18 | enet | 17 | 0.24 | 1.1e-06 | 5.7 | 8.0 | 1.8e-15 | 0.68 | 0.09 | 0.85 | TRUE |
21 | GTEx | Skin Not Sun Exposed Suprapubic | GNL3 | 0.07 | 0.06 | lasso | 4 | 0.06 | 4.5e-04 | 4.6 | 6.2 | 6.6e-10 | 0.73 | 0.06 | 0.80 | FALSE |
22 | GTEx | Skin Sun Exposed Lower leg | RFT1 | 0.18 | 0.16 | enet | 7 | 0.13 | 1.1e-10 | 5.7 | 5.7 | 1.2e-08 | 0.35 | 0.96 | 0.04 | FALSE |
23 | GTEx | Small Intestine Terminal Ileum | RFT1 | 0.20 | 0.20 | enet | 19 | 0.11 | 2.2e-03 | 5.7 | 5.2 | 2.4e-07 | 0.32 | 0.23 | 0.12 | FALSE |
24 | GTEx | Spleen | RFT1 | 0.23 | 0.22 | enet | 7 | 0.13 | 3.6e-04 | 5.7 | 5.7 | 1.2e-08 | 0.35 | 0.24 | 0.10 | FALSE |
25 | GTEx | Stomach | RFT1 | 0.23 | 0.03 | enet | 19 | 0.06 | 6.3e-04 | 5.7 | 7.5 | 5.5e-14 | 0.75 | 0.07 | 0.86 | TRUE |
26 | GTEx | Testis | RFT1 | 0.20 | 0.12 | enet | 8 | 0.10 | 2.9e-05 | 5.7 | 5.7 | 1.0e-08 | 0.35 | 0.87 | 0.04 | FALSE |
27 | GTEx | Thyroid | RFT1 | 0.36 | 0.33 | enet | 17 | 0.35 | 2.4e-27 | 5.7 | 5.1 | 3.0e-07 | 0.27 | 0.96 | 0.04 | FALSE |
28 | METSIM | Adipose | RFT1 | 0.13 | 0.19 | lasso | 7 | 0.18 | 7.8e-27 | 5.7 | 5.7 | 1.3e-08 | 0.36 | 0.96 | 0.04 | FALSE |
29 | YFS | Blood | ITIH4 | 0.63 | 0.34 | enet | 95 | 0.50 | 2.9e-192 | 7.0 | -6.1 | 1.4e-09 | -0.57 | 0.01 | 0.99 | FALSE |
30 | YFS | Blood | TMEM110 | 0.11 | 0.08 | lasso | 9 | 0.09 | 3.8e-29 | 5.7 | 6.0 | 2.3e-09 | 0.73 | 0.81 | 0.19 | FALSE |
31 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RFT1 | 0.18 | 0.10 | lasso | 7 | 0.10 | 1.8e-08 | 6.6 | 6.7 | 1.5e-11 | 0.97 | 0.00 | 1.00 | FALSE |
32 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TMEM110 | 0.19 | 0.13 | blup | 59 | 0.13 | 4.2e-11 | 5.9 | 6.8 | 8.5e-12 | 0.84 | 0.10 | 0.90 | FALSE |
33 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GLT8D1 | 0.10 | 0.01 | enet | 7 | 0.03 | 4.4e-06 | 5.6 | 5.6 | 2.1e-08 | 0.45 | 0.00 | 0.96 | TRUE |
34 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RFT1 | 0.10 | 0.08 | enet | 11 | 0.15 | 2.3e-29 | 6.4 | 7.6 | 3.2e-14 | 0.80 | 0.03 | 0.97 | FALSE |
35 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM110 | 0.13 | 0.09 | lasso | 3 | 0.10 | 5.9e-20 | 6.2 | 6.4 | 1.4e-10 | 0.82 | 0.43 | 0.57 | FALSE |
36 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RFT1 | 0.14 | 0.08 | enet | 12 | 0.15 | 5.5e-08 | 6.6 | 7.5 | 4.4e-14 | 0.78 | 0.01 | 0.98 | FALSE |
37 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TMEM110 | 0.24 | 0.09 | blup | 59 | 0.14 | 1.4e-07 | 5.9 | 6.0 | 1.9e-09 | 0.76 | 0.02 | 0.97 | FALSE |
38 | The Cancer Genome Atlas | Colon Adenocarcinoma | RFT1 | 0.10 | 0.05 | enet | 12 | 0.05 | 1.0e-03 | 6.7 | 7.5 | 5.8e-14 | 0.87 | 0.01 | 0.94 | FALSE |
39 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMEM110 | 0.21 | 0.14 | lasso | 3 | 0.13 | 5.1e-08 | 5.2 | 5.2 | 1.9e-07 | 0.64 | 0.22 | 0.78 | FALSE |
40 | The Cancer Genome Atlas | Esophageal Carcinoma | TMEM110 | 0.35 | 0.07 | enet | 18 | 0.21 | 3.2e-07 | 6.2 | 5.7 | 1.4e-08 | 0.72 | 0.05 | 0.86 | FALSE |
41 | The Cancer Genome Atlas | Glioblastoma Multiforme | RFT1 | 0.20 | 0.14 | enet | 11 | 0.09 | 8.8e-04 | 5.7 | 7.1 | 1.6e-12 | 0.63 | 0.12 | 0.47 | FALSE |
42 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RFT1 | 0.14 | 0.10 | lasso | 4 | 0.12 | 8.4e-14 | 5.7 | 7.2 | 7.8e-13 | 0.62 | 0.62 | 0.38 | TRUE |
