Best TWAS P=4.73e-14 · Best GWAS P=4.59e-14 conditioned to 0.224
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DDX4 | 0.08 | 0.07 | bslmm | 390 | 0.08 | 1.7e-10 | 6.7 | -6.7 | 2.7e-11 | -0.85 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Brain Cerebellum | SLC38A9 | 0.26 | 0.13 | lasso | 4 | 0.10 | 7.4e-04 | 7.2 | 6.9 | 3.9e-12 | 0.84 | 0.03 | 0.94 | FALSE |
| 3 | GTEx | Brain Hippocampus | GZMA | 0.32 | 0.00 | lasso | 6 | 0.02 | 1.3e-01 | 4.7 | 6.5 | 7.3e-11 | 0.37 | 0.08 | 0.21 | TRUE |
| 4 | GTEx | Breast Mammary Tissue (Female) | GPX8 | 0.04 | 0.00 | lasso | 2 | 0.03 | 5.0e-02 | 7.1 | -6.8 | 1.2e-11 | -0.89 | 0.05 | 0.25 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | DDX4 | 0.07 | 0.08 | lasso | 2 | 0.07 | 1.5e-09 | 6.6 | -6.7 | 2.3e-11 | -0.79 | 0.16 | 0.84 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PPAP2A | 0.06 | 0.03 | lasso | 1 | 0.03 | 1.1e-06 | 7.3 | -7.3 | 2.9e-13 | -0.78 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SLC38A9 | 0.04 | 0.02 | enet | 7 | 0.03 | 6.6e-03 | 7.0 | 6.8 | 8.0e-12 | 0.86 | 0.02 | 0.75 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC38A9 | 0.03 | 0.04 | blup | 52 | 0.04 | 2.0e-04 | 7.2 | 7.5 | 4.7e-14 | 0.95 | 0.03 | 0.97 | TRUE |