43 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM110 | 0.27 | 0.10 | blup | 59 | 0.14 | 3.0e-15 | 5.7 | 6.6 | 4.9e-11 | 0.84 | 0.01 | 0.99 | TRUE |
44 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RFT1 | 0.15 | 0.21 | lasso | 8 | 0.22 | 1.4e-24 | 5.7 | 6.5 | 8.8e-11 | 0.49 | 0.62 | 0.38 | FALSE |
45 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM110 | 0.29 | 0.16 | lasso | 6 | 0.17 | 1.8e-18 | 6.1 | 6.4 | 1.9e-10 | 0.78 | 0.47 | 0.53 | FALSE |
46 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RFT1 | 0.24 | 0.12 | lasso | 5 | 0.20 | 1.3e-11 | 6.4 | 7.3 | 2.3e-13 | 0.81 | 0.02 | 0.98 | FALSE |
47 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SPCS1 | 0.28 | 0.04 | lasso | 2 | 0.01 | 4.6e-02 | 5.6 | 5.5 | 4.4e-08 | 0.53 | 0.00 | 0.95 | FALSE |
48 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TMEM110 | 0.21 | 0.10 | lasso | 4 | 0.08 | 2.3e-05 | 5.9 | 6.4 | 1.6e-10 | 0.78 | 0.08 | 0.92 | FALSE |
49 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GLT8D1 | 0.22 | 0.08 | lasso | 1 | 0.07 | 8.5e-09 | 5.6 | 5.6 | 1.7e-08 | 0.54 | 0.00 | 1.00 | FALSE |
50 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NISCH | 0.06 | 0.05 | lasso | 4 | 0.04 | 7.5e-06 | 6.0 | 5.9 | 2.8e-09 | 0.54 | 0.00 | 1.00 | FALSE |
51 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PBRM1 | 0.12 | 0.02 | enet | 7 | 0.04 | 2.1e-05 | 6.0 | 5.2 | 2.3e-07 | 0.51 | 0.00 | 0.99 | FALSE |
52 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RFT1 | 0.22 | 0.28 | enet | 13 | 0.31 | 2.5e-36 | 5.7 | 6.8 | 1.2e-11 | 0.62 | 0.64 | 0.36 | FALSE |
53 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SPCS1 | 0.15 | 0.03 | lasso | 3 | 0.04 | 4.3e-05 | 5.6 | 6.3 | 2.2e-10 | 0.58 | 0.00 | 0.96 | FALSE |
54 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TMEM110 | 0.13 | 0.06 | blup | 59 | 0.08 | 3.3e-09 | 3.2 | 5.8 | 5.1e-09 | 0.67 | 0.78 | 0.22 | FALSE |
55 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RFT1 | 0.31 | 0.07 | blup | 45 | 0.19 | 1.8e-09 | 5.3 | 8.1 | 7.0e-16 | 0.86 | 0.02 | 0.98 | TRUE |
56 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SFMBT1 | 0.17 | 0.08 | lasso | 2 | 0.06 | 5.5e-04 | 6.6 | 6.7 | 2.4e-11 | 0.97 | 0.02 | 0.94 | FALSE |
57 | The Cancer Genome Atlas | Lung Adenocarcinoma | GNL3 | 0.20 | 0.07 | lasso | 3 | 0.07 | 1.0e-08 | 6.0 | 5.4 | 8.5e-08 | 0.54 | 0.00 | 1.00 | FALSE |
58 | The Cancer Genome Atlas | Lung Adenocarcinoma | RFT1 | 0.14 | 0.11 | blup | 45 | 0.11 | 1.9e-12 | 6.4 | 7.2 | 6.6e-13 | 0.92 | 0.01 | 0.99 | FALSE |
59 | The Cancer Genome Atlas | Lung Adenocarcinoma | SPCS1 | 0.11 | 0.00 | blup | 41 | 0.01 | 9.9e-03 | -3.7 | 6.3 | 3.4e-10 | 0.36 | 0.01 | 0.40 | TRUE |
60 | The Cancer Genome Atlas | Lung Adenocarcinoma | TMEM110 | 0.16 | 0.13 | lasso | 3 | 0.12 | 2.1e-14 | 6.2 | 6.2 | 7.1e-10 | 0.76 | 0.41 | 0.59 | FALSE |
61 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RFT1 | 0.07 | 0.03 | enet | 7 | 0.06 | 1.2e-07 | 6.1 | 7.7 | 1.1e-14 | 0.75 | 0.02 | 0.98 | FALSE |
62 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TMEM110 | 0.19 | 0.10 | lasso | 5 | 0.11 | 2.1e-12 | 6.2 | 5.9 | 2.8e-09 | 0.71 | 0.39 | 0.61 | FALSE |
63 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | GLT8D1 | 0.20 | 0.05 | lasso | 1 | 0.04 | 1.0e-03 | 5.6 | 5.6 | 1.7e-08 | 0.54 | 0.00 | 0.97 | FALSE |
64 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RFT1 | 0.21 | 0.10 | lasso | 6 | 0.23 | 1.9e-15 | 6.6 | 7.5 | 9.2e-14 | 0.82 | 0.01 | 0.99 | FALSE |
65 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SPCS1 | 0.28 | 0.08 | lasso | 3 | 0.07 | 1.9e-05 | 4.6 | 5.2 | 2.5e-07 | 0.54 | 0.02 | 0.94 | FALSE |
66 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TMEM110 | 0.20 | 0.13 | blup | 59 | 0.15 | 3.0e-10 | 7.0 | 6.7 | 2.2e-11 | 0.82 | 0.00 | 1.00 | FALSE |
67 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RFT1 | 0.41 | 0.17 | enet | 12 | 0.16 | 2.4e-07 | 5.7 | 7.1 | 1.1e-12 | 0.66 | 0.28 | 0.70 | FALSE |
68 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TMEM110 | 0.36 | 0.05 | blup | 59 | 0.08 | 3.4e-04 | 6.2 | 6.0 | 1.7e-09 | 0.77 | 0.02 | 0.65 | FALSE |
69 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RFT1 | 0.23 | 0.09 | blup | 45 | 0.08 | 3.8e-04 | 5.0 | 6.4 | 1.6e-10 | 0.58 | 0.23 | 0.32 | FALSE |
70 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | TMEM110 | 0.26 | 0.09 | lasso | 4 | 0.09 | 1.6e-04 | 6.0 | 6.0 | 1.8e-09 | 0.74 | 0.15 | 0.68 | FALSE |
71 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RFT1 | 0.18 | 0.09 | blup | 45 | 0.09 | 4.8e-10 | 6.6 | 6.7 | 2.3e-11 | 0.93 | 0.01 | 0.99 | FALSE |
72 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SFMBT1 | 0.27 | 0.07 | lasso | 7 | 0.06 | 2.9e-07 | 6.6 | 6.0 | 1.6e-09 | 0.97 | 0.01 | 0.99 | FALSE |
73 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM110 | 0.20 | 0.06 | blup | 59 | 0.10 | 1.2e-10 | 7.0 | 6.7 | 2.8e-11 | 0.83 | 0.00 | 1.00 | FALSE |
74 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RFT1 | 0.16 | 0.12 | enet | 16 | 0.14 | 1.7e-08 | 6.6 | 7.4 | 1.1e-13 | 0.90 | 0.00 | 0.99 | FALSE |
75 | The Cancer Genome Atlas | Soft Tissue Sarcoma | TMEM110 | 0.12 | 0.07 | blup | 59 | 0.12 | 7.5e-08 | 6.8 | 6.1 | 8.8e-10 | 0.73 | 0.02 | 0.98 | TRUE |
76 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RFT1 | 0.29 | 0.04 | blup | 45 | 0.11 | 8.2e-04 | 6.4 | 7.9 | 3.9e-15 | 0.79 | 0.01 | 0.86 | FALSE |
77 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | TMEM110 | 0.33 | 0.15 | enet | 10 | 0.16 | 4.6e-05 | 6.1 | 5.6 | 2.2e-08 | 0.57 | 0.03 | 0.65 | FALSE |
78 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RFT1 | 0.13 | 0.05 | blup | 45 | 0.10 | 6.9e-08 | 6.6 | 8.1 | 7.3e-16 | 0.85 | 0.01 | 0.99 | FALSE |
79 | The Cancer Genome Atlas | Stomach Adenocarcinoma | TMEM110 | 0.19 | 0.12 | blup | 59 | 0.13 | 1.6e-09 | 6.0 | 6.4 | 1.7e-10 | 0.79 | 0.30 | 0.70 | FALSE |
80 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RFT1 | 0.39 | 0.22 | lasso | 4 | 0.25 | 3.1e-09 | 6.5 | 7.0 | 3.1e-12 | 0.94 | 0.01 | 0.99 | FALSE |
81 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TMEM110 | 0.20 | 0.01 | lasso | 2 | 0.09 | 3.2e-04 | 7.0 | 7.0 | 2.0e-12 | 0.97 | 0.00 | 0.89 | FALSE |
82 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM110 | 0.09 | 0.00 | blup | 59 | 0.02 | 1.0e-02 | 5.2 | 5.4 | 6.9e-08 | 0.60 | 0.02 | 0.21 | FALSE |
83 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RFT1 | 0.29 | 0.15 | blup | 45 | 0.15 | 6.5e-05 | 6.1 | 8.0 | 1.6e-15 | 0.85 | 0.01 | 0.87 | FALSE